Caspase-2 promotes cytoskeleton protein degradation during apoptotic cell death

Cell Death and Disease

Volumn 4, Issue 12, 2013, Pages

  Vakifahmetoglu Norberg, H ^a,f   Norberg, E ^a,f,g   Perdomo, A B ^b   Olsson, M ^a   Ciccosanti, F ^b   Orrenius, S ^a   Fimia, G M ^b,c   Piacentini, M ^b,d   Zhivotovsky, B ^a,e  

^a KAROLINSKA INSTITUTE   (Sweden)

^b NATIONAL INSTITUTE FOR INFECTIOUS DISEASES L SPALLANZANI   (Italy)

^c UNIVERSITY OF SALENTO   (Italy)

^d UNIVERSITY OF ROME TOR VERGATA   (Italy)

^e MOSCOW STATE UNIVERSITY   (Russian Federation)

^f HARVARD MEDICAL SCHOOL   (United States)

^g DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

apoptosis; caspase 2; cytoskeleton protein; protein degradation; proteomics

Indexed keywords

CASPASE 2; CYTOSKELETON PROTEIN; PACLITAXEL; PROFILIN; RECOMBINANT SOMATOMEDIN C; SMALL INTERFERING RNA; STATHMIN; THAPSIGARGIN; TROPOMYOSIN; TUNICAMYCIN;

AFFINITY CHROMATOGRAPHY; APOPTOSIS; ARTICLE; CELL DEATH; CELL FRACTIONATION; CELL LYSATE; CONTROLLED STUDY; CYTOFLUOROMETRY; CYTOSKELETON; CYTOSOLIC FRACTION; DNA DAMAGE; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; IN VITRO STUDY; POLYACRYLAMIDE GEL ELECTROPHORESIS; PRIORITY JOURNAL; PROTEIN CONTENT; PROTEIN DEGRADATION; TWO DIMENSIONAL DIFFERENCE GEL ELECTROPHORESIS; UBIQUITINATION; WESTERN BLOTTING;

APOPTOSIS; CASPASE 2; CYSTEINE ENDOPEPTIDASES; CYTOSKELETAL PROTEINS; ELECTROPHORESIS, GEL, TWO-DIMENSIONAL; ENDOPLASMIC RETICULUM STRESS; HCT116 CELLS; HUMANS; PROTEOMICS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; TANDEM MASS SPECTROMETRY;

EID: 84891769542     PISSN: None     EISSN: 20414889     Source Type: Journal    
DOI: 10.1038/cddis.2013.463     Document Type: Article

References (38)

