Production of citrinin-free Monascus pigments by submerged culture at low pH

Enzyme and Microbial Technology

Volumn 55, Issue , 2014, Pages 50-57

  Kang, Biyu ^a,c   Zhang, Xuehong ^b   Wu, Zhenqiang ^c   Wang, Zhilong ^a,b   Park, Sunghoon ^d  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b Shanghai Jiao Tong University   (China)

^c SOUTH CHINA UNIVERSITY OF TECHNOLOGY   (China)

^d Pusan National University   (South Korea)

Author keywords

Citrinin; Monascus pigments; Nitrogen source; PH; Secondary metabolite

Indexed keywords

BIOCHEMISTRY; BIOSYNTHESIS; FERMENTATION; NONIONIC SURFACTANTS; PH;

CITRININ; EXTRACTIVE FERMENTATION; MICROBIAL FERMENTATION; MONASCUS FERMENTATIONS; MONASCUS PIGMENT; MONOSODIUM GLUTAMATE; NITROGEN SOURCES; SECONDARY METABOLITES;

NITROGEN;

AMMONIUM SULFATE; CITRININ; GLUTAMATE SODIUM; NITROGEN; SODIUM NITRATE; TRITON X 100;

ANIMAL CELL; AQUEOUS SOLUTION; ARTICLE; CHEMICAL COMPOSITION; CONTROLLED STUDY; CULTURE MEDIUM; DRUG MANUFACTURE; DRUG SCREENING; DRUG SYNTHESIS; EXTRACTIVE FERMENTATION; FUNGAL STRAIN; MAIZE; MICELLE; MONASCUS; MONASCUS PURPUREUS; NONHUMAN; PH; PIGMENT CELL; SUBMERGED FERMENTATION;

CITRININ; MONASCUS PIGMENTS; NITROGEN SOURCE; PH; SECONDARY METABOLITE;

AMMONIUM SULFATE; CHROMATOGRAPHY, THIN LAYER; CITRININ; CULTURE MEDIA; FERMENTATION; FLOUR; FOOD CONTAMINATION; HYDROGEN-ION CONCENTRATION; MICELLES; MONASCUS; MYCOLOGY; NITRATES; NITROGEN; OCTOXYNOL; PIGMENTS, BIOLOGICAL; SODIUM GLUTAMATE; SOLUTIONS; ZEA MAYS;

EID: 84891785023     PISSN: 01410229     EISSN: 18790909     Source Type: Journal    
DOI: 10.1016/j.enzmictec.2013.12.007     Document Type: Article

References (40)

