Intravenous levetiracetam in children with seizures: A prospective safety study

Journal of Child Neurology

Volumn 25, Issue 5, 2010, Pages 551-555

  Ng, Yu Tze ^a   Hastriter, V ^a   Cardenas, Javier F ^a   Khoury, Emily M ^a   Chapman, Kevin E ^a  

^a BARROW NEUROLOGICAL INSTITUTE   (United States)

Author keywords

Antiepileptic drugs; Children; Epilepsy; Intravenous; Levetiracetam

Indexed keywords

ETIRACETAM;

ADOLESCENT; ARTICLE; CHILD; CHILDHOOD DISEASE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG SAFETY; DRUG TOLERABILITY; FATIGUE; FEMALE; FEVER; HUMAN; INFANT; LOADING DRUG DOSE; MALE; PRESCHOOL CHILD; PRIORITY JOURNAL; RESTLESSNESS; SCHOOL CHILD; SEIZURE; SINGLE DRUG DOSE; SOMNOLENCE;

ADOLESCENT; ANTICONVULSANTS; CHILD; CHILD, PRESCHOOL; DRUG THERAPY, COMBINATION; DRUG TOXICITY; EPILEPSY; FEMALE; HUMANS; INFANT; INFUSIONS, INTRAVENOUS; MALE; PIRACETAM; PROSPECTIVE STUDIES; REGRESSION ANALYSIS; SEIZURES; TIME FACTORS; TREATMENT OUTCOME;

EID: 77953111185     PISSN: 08830738     EISSN: 17088283     Source Type: Journal    
DOI: 10.1177/0883073809348795     Document Type: Article

References (16)

1. Rzany B, Correia O, Kelly JP, Naldi L, Auquier A, Stern R. Risk of Stevens-Johnson syndrome and toxic epidermal necro-lysis during first weeks of antiepileptic therapy: a case control study. Study group of the international case control study on severe cutaneous adverse reactions. Lancet. 1999;353(9171): 2190-2194.
2. Schlienger RG, Shear NH. Antiepileptic drug hypersensitivity syndrome. Epilepsia. 1998;39(suppl 7):S3-S7.
3. Livingston S, Pauli LL, Pruce I, Kramer II. Phenobarbital vs. phenytoin for grand mal epilepsy. Am Fam Physician. 1980;22(2): 123-127.
4. Keppra [package insert]. Smyrna, GA: UCB, Inc; 2008.
5. Sirsi D, Safdieh JE. The safety of levetiracetam. Expert Opin Drug Saf. 2007;6(3):241-250.
6. Lynch BA, Lambeng M, Nocka K, et al. The synaptic vesicle protein SV2A is the binding site for the antiepileptic drug levetiracetam. Proc Natl Acad Sci USA. 2004;101(26): 9861-9866.
7. Goraya JS, Khurana DS, Valencia I, et al. Intravenous levetiracetam in children with epilepsy. Pediatr Neurol. 2008;38(3): 177-180.
8. Haberlandt E, Sigl SB, Scholl-Buergi S, et al. Levetiracetam in the treatment of two children with myoclonic status epilepticus. Eur J Paediatr Neurol. 2008. [Epub ahead of print&rsqb.
9. Snoeck E, Jacmin P, Sargenti-Maier ML, Stockis A. Modeling and simulation of intravenous levetiracetam pharmacokinetic profiles in children to evaluate dose adaptation rules. Epilepsy Res. 2007;76(2-3):140-147.
10. Glauser TA, Ayala R, Elterman RD, et al. Double-blind placebocontrolled trial of adjunctive levetiracetam in pediatric partial seizures. Neurology. 2006;66(11):1654-1660.
11. Wheless JW, Ng YT. Levetiracetam in refractory pediatric epilepsy. J Child Neurol. 2002;17(6):413-415.
12. Wheless JW, Clarke D, Hovinga CA, et al. Rapid infusion of a loading dose of intravenous levetiracetam with minimal dilution: a safety study. J Child Neurol. 2009;24(8):946-951.
13. Kimland E, Hojeberg B, von Euler M. Levetiracetam-induced thrombocytopenia. Epilepsia. 2004;45(7):877-878.
14. Meschede A, Runge U, Sabolek M. Thrombocytopenia during levetiracetam therapy. Epilepsy Res. 2008;80(1):91-92.
15. Ruegg S, Naegelin Y, Hardmeier M, Winkler DT, Marsch S, Fuhr P. Intravenous levetiracetam: treatment experience with the first 50 critically ill patients. Epilepsy Behav. 2008;12(3): 477-480.
16. Murphy K, Delanty N. Primary generalized epilepsies. Curr Treat Options Neurol. 2000;2(6):527-542.