Expression and modulation of LL-37 in normal human keratinocytes, HaCaT cells, and inflammatory skin diseases

Journal of Korean Medical Science

Volumn 20, Issue 4, 2005, Pages 649-654

  Ji, Eun Kim ^a   Beom, Joon Kim ^a   Mi, Sook Jeong ^b   Seong, Jun Seo ^a,c   Myeung, Nam Kim ^a   Chang, Kwun Hong ^a   Byung, In Ro ^a  

^a Chung Ang University   (South Korea)

^b Chung Ang Medical Research Center   (South Korea)

^c Chung Ang University   (South Korea)

Author keywords

CAP18 lipopolysaccharide binding protein: LL 37; Dermatitis, Atopic; HaCaT Cell; Keratinocytes; Psoriasis

Indexed keywords

EID: 24644496354     PISSN: 10118934     EISSN: None     Source Type: Journal    
DOI: 10.3346/jkms.2005.20.4.649     Document Type: Article

References (26)

1. Nizet V, Ohtake T, Lauth X, Trowbridge J, Rudisill J, Dorschner RA, Pestonjamasp V, Piraino V, Huttner K, Gallo RL. Innate antimicrobial peptide protects the skin from invasive bacterial infection. Nature 2001; 414: 454-7.
2. Fulton C, Anderson GM, Zasloff M, Bull R, Quinn AG. Expression of natural peptide antibiotics in human skin. Lancet 1997; 350: 1750-1.
3. Alice LY, Delphin D, Annie VW, Christina PH, Erika VV, Lide L, Tomas G. Human β-defensin-2 production in keratinocytes is regulated by interleukin-1, bacteria, and the state of differentiation. J Invest Dermatol 2002; 118: 27.
4. Murakami M, Ohtake T, Dorschner RA, Gallo RL. Cathelicidin antimicrobial peptides are expressed in salivary glands and saliva. J Den Res 2002; 81: 845-50.
5. Woo JS, Jeong JY, Hwang YJ, Chae SW, Hwang SJ, Lee HM. Expression of cathelicidin in human salivary glands. Arch Otolaryngol Head Neck Surg 2003; 129: 211-4.
6. Park YM. Application of toll-like receptor in dermatological scope. Korean J Invest Dermatol 2003; 10: 1-5.
7. Pivarcsi A, Koreck A, Bodai L, Szell M, Szeg C, Belso N, Kenderessy-Szabo A, Bata-Csorgo Z, Dobozy A, Kemeny L. Differentiation-regulated expression of Toll-like receptors 2 and 4 in HaCaT keratinocytes. Arch Dermatol Res 2004; 296: 120-4.
8. Frohm M, Agerberth B, Ahangari G, Stahle-Backdahl M, Liden S, Wigzell H, Gudmundsson GH. The expression of the gene coding for the antibacterial peptide LL-37 is induced in human keratinocytes during inflammatory disorders. J Biol Chem 1997; 272: 15258-63.
9. Seo SJ, Ahn SW, Hong CK, Ro BI. Expressions of beta-defensins in human keratinocyte cell lines. J Dermatol Sci 2001; 27: 183-91.
10. Gallo RL, Huttner KM. Antimicrobial peptides: an emerging concept in cutaneous biology. J Invest Dermatol 1998; 111: 739-43.
11. Yang D, Chertov O, Bykovskaia SN, Chen Q, Buffo MJ, Shogan J, Anderson M, Schroder JM, Wang VM, Howard OM, Oppenheim JJ. Beta-defensins: linking innate and adaptive immunity through dendritic and T cell CCR6. Science 1999; 286: 525-8.
12. Grossman RM, Krueger J, Yourish D, Granelli-Piperno A, Murphy DP, May LT, Kupper TS, Sehgal PB, Gottlieb AB. Interleukin 6 is expressed in high levels in psoriatic skin and stimulates proliferation of cultured human keratinocytes. Proc Natl Acad Sci USA 1989; 86: 6367-71.
13. Ong PY, Ohtake T, Brandt C, Strickland I, Boguniewicz M, Ganz T, Gallo RL, Leung DY. Endogenous antimicrobial peptides and skin infections in atopic dermatitis. N Eng J Med 2002; 347: 1151-60.
14. Leung DY. Atopic dermatitis: new insights and opportunities for therapeutic intervention. J Allergy Clin Immunol 2000; 105: 860-76.
15. Nizet V, Gallo RL. Cathelicidins and innate defense against invasive bacterial infection. Scand J Infect Dis 2003; 35: 670-6.
16. Murakami M, Ohtake T, Dorschner RA, Schittek B, Garbe C, Gallo RL. Cathelicidin anti-microbial peptide expression in sweat, an innate defense system for the skin. J Invest Dermatol 2002; 119: 1090-5.
17. Zaiou M, Nizet V, Gallo RL. Antimicrobial and protease inhibitory functions of the human cathelicidin (hCAP18/LL-37) prosequence. J Invest Dermatol 2003; 120: 810-6.
18. Dorschner RA, Pestonjamasp VK, Tamakuwala S, Ohtake T, Rudisill J, Nizet V. Cutaneous injury induces the release of cathelicidin antimicrobial peptides active against group A Streptococcus. J Invest Dermatol 2001; 117: 91-7.
19. Larrick JW, Hirata M, Balint RF, Lee J, Zhong K, Wright SC. Human CAP18: a novel antimicrobial lipopolysacharide-binding protein. Infect Immunol 1995; 63: 1291-7.
20. Harder J, Meyer-Hoffert U, Teran LM, Schwichtenberg L, Bartels J, Maune S, Schroder JM. Mucoid Pseudomonas aeruginosa, TNF-alpha, and IL-1beta, but not IL-6, induce human beta-defensin-2 in repiratory epithelia. Am J Respir Cell Mol Biol 2000; 22: 714-21.
21. Koczulla R, Von Degenfeld G, Kupatt C, Krotz F, Zahler S, Gloe T, Issbrucker K, Unterberger P, Zaiou M, Lebherz C, Karl A, Raake P, Prosser A, Boekstegers P, Welsch U, Hiemstra PS, Vogelmeier C, Gallo RL, Clauss M, Bals R. An angiogenic role for the human peptide antibiotic LL-37/hCAP-18. J Clin Invest 2003; 111: 1643-5.
22. Yang D, Chen Q, Schmidt AP, Anderson GM, Wang JM, Wooters J, Oppenheim JJ, Chertov O. LL-37, the neutrophil granule- and epithelial cell-derived cathelicidin, utilizes formyl peptide receptor-like 1(FPRL1) as a receptor to chemoattract human peripheral blood neutrophils, monocytes, and T cells. J Exp Med 2000; 192: 1069-74.
23. Dorschner RA, Lin KH, Murakami M, Gallo RL. Neonatal skin in mice and humans expresses increased levels of antimicrobial peptides: innate immunity during development of the adaptive response. Pediatr Res 2003; 53: 566-72.
24. Zanetti M, Gennaro R, Romeo D. Cathelicidins: a novel protein family with a common proregion and a variable antimicrobial domain. FEBS Lett 1995; 374: 1-5.
25. Harder J, Bartels J, Christophers E, Schroder JM. A peptide antibiotic from human skin. Nature 1997; 387: 861.
26. Kim ST, Chang YS, Cha HE, Kim HB, Hwang YJ, Lee HS. Antimicrobial peptide (LL-37) expression in nasal mucosa. Korean J Otolaryngol-Head Neck Surg 2001; 44: 1048-52.