메뉴 건너뛰기




Volumn 15, Issue 1, 2011, Pages 1-7

Levetiracetam: Safety and efficacy in neonatal seizures

Author keywords

Levetiracetam; Newborn; Phenobarbital; Prematurity; Seizures

Indexed keywords

ETIRACETAM; PHENOBARBITAL; PYRIDOXINE;

EID: 78651378781     PISSN: 10903798     EISSN: 15322130     Source Type: Journal    
DOI: 10.1016/j.ejpn.2010.10.003     Document Type: Article
Times cited : (124)

References (49)
  • 1
    • 0002109095 scopus 로고    scopus 로고
    • Neonatal seizures
    • Volpe 5th ed W.B. Saunders Philadelphia
    • J.J. Volpe Neonatal seizures Volpe 5th ed Neurology of the newborn vol. 2008 2008 W.B. Saunders Philadelphia 203 244
    • (2008) Neurology of the Newborn , vol.2008 , pp. 203-244
    • Volpe, J.J.1
  • 2
    • 0027500117 scopus 로고
    • Electrographic seizures in preterm and full-term neonates: Clinical correlates, associated brain lesions, and risk for neurologic sequelae
    • M.S. Scher, K. Aso, and M.E. Beggarly Electrographic seizures in preterm and full-term neonates: clinical correlates, associated brain lesions, and risk for neurologic sequelae Pediatrics 91 1993 128 134
    • (1993) Pediatrics , vol.91 , pp. 128-134
    • Scher, M.S.1    Aso, K.2    Beggarly, M.E.3
  • 3
    • 35948966025 scopus 로고    scopus 로고
    • Long-term prognosis in children with neonatal seizures: A population-based study
    • G.M. Ronen, D. Buckley, S. Penney, and D.L. Streiner Long-term prognosis in children with neonatal seizures: a population-based study Neurology 69 2007 1816 1822
    • (2007) Neurology , vol.69 , pp. 1816-1822
    • Ronen, G.M.1    Buckley, D.2    Penney, S.3    Streiner, D.L.4
  • 4
    • 0033841360 scopus 로고    scopus 로고
    • Electrographic seizures in neonates correlate with poor neurodevelopmental outcome
    • M.C. McBride, N. Laroia, and R. Guillet Electrographic seizures in neonates correlate with poor neurodevelopmental outcome Neurology 55 2005 506 513
    • (2005) Neurology , vol.55 , pp. 506-513
    • McBride, M.C.1    Laroia, N.2    Guillet, R.3
  • 5
    • 34547522707 scopus 로고    scopus 로고
    • Neonatal seizures: Multicenter variability in current treatment practices
    • A.I. Bartha, J. Shen, and K.H. Katz Neonatal seizures: multicenter variability in current treatment practices Pediatr Neurol 37 2007 85 90
    • (2007) Pediatr Neurol , vol.37 , pp. 85-90
    • Bartha, A.I.1    Shen, J.2    Katz, K.H.3
  • 8
    • 0038389588 scopus 로고    scopus 로고
    • Antiepileptic drugs and apoptosis in the developing brain
    • P. Bittigau, M. Sifringer, and C. Ikonomidou Antiepileptic drugs and apoptosis in the developing brain Ann N Y Acad Sci 993 2003 103 114
    • (2003) Ann N y Acad Sci , vol.993 , pp. 103-114
    • Bittigau, P.1    Sifringer, M.2    Ikonomidou, C.3
  • 9
    • 0018414964 scopus 로고
    • Side effects of phenobarbital in toddlers
    • C.S. Camfield, S. Chaplin, and A.B. Doyle Side effects of phenobarbital in toddlers J Pediatr 95 1979 361 365
    • (1979) J Pediatr , vol.95 , pp. 361-365
    • Camfield, C.S.1    Chaplin, S.2    Doyle, A.B.3
  • 10
    • 33745665605 scopus 로고    scopus 로고
    • Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures
    • N159 Study Group
