Fluorophore-labeled cyclooxygenase-2 inhibitors for the imaging of cyclooxygenase-2 overexpression in cancer: Synthesis and biological studies

ChemMedChem

Volumn 9, Issue 1, 2014, Pages 109-116

  Bhardwaj, Atul ^a   Kaur, Jatinder ^a   Wuest, Frank ^a   Knaus, Edward E ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

cancer; cyclooxygenases; enzymes; fluorescence; inhibitors; medicinal chemistry

Indexed keywords

2 (4 ISOBUTYLPHENYL)PROPIONIC ACID 2 (7 NITROBENZO[1,2,5]OXADIAZO 4 YLAMINO)ETHYL ESTER; 2 (6 METHOXYNAPHTHALEN 2 YL)PROPIONIC ACID 2 (7 NITROBENZO[1,2,5]OXADIAZOL 4 YLAMINO)ETHYL ESTER; 4 CHLORO 7 NITROBENZOFURAZAN; 4',6 DIAMIDINO 2 PHENYLINDOLE; 7 NITROBENZOFURAZAN; BENZENESULFONAMIDE DERIVATIVE; BENZOFURAN DERIVATIVE; CELECOXIB; CYCLOOXYGENASE 1 INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; ESTER DERIVATIVE; IBUPROFEN; N (7 NITROBENZO[C][1,2,5]OXADIAZOL 4 YL) 4 [5 (4 TOLYL) 3 (TRIFLUOROMETHYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; N [2 [(7 NITROBENZO[C][1,2,5]OXADIAZOL 4 YL)AMINO]ETHYL] 4 [5 (4 TOLYL) 3 (TRIFLUOROMETHYL) 1H PYRAZOL 1 YL]BENZENESULFONAMIDE; NAPROXEN; UNCLASSIFIED DRUG;

ARTICLE; CANCER CELL CULTURE; COLON CANCER; CONTROLLED STUDY; CRYSTAL STRUCTURE; DRUG BINDING SITE; DRUG LABELING; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; FLUORESCENCE IMAGING; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; PHARMACOPHORE; PRIORITY JOURNAL; STUDY;

CANCER; CYCLOOXYGENASES; ENZYMES; FLUORESCENCE; INHIBITORS; MEDICINAL CHEMISTRY;

ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CELL LINE, TUMOR; COLONIC NEOPLASMS; CYCLOOXYGENASE 1; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITORS; CYCLOOXYGENASE INHIBITORS; FLUORESCENT DYES; HCT116 CELLS; HUMANS; IBUPROFEN; MICROSCOPY, CONFOCAL; NAPROXEN; PROTEIN BINDING; PYRAZOLES; SULFONAMIDES;

EID: 84891747080     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300355     Document Type: Article

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