Effects of biasing the location of stimulus presentation, and the muscarinic cholinergic receptor antagonist scopolamine, on performance of a 5-choice serial reaction time attention task in rats

Behavioural Pharmacology

Volumn 17, Issue 1, 2006, Pages 71-85

  Shannon, Harlan E ^a   Eberle, Elizabeth L ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Attention; Five choice serial reaction time; Metscopolamine; Rat; Scopolamine

Indexed keywords

MUSCARINIC RECEPTOR BLOCKING AGENT; SCOPOLAMINE;

ARTICLE; MALE; MENTAL PERFORMANCE; NONHUMAN; RAT; REACTION TIME; STIMULUS RESPONSE; TASK PERFORMANCE; TRAINING;

ANIMALS; ATTENTION; CHOICE BEHAVIOR; CONDITIONING, OPERANT; INJECTIONS, SUBCUTANEOUS; MALE; MUSCARINIC ANTAGONISTS; N-METHYLSCOPOLAMINE; ORIENTATION; PATTERN RECOGNITION, VISUAL; PREMEDICATION; PROBABILITY LEARNING; RATS; RATS, SPRAGUE-DAWLEY; REACTION TIME; SCOPOLAMINE; SERIAL LEARNING;

EID: 30344471035     PISSN: 09558810     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.fbp.0000189813.54178.e3     Document Type: Article

References (16)

1. Abood LG, Biel JH (1962). Anticholinergic psychotomimetic agents. Int Rev Neurobiol 4:217-273.
2. Anonymous (2000). National Institutes of Health Consensus Development Conference statement: diagnosis and treatment of attention-deficit/hyperactivity disorder (ADHD). J Am Acad Child Adolesc Psychiatry 39: 182-193.
3. Chintoh A, Fulton J, Koziel N, Aziz M, Sud M, Yeomans JS (2003). Role of cholinergic receptors in locomotion induced by scopolamine and oxotremorine-M. Pharmacol Biochem Behav 76:53-61.
4. Folstein MG, Folstein SE, McHugh PR (1975). 'Mini-mental state'. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 12:189-198.
5. Jones DN, Higgins GA (1995). Effect of scopolamine on visual attention in rats. Psychopharmacology 120:142-149.
6. Jones DN, Barnes JC, Kirkby DL, Higgins GA (1995). Age associated impairments in a test of attention: evidence for involvement of cholinergic systems. J Neurosci 15:7282-7292.
7. Joyce EM, Koob GF (1981). Amphetamine, scopolamine and caffeine-induced locomotor activity following 6-hydroxydopamine lesions of the mesolimbic dopamine system. Psychopharmacology 73:311-313.
8. Keefe RSE, Goldberg TE, Harvey PD, Gold JM, Poe MP, Coughenour L (2004). The Brief Assessment of Cognition with a standard neurocognitive battery. Schizophr Res 68:283-297.
9. McKeith IG, Burn D (2000). Spectrum of Parkinson's disease, Parkinson's dementia, and Lewy body dementia. Dementia 18:865-883.
10. Mirza N, Stolerman IP (2000). The role of nicotinic and muscarinic acetylcholine receptors in attention. Psychopharmacology 148:243-250.
11. Muir JL, Everitt BJ, Robbins TW (1994). AMPA-induced excitotoxic lesions of the basal forebrain: a significant role for the cortical cholinergic system in attentional function. J Neurosci 14:2313-2326.
12. Robbins TW (2002). The 5-choice serial reaction time task: behavioural pharmacology and functional neurochemistry. Psychopharmacology 163: 362-380.
13. Robbins TW, Everitt BJ (1995). Arousal systems and attention. In: Gazzinga M, editor. The cognitive neurosciences. Cambridge, Massachusetts: MIT Press. pp. 703-725.
14. Rosvold HE, Mirsky AF, Sarason I, Bransome ED Jr, Beck LH (1956). A continuous performance test of brain damage. J Consult Psychol 20:343-350.
15. Schretlen D, Bobholz JH, Brandt J (1996). Development and psychometric properties of the Brief Test of Attention. Clin Neuropsychol 10: 80-89.
16. Wender PH, Wolf LE, Wasserstein J (2001). Adults with ADHD. An overview. Ann NY Acad Sci 931:1-16.