Bufalin and cinobufagin induce apoptosis of human hepatocellular carcinoma cells via Fas- and mitochondria-mediated pathways

Cancer Science

Volumn 102, Issue 5, 2011, Pages 951-958

  Qi, Fanghua ^a,b   Inagaki, Yoshinori ^a   Gao, Bo ^c   Cui, Xiaoyan ^a   Xu, Huanli ^a   Kokudo, Norihiro ^a   Li, Anyuan ^b   Tang, Wei ^a  

^a UNIVERSITY OF TOKYO   (Japan)

^b SHANDONG PROVINCIAL HOSPITAL AFFILIATED TO SHANDONG UNIVERSITY   (China)

^c Anhui Jinchan Biochemical Co Ltd   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BENZYLOXYCARBONYLASPARTYLGLUTAMYLVALYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLISOLEUCYLGLUTAMYLTHREONYLASPARTYL FLUOROMETHYL KETONE; BENZYLOXYCARBONYLLEUCYLGLUTAMYLHISTIDYLASPARTYL FLUOROMETHYL KETONE; BUFALIN; CASPASE 10; CASPASE 3; CASPASE 8; CASPASE 9; CASPASE INHIBITOR; CINOBUFAGIN; CYTOCHROME C; FAS ANTIGEN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROTEIN BAX; PROTEIN BCL 2; PROTEIN BID;

ANTIGEN EXPRESSION; ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL DESTRUCTION; CELL STRAIN HEPG2; CELL STRUCTURE; CONTROLLED STUDY; ENZYME ACTIVATION; HUMAN; HUMAN CELL; IC 50; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE POTENTIAL; PRIORITY JOURNAL; PROTEIN CLEAVAGE; PROTEIN EXPRESSION; PROTEIN INDUCTION; PROTEIN SECRETION; PROTEIN SYNTHESIS INHIBITION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; BLOTTING, WESTERN; BUFANOLIDES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; HUMANS; LIVER NEOPLASMS; MITOCHONDRIA; SIGNAL TRANSDUCTION;

EID: 79954672344     PISSN: 13479032     EISSN: 13497006     Source Type: Journal    
DOI: 10.1111/j.1349-7006.2011.01900.x     Document Type: Article

References (33)

