Putative roles of retinoblastoma protein in apoptosis

Apoptosis

Volumn 2, Issue 1, 1997, Pages 5-18

  Dou, Q Ping ^a  

^a UNIVERSITY OF PITTSBURGH CANCER INSTITUTE   (United States)

Author keywords

Apoptosis; cdk kinases; Cell cycle; ICE like proteases; Phosphatases; RB

Indexed keywords

EID: 0002187866     PISSN: 13608185     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (98)

1. Pardee AB, Dubrow R, Hamlin JL, Kletzien RF. Animal cell cycle. Ann. Rev Biochem 1978; 47: 715-750.
2. Baserga R. The Biology of cell reproduction. Cambridge, MA (USA): Harvard University Press, 1985: 134-165.
3. 1 events and regulation of cell proliferation. Science 1989; 246: 603-608.
4. Hartwell LH, Kastan MB. Cell cycle control and cancer. Science 1994; 266: 1821-1828.
5. Pardee AB. A restriction point for control of normal animal cell proliferation. Proc Natl Acad Sci USA 1974; 71: 1286-1290.
6. Hollingsworth RE Jr, Chen P-L, Lee W-H. Integration of cell cycle control with transcriptional regulation by the retinoblastoma protein. Curr Opin Cell Biol 1993; 5: 194-200.
7. Wang JYJ, Knudsen ES, Welch PJ. The retinoblastoma tumor suppressor protein. Adv Cancer Res 1994; 64: 25-85.
8. Weinberg RA. The retinoblastoma protein and cell cycle control. Cell 1995; 81: 323-330.
9. Chen P-L, Scully P, Shew J-Y, Wang JYJ, Lee W-H. Phosphorylation of the retinoblastoma gene product is mediated during the cell cycle and cellular differentiation. Cell 1989; 58: 1193-1198.
10. Gu W, Schneider JW, Condorelli G, Kaushal S, Mahdavi V, Nadal-Ginard B. Interaction of myogenic factors and the retinoblastoma protein mediates muscle cell commitment and differentiation. Cell 1993; 72: 309-324.
11. Furukawa Y, DeCaprio JA, Freedman A, et al. Expression and state of phosphorylation of the retinoblastoma susceptibility gene product in cycling and noncycling human hematopoietic cells. Proc Natl Acad Sci USA 1990; 87: 2770-2774.
12. Stein GH, Beeson M, Gordon L. Failure to phosphorylate the retinoblastoma gene product in senescent human fibroblasts. Science 1990; 249: 666-668.
13. Futreal PA, Barrett JC. Failure of senescent cells to phosphorylate the RB protein. Oncogene 1991; 6: 1109-1113.
14. Hunter T, Pines J. Cyclins and cancer II: cyclin D and CDK inhibitors come of age. Cell 1994; 79: 573-582.
15. 1 cyclin-dependent kinases. Genes Dev 1995; 9: 1149-1163.
16. Ludlow JW, Glendening CL, Livingston DM, DeCaprio JA. Specific enzymatic dephospharylation of the retinoblastoma protein. Mol Cell Biol 1993; 13: 367-372.
17. Nevins JR. E2F: a link between the Rb tumor suppressor protein and viral cticoproteins. Science 1992; 258: 424-429.
18. Hinds PW, Mittnacht S, Dulic V, Arnold A, Reed SI, Weinberg RA. Regulation of retinoblastoma protein functions by ectopic expression of human cyclins. Cell 1992; 70: 993-1006.
19. Ewen ME, Sluss HK, Sherr CL, Matsushime H, Kato J-Y, Livingston DM Functional interactions of the retinoblastoma protein with mammalian D-type cyclins. Cell 1993; 73: 487-497.
20. Dou QP, Pardee AB. Transcriptional activation of thymidine kinase, a marker for cell cycle control. Prog Nuc Acid Res Mol Biol 1996; 53: 197-217.
