Identification of a hidden strain switch provides clues to an ancient structural mechanism in protein kinases

Proceedings of the National Academy of Sciences of the United States of America

Volumn 110, Issue 3, 2013, Pages 924-929

  Oruganty, Krishnadev ^a   Talathi, Nakul Suhas ^a   Wood, Zachary A ^a   Kannan, Natarajan ^a,b  

^a University of Georgia ^*  (United States)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Allostery; Conformational strain; DFG flip; Hydrophobic spine; Ramachandran plot

Indexed keywords

ARGININE; ASPARTIC ACID; AURORA A KINASE; PHOSPHATE; PROTEIN KINASE; PROTEIN KINASE INHIBITOR;

ALLOSTERISM; ARTICLE; CATALYSIS; CONTROLLED STUDY; CRYSTAL STRUCTURE; ENZYME ACTIVATION; ENZYME ACTIVE SITE; ENZYME ANALYSIS; ENZYME CONFORMATION; ENZYME MECHANISM; ENZYME PHOSPHORYLATION; ENZYME REGULATION; ENZYME STRUCTURE; EUKARYOTE; GENE MUTATION; GEOMETRY; HYDROGEN BOND; HYDROPHOBICITY; MATHEMATICAL COMPUTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN MOTIF;

AMINO ACID SUBSTITUTION; AURORA KINASES; CATALYSIS; CATALYTIC DOMAIN; CONSERVED SEQUENCE; ENZYME ACTIVATION; EVOLUTION, MOLECULAR; HUMANS; HYDROGEN BONDING; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PHOSPHORYLATION; PROTEIN CONFORMATION; PROTEIN KINASES; PROTEIN-SERINE-THREONINE KINASES;

EUKARYOTA;

EID: 84872581221     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.1207104110     Document Type: Article

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