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European Journal of Medicinal Chemistry

Volumn 73, Issue , 2014, Pages 46-55

Design, synthesis and anticancer activity evaluation of novel C14 heterocycle substituted epi-triptolide

(4) Xu, Hongtao a Tang, Huanyu a Feng, Huijin a Li, Yuanchao a

a SHANGHAI INSTITUTE OF MATERIA MEDICA (China)

Author keywords

Anticancer; Heterocycle; PC 3; SKOV 3; Synthesis; Triptolide

Indexed keywords

ANTINEOPLASTIC AGENT; HYDROXYL GROUP; NATURAL PRODUCT; TRIPTOLIDE;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CYTOTOXICITY; DRUG DESIGN; DRUG SYNTHESIS; STRUCTURE ACTIVITY RELATION; TUMOR CELL LINE;

ANTICANCER; HETEROCYCLE; PC-3; SKOV-3; SYNTHESIS; TRIPTOLIDE;

ANTINEOPLASTIC AGENTS; CELL CULTURE TECHNIQUES; CELL LINE, TUMOR; CELL SURVIVAL; DITERPENES; DRUG DESIGN; EPOXY COMPOUNDS; HETEROCYCLIC COMPOUNDS; HUMANS; MOLECULAR STRUCTURE; PHENANTHRENES; STEREOISOMERISM;

EID: 84891616077 PISSN: 02235234 EISSN: 17683254 Source Type: Journal
DOI: 10.1016/j.ejmech.2013.11.044 Document Type: Article

Times cited : (44)

References (35)

1
- 0015494046
- S.M. Kupchan, W.A. Court, R.G. Dailey Jr., C.J. Gilmore, and R.F. Bryan J. Am. Chem. Soc. 94 1972 7194 7195
- (1972) J. Am. Chem. Soc. , vol.94 , pp. 7194-7195
- Kupchan, S.M.¹ Court, W.A.² Dailey, Jr.R.G.³ Gilmore, C.J.⁴ Bryan, R.F.⁵

2
- 0016255753
- S.M. Kupchan, and R.M. Schubert Science 185 1974 791 793
- (1974) Science , vol.185 , pp. 791-793
- Kupchan, S.M.¹ Schubert, R.M.²

3
- 0000597684
- K.Y. Lee, W.T. Chang, D.-M. Qiu, P.N. Kao, and G.D. Rosen J. Biol. Chem. 274 1999 13451 13455
- (1999) J. Biol. Chem. , vol.274 , pp. 13451-13455
- Lee, K.Y.¹ Chang, W.T.² Qiu, D.-M.³ Kao, P.N.⁴ Rosen, G.D.⁵

4
- 0027940601
- Y.L. Zheng, J.F. Lin, C.C. Lin, and Y. Xu Acta Pharm. Sin. 15 1994 540 543
- (1994) Acta Pharm. Sin. , vol.15 , pp. 540-543
- Zheng, Y.L.¹ Lin, J.F.² Lin, C.C.³ Xu, Y.⁴

5
- 0026271754
- J.R. Zheng, K.X. Gu, L.F. Xu, J.W. Gao, Y.H. Yu, and M.Y. Tang Acta Acad. Med. Sin. 13 1991 391 397
- (1991) Acta Acad. Med. Sin. , vol.13 , pp. 391-397
- Zheng, J.R.¹ Gu, K.X.² Xu, L.F.³ Gao, J.W.⁴ Yu, Y.H.⁵ Tang, M.Y.⁶

6
- 0029008895
- W.Z. Gu, R. Chen, S. Brandwein, J. McAlpine, and N. Burres Int. J. Immunopharmacol. 17 1995 351 356
- (1995) Int. J. Immunopharmacol. , vol.17 , pp. 351-356
- Gu, W.Z.¹ Chen, R.² Brandwein, S.³ McAlpine, J.⁴ Burres, N.⁵

7
- 0026722307
- S.X. Yang, H.L. Gao, S.S. Xie, W.R. Zhang, and Z.Z. Long Int. J. Immunopharmacol. 14 1992 963 969
- (1992) Int. J. Immunopharmacol. , vol.14 , pp. 963-969
- Yang, S.X.¹ Gao, H.L.² Xie, S.S.³ Zhang, W.R.⁴ Long, Z.Z.⁵

8
- 0033532177
- D.M. Qiu, G.H. Zhao, Y. Aoki, L.F. Shi, A. Uyei, S. Nazarian, J.C.H. Ng, and P.N. Kao J. Biol. Chem. 274 1999 13443 13450
- (1999) J. Biol. Chem. , vol.274 , pp. 13443-13450
- Qiu, D.M.¹ Zhao, G.H.² Aoki, Y.³ Shi, L.F.⁴ Uyei, A.⁵ Nazarian, S.⁶ Ng, J.C.H.⁷ Kao, P.N.⁸

9
- 0028912082
- Q.S. Zhen, X. Ye, and Z.J. Wei Contraception 51 1995 121 129
- (1995) Contraception , vol.51 , pp. 121-129
- Zhen, Q.S.¹ Ye, X.² Wei, Z.J.³

10
- 0023433772
- J.R. Zheng, J.L. Fang, K.X. Gