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Volumn 39, Issue 12, 2013, Pages 1969-1979

Control of genetic regulatory networks: Opportunities and challenges

Author keywords

Genetic regulatory network (GRN); Negative feedback; Noise; Positive feedback; Systems biology

Indexed keywords

BIOLOGICAL NETWORKS; CONTROL PROBLEMS; GENETIC REGULATORY NETWORKS; LIFE-SCIENCES; NOISE; PERSONALIZED MEDICINES; SYNTHETIC BIOLOGY; SYSTEMS BIOLOGY;

EID: 84891652779     PISSN: 02544156     EISSN: None     Source Type: Journal    
DOI: 10.3724/SP.J.1004.2013.01969     Document Type: Review
Times cited : (25)

References (106)
  • 1
    • 0037288767 scopus 로고    scopus 로고
    • Systems biology: Integrating technology, biology, and computation
    • Hood L. Systems biology: integrating technology, biology, and computation. Mechanisms of Ageing and Development, 2003, 124(1): 9-16
    • (2003) Mechanisms of Ageing and Development , vol.124 , Issue.1 , pp. 9-16
    • Hood, L.1
  • 2
    • 7444253428 scopus 로고    scopus 로고
    • Systems biology and new technologies enable predictive and preventative medicine
    • Hood L, Health J R, Phelps M E, Lin B Y. Systems biology and new technologies enable predictive and preventative medicine. Science, 2004, 306(5696): 640-643
    • (2004) Science , vol.306 , Issue.5696 , pp. 640-643
    • Hood, L.1    Health, J.R.2    Phelps, M.E.3    Lin, B.Y.4
  • 3
    • 0036500993 scopus 로고    scopus 로고
    • Systems biology: A brief overview
    • Kitano H. Systems biology: a brief overview. Science, 2002, 295(5560): 1662-1664
    • (2002) Science , vol.295 , Issue.5560 , pp. 1662-1664
    • Kitano, H.1
  • 5
    • 52949134588 scopus 로고    scopus 로고
    • Biology from the bottom up
    • Benner S. Biology from the bottom up. Nature, 2008, 452(7188): 692-694
    • (2008) Nature , vol.452 , Issue.7188 , pp. 692-694
    • Benner, S.1
  • 6
    • 19344375343 scopus 로고    scopus 로고
    • The meaning of systems biology
    • Kirschner M W. The meaning of systems biology. Cell, 2005, 121(4): 503-504
    • (2005) Cell , vol.121 , Issue.4 , pp. 503-504
    • Kirschner, M.W.1
  • 8
    • 84888300232 scopus 로고    scopus 로고
    • Systems biology: Its past, present and potential
    • Mendoza E R. Systems biology: its past, present and potential. Philippine Science Letter, 2009, 2(1): 16-34
    • (2009) Philippine Science Letter , vol.2 , Issue.1 , pp. 16-34
    • Mendoza, E.R.1
  • 9
    • 10444264607 scopus 로고    scopus 로고
    • Some new directions in control theory inspired by systems biology
    • Sontag E D. Some new directions in control theory inspired by systems biology. Systems Biology, 2004, 1(1): 9-18
    • (2004) Systems Biology , vol.1 , Issue.1 , pp. 9-18
    • Sontag, E.D.1
  • 10
    • 0029028963 scopus 로고
    • Circuit simulation of genetic networks
    • McAdams H, Shapiro L. Circuit simulation of genetic networks. Science, 1995, 269(5224): 650-656
    • (1995) Science , vol.269 , Issue.5224 , pp. 650-656
    • Mcadams, H.1    Shapiro, L.2
  • 16
    • 84891651266 scopus 로고    scopus 로고
    • Modeling and dynamical behaviors of several circuits in genetic regulatory networks
    • Wuhan University, China
    • Wang Pei. Modeling and Dynamical Behaviors of Several Circuits in Genetic Regulatory Networks [Ph. D. dissertation], Wuhan University, China, 2012