    • T.A. Glauser, R. Ayala, R.D. Elterman, W.G. Mitchell, C.B. Van Orman, L.J. Gauer N159 Study Group Double-blind placebo-controlled trial of adjunctive levetiracetam in pediatric partial seizures Neurology 66 2006 1654 1660
    • (2006) Neurology , vol.66 , pp. 1654-1660
    • Glauser, T.A.1    Ayala, R.2    Elterman, R.D.3    Mitchell, W.G.4    Van Orman, C.B.5    Gauer, L.J.6
  • 11
    • 34247270757 scopus 로고    scopus 로고
    • Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy
    • S. Grosso, D.M. Cordelli, and E. Franzoni Efficacy and safety of levetiracetam in infants and young children with refractory epilepsy Seizure 16 2007 345 350
    • (2007) Seizure , vol.16 , pp. 345-350
    • Grosso, S.1    Cordelli, D.M.2    Franzoni, E.3
  • 12
    • 34249799027 scopus 로고    scopus 로고
    • Efficacy and tolerability of levetiracetam in children younger than 4 years: A retrospective review
    • M.S. Perry, and M. Benatar Efficacy and tolerability of levetiracetam in children younger than 4 years: a retrospective review Epilepsia 48 2007 1123 1127
    • (2007) Epilepsia , vol.48 , pp. 1123-1127
    • Perry, M.S.1    Benatar, M.2
  • 13
    • 40349111143 scopus 로고    scopus 로고
    • Response of infantile spasms to levetiracetam
    • M.A. Mikati, D. El Banna, D. Sinno, and S. Mroueh Response of infantile spasms to levetiracetam Neurology 70 2008 574 575
    • (2008) Neurology , vol.70 , pp. 574-575
    • Mikati, M.A.1    El Banna, D.2    Sinno, D.3    Mroueh, S.4
  • 15
    • 27644557878 scopus 로고    scopus 로고
    • Levetiracetam in children with refractory epilepsy: A multicenter open label study in Germany
    • J. Opp, I. Tuxhorn, and T. May Levetiracetam in children with refractory epilepsy: a multicenter open label study in Germany Seizure 14 2005 476 484
    • (2005) Seizure , vol.14 , pp. 476-484
    • Opp, J.1    Tuxhorn, I.2    May, T.3
  • 16
    • 18144398574 scopus 로고    scopus 로고
    • Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain
    • D. Manthey, S. Asimiadou, and V. Stefovska Sulthiame but not levetiracetam exerts neurotoxic effect in the developing rat brain Exp Neurol 193 2005 497 503
    • (2005) Exp Neurol , vol.193 , pp. 497-503
    • Manthey, D.1    Asimiadou, S.2    Stefovska, V.3
  • 17
    • 40049108004 scopus 로고    scopus 로고
    • HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam
    • R. Trollmann, K. Strasser, and S. Keller HIF-1-regulated vasoactive systems are differentially involved in acute hypoxic stress responses of the developing brain of newborn mice and are not affected by levetiracetam Brain Res 1199 2008 27 36
    • (2008) Brain Res , vol.1199 , pp. 27-36
    • Trollmann, R.1    Strasser, K.2    Keller, S.3
  • 18
    • 0034922707 scopus 로고    scopus 로고
    • Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia
    • E. Hanon, and H. Klitgaard Neuroprotective properties of the novel antiepileptic drug levetiracetam in the rat middle cerebral artery occlusion model of focal cerebral ischemia Seizure 10 2001 287 293
    • (2001) Seizure , vol.10 , pp. 287-293
    • Hanon, E.1    Klitgaard, H.2
  • 19
    • 0031908063 scopus 로고    scopus 로고
    • Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy
    • W. Löscher, D. Hönack, and C. Rundfeldt Antiepileptogenic effects of the novel anticonvulsant levetiracetam (ucb L059) in the kindling model of temporal lobe epilepsy J Pharmacol Exp Ther 284 1998 474 479
    • (1998) J Pharmacol Exp Ther , vol.284 , pp. 474-479
    • Löscher, W.1    Hönack, D.2    Rundfeldt, C.3
  • 20
    • 9144234719 scopus 로고    scopus 로고
    • Levetiracetam protects against kainic acid-induced toxicity
    • H. Marini, C. Costa, and M. Passaniti Levetiracetam protects against kainic acid-induced toxicity Life Sci 74 2004 1253 1264
    • (2004) Life Sci , vol.74 , pp. 1253-1264
    • Marini, H.1    Costa, C.2    Passaniti, M.3
  • 21
    • 38949184571 scopus 로고    scopus 로고
    • Intravenous levetiracetam in children with epilepsy
    • J.S. Goraya, D.S. Khurana, and I. Valencia Intravenous levetiracetam in children with epilepsy Pediatr Neurol 38 2008 177 180
    • (2008) Pediatr Neurol , vol.38 , pp. 177-180
    • Goraya, J.S.1    Khurana, D.S.2    Valencia, I.3
  • 22
    • 34249852186 scopus 로고    scopus 로고
    • Levetiracetam for the treatment of neonatal seizures
    • M.T. Shoemaker, and J.S. Rotenberg Levetiracetam for the treatment of neonatal seizures J Child Neurol 22 2007 95 98
    • (2007) J Child Neurol , vol.22 , pp. 95-98
    • Shoemaker, M.T.1    Rotenberg, J.S.2
  • 23
    • 77549083859 scopus 로고    scopus 로고
    • Levetiracetam in the treatment of neonatal seizures: A pilot study
    • A. Fürwentsches, C. Bussmann, and G. Ramantani Levetiracetam in the treatment of neonatal seizures: a pilot study Seizure 19 2010 185 189
    • (2010) Seizure , vol.19 , pp. 185-189
    • Fürwentsches, A.1    Bussmann, C.2    Ramantani, G.3
  • 24
    • 0027321870 scopus 로고
    • Prognostic value of background patterns in the neonatal EEG
    • G.L. Holmes, and C.T. Lombroso Prognostic value of background patterns in the neonatal EEG J Clin Neurophysiol 10 1993 323 352
    • (1993) J Clin Neurophysiol , vol.10 , pp. 323-352
    • Holmes, G.L.1    Lombroso, C.T.2
  • 25
    • 43649108515 scopus 로고    scopus 로고
    • Neonatal seizures: Dilemmas in workup and management
    • H. Bassan, Y. Bental, and E. Shany Neonatal seizures: dilemmas in workup and management Pediatr Neurol 38 2008 415 421
    • (2008) Pediatr Neurol , vol.38 , pp. 415-421
    • Bassan, H.1    Bental, Y.2    Shany, E.3
  • 26
    • 33750684965 scopus 로고    scopus 로고
    • Effects of seizures on developmental processes in the immature brain
    • DOI 10.1016/S1474-4422(06)70626-3, PII S1474442206706263
    • Y. Ben-Ari, and G.L. Holmes Effects of seizures on developmental processes in the immature brain Lancet Neurol 5 2006 1055 1063 (Pubitemid 44709981)
    • (2006) Lancet Neurology , vol.5 , Issue.12 , pp. 1055-1063
    • Ben-Ari, Y.1    Holmes, G.L.2
  • 27
    • 34249801473 scopus 로고    scopus 로고
    • Neonatal seizures: Gaps between the laboratory and the clinic
    • C.T. Lombroso Neonatal seizures: gaps between the laboratory and the clinic Epilepsia 2 48 Suppl 2006 83 106
    • (2006) Epilepsia , vol.2 , Issue.48 SUPPL. , pp. 83-106
    • Lombroso, C.T.1
  • 28
    • 59749103891 scopus 로고    scopus 로고
    • Carmant. Neonatal seizures: Do they damage the brain?
