Deletion of pigR gene in Monascus ruber leads to loss of pigment production

Biotechnology Letters

Volumn 35, Issue 9, 2013, Pages 1425-1432

  Xie, Nana ^a   Liu, Qingpei ^a   Chen, Fusheng ^a,b  

^a HUAZHONG AGRICULTURAL UNIVERSITY   (China)

^b State Key Laboratory of Agricultural Microbiology   (China)

Author keywords

Biosynthesis; Monascus ruber; Pigment; Regulator; trpC promoter

Indexed keywords

MOLECULAR ANALYSIS; MONASCUS; PIGMENT PRODUCTION; RED PIGMENTS; REGULATOR; TRADITIONAL FOOD; TRPC PROMOTER;

BIOCHEMISTRY; BIOSYNTHESIS; FOOD ADDITIVES; GENES; PIGMENTS;

TRANSCRIPTION;

FOOD DYE; FUNGAL DNA; PIGMENT; TRANSCRIPTION FACTOR;

ARTICLE; BIOSYNTHESIS; CHEMISTRY; DNA SEQUENCE; GENE DELETION; GENE EXPRESSION REGULATION; GENETIC COMPLEMENTATION; GENETICS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; METABOLISM; MOLECULAR GENETICS; MONASCUS; NUCLEOTIDE SEQUENCE; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DNA, FUNGAL; FOOD COLORING AGENTS; GENE DELETION; GENE EXPRESSION REGULATION, FUNGAL; GENETIC COMPLEMENTATION TEST; MOLECULAR SEQUENCE DATA; MONASCUS; PIGMENTS, BIOLOGICAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; SEQUENCE ANALYSIS, DNA; TRANSCRIPTION FACTORS;

EID: 84880995258     PISSN: 01415492     EISSN: 15736776     Source Type: Journal    
DOI: 10.1007/s10529-013-1219-1     Document Type: Article

References (15)

1. Blanc PJ, Laussac JP, Le Bars J, Le Bars P, Loret MO, Pareillieux A, Prome D, Prome JC, Santerre AL, Goma G (1995) Characterization of monascidin A from Monascus as citrinin. Int J Food Microbiol 27: 201-213.
2. Campoy S, Rumbero A, Martí JF, Liras P (2006) Characterization of a hyperpigmenting mutant of Monascus purpureus IB1: identification of two novel pigment chemical structures. Appl Microbiol Biotechnol 70: 488-496.
3. Chen YP, Tseng CP, Liaw LL, Wang CL, Chen I-C, Wu WJ, Wu MD, Yuan GF (2008) Cloning and characterization of monacolin K biosynthetic gene cluster from Monascus pilosus. J Agric Food Chem 56: 5639-5646.
4. Feng Y, Shao Y, Chen F (2012) Monascus pigments. Appl Microbiol Biotechnol 96: 1421-1440.
5. Hajjaj H, Klaébé A, Loret MO, Goma G, Blanc PJ, Francois J (1999) Biosynthetic pathway of citrinin in the filamentous fungus Monascus ruber as revealed by 13C nuclear magnetic resonance. Appl Environ Microbiol 65: 311-314.
6. Hsu LC, Hsu YW, Liang TH, Kuo YH, Pan TM (2011) Anti-tumor and anti-inflammatory properties of ankaflavin and monaphilone A from Monascus purpureus NTU 568. J Agric Food Chem 59: 1124-1130.
7. Li L, Shao Y, Li Q, Yang S, Chen F (2010) Identification of Mga1, a G-protein α-subunit gene involved in regulating citrinin and pigment production in Monascus ruber M7. FEMS Microbiol Lett 308: 108-114.
8. Lin YL, Wang TH, Lee MH, Su NW (2008) Biologically active components and nutraceuticals in the Monascus-fermented rice: a review. Appl Microbiol Biotechnol 77: 965-973.
9. Nimnoi P, Lumyong S (2011) Improving solid-state fermentation of Monascus purpureus on agricultural products for pigment production. Food Bioprocess Technol 4: 1384-1390.
10. Shao Y, Ding Y, Zhao Y, Yang S, Xie B, Chen F (2009) Characteristic analysis of transformants in T-DNA mutation library of Monascusruber. World J Microb Biot 25: 989-995.
11. Shimizu T, Kinoshita H, Ishihara S, Sakai K, Nagai S, Nihira T (2005) Polyketide synthase gene responsible for citrinin biosynthesis in Monascus purpureus. Appl Environ Microb 71: 3453-3457.
12. Shimizu T, Kinoshita H, Nihira T (2007) Identification and in vivo functional analysis by gene disruption of ctnA, an activator gene involved in citrinin biosynthesis in Monascus purpureus. Appl Environ Microb 73: 5097-5103.
13. Yongsmith B, Krairak S, Bavavoda R (1994) Production of yellow pigments in submerged culture of a mutant of Monascus spp. J Fermen Bioeng 78: 223-228.
14. Yu JH, Hamari Z, Han KH, Seo JA, Reyes-Dominguez Y, Scazzocchio C (2004) Double-joint PCR: a PCR-based molecular tool for gene manipulations in filamentous fungi. Fungal Genet Biol 41: 973-981.
15. Zheng Y, Xin Y, Shi X, Guo Y (2010) Anti-cancer effect of rubropunctatin against human gastric carcinoma cells BGC-823. Appl Microbiol Biotechnol 88: 1169-1177.