    • (2012)
    • Wang, P.1
  • 17
    • 78650373804 scopus 로고    scopus 로고
    • Network medicine: A network-based approach to human disease
    • Barabási A, Gulbahce N, Loscalzo J. Network medicine: a network-based approach to human disease. Nature Reviews Genetics, 2011, 12(1): 56-68
    • (2011) Nature Reviews Genetics , vol.12 , Issue.1 , pp. 56-68
    • Barabási, A.1    Gulbahce, N.2    Loscalzo, J.3
  • 18
    • 0033782304 scopus 로고    scopus 로고
    • Modeling transcriptional control in gene networks-methods, recent results, and future directions
    • Smolen P, Baxter D A, Byrne J H. Modeling transcriptional control in gene networks-methods, recent results, and future directions. Bulletin of Mathematical Biology, 2000, 62(2): 247-292
    • (2000) Bulletin of Mathematical Biology , vol.62 , Issue.2 , pp. 247-292
    • Smolen, P.1    Baxter, D.A.2    Byrne, J.H.3
  • 19
    • 54249116230 scopus 로고
    • Genetic regulatory mechanisms in the synthesis of proteins
    • Jacob F, Monod J. Genetic regulatory mechanisms in the synthesis of proteins. Journal of Molecular Biology, 1961, 3(3): 318-356
    • (1961) Journal of Molecular Biology , vol.3 , Issue.3 , pp. 318-356
    • Jacob, F.1    Monod, J.2
  • 22
    • 84891642413 scopus 로고
    • Biocybernetics
    • Gu Fan-Ji. Biocybernetics. Chinese Journal of Nature, 1984, 7(10): 757-760
    • (1984) Chinese Journal of Nature , vol.7 , Issue.10 , pp. 757-760
    • Gu, F.-J.1
  • 23
    • 82655172398 scopus 로고    scopus 로고
    • Global relative parameter sensitivities of the feed-forward loops in genetic networks
    • Wang P, Lv J H, Ogorzalek M J. Global relative parameter sensitivities of the feed-forward loops in genetic networks. Neurocomputing, 2012, 78(1): 155-165
    • (2012) Neurocomputing , vol.78 , Issue.1 , pp. 155-165
    • Wang, P.1    Lv, J.H.2    Ogorzalek, M.J.3
  • 24
    • 84873560548 scopus 로고    scopus 로고
    • Global relative input-output sensitivities of the feed-forward loops in genetic networks
    • Hefei, China, USA: IEEE
    • Wang P, Lv J H, Zhang Y H, Ogorzalek M J. Global relative input-output sensitivities of the feed-forward loops in genetic networks. In: Proceedings of the 31st Chinese Control Conference. Hefei, China, USA: IEEE, 2012. 7376-7381
    • (2012) Proceedings of the 31st Chinese Control Conference , pp. 7376-7381
    • Wang, P.1    Lv, J.H.2    Zhang, Y.H.3    Ogorzalek, M.J.4
  • 25
    • 0036207347 scopus 로고    scopus 로고
    • Modeling and simulation of genetic regulatory systems: A literature review
    • de Jong H. Modeling and simulation of genetic regulatory systems: a literature review. Journal of Computational Biology, 2002, 9(1): 67-103
    • (2002) Journal of Computational Biology , vol.9 , Issue.1 , pp. 67-103
    • de Jong, H.1
  • 28
    • 45849093636 scopus 로고    scopus 로고
    • Boolean network model predicts cell cycle sequence of fission yeast
    • Davidich M I, Bornholdt S. Boolean network model predicts cell cycle sequence of fission yeast. PLoS One, 2008, 3(2): e1672
    • (2008) PLoS One , vol.3 , Issue.2
    • Davidich, M.I.1    Bornholdt, S.2
  • 30
    • 0015609281 scopus 로고
    • The logical analysis of continuous, non-linear biochemical control networks