1. Juzlova P., Martinkova L., Kren V. Secondary metabolites of the fungus Monascus: review. J Ind Microbiol 1996, 6:163-170.
2. Feng Y., Shao Y., Chen F. Monascus pigments. Appl Microbiol Biotechnol 2012, 96:1421-1440.
3. Blanc P.J., Laussac J.P., Bars J.L., Bars P.L., Loret M.O., Pareilleux A., et al. Characterization of monascidin A from Monascus as citrinin. Int J Food Microbiol 1995, 27:201-213.
4. Lee C.-L., Pan T.-M. Development of Monascus fermentation technology for high hypolipidemic effect. Appl Microbiol Biotechnol 2012, 94:1449-1459.
5. Eisenbrand G. Toxicological evaluation of red mould rice. Mol Nutr Food Res 2006, 50:322-327.
6. Mapari S.A.S., Thrane U., Meyer A.S. Fungal polyketide azaphilone pigments as future natural food colorants. Trends Biotechnol 2010, 28:300-307.
7. Tsukahara M., Shinzato N., Tamaki Y., Namihira T., Matsui T. Red yeast rice fermentation by selected Monascus sp. with deep-red color, lovastatin production but no citrinin, and effect of temperature-shift cultivation on lovastatin production. Appl Biochem Biotechnol 2009, 158:476-482.
8. Shimizu T., Kinoshita H., Ishihara S., Sakai K., Nagai S., Nihira T. Polyketide synthase gene responsible for citrinin biosynthesis in Monascus purpureus. Appl Environ Microbiol 2005, 71(7):3453-3457.
9. Sakai K., Kinoshita H., Shimizu T., Nihira T. Construction of a citrinin gene cluster expression system in heterologous Aspergillus oryzae. J Biosci Bioeng 2008, 5:466-472.
10. Chen Y.-P., Tseng C.-P., Chien I.-L., Wang W.-Y., Liaw L.-L., Yuan G.-F. Exploring the distribution of citrinin biosynthesis related genes among Monascus species. J Agric Food Chem 2007, 56:11767-11772.
11. Xu M.-J., Yang Z.-L., Liang Z.-Z., Zhou S.-L. Construction of a Monascus purpureus mutant showing lower citrinin and higher pigment production by replacement of ctnA with pks1 without using vector and resistance gene. J Agric Food Chem 2009, 57:9764-9768.
12. Jia X.Q., Xu Z.N., Zhou L.P., Sung C. Elimination of the mycotoxin citrinin production in the industrial important strain Mona scus purpureus SM001. Metab Eng 2010, 12:1-7.
13. Pastrana L., Loret M.O., Blanc P.J., Goma G. Production of citrinin by Monascus ruber submerged culture in chemically defined media. Acta Biotechnol 1996, 16(4):315-319.
14. Wang J.-J., Lee C.-L., Pan T.-M. Improvement of monacolin K, c-aminobutyric acid and citrinin production ratio as a function of environmental conditions of Monascus purpureus NTU 601. J Ind Microbiol Biotechnol 2003, 30:669-676.
15. Carels M., Hepherd D. The effect of different nitrogen sources on pigment production and sporulation of Monascus species in submerged shaken culture. Can J Microbiol 1977, 23:1360-1372.
16. Wong H.C., Lin Y.C., Koehler P.E. Regulation of growth and pigmentation of Monascus purpureus by carbon and nitrogen concentrations. Mycologia 1981, 73:649-654.
17. Hajjaj H., Blanc P.J., Groussac E., Goma G., Uribelarrea J.L., Loubiere P. Improvement of red pigment/citrinin production ratio as a function of environmental conditions by Monascus rubber. Bioetchnol Bioeng 1999, 64(4):497-501.
18. Lee C.-L., Hung H.-K., Wang J.-J., Pan T.-M. Improving the ratio of Monacolin K to citrinin production of Monascus purpureus NTU 568 under Dioscorea medium through the mediation of pH value and ethanol addition. J Agric Food Chem 2007, 55:6493-6502.
19. Orozco S.F.B., Kilikian B.V. Effect of pH on citrinin and red pigments production by Monascus purpureus CCT3 802. World J Microbiol Biotechnol 2008, 24:263-268.
20. Hu Z., Zhang X., Wu Z., Qi H., Wang Z. Perstraction of intracellular pigments by submerged cultivation of Monascus in nonionic surfactant micelle aqueous solution. Appl Microbiol Biotechnol 2012, 94:81-89.
21. Hu Z., Zhang X., Wu Z., Qi H., Wang Z. Export of intracellular Monascus pigments by two-stage microbial fermentation in nonionic surfactant micelle aqueous solution. J Biotechnol 2012, 162:202-209.
22. Kang B., Zhang X., Wu Z., Qi H., Wang Z. Solubilization capacity of nonionic surfactant micelles strong influence on export of intracellular pigments in Monascus fermentation. Microbiol Biotechnol 2013, 6(5):640-650.
23. Wang Y., Zhang B., Lu L., Huang Y., Xu G. Enhanced production of pigments by addition of surfactants in submerged fermentation of Monascus purpureus H1102. J Sci Food Agric 2013, 93:3339-3344.
24. Kang B., Zhang X., Wu Z., Qi H., Wang Z. Effect of pH and nonionic surfactant on component profile of intracellular and extracellular Monascus pigments. Process Biochem 2013, 48:759-767.
25. Babitha S., Soccol C.R., Pandey A. Effect of stress on growth, pigment production and morphology of Monascus sp. in solid cultures. J Basic Microbiol 2007, 47:118-126.
26. Zheng Y., Xin Y., Guo Y. Study on the fingerprint profile of Monascus products with HPLC-FD, FAD and MS. Food Chem 2009, 113:705-711.
27. Martinkova L., Juzlova P., Vesely D. Biological activity of polyketide pigments produced by the fungus Monascus. J Appl Bacteriol 1995, 79:606-619.
28. Huang Z., Xu Y., Li L., Li Y. Two new Monascus metabolites with strong blue fluorescence isolated from red yeast rice. J Agric Food Chem 2007, 56(1):112-118.
29. Babitha S., Soccol C.R., Pandey A. Jackfruit seed-a novel substrate for the production of Monascus pigments through solid-state fermentation. Food Technol Biotechnol 2006, 44(4):471-645.
30. Wong H.C., Koehler P.E. Production of water-soluble Monascus pigments. J Food Sci 1983, 48(4):1200-1203.
31. Lin T.F., Yakushijin K., Buchi G.H., Demain A.L. Formation of water-soluble Monascus red pigments by biological and semi-synthetic processes. J Ind Microbiol 1992, 9:173-179.
32. Jung H., Kim C., Kim K., Shin C.S. Color characteristics of Monascus pigments derived by fermentation with various amino acids. J Agric Food Chem 2003, 51:1302-1306.
33. Lin W.-Y., Chang J.-Y., Hish C.-H., Pan T.-M. Profiling the Monascus pilosus proteome during nitrogen limitation. J Agric Food Chem 2008, 56:433-441.
34. Arai T., Umemura S., Ota T., Ogihara J., Kasumi T. Effects of inorganic nitrogen sources on the production of PP-V [(10Z)-12-carboxyl-monascrubramine] and the expression of the nitrate assimilation gene cluster by Penicillium sp. AZ. Biosci Biotechnol Biochem 2012, 76(1):120-124.
35. Balakrishnan B., Karki S., Chiu S.-H., Kim H.-J., Suh J.-W., Nam B., et al. Genetic localization and in vivo characterization of a Monascus azaphilone pigments biosynthetic gene cluster. Appl Microbiol Biotechnol 2013, 97:6337-6345.
36. Xie N., Liu Q., Chen F. Deletion of pigR gene in Monascus ruber leads to loss of pigment production. Biotechnol Lett 2013, 35(9):1425-1432.
37. Brakhage A., Schroeckh V. Fungal secondary metabolites-strategies to activate silent gene clusters. Fungal Genet Biol 2011, 48:15-22.
38. Shimizu T., Kinoshita H., Nihira T. Identification and in vivo functional analysis by gene disruption of ctnA: an activator gene involved in citrinin biosynthesis. Appl Environ Microbiol 2007, 73(16):5097-5103.
39. Tilburn J., Sarkar S., Widdick D.A., Espeso E.A., Orejas M., Mungroo J., et al. The Aspergillus PacC zinc finger transcription factor mediates regulation of both acid- and alkaline-expressed genes by ambient pH. EMBO J 1995, 14(4):779-790.
40. Caddick M.X., Brownlee A.G., Arst H.N. Regulation of gene expression by pH of the growth medium in Aspergillus nidulans. Mol Gen Genet 1986, 203:346-353.