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Bioorganic and Medicinal Chemistry Letters

Volumn 24, Issue 2, 2014, Pages 649-653

The effect of chain length and unsaturation on Mtb Dxr inhibition and antitubercular killing activity of FR900098 analogs

(10) Jackson, Emily R a San Jose, Géraldine a Brothers, Robert C a Edelstein, Emma K a Sheldon, Zachary a Haymond, Amanda b Johny, Chinchu b Boshoff, Helena I c Couch, Robin D b Dowd, Cynthia S a

a GEORGE WASHINGTON UNIVERSITY (United States)

b GEORGE MASON UNIVERSITY (United States)

c NATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES (United States)

Author keywords

Antibiotic; Dxr; Mycobacterium tuberculosis; Nonmevalonate pathway

Indexed keywords

3 (N ACETYL N HYDROXYAMINO)PROPYLPHOSPHONIC ACID; BACTERIAL PROTEIN; CARBENE; FOSMIDOMYCIN; MYCOBACTERIUM TUBERCULOSIS DXR PROTEIN; TUBERCULOSTATIC AGENT; UNCLASSIFIED DRUG; 1 DEOXY DEXTRO XYLULOSE 5 PHOSPHATE REDUCTOISOMERASE; FR 900098; ISOPRENOID; OXIDOREDUCTASE;

ANTIMICROBIAL ACTIVITY; ARTICLE; DRUG MECHANISM; DRUG POTENCY; DRUG SYNTHESIS; ENZYME INHIBITION; GROWTH INHIBITION; IC 50; LIPOPHILICITY; MINIMUM INHIBITORY CONCENTRATION; MYCOBACTERIUM TUBERCULOSIS; NONHUMAN; STRUCTURE ACTIVITY RELATION; ANTIBACTERIAL ACTIVITY; ANTITUBERCULAR ACTIVITY; ARBUZOV REACTION; BACILLUS SUBTILIS; BACTERICIDAL ACTIVITY; ESCHERICHIA COLI; ESTERIFICATION;

MYCOBACTERIUM TUBERCULOSIS;

ANTIBIOTIC; DXR; MYCOBACTERIUM TUBERCULOSIS; NONMEVALONATE PATHWAY;

ANTITUBERCULAR AGENTS; DRUG RESISTANCE, MULTIPLE, BACTERIAL; FOSFOMYCIN; MICROBIAL SENSITIVITY TESTS; MYCOBACTERIUM TUBERCULOSIS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84891863728 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.11.067 Document Type: Article

Times cited : (27)

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