1. Villanueva A, Minguez B, Forner A, Reig M, Llovet JM. Hepatocellular carcinoma: novel molecular approaches for diagnosis, prognosis, and therapy. Annu Rev Med 2010; 61: 317-28.
2. Aravalli RN, Steer CJ, Cressman EN. Molecular mechanisms of hepatocellular carcinoma. Hepatology 2008; 48: 2047-63.
3. El-Serag HB, Marrero JA, Rudolph L, Reddy KR. Diagnosis and treatment of hepatocellular carcinoma. Gastroenterology 2008; 134: 1752-63.
4. Thomas M. Molecular targeted therapy for hepatocellular carcinoma. J Gastroenterol 2009; 44: 136-41.
5. Tsuchiya M, Kono H, Matsuda M, Fujii H, Rusyn I. Protective effect of Juzen-taiho-to hepatocarcinogenesis is mediated through the inhibition of kupffer cell-induced oxidative stress. Int J Cancer 2008; 123: 2503-11.
6. Zhang Y, Tang X, Liu X, Li F, Lin X. Simultaneous determination of three bufadienolides in rat plasma after intravenous administration of bufadienolides extract by ultra performance liquid chromatography electrospray ionization tandem mass spectrometry. Anal Chim Acta 2008; 610: 224-31.
7. Wang Z, Wen J, Zhang J, Ye M, Guo D. Simultaneous determination of four bufadienolides in human liver by high-performance liquid chromatography. Biomed Chromatogr 2004; 18: 318-22.
8. Chen A, Yu J, Zhang L et al. Microarray and biochemical analysis of bufalin-induced apoptosis of HL-60 cells. Biotechnol Lett 2009; 31: 487-94.
9. Kawazoe N, Watabe M, Masuda Y, Nakajo S, Nakaya K. Tiam1 is involved in the regulation of bufalin-induced apoptosis in human leukemia cells. Oncogene 1999; 18: 2413-21.
10. Watabe M, Ito K, Masuda Y, Nakajo S, Nakaya K. Activation of AP-1 is required for bufalin-induced apoptosis in human leukemia U937 cells. Oncogene 1998; 16: 779-87.
11. Masuda Y, Kawazoe N, Nakajo S, Yoshida T, Kuroiwa Y, Nakaya K. Bufalin induces apoptosis and influences the expression of apoptosis-related genes in human leukemia cells. Leuk Res 1995; 19: 549-56.
12. Yu CH, Kan SF, Pu HF, Jea Chien E, Wang PS. Apoptotic signaling in bufalin- and cinobufagin-treated androgen-dependent and -independent human prostate cancer cells. Cancer Sci 2008; 99: 2467-76.
13. Han KQ, Huang G, Gu W, Su YH, Huang XQ, Ling CQ. Anti-tumor activities and apoptosis-regulated mechanisms of bufalin on the orthotopic transplantation tumor model of human hepatocellular carcinoma in nude mice. World J Gastroenterol 2007; 13: 3374-9.
14. Meng Z, Yang P, Shen Y et al. Pilot study of huachansu in patients with hepatocellular carcinoma, non-small-cell lung cancer, or pancreatic cancer. Cancer 2009; 115: 5309-18.
15. Qi F, Li A, Inagaki Y et al. Antitumor activity of extracts and compounds from the skin of the toad Bufo bufo gargarizans Cantor. Int Immunopharmacol 2010. doi:.
16. Qi FH, Li AY, Lv H et al. Apoptosis-inducing effect of cinobufacini, Bufo bufo gargarizans Cantor skin extract, on human hepatoma cell line BEL-7402. Drug Discov Ther 2008; 2: 339-43.
17. Qi F, Li A, Zhao L et al. Cinobufacini, an aqueous extract from Bufo bufo gargarizans Cantor, induces apoptosis through a mitochondria-mediated pathway in human hepatocellular carcinoma cells. J Ethnopharmacol 2010; 128: 654-61.
18. Wang DL, Qi FH, Xu HL et al. Apoptosis-inducing activity of compounds screened and characterized from cinobufacini by bioassay-guided isolation. Mol Med Report 2010; 3: 717-22.
19. Inagaki Y, Tang W, Zhang L, Du GH, Xu WF, Kokudo N. Novel aminopeptidase N (APN/CD13) inhibitor 24F can suppress invasion of hepatocellular carcinoma cells as well as angiogenesis. Biosci Trends 2010; 4: 56-60.
20. Yan G, Duan RH, Yin K et al. Inhibition of survivin expression to induce the apoptosis of hepatocarcinoma cells by adenovirus-mediated siRNA. Biosci Trends 2008; 2: 88-93.
21. Gross A, McDonnell JM, Korsmeyer SJ. BCL-2 family members and the mitochondria in apoptosis. Genes Dev 1999; 13: 1899-911.
22. Hellbrand EE, Varbiro G. Development of mitochondrial permeability transition inhibitory agents: a novel drug target. Drug Discov Ther 2010; 4: 54-61.
23. 3)-induced apoptosis in human glioblastoma cells. Cancer Sci 2005; 96: 825-33.
24. Yin XM. Bid, a BH3-only multi-functional molecule, is at the cross road of life and death. Gene 2006; 369: 7-19.
25. Xian M, Ito K, Nakazato T et al. Zerumbone, a bioactive sesquiterpene, induces G2/M cell cycle arrest and apoptosis in leukemia cells via a Fas- and mitochondria-mediated pathway. Cancer Sci 2007; 98: 118-26.
26. Debatin KM, Krammer PH. Death receptors in chemotherapy and cancer. Oncogene 2004; 23: 2950-66.
27. Green DR. Apoptotic pathways: ten minutes to dead. Cell 2005; 121: 671-4.
28. Scovassi AI, Poirier GG. Poly (ADP-ribosylation) and apoptosis. Mol Cell Biochem 1999; 199: 125-37.
29. Goto M. Elevation of soluble Fas (APO-1, CD95) ligand in natural aging and Werner syndrome. Biosci Trends 2008; 2: 124-7.
30. Wajant H. The Fas signaling pathway: more than a paradigm. Science 2002; 296: 1635-6.
31. Abd El-Ghany RM, Sharaf NM, Kassem LA, Mahran LG, Heikal OA. Thymoquinone triggers anti-apoptotic signaling targeting death ligand and apoptotic regulators in a model of hepatic ischemia reperfusion injury. Drug Discov Ther 2009; 3: 296-306.
32. Milhas D, Cuvillier O, Therville N et al. Caspase-10 triggers Bid cleavage and caspase cascade activation in FasL-induced apoptosis. J Bio Chem 2006; 280: 19836-42.
33. Roucou X, Montessuit S, Antonsson B, Martinou JC. Bax oligomerization in mitochondrial membranes requires tBid (caspase-8-cleaved Bid) and a mitochondrial protein. Biochem J 2002; 368: 915-21.