1. Kumar S. Caspase function in programmed cell death. Cell Death Differ 2007; 14: 32-43
2. Lamkanfi M, Festjens N, Declercq W, Vanden Berghe T, Vandenabeele P. Caspases in cell survival, proliferation and differentiation. Cell Death Differ 2007; 14: 44-55
3. Kumar S, Kinoshita M, Noda M, Copeland NG, Jenkins NA. Induction of apoptosis by the mouse Nedd2 gene, which encodes a protein similar to the product of the Caenorhabditis elegans cell death gene ced-3 and the mammalian IL-1 beta-converting enzyme. Genes Dev 1994; 8: 1613-1626
4. Yuan J, Shaham S, Ledoux S, Ellis HM, Horvitz HR. The C. elegans cell death gene ced-3 encodes a protein similar to mammalian interleukin-1 beta-converting enzyme. Cell 1993; 75: 641-652
5. Zhivotovsky B, Orrenius S. Caspase-2 function in response to DNA damage. Biochem Biophys Res Commun 2005; 331: 859-867
6. Ho LH, Read SH, Dorstyn L, Lambrusco L, Kumar S. Caspase-2 is required for cell death induced by cytoskeletal disruption. Oncogene 2008; 27: 3393-3404
7. Nutt LK, Margolis SS, Jensen M, Herman CE, Dunphy WG, Rathmell JC et al. Metabolic regulation of oocyte cell death through the CaMKII-mediated phosphorylation of caspase-2. Cell 2005; 123: 89-103
8. Vakifahmetoglu H, Olsson M, Orrenius S, Zhivotovsky B. Functional connection between p53 and caspase-2 is essential for apoptosis induced by DNA damage. Oncogene 2006; 25: 5683-5692
9. Vakifahmetoglu-Norberg H, Zhivotovsky B. The unpredictable caspase-2: What can it dö Trends Cell Biol 2010; 20: 150-159
10. Kumar S. Caspase 2 in apoptosis, the DNA damage response and tumour suppression: Enigma no more? Nat Rev Cancer 2009; 9: 897-903
11. Baliga BC, Colussi PA, Read SH, Dias MM, Jans DA, Kumar S. Role of prodomain in importin-mediated nuclear localization and activation of caspase-2. J Biol Chem 2003; 278: 4899-4905
12. Butt AJ, Harvey NL, Parasivam G, Kumar S. Dimerization and autoprocessing of the Nedd2 (caspase-2) precursor requires both the prodomain and the carboxyl-Terminal regions. J Biol Chem 1998; 273: 6763-6768
13. Thornberry NA, Rano TA, Peterson EP, Rasper DM, Timkey T, Garcia-Calvo M et al. A combinatorial approach defines specificities of members of the caspase family and granzyme B. Functional relationships established for key mediators of apoptosis. J Biol Chem 1997; 272: 17907-17911
14. Talanian RV, Quinlan C, Trautz S, Hackett MC, Mankovich JA, Banach D et al. Substrate specificities of caspase family proteases. J Biol Chem 1997; 272: 9677-9682
15. Mancini M, Machamer CE, Roy S, Nicholson DW, Thornberry NA, Casciola-Rosen LA et al. Caspase-2 is localized at the Golgi complex and cleaves golgin-160 during apoptosis. J Cell Biol 2000; 149: 603-612
16. Rotter B, Kroviarski Y, Nicolas G, Dhermy D, Lecomte MC. AlphaII-spectrin is an in vitro target for caspase-2, and its cleavage is regulated by calmodulin binding. Biochem J 2004; 378(Pt 1): 161-168
17. Panaretakis T, Laane E, Pokrovskaja K, Bjorklund AC, Moustakas A, Zhivotovsky B et al. Doxorubicin requires the sequential activation of caspase-2, protein kinase Cdelta, and c-Jun NH2-Terminal kinase to induce apoptosis. Mol Biol Cell 2005; 16: 3821-3831
18. Luo X, Budihardjo I, Zou H, Slaughter C, Wang X. Bid, a Bcl2 interacting protein, mediates cytochrome c release from mitochondria in response to activation of cell surface death receptors. Cell 1998; 94: 481-490
19. Guo Y, Srinivasula SM, Druilhe A, Fernandes-Alnemri T, Alnemri ES. Caspase-2 induces apoptosis by releasing proapoptotic proteins from mitochondria. J Biol Chem 2002; 277: 13430-13437
20. Sakahira H, Enari M, Nagata S. Cleavage of CAD inhibitor in CAD activation and DNA degradation during apoptosis. Nature 1998; 391: 96-99
21. Dahal GR, Karki P, Thapa A, Shahnawaz M, Shin SY, Lee JS et al. Caspase-2 cleaves DNA fragmentation factor (DFF45)/inhibitor of caspase-Activated DNase (ICAD). Arch Biochem Biophys 2007; 468: 134-139
22. Hermel E, Gafni J, Propp SS, Leavitt BR, Wellington CL, Young JE et al. Specific caspase interactions and amplification are involved in selective neuronal vulnerability in Huntington's disease. Cell Death Differ 2004; 11: 424-438
23. Gu Y, Sarnecki C, Aldape RA, Livingston DJ, Su MS. Cleavage of poly(ADP-ribose) polymerase by interleukin-1 beta converting enzyme and its homologs TX and Nedd-2. J Biol Chem 1995; 270: 18715-18718
24. Paroni G, Mizzau M, Henderson C, Del Sal G, Schneider C, Brancolini C. Caspasedependent regulation of histone deacetylase 4 nuclear-cytoplasmic shuttling promotes apoptosis. Mol Biol Cell 2004; 15: 2804-2818
25. Aho S. Plakin proteins are coordinately cleaved during apoptosis but preferentially through the action of different caspases. Exp Dermatol 2004; 13: 700-707
26. Oliver TG, Meylan E, Chang GP, XueW, Burke JR, Humpton TJ et al. Caspase-2-mediated cleavage of Mdm2 creates a p53-induced positive feedback loop. Mol Cell 2011; 43: 57-71
27. Schweizer A, Roschitzki-Voser H, Amstutz P, Briand C, Gulotti-Georgieva M, Prenosil E et al. Inhibition of caspase-2 by a designed ankyrin repeat protein: Specificity, structure, and inhibition mechanism. Structure 2007; 15: 625-636
28. Karki P, Dahal GR, Shin SY, Lee JS, Cho B, Park IS. Efficient cleavage of Bid and procaspase-7 by caspase-2 at lower pH. Protein Pept Lett 2008; 15: 1044-1049
29. Wejda M, Impens F, Takahashi N, Van Damme P, Gevaert K, Vandenabeele P. Degradomics reveals that cleavage specificity profiles of caspase-2 and effector caspases are alike. J Biol Chem 2012; 287: 33983-33995
30. Olsson M, Vakifahmetoglu H, Abruzzo PM, Hogstrand K, Grandien A, Zhivotovsky B. DISC-mediated activation of caspase-2 in DNA damage-induced apoptosis. Oncogene 2009; 28: 1949-1959
31. Mhaidat NM, Thorne RF, de Bock CE, Zhang XD, Hersey P. Melanoma cell sensitivity to docetaxel-induced apoptosis is determined by class III beta-Tubulin levels. FEBS Lett 2008; 582: 267-272
32. Ark M, Ozdemir A, Polat B. Ouabain-induced apoptosis and Rho kinase: A novel caspase-2 cleavage site and fragment of Rock-2. Apoptosis 2010; 15: 1494-1506
33. Kong JY, Rabkin SW. Cytoskeletal actin degradation induced by lovastatin in cardiomyocytes is mediated through caspase-2. Cell Biol Int 2004; 28: 781-790
34. Ndozangue-Touriguine O, Hamelin J, Breard J. Cytoskeleton and apoptosis. Biochem Pharmacol 2008; 76: 11-18
35. Burnett BG, Andrews J, Ranganathan S, Fischbeck KH, Di Prospero NA. Expression of expanded polyglutamine targets profilin for degradation and alters actin dynamics. Neurobiol Dis 2008; 30: 365-374
36. Liu Z, Lu H, Shi H, Du Y, Yu J, Gu S et al. PUMA overexpression induces reactive oxygen species generation and proteasome-mediated stathmin degradation in colorectal cancer cells. Cancer Res 2005; 65: 1647-1654
37. Norberg E, Karlsson M, Korenovska O, Szydlowski S, Silberberg G, Uhlen P et al. Critical role for hyperpolarization-Activated cyclic nucleotide-gated channel 2 in the AIF-mediated apoptosis. EMBO J 2010; 29: 3869-3878
38. Perdomo AB, Ciccosanti F, Iacono OL, Angeletti C, Corazzari M, Daniele N et al. Liver protein profiling in chronic hepatitis C: Identification of potential predictive markers for interferon therapy outcome. J Proteome Res 2012; 11: 717-727