    • M.P. Thibeault-Eybalin, and A. Lortie Carmant. Neonatal seizures: do they damage the brain? Pediatr Neurol 40 2009 175 180
    • (2009) Pediatr Neurol , vol.40 , pp. 175-180
    • Thibeault-Eybalin, M.P.1    Lortie, A.2
  • 29
    • 14644390865 scopus 로고    scopus 로고
    • Neonatal seizures: After all these years we still love what doesn't work
    • R. Sankar, and M.J. Painter Neonatal seizures: after all these years we still love what doesn't work Neurology 64 2005 776 777
    • (2005) Neurology , vol.64 , pp. 776-777
    • Sankar, R.1    Painter, M.J.2
  • 30
    • 0033549786 scopus 로고    scopus 로고
    • Phenobarbital compared with phenytoin for the treatment of neonatal seizures
    • M.J. Painter, M.S. Scher, and A.D. Stein Phenobarbital compared with phenytoin for the treatment of neonatal seizures N Engl J Med 341 1999 485 489
    • (1999) N Engl J Med , vol.341 , pp. 485-489
    • Painter, M.J.1    Scher, M.S.2    Stein, A.D.3
  • 32
    • 65549114605 scopus 로고    scopus 로고
    • Controversies in neonatal seizure management
    • H.C. Glass, and E. Wirrell Controversies in neonatal seizure management J Child Neurol 24 2009 591 599
    • (2009) J Child Neurol , vol.24 , pp. 591-599
    • Glass, H.C.1    Wirrell, E.2
  • 33
    • 0035849144 scopus 로고    scopus 로고
    • The teratogenicity of anticonvulsant drugs
    • L.B. Holmes, E.A. Harvey, and B.A. Coull The teratogenicity of anticonvulsant drugs N Engl J Med 344 2001 1132 1138
    • (2001) N Engl J Med , vol.344 , pp. 1132-1138
    • Holmes, L.B.1    Harvey, E.A.2    Coull, B.A.3
  • 34
    • 0028799430 scopus 로고
    • In utero exposure to phenobarbital and intelligence deficits in adult men
    • J.M. Reinisch, S.A. Sanders, E.L. Mortensen, and D.B. Rubin In utero exposure to phenobarbital and intelligence deficits in adult men JAMA 274 1995 1518 1525
    • (1995) JAMA , vol.274 , pp. 1518-1525
    • Reinisch, J.M.1    Sanders, S.A.2    Mortensen, E.L.3    Rubin, D.B.4
  • 35
    • 0032915040 scopus 로고    scopus 로고
    • Does perinatal phenobarbital exposure affect developmental outcome at age 2?
    • J.A. Thorp, M. O'Connor, A.M. Jones, E.L. Hoffman, and B. Belden Does perinatal phenobarbital exposure affect developmental outcome at age 2? Am J Perinatol 16 1999 51 60
    • (1999) Am J Perinatol , vol.16 , pp. 51-60
    • Thorp, J.A.1    O'Connor, M.2    Jones, A.M.3    Hoffman, E.L.4    Belden, B.5
  • 36
    • 0033887921 scopus 로고    scopus 로고
    • Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems
    • A.B. Dessens, P.T. Cohen-Kettenis, and G.J. Mellenbergh Association of prenatal phenobarbital and phenytoin exposure with small head size at birth and with learning problems Acta Paediatr 89 2000 533 541
    • (2000) Acta Paediatr , vol.89 , pp. 533-541
    • Dessens, A.B.1    Cohen-Kettenis, P.T.2    Mellenbergh, G.J.3
  • 37
    • 0025012995 scopus 로고
    • Phenobarbital for febrile seizures - Effects on intelligence and on seizure recurrence
    • J.R. Farwell, Y.J. Lee, and D.G. Hirtz Phenobarbital for febrile seizures - effects on intelligence and on seizure recurrence N Engl J Med 322 1990 364 369
    • (1990) N Engl J Med , vol.322 , pp. 364-369
    • Farwell, J.R.1    Lee, Y.J.2    Hirtz, D.G.3
  • 39
    • 0034864245 scopus 로고    scopus 로고
    • Pharmacokinetics of levetiracetam
    • R.A. Radtke Pharmacokinetics of levetiracetam Epilepsia 4 42 Suppl 2001 24 27
    • (2001) Epilepsia , vol.4 , Issue.42 SUPPL. , pp. 24-27
    • Radtke, R.A.1
  • 40
    • 65549121241 scopus 로고    scopus 로고
    • Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures
    • Levetiracetam N01009 Study Group
    • J.E. Piña-Garza, D.R. Nordli Jr., D. Rating, H. Yang, J. Schiemann-Delgado, B. Duncan Levetiracetam N01009 Study Group Adjunctive levetiracetam in infants and young children with refractory partial-onset seizures Epilepsia 50 2009 1141 1149
    • (2009) Epilepsia , vol.50 , pp. 1141-1149
    • Piña-Garza, J.E.1    Nordli Jr., D.R.2    Rating, D.3    Yang, H.4    Schiemann-Delgado, J.5    Duncan, B.6
  • 41
    • 47049102489 scopus 로고    scopus 로고
    • Off-label use of antiepileptic drugs for the treatment of neonatal seizures
    • F.S. Silverstein, and D.M. Ferriero Off-label use of antiepileptic drugs for the treatment of neonatal seizures Pediatr Neurol 39 2008 77 79
    • (2008) Pediatr Neurol , vol.39 , pp. 77-79
    • Silverstein, F.S.1    Ferriero, D.M.2
  • 42
    • 35148821932 scopus 로고    scopus 로고
    • Neurological Progress: Neonatal seizures
    • F.S. Silverstein, and F.E. Jensen Neurological Progress: neonatal seizures Ann Neurol 62 2007 112 120
    • (2007) Ann Neurol , vol.62 , pp. 112-120
    • Silverstein, F.S.1    Jensen, F.E.2
  • 43
    • 69149101794 scopus 로고    scopus 로고
    • Interobserver agreement in neonatal seizure identification
    • A. Malone, C. Anthony Ryan, and A. Fitzgerald Interobserver agreement in neonatal seizure identification Epilepsia 50 2009 2097 2101
    • (2009) Epilepsia , vol.50 , pp. 2097-2101
    • Malone, A.1    Anthony Ryan, C.2    Fitzgerald, A.3
  • 44
    • 33646380349 scopus 로고    scopus 로고
    • The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants
    • H. Tekgul, K. Gauvreau, and J. Soul The current etiologic profile and neurodevelopmental outcome of seizures in term newborn infants Pediatrics 117 2006 1270 1280
    • (2006) Pediatrics , vol.117 , pp. 1270-1280
    • Tekgul, H.1    Gauvreau, K.2    Soul, J.3
  • 46
    • 34249807897 scopus 로고    scopus 로고
    • Pharmacokinetics of levetiracetam in infants and young children with epilepsy
    • T.A. Glauser, W.G. Mitchell, and A. Weinstock Pharmacokinetics of levetiracetam in infants and young children with epilepsy Epilepsia 48 2007 1117 1122
    • (2007) Epilepsia , vol.48 , pp. 1117-1122
    • Glauser, T.A.1    Mitchell, W.G.2    Weinstock, A.3
  • 47
    • 0025967230 scopus 로고
    • Postnatal epilepsy after EEG-confirmed neonatal seizures
    • R.R. Clancy, and A. Legido Postnatal epilepsy after EEG-confirmed neonatal seizures Epilepsia 32 1991 69 76
    • (1991) Epilepsia , vol.32 , pp. 69-76
    • Clancy, R.R.1    Legido, A.2
  • 48
    • 34250374395 scopus 로고    scopus 로고
    • Seizure recurrence and developmental disabilities after neonatal seizures: Outcomes are unrelated to use of phenobarbital prophylaxis
    • R. Guillet, and J. Kwon Seizure recurrence and developmental disabilities after neonatal seizures: outcomes are unrelated to use of phenobarbital prophylaxis J Child Neurol 22 2007 389 395
    • (2007) J Child Neurol , vol.22 , pp. 389-395
    • Guillet, R.1    Kwon, J.2
  • 49
    • 37349043676 scopus 로고    scopus 로고
    • Preterm infants with video-EEG confirmed seizures: Outcome at 30 months of age
    • F. Pisani, A.L. Barilli, L. Sisti, G. Bevilacqua, and S. Seri Preterm infants with video-EEG confirmed seizures: outcome at 30 months of age Brain Dev 30 2008 20 30
    • (2008) Brain Dev , vol.30 , pp. 20-30
    • Pisani, F.1    Barilli, A.L.2    Sisti, L.3    Bevilacqua, G.4    Seri, S.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.