21. Lee EY-HP, Chang C-Y, Hu N, et al. Mice deficient for Rb are nonviable and show defects in neurogenesis and haematopoiesis. Nature 1992; 359: 288-294.
22. Jacks T, Fazeli A Schimitt EM, Bronson RT, Goodell MA, Weinberg RA. Effects of an Rb mutation in the mouse. Nature 1992; 359: 295-300.
23. Clarke AR, Maandag ER, van Roon M, et al. Requirement for a functional Rb-1 gene in murine development. Nature 1992; 359: 328-330.
24. Szekely L, Jiang W-Q, Bulic-Jakus F, et al. Cell type and differentiation dependent heterogeneity in retinoblastoma protein expression in SCID mouse fetuses. Cell Growth Diff 1992; 3: 149-156.
25. Kiyokawa H, Richon VM, Rifkind RA, Marks PA. Suppression of cyclin-dependent kinase 4 during induced differentiation of erythroleukemia cells. Mol Cell Biol 1994; 14: 7195-7203.
26. 1 cyclins D2 and D3 but not D1. Proc Natl Acad Sci USA 1993; 90: 11513-11517.
27. Steinman RA, Hoffman B, Iro A, Guillouf C, Liebermann DA, El-Houseini ME. Induction of p21 (WAF-1/CIP1) during differentiation. Oncogene 1994; 9: 3389-3396.
28. Iavarone A, Garg P, Lasorella A, Hsu J, Israel M. The helix-loop-helix Id-2 enhances cell proliferation and binds to the retinoblastoma protein. Genes Dev 1994; 8: 1270-1284.
29. Goldstein S. Replicative senescence: the human fibroblast comes of age. Science 1990; 249: 1129-1133.
30. Dulic V, Drullinger LF, Lees E, Reed SI, Stein GH. Altered regulation of G1 cyclins in senescent human diploid fibroblasts: accumulation of inactive cyclin E-cdk2 and cyclin D1-cdk2 complexes. Proc Natl Acad Sci USA 1993; 90: 11034-11038.
31. Noda A, Ning Y, Venable SF, Pereira-Smith OM, Smith JR. Cloning of senescent cell-derived inhibitors of DNA synthesis using an expression screen. Exp Cell Res 1994; 211: 90-98.
32. 1 arrest and apoptosis. Proc Natl Acad Sci USA 1995; 92: 9019-9023.
33. An B, Doa QP. Cleavage of retinoblastoma protein during apoptosis: an interleukin 1β-ccnverting enzyme-like protease as candidate. Cancer Res 1996; 56: 438-442.
34. Wang H, Grand RJA, Milner AE, Armitage RJ, Gordon J, Gregory CD. Repression of apoptosis in human B-lymphoma cells by CD40-ligand and Bcl-2: relationship to the cell-cycle and role of the retinoblastoma protein. Oncogene 1996; 13: 373-379.
35. Morana SJ, Wolf CM, Li J, Reynolds JE, Brown MK, Eastman A. The involvement of protein phosphatases in the activation of ICE/CED-3 protease, intracellular acidification, DNA digestion, andapoptosis. J Biol Chem 1996; 271: 18263-18271.
36. Dou QP, An B, Antoku K, Johnson DE. Fas stimulation induces RB dephosphorylation and proteolysis that is blocked by inhibitors of the ICE-like protease family. J Cell Biochem; in press.
37. Fan G, Ma X, Kren BT, Steer C. The retinoblastoma gene product inhibits TGF-β1 induced apoptosis in primary rat hepatocytes and human HuH-7 hepatoma cells. Oncogene 1996; 12: 1909-1919.
38. 1 arrest involves pRB-related proteins and is disrupted by the human papillomavirus 16 E7 oncoprotein. Proc Natl Acad Sci USA 1994; 91: 5320-5324.
39. Demers GW, Foster SA, Halbert CL, Galloway DA. Growth arrest by induction of p53 in DNA damaged keratinocytes is bypassed by human papillomavirus 16 E7. Proc Natl Acad Sci USA 1994; 91: 4382-4386.