    • Glass L, Kauffman S A. The logical analysis of continuous, non-linear biochemical control networks. Journal of Theoretical Biology, 1973, 39(1): 103-129
    • (1973) Journal of Theoretical Biology , vol.39 , Issue.1 , pp. 103-129
    • Glass, L.1    Kauffman, S.A.2
  • 31
    • 0018168876 scopus 로고
    • Stable oscillations in mathematical models of biological control systems
    • Glass L, Pasternack J S. Stable oscillations in mathematical models of biological control systems. Journal of Mathematical Biology, 1978, 6(3): 207-223
    • (1978) Journal of Mathematical Biology , vol.6 , Issue.3 , pp. 207-223
    • Glass, L.1    Pasternack, J.S.2
  • 32
    • 62349126975 scopus 로고    scopus 로고
    • Hybrid modeling in biochemical systems theory by means of functional petri nets
    • Wu J L, Voit E. Hybrid modeling in biochemical systems theory by means of functional petri nets. Journal of Bioinformatics and Computational Biology, 2009, 7(1): 107-134
    • (2009) Journal of Bioinformatics and Computational Biology , vol.7 , Issue.1 , pp. 107-134
    • Wu, J.L.1    Voit, E.2
  • 34
    • 27144450537 scopus 로고    scopus 로고
    • Less is more in modeling large genetic networks
    • Bornholdt S. Less is more in modeling large genetic networks. Science, 2005, 310(5747): 449-451
    • (2005) Science , vol.310 , Issue.5747 , pp. 449-451
    • Bornholdt, S.1
  • 35
    • 84891650344 scopus 로고    scopus 로고
    • Functions of gene autoregulatory circuits
    • Yuan Zhan-Jiang, Zhang Jia-Jun, Zhou Tian-Shou. Functions of gene autoregulatory circuits. Acta Biophysica Sinica, 2010, 26(6): 457-471
    • (2010) Acta Biophysica Sinica , vol.26 , Issue.6 , pp. 457-471
    • Yuan, Z.-J.1    Zhang, J.-J.2    Zhou, T.-S.3
  • 37
    • 0036578795 scopus 로고    scopus 로고
    • Network motifs in the transcriptional regulation network of Escherichia coli
    • Shen-Orr S, Milo R, Mangan S, Alon U. Network motifs in the transcriptional regulation network of Escherichia coli. Nature Genetics, 2002, 31: 64-68
    • (2002) Nature Genetics , vol.31 , pp. 64-68
    • Shen-Orr, S.1    Milo, R.2    Mangan, S.3    Alon, U.4
  • 39
    • 24144451839 scopus 로고    scopus 로고
    • Noise characteristics of feed forward loops
    • Ghosh B, Karmakar R, Bose I. Noise characteristics of feed forward loops. Physical Biology, 2005, 2(1): 36-45
    • (2005) Physical Biology , vol.2 , Issue.1 , pp. 36-45
    • Ghosh, B.1    Karmakar, R.2    Bose, I.3
  • 40
    • 46849090495 scopus 로고    scopus 로고
    • Robust, tunable biological oscillations from interlinked positive and negative feedback loops
    • Tsai T Y, Choi Y S, Ma W Z, Pomerening J R, Tang C, Ferrell J E Jr. Robust, tunable biological oscillations from interlinked positive and negative feedback loops. Science, 2008, 321(5885): 126-129
    • (2008) Science , vol.321 , Issue.5885 , pp. 126-129
    • Tsai, T.Y.1    Choi, Y.S.2    Ma, W.Z.3    Pomerening, J.R.4    Tang, C.5    Ferrell, Jr.J.E.6
  • 42
    • 38349013623 scopus 로고    scopus 로고
    • Coupled feedback loops form dynamic motifs of cellular networks
    • Kim J R, Yoon Y, Cho K H. Coupled feedback loops form dynamic motifs of cellular networks. Biophysical Journal, 2008, 94(2): 359-365
    • (2008) Biophysical Journal , vol.94 , Issue.2 , pp. 359-365
    • Kim, J.R.1    Yoon, Y.2    Cho, K.H.3
  • 46
