Levetiracetam in children with refractory status epilepticus

Epilepsy and Behavior

Volumn 14, Issue 1, 2009, Pages 215-218

  Gallentine, William B ^a   Hunnicutt, Addie S ^a   Husain, Aatif M ^a,b  

^a DUKE UNIVERSITY MEDICAL CENTER   (United States)

^b DURHAM VA MEDICAL CENTER   (United States)

Author keywords

Children; Levetiracetam; Status epilepticus

Indexed keywords

ACETAZOLAMIDE; ANTICONVULSIVE AGENT; BIOTIN; DIAZEPAM; ETIRACETAM; FOLINIC ACID; FOSPHENYTOIN SODIUM; LORAZEPAM; MIDAZOLAM; PENTOBARBITAL; PHENOBARBITAL; PROPOFOL; PYRIDOXINE; TOPIRAMATE; VALPROIC ACID; ZONISAMIDE;

ADJUVANT THERAPY; ARTICLE; BRADYCARDIA; CHILD; CHILD HEALTH CARE; CLINICAL ARTICLE; CONTINUOUS INFUSION; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG RESPONSE; DRUG SAFETY; DRUG WITHDRAWAL; ELECTROENCEPHALOGRAPHY; EPILEPTIC STATE; FEMALE; HUMAN; HYPOTENSION; INFANT; LIVER FAILURE; MALE; METABOLIC ACIDOSIS; NEWBORN; RECTUM HEMORRHAGE; SIDE EFFECT; UNSPECIFIED SIDE EFFECT;

ADOLESCENT; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; DRUG RESISTANCE; ELECTROENCEPHALOGRAPHY; FEMALE; HUMANS; INFANT; INJECTIONS, INTRAVENOUS; INTUBATION, GASTROINTESTINAL; MALE; PIRACETAM; STATUS EPILEPTICUS;

EID: 58149154641     PISSN: 15255050     EISSN: 15255069     Source Type: Journal    
DOI: 10.1016/j.yebeh.2008.09.028     Document Type: Article

References (21)

1. DeLorenzo R.J., Hauser W.A., and Towne A.R. A prospective, population-based epidemiologic study of status epilepticus in Richmond, Virginia. Neurology 46 (1996) 1029-1035
2. Sahin M., Menache C.C., Holmes G.L., and Riviello J.J. Outcome of severe refractory status epilepticus in children. Epilepsia 42 (2001) 1461-1467
3. Metsaranta P., Koivikko M., Peltola J., and Eriksson K. Outcome after prolonged convulsive seizures in 186 children: low morbidity, no mortality. Dev Med Child Neurol 46 (2004) 4-8
4. Gilbert D.L., Gartside P.S., and Glauser T.A. Efficacy and mortality in treatment of refractory generalized convulsive status epilepticus in children: a meta-analysis. J Child Neurol 14 (1999) 602-609
5. Towne A.R., Pellock J.M., Ko D., et al. Determinants of mortality in status epilepticus. Epilepsia 35 (1994) 27-34
6. Kalviainen R., Eriksson K., and Parviainen I. Refractory generalized convulsive status epilepticus: a guide to treatment. CNS Drugs 19 (2005) 759-768
7. Vigevano F. Levetiracetam in pediatrics. J Child Neurol 20 (2005) 87-93
8. Glauser T.A., Ayala R., Elterman R.D., et al. Double-blind placebo controlled trial of adjunctive levetiracetam in pediatric partial seizures. Neurology 66 (2006) 1654-1660
9. Gillard M., Chatelain P., and Fuks B. Binding characteristics of levetiracetam to synaptic vesicle protein 2A (SVA2) in human brain and in CHO cells expressing the human recombinant protein. Eur J Pharmacol 536 (2006) 102-108
10. French J., and Arrigo C. Rapid onset of action of levetiracetam in refractory epilepsy patients. Epilepsia 46 (2005) 324-326
11. Ramael S., De Smedt F., Toublanc N., et al. Single-dose bioavailability of levetiracetam intravenous infusion relative to oral tablets and multiple-dose pharmacokinetics and tolerability of levetiracetam intravenous infusion compared with placebo in healthy subjects. Clin Ther 28 (2006) 734-744
12. Abend N.S., and Duglos D.J. Treatment of refractory status epilepticus: literature review and a proposed protocol. Pediatr Neurol 38 (2008) 377-390
13. Mazarati A.M., Baldwin R., Klitgaard H., Matagne A., and Wasterlain C.G. Anticonvulsant effects of levetiracetam and levetiracetam-diazepam combinations in experimental status epilepticus. Epilepsy Res 58 (2004) 167-174
14. Rossetti A.O., and Bromfield E.B. Levetiracetam in the treatment of status epilepticus in adults: a study of 13 episodes. Eur Neurol 54 (2005) 34-38
15. Rossetti A.O., and Bromfield E.B. Determinants of success in the use of oral levetiracetam in status epilepticus. Epilepsy Behav 8 (2006) 651-654
16. Patel N.C., Landan I.R., Levin J., Szaflarski J., and Wilner A.N. The use of levetiracetam in refractory status epilepticus. Seizure 15 (2006) 137-141
17. Rupprecht S., Franke K., Fitzek S., Witte O.W., and Hagemann G. Levetiracetam as a treatment option in nonconvulsive status epilepticus. Epilepsy Res 73 (2007) 238-244
18. Knake S., Gruener J., Hattemer K., et al. Intravenous levetiracetam in the treatment of benzodiazepine refractory status epilepticus. J Neurol Neurosurg Psychiatry 79 (2008) 588-589
19. Goraya J.S., Divya S.K., Valencia I., et al. Intravenous levetiracetam in children with epilepsy. Pediatri Neurol 38 (2008) 177-180
20. Trabacca A., Profice P., Costanza M.C., Gesualdi M., and De Rinaldis M. Levetiracetam in nonconvulsive status epilepticus in childhood: a case report. J Child Neurol 22 (2007) 639-641
21. Alehan F., Ozcay F., and Haberal M. The use of levetiracetam in a child with nonconvulsive status epilepticus. J Child Neurol 23 (2008) 331-333