40. Peled A, Zipori D, Rotter V. Cooperation between p53-dependent and p53-independent apoptotic pathways in myeloid cells. Cancer Res 1996; 56: 2148-2156.
41. Canman CE, Gilmer TM, Coutts SB, Kastan MB. Growth factor modulation of p53-mediated growth arrest versus apoptosis. Genes Dev 1995; 9: 600-611.
42. Ryan JJ, Danish R, Gottlieb CA, Clarke MF. Cell cycle analysis of p53-induced cell death in mutine erythroleukemia cells. Mol Cell Biol 1993; 13: 711-719.
43. Yonish-Rouach E, Grunwald D, Wilder S, et al. p53-mediated cell death : relationship to cell cycle control. Mol Cell Biol 1993; 13: 1415-1423.
44. Vesdy J, Havlicek L, Strnad M, et al. Inhibition of cyclin-dependent kinases by purine analogues. Eur Biochem 1994; 224: 771-786.
45. 1 between the cyclin D and cyclin E restriction points. Cancer Res 1994; 54: 3136-3139.
46. Shiff SJ, Qiao L, Tsai L-L, Rigas B. Sulindac sulfide, an aspirin-like compound, inhibits proliferation, causes cell cycle quiescence, and induces apoptosis in HT-29 colon adenocarcinoma cells. J Clin Invest 1995; 96: 491-503.
47. Poon RYC, Jiang W, Toyoshima H, Hunter T. Cyclin-dependent kinases are inactivated by a combination of p21 and Thr-14/ Tyr-15 phosphorylation after UV-induced DNA damage. J Biol Chem 1996; 271: 13283-13291.
48. Suganuma M, Fujik H, Furuya-Suguri H, et al. Calyculin A, an inhibitor of protein phosphatases, a potent tumor promoter on CD-1 mouse skin. Cancer Res 1990; 50: 3521-3525.
49. Cohen P, Holmes CFB, Tsukitani Y. Okadaic acid: a new probe for the study of cellular regulation. TIBS 1990; 15: 98-102.
50. An B, Johnson DE, Jin J-R, Antoku K, Dou QP Bcl-2 and CrmA-inhibitable dephosphorylation and cleavage of retinoblastoma protein during etoposide-induced apoptosis. Submitted
51. Thornberry NA, Bull HG, CalaycayJR, et al. A novel heterodimeric cystein protease is required for interleukin-1β processing in monocytes. Nature 1992; 356: 768-774.
52. Miura M, Zhu H, Rotollo R, Hartweig EA, Yuan J. Induction of apoptosis in fibroblasts by IL-1β-converting enzyme, a mammalian homolog of the C. elegans cell death gene ced-3. Cell 1993; 75: 653-660.
53. Ray CA, Black RA, Kronheim SR, et al. Viral inhibition of inflammation: cowpox virus encodes an inhibitor of the interleukin-1β-converting enzyme. Cell 1992; 69: 597-604.
54. Bhalla K, Nayak R, Grant S. Isolation and characterization of deaxycytidine kinase-deficient human promyelocytic leukemic cell line highly resistant to 1-β-D-arabinofuraosylcytosine. Cancer Res 1984; 44: 5029-5037.
55. Dou QP, Lui VWY. Failure to dephosphorylate retinoblastoma protein in drug-resistant cells. Cancer Res 1995; 55: 5222-5225.
56. Ludlow JW, DeCaprio JA, Huang C-M, Lee W-H, Paucha E, Livingston DM. SV40 large T antigen binds preferentially to the underphosphorylated member of the retinoblastoma susceptibility gene product family. Cell 1989; 56: 57-65.
57. Hu Q, Bautista C, Edwards GM, Defeo-Jones D, Jones RE, Harlow E. Antibodies specific for the human retinoblastoma protein identify a family of related polypeptides. Mol Cell Biol 1991; 11: 5792-5799.
58. Fattman CL, Dou QP. Distinct ICE-like proteases mediate cleavage of retinoblastoma protein and poly(ADP-ribose) polymerase during apoptosis. Submitted.