    • 78649564171 scopus 로고    scopus 로고
    • Global analysis of phase locking in gene expression during cell cycle: the potential in network modeling
    • Gao S, Hartman J L I V, Carter J L, Hessner M J, Wang X. Global analysis of phase locking in gene expression during cell cycle: the potential in network modeling. BMC Systems Biology, 2010, 4: 167
    • (2010) BMC Systems Biology , vol.4 , pp. 167
    • Gao, S.1    Hartman, J.L.I.V.2    Carter, J.L.3    Hessner, M.J.4    Wang, X.5
  • 47
    • 84867540722 scopus 로고    scopus 로고
    • Inferring topologies of complex networks with hidden variables
    • Wu X,Wang W, Zheng W X. Inferring topologies of complex networks with hidden variables. Physical Review E, 2012, 86: 046106
    • (2012) Physical Review E , vol.86 , pp. 046106
    • Wu, X.1    Wang, W.2    Zheng, W.X.3
  • 49
    • 34249079154 scopus 로고    scopus 로고
    • Network motifs: Theory and experimental approaches
    • Alon U. Network motifs: theory and experimental approaches. Nature Reviews Genetics, 2007, 8(6): 450-461
    • (2007) Nature Reviews Genetics , vol.8 , Issue.6 , pp. 450-461
    • Alon, U.1
  • 50
    • 0242364231 scopus 로고    scopus 로고
    • The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks
    • Mangan S, Zaslaver A, Alon U. The coherent feedforward loop serves as a sign-sensitive delay element in transcription networks. Journal of Molecular Biology, 2003, 334(2): 197-204
    • (2003) Journal of Molecular Biology , vol.334 , Issue.2 , pp. 197-204
    • Mangan, S.1    Zaslaver, A.2    Alon, U.3
  • 51
    • 33746428728 scopus 로고    scopus 로고
    • A coherent feed-forward loop with a SUM input function prolongs flagella expression in Escherichia coli
    • Kalir S, Mangan S, Alon U. A coherent feed-forward loop with a SUM input function prolongs flagella expression in Escherichia coli. Molecular Systems Biology, 2005, 1: 0006
    • (2005) Molecular Systems Biology , vol.1 , pp. 0006
    • Kalir, S.1    Mangan, S.2    Alon, U.3
  • 53
    • 71149099313 scopus 로고    scopus 로고
    • The incoherent feedforward loop can provide fold-change detection in gene regulation
    • Goentoro L, Shoval O, Kirschner M W, Alon U. The incoherent feedforward loop can provide fold-change detection in gene regulation. Molecular Cell, 2009, 36(5): 894-899
    • (2009) Molecular Cell , vol.36 , Issue.5 , pp. 894-899
    • Goentoro, L.1    Shoval, O.2    Kirschner, M.W.3    Alon, U.4
  • 54
    • 27844551326 scopus 로고    scopus 로고
    • Dynamic properties of network motifs contribute to biological network organization
    • Prill R J, Iglesias P A, Levchenko A. Dynamic properties of network motifs contribute to biological network organization. PLoS Biology, 2005, 3: e343
    • (2005) PLoS Biology , vol.3
    • Prill, R.J.1    Iglesias, P.A.2    Levchenko, A.3
  • 55
    • 68749118345 scopus 로고    scopus 로고
    • Defining network topologies that can achieve biochemical adaptation
    • Ma W Z, Trusina A, EI-Samad H, Lim W A, Tang C. Defining network topologies that can achieve biochemical adaptation. Cell, 2009, 138(4): 760-773
    • (2009) Cell , vol.138 , Issue.4 , pp. 760-773
    • Ma, W.Z.1    Trusina, A.2    EI-Samad, H.3    Lim, W.A.4    Tang, C.5
  • 56
    • 77950360497 scopus 로고    scopus 로고
    • Remarks on feedforward circuits, adaptation, and pulse memory
    • Sontag E D. Remarks on feedforward circuits, adaptation, and pulse memory. IET Systems Biology, 2010, 4(1): 39-51
    • (2010) IET Systems Biology , vol.4 , Issue.1 , pp. 39-51
    • Sontag, E.D.1
  • 60
    • 58149232581 scopus 로고    scopus 로고
    • Sensitivity analysis: From model parameters to system behaviour
    • Ingalls B. Sensitivity analysis: from model parameters to system behaviour. Essays in Biochemistry, 2008, 45(1): 177-193
    • (2008) Essays in Biochemistry , vol.45 , Issue.1 , pp. 177-193
    • Ingalls, B.1
  • 61
    • 0004178386 scopus 로고    scopus 로고
    • Beijing: Publishing House of Electronics Industry
    • Khalil H K. Nonlinear Systems (3rd edition). Beijing: Publishing House of Electronics Industry, 2001. 99-102
    • (2001) Nonlinear Systems (3rd Edition) , pp. 99-102
    • Khalil, H.K.1
  • 63
    • 0032406131 scopus 로고    scopus 로고
    • Non-linear optimization of biochemical pathways: Applications to metabolic engineering and parameter estimation
    • Mendes P, Kell D. Non-linear optimization of biochemical pathways: applications to metabolic engineering and parameter estimation. Bioinformatics, 1998, 14(10): 869-883
    • (1998) Bioinformatics , vol.14 , Issue.10 , pp. 869-883
    • Mendes, P.1    Kell, D.2
  • 64
    • 84872673733 scopus 로고    scopus 로고
    • Control of few node genetic regulatory networks
    • Ye Wei-Ming, Lv Bin-Bin, Zhao Chen, Di Zeng-Ru. Control of few node genetic regulatory networks. Acta Physica Sinica, 2013, 62(1): 010507
    • (2013) Acta Physica Sinica , vol.62 , Issue.1 , pp. 010507
    • Ye, W.-M.1    Lv, B.-B.2    Zhao, C.3    Di, Z.-R.4
  • 66
    • 0034688174 scopus 로고    scopus 로고
    • Construction of a genetic toggle switch in Escherichia coli
    • Gardner T S, Cantor C R, Collins J J. Construction of a genetic toggle switch in Escherichia coli. Nature, 2000, 403(6767): 339-342
    • (2000) Nature , vol.403 , Issue.6767 , pp. 339-342
    • Gardner, T.S.1    Cantor, C.R.2    Collins, J.J.3
  • 67
    • 80052953521 scopus 로고    scopus 로고
    • Ultimate boundedness of stochastic Hopfield neural networks with time-varying delays
    • Wan L, Zhou Q H, Wang P. Ultimate boundedness of stochastic Hopfield neural networks with time-varying delays. Neurocomputing, 2011, 74(17): 2967-2971
    • (2011) Neurocomputing , vol.74 , Issue.17 , pp. 2967-2971
    • Wan, L.1    Zhou, Q.H.2    Wang, P.3
  • 68
    • 80054882307 scopus 로고    scopus 로고
    • Ultimate boundedness and an attractor for stochastic Hopfield neural networks with time-varying delays
    • Wan L, Zhou Q H, Wang P. Ultimate boundedness and an attractor for stochastic Hopfield neural networks with time-varying delays. Nonlinear Analysis: Real World Applications, 2012, 13(2): 953-958
    • (2012) Nonlinear Analysis: Real World Applications , vol.13 , Issue.2 , pp. 953-958
    • Wan, L.1    Zhou, Q.H.2    Wang, P.3
  • 69
    • 54949090316 scopus 로고    scopus 로고
    • External stimuli mediate collective rhythms: Artificial control strategies
    • Zhou T S, Zhang J J, Yuan Z J, Xu A L. External stimuli mediate collective rhythms: artificial control strategies. PLoS One, 2007, 2: e231
    • (2007) PLoS One , vol.2
    • Zhou, T.S.1    Zhang, J.J.2    Yuan, Z.J.3    Xu, A.L.4
  • 70
    • 19944377766 scopus 로고    scopus 로고
    • Synchrony in a population of hysteresis-based genetic oscillators
    • Kuznetsov A, Kaern M, Kopell N. Synchrony in a population of hysteresis-based genetic oscillators. SIAM Journal on Applied Mathematics, 2004, 65(2): 392-425
    • (2004) SIAM Journal on Applied Mathematics , vol.65 , Issue.2 , pp. 392-425
    • Kuznetsov, A.1    Kaern, M.2    Kopell, N.3
  • 71
    • 84855793231 scopus 로고    scopus 로고
    • Weak attractor for stochastic Cohen-Grossberg neural networks with delays
    • Wan L, Zhou Q H, Wang P. Weak attractor for stochastic Cohen-Grossberg neural networks with delays. Nonlinear Dynamics, 2012, 67(3): 1753-1759
    • (2012) Nonlinear Dynamics , vol.67 , Issue.3 , pp. 1753-1759
    • Wan, L.1    Zhou, Q.H.2    Wang, P.3
  • 72
    • 2942718723 scopus 로고    scopus 로고
    • Control of stochasticity in Eukaryotic gene expression
    • Raser J M, O'Shea E K. Control of stochasticity in Eukaryotic gene expression. Science, 2004, 304(5678): 1811-1814
    • (2004) Science , vol.304 , Issue.5678 , pp. 1811-1814
    • Raser, J.M.1    O'shea, E.K.2
  • 73
    • 34247893807 scopus 로고    scopus 로고
    • Noise-induced synchronization and clustering in ensembles of uncoupled limit-cycle oscillations
    • Nakao H, Arai K, Kawamura Y. Noise-induced synchronization and clustering in ensembles of uncoupled limit-cycle oscillations. Physical Review Letters, 2007, 98(18): 184101
    • (2007) Physical Review Letters , vol.98 , Issue.18 , pp. 184101
    • Nakao, H.1    Arai, K.2    Kawamura, Y.3
  • 74
    • 0345359924 scopus 로고    scopus 로고
    • A positive-feedback-based bistable "memory module" that governs a cell fate decision
    • Xiong W, Ferrell J E Jr. A positive-feedback-based bistable "memory module" that governs a cell fate decision. Nature, 2003, 426(6965): 460-465
    • (2003) Nature , vol.426 , Issue.6965 , pp. 460-465
    • Xiong, W.1    Ferrell, Jr.J.E.2
  • 76
    • 38749133407 scopus 로고    scopus 로고
    • Noise-induced switches in network systems of the genetic toggle switch
    • Wang J W, Zhang J J, Yuan Z J, Zhou T S. Noise-induced switches in network systems of the genetic toggle switch. BMC Systems Biology, 2007, 1(1): 50
    • (2007) BMC Systems Biology , vol.1 , Issue.1 , pp. 50
    • Wang, J.W.1    Zhang, J.J.2    Yuan, Z.J.3    Zhou, T.S.4
  • 81
    • 80053088982 scopus 로고    scopus 로고
    • Synchronized switching induced by colored noise in the genetic toggle switch systems coupled by quorum sensing mechanism
    • Yantai, China, USA: IEEE
    • Wang P, Lv J H, Maciej O J. Synchronized switching induced by colored noise in the genetic toggle switch systems coupled by quorum sensing mechanism. In: Proceedings of the 30th Chinese Control Conference. Yantai, China, USA: IEEE, 2011. 6605-6609
    • (2011) Proceedings of the 30th Chinese Control Conference , pp. 6605-6609
    • Wang, P.1    Lv, J.H.2    Maciej, O.J.3
  • 82
    • 0001549388 scopus 로고
    • Feedback loops, stability and multistationarity in dynamical systems
    • Plahte E, Mestl T, Omholt S W. Feedback loops, stability and multistationarity in dynamical systems. Journal of Biological Systems, 1995, 3(2): 409-414
    • (1995) Journal of Biological Systems , vol.3 , Issue.2 , pp. 409-414
    • Plahte, E.1    Mestl, T.2    Omholt, S.W.3
  • 83
    • 0001923376 scopus 로고    scopus 로고
    • Necessary conditions for multistationarity and stable periodicity
    • Snoussi E H. Necessary conditions for multistationarity and stable periodicity. Journal of Biological Systems, 1998, 6(1): 3-9
    • (1998) Journal of Biological Systems , vol.6 , Issue.1 , pp. 3-9
    • Snoussi, E.H.1
  • 85
    • 38949194331 scopus 로고    scopus 로고
    • Noise propagation and signaling sensitivity in biological networks: A role for positive feedback
    • Hornung G, Barkai N. Noise propagation and signaling sensitivity in biological networks: a role for positive feedback. PLoS Computational Biology, 2008, 4: e8
    • (2008) PLoS Computational Biology , vol.4
    • Hornung, G.1    Barkai, N.2
  • 86
    • 68949136612 scopus 로고    scopus 로고
    • Interlinking positive and negative feedback loops creates a tunable motif in gene regulatory networks
    • Tian X J, Zhang X P, Liu F, Wang W. Interlinking positive and negative feedback loops creates a tunable motif in gene regulatory networks. Physical Review E, 2009, 80: 011926
    • (2009) Physical Review E , vol.80 , pp. 011926
    • Tian, X.J.1    Zhang, X.P.2    Liu, F.3    Wang, W.4
  • 87
  • 88
    • 34247893962 scopus 로고    scopus 로고
    • Dynamics of a minimal model of interlocked positive and negative feedback loops of transcriptional regulation by cAMP-response element binding proteins
    • Song H, Smolen P, Av-Ron E, Baxter D A, Byrne J H. Dynamics of a minimal model of interlocked positive and negative feedback loops of transcriptional regulation by cAMP-response element binding proteins. Biophysical Journal, 2007, 92(10): 3407-3424
    • (2007) Biophysical Journal , vol.92 , Issue.10 , pp. 3407-3424
    • Song, H.1    Smolen, P.2    Av-Ron, E.3    Baxter, D.A.4    Byrne, J.H.5
  • 90
    • 27144517984 scopus 로고    scopus 로고
    • Interlinked fast and slow positive feedback loops drive reliable cell decisions
    • Brandman O, Ferrell J E Jr, Li R, Meyer T. Interlinked fast and slow positive feedback loops drive reliable cell decisions. Science, 2005, 310(5747): 496-498
    • (2005) Science , vol.310 , Issue.5747 , pp. 496-498
    • Brandman, O.1    Ferrell, Jr.J.E.2    Li, R.3    Meyer, T.4
  • 91
    • 34848860189 scopus 로고    scopus 로고
    • Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling
    • Zhang X P, Cheng Z, Liu F, Wang W. Linking fast and slow positive feedback loops creates an optimal bistable switch in cell signaling. Physical Review E, 2007, 76: 031924
    • (2007) Physical Review E , vol.76 , pp. 031924
    • Zhang, X.P.1    Cheng, Z.2    Liu, F.3    Wang, W.4
  • 92
    • 63549128842 scopus 로고    scopus 로고
    • Dynamics of the interlocked positive feedback loops explaining the robust epigenetic switching in Candida albicans
    • Sriram K, Soliman S, Fages F. Dynamics of the interlocked positive feedback loops explaining the robust epigenetic switching in Candida albicans. Journal of Theoretical Biology, 2009, 258(1): 71-88
    • (2009) Journal of Theoretical Biology , vol.258 , Issue.1 , pp. 71-88
    • Sriram, K.1    Soliman, S.2    Fages, F.3
  • 93
    • 63249118904 scopus 로고    scopus 로고
    • Interlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memory
    • Smolen P, Baxter D A, Byrne J H. Interlinked dual-time feedback loops can enhance robustness to stochasticity and persistence of memory. Physical Review E, 2009, 79: 031902
    • (2009) Physical Review E , vol.79 , pp. 031902
    • Smolen, P.1    Baxter, D.A.2    Byrne, J.H.3
  • 95
    • 79961065557 scopus 로고    scopus 로고
    • Robust network clocks: Design of genetic oscillators as a complex combinatorial optimization problem
    • Kobayashi Y, Shibata T, Kuramoto Y, Mikhailov A S. Robust network clocks: design of genetic oscillators as a complex combinatorial optimization problem. Physical Review E, 2011, 83: 060901
    • (2011) Physical Review E , vol.83 , pp. 060901
    • Kobayashi, Y.1    Shibata, T.2    Kuramoto, Y.3    Mikhailov, A.S.4
  • 97
    • 84891639157 scopus 로고    scopus 로고
    • Cybernetics and entropy theory in the biofeedback therapy
    • Zhao Yan, Wang Ting-Huai. Cybernetics and entropy theory in the biofeedback therapy. Chinese Journal of Practical Nervous Diseases, 2009, 12(13): 41-44
    • (2009) Chinese Journal of Practical Nervous Diseases , vol.12 , Issue.13 , pp. 41-44
    • Zhao, Y.1    Wang, T.-H.2
  • 98
    • 78651333222 scopus 로고    scopus 로고
    • Global convergence of quorum-sensing networks
    • Russo G, Slotine J J E. Global convergence of quorum-sensing networks. Physical Review E, 2010, 82: 041919
    • (2010) Physical Review E , vol.82 , pp. 041919
    • Russo, G.1    Slotine, J.J.E.2
  • 100
    • 84877331829 scopus 로고    scopus 로고
    • Problems and challenges in control theory under complex dynamical network environments
    • Chen Guan-Rong. Problems and challenges in control theory under complex dynamical network environments. Acta Automatica Sinica, 2013, 39(4): 312-321
    • (2013) Acta Automatica Sinica , vol.39 , Issue.4 , pp. 312-321
    • Chen, G.-R.1
  • 101
    • 84865545626 scopus 로고    scopus 로고
    • Developing objective sensitivity analysis of periodic systems: Case studies of biological oscillators
    • Lu Bao-Yun, Yue Hong, Developing objective sensitivity analysis of periodic systems: case studies of biological oscillators. Acta Automatica Sinica, 2012, 38(7): 1065-1073
    • (2012) Acta Automatica Sinica , vol.38 , Issue.7 , pp. 1065-1073
    • Lu, B.-Y.1    Yue, H.2
  • 102
    • 67449141030 scopus 로고    scopus 로고
    • Chaotic expression dynamics implies pluripotency: When theory and experiment meet
    • Furusawa C, Kaneko K. Chaotic expression dynamics implies pluripotency: when theory and experiment meet. Biology Direct, 2009, 4: 17
    • (2009) Biology Direct , vol.4 , pp. 17
    • Furusawa, C.1    Kaneko, K.2
  • 104
    • 3042767202 scopus 로고    scopus 로고
    • MicroRNAs: Small RNAs with a big role in gene regulation
    • He L, Hannon G J. MicroRNAs: small RNAs with a big role in gene regulation. Nature Reviews Genetics, 2004, 5(7): 522-531
    • (2004) Nature Reviews Genetics , vol.5 , Issue.7 , pp. 522-531
    • He, L.1    Hannon, G.J.2
  • 105
    • 84891638812 scopus 로고    scopus 로고
    • Analysis and control of genetic regulatory networks
    • University of Science and Technology of China, China
    • Pan Wei. Analysis and Control of Genetic Regulatory Networks [Master dissertation], University of Science and Technology of China, China, 2011
    • (2011)
    • Pan, W.1


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