Reduction biodegradable brushed PDMAEMA derivatives synthesized by atom transfer radical polymerization and click chemistry for gene delivery

Acta Biomaterialia

Volumn 9, Issue 8, 2013, Pages 7758-7766

  Liu, Jia ^a   Xu, Yanglin ^b   Yang, Qizhi ^a   Li, Cao ^a,c   Hennink, Wim E ^d   Zhuo, Renxi ^a   Jiang, Xulin ^a  

^a WUHAN UNIVERSITY   (China)

^b Hubei Research Institute of Products Quality Supervision and Inspection   (China)

^c HUBEI UNIVERSITY   (China)

^d UTRECHT UNIVERSITY   (Netherlands)

Author keywords

Bioreducible; Click reaction; Disulfide bond; Polyaspartamide; Polymeric gene vector

Indexed keywords

AMINO ACIDS; BIODEGRADABLE POLYMERS; BIOMOLECULES; COVALENT BONDS; DNA; GENE TRANSFER; GENES; MOLECULAR WEIGHT; REDUCTION; SULFUR COMPOUNDS; SYNTHESIS (CHEMICAL);

BIOREDUCIBLE; CLICK REACTION; DISULPHIDE BONDS; GENE VECTORS; LOW MOLECULAR WEIGHT; PDMAEMA; POLY((2DIMETHYLAMINO)ETHYL METHACRYLATE); POLYASPARTAMIDES; POLYMERIC GENE VECTOR; SYNTHESISED;

ATOM TRANSFER RADICAL POLYMERIZATION;

DITHIOTHREITOL; FUNCTIONAL GROUP; PLASMID DNA; POLYASPARTIC ACID; POLYCATION; POLYETHYLENEIMINE; POLYMER; POLYPEPTIDE; POLY[2 (DIMETHYLAMINO)ETHYL METHACRYLATE]; POLY[[(PROPARGYLCARBAMIC ACID)CYSTAMINE] ALPHA,BETA ASPARTAMIDE; UNCLASSIFIED DRUG; DRUG IMPLANT; METHACRYLIC ACID DERIVATIVE; NYLON; POLY(2-(DIMETHYLAMINO)ETHYL METHACRYLATE); POLY(2 (DIMETHYLAMINO)ETHYL METHACRYLATE);

AGAR GEL ELECTROPHORESIS; ARTICLE; ATOM TRANSFER RADICAL POLYMERIZATION; BIOCOMPATIBILITY; BIODEGRADABILITY; CELLULAR DISTRIBUTION; CLICK CHEMISTRY; CONTROLLED STUDY; CYTOTOXICITY; DISULFIDE BOND; GENE VECTOR; HUMAN; HUMAN CELL; IN VITRO GENE TRANSFER; IN VITRO STUDY; MOLECULAR WEIGHT; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PRIORITY JOURNAL; REDUCTION; SYNTHESIS; ZETA POTENTIAL; ADMINISTRATION AND DOSAGE; BIODEGRADABLE IMPLANT; CHEMISTRY; DIFFUSION; DRUG IMPLANT; GENETIC TRANSFECTION; GENETICS; HEK293 CELL LINE; MATERIALS TESTING; OXIDATION REDUCTION REACTION; PLASMID; PROCEDURES; SURFACE PROPERTY; CELL STRAIN HEK293; METHODOLOGY;

ABSORBABLE IMPLANTS; CLICK CHEMISTRY; DIFFUSION; DRUG IMPLANTS; HEK293 CELLS; HUMANS; MATERIALS TESTING; METHACRYLATES; NYLONS; OXIDATION-REDUCTION; PLASMIDS; POLYMERS; SURFACE PROPERTIES; TRANSFECTION;

EID: 84891712440     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.04.046     Document Type: Article

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