59. Martin SJ, Green DR. Protease activation during apoptosis: death by a thousand cuts? Cell 1995; 82: 349-352.
60. White E. Life, death, and the pursuit of apoptosis. Genes Dev 1996; 10: 1-15.
61. Kaufmann SH. Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note Cancer Res 1989; 49: 5870-5878.
62. Kaufmann SH, Desnoyers S, Ottaviano Y, Davidson NE, Poirier GG. Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis. Cancer Res 1993; 53: 3976-3985.
63. Casciola-Rosen LA, Miller DK, Anhalt GJ, Rosen A. Specific cleavage of the 70-kDa protein component of the U1 small nuclear rebonucleoprotein is a characteristic biochemical feature of apoptotic cell death. J Biol Chem 1994; 269: 30757-30760.
64. Lazebnik YA, Takahashi A, Moir RD, et al. Studies of the lamin proteinase reveal multiple parallel biochemical pathways during apoptotic execution. Proc Natl Acad Sci USA 1995; 92: 9042-9046.
65. Kayalar C, Ord T, Testa MP, Zhong L-T, Bredesen DE. Cleavage of actin by interleukin 1β-converting enzyme to reverse DNase I inhibition. Proc Natl Acad Sci USA 1996; 93: 2234-2238.
66. Wang X, Zelenski NG, Yang J, Sakai J, Brown MS, Goldstein JL. Cleavage of sterol regulatory element binding proteins (SREBPs) by CPP32 during apoptosis. EMBO J 1996; 15: 1012-1020.
67. Song Q, Lees-Miller SP, Kumar S, et al. DNA-dependent protein kinase catalytic subunit: a target for an ICE-like protease in apoptosis. EMBO J 1996; 15: 3238-3246.
68. Lazebnik YA, Kaufmann SH, Desnoyers S, Poirier GG, Earnshaw WC. Cleavage of poly(ADP-ribose) polymerase by a proteinase with properties like ICE. Nature 1994; 371: 346-347.
69. Enari M, Hug H, Nagata S. Involvement of an ICE-like protease in Fas-mediated apoptosis. Nature 1995; 375: 78-81.
70. Tewari M, Quan LT, O'Rourke K, et al. Yama/CPP32β, a mammalian homolog of CED-3, is a CrmA-inhibitable protease that cleaves the death substrate poly(ADP-ribose) polymerase. Cell 1995; 81: 801-809.
71. Browne SJ, Williams AC, Hague A, Butt AJ, Paraskeva C. Loss of APC protein expressed by human colonic epithelial cells and the appearance of a specific low-molecular-weight form is associated with apoptosis in vitro. Int J Cancer 1994; 59: 56-64.
72. An B, Jin J-R, Lin P, Dou QP. Failure to activate interleukin 1β-converting enzyme-like proteases and to cleave retinoblastoma protein in drug-resistant cells. FEBS Letters 1996; 399: 153-162..
73. Hass-Kogan DA, Kogan SC, Levi D, et al. Inhibition of apoptosis by the retinoblastoma gene product. EMBO J 1995; 14: 461-472.
74. Haupt Y, Rowan S, Oren M. p53-mediated apoptosis in Hela cells can be overcome by excess pRB. Oncogene 1995; 10: 1563-1571.
75. Berry DE, Lu Y, Schmidt B, et al. Retinoblastoma protein inhibits IFN-γ induced apoptosis. Oncogene 1996; 12: 1809-1819.
76. Kranenburg O, van der Eb AJ, Zantema A. Cyclin D1 is an essential mediator of apoptotic neuronal cell death. EMBO J 1996; 15: 46-54.
77. Qin X-Q, Livingston DM, Kaelin Jr WG, Adams PD. Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis. Proc Natl Acad Sci USA 1994; 91: 10918-10922.
78. Morgenbesser SD, Williams BO, Jacks T, DePinho RA. p53-dependent apoptosis produced by Rb-deficiency in the developing mouse lens. Nature 1994; 371: 72-74.
79. Almasan A, Yin Y, Kelly RE, et al. Deficiency of retinoblastoma protein leads to inappropriate S-phase entry activation of E2F-responsive genes, and apcptosis. Proc Natl Acad Sci USA 1995; 92: 5436-5440.
80. Shenk T, Flint J. Transcriptional and transforming activities of the adenovirus E1A proteins. ADv Cancer Res 1991; 57: 47-85.
81. Rao L, Debbas M, Sabbatini P, Hockenbery D, Korsmeyer S, White E. The adenovirus E1A proteins induce apoptosis, which is inhibited by the E1B 19-kDa and Bcl-2 proteins. Proc Natl Acad Sci USA 1992; 89: 7742-7746.
82. White E, Cipriani R, Sabbatini P, Denton A. Adenovirus E1B 19-kilodalton protein overcomes the cytotoxicity of E1A proteins. J Virol 1991; 65: 2968-2978.
83. Howes KA, Ransom N, Papermaster DS, Lasudry JGH, Albert DM, Windle JJ. Apoptosis or retinoblastoma: alternative fates of photoreceptors expressing the HPV-16 E7 gene in the presence or absence of p53. Genes Dev 1994; 8: 1300-1310.
84. Pan H, Griep AE. Altered cell cycle regulation in the lens of HPV-16 E6 or E7 transgenic mice: implications for tumor suppressor gene function in development. Genes Dev 1994; 8: 1285-1299.
85. White AE, Livanos EM, Tlsty TD. Differential disruption of genomic integrity and cell cycle regulation in normal human fibroblasts by the HPV oncoproteins. Genes Dev 1994; 8: 666-677.
86. Janicke RU, Lin XY, Lee FHH, Porter AG. Cyclin D3 sensitizes tumor cells to tumor necrosis factor-induced, c-Myc-dependent apoptosis. Mol Cell Biol 1996; 16: 5245-5253.
87. Wang J, Walsh K. Resistance to apoptosis confered by cdk inhibitors during myocyte differentiation. Science 1996; 273: 359-361.
88. Meikrantz W, Gisselbrecht S, Tam SW, Schlegel R. Activation of cyclin A-dependent protein kinases during apoptosis. Proc Natl Acad Sci USA 1994; 91: 3754-3758.
89. Hoang AT, Cohen KJ, Barrett JF, Bergstrom DA, Dang CV. Participatian of cyclin A in Myc-induced apoptosis. Proc Natl Acad Sci USA 1994; 91: 6875-6879.
90. 34cdc2 activation required for apoptosis. Science 1994; 263: 1143-1145.
91. Shi L, Chen G, He D, Bosc DG, Utchfield DW, Greenberg AH. Grazyme B induces apoptosis and cyclin A-associated cyclin-depsndent kinase activity in all stages of the cell cycle J Immunol 1996; 157: 2381-2385.
92. Meikrantz W, Schlegel R. Suppression of apoptosis by dominant negative mutants of cyclin-depandent protein kinases. J Biol Chem 1996; 271: 10205-10209.
93. Dou QP, An B, Yu C. Activation of cyclin E-dependent kinase by DNA-damage signals during apoptosis. Biochem Biophys Res Commun 1995; 214: 771-780.
94. Wu X, Levine AJ. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci USA 1994; 91: 3602-3606.
95. Shan B, Lee W-H. Deregulated expression of E2F-1 induces S-phase entry and leads to apoptosis. Mol Cell Biol 1994; 14: 8166-8173.
96. Kowalik TF, DeGregori J, Schwarz JK, Nevins JR. E2F1 overexpression in quiescent fibroblasts leads to induction of cellular DNA synthesis and apoptosis. J Virol 1995; 69: 2491-2500.
97. Gajate C, Alonso MT, Schimmang T, Mollinedo F. C-Fos is not essential for apoptosis. Biochem Biophys Res Commun 1996; 218: 267-272.
98. Durfee T, Becherer K, Chen P-L, et al. The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit. Genes Dev 1993; 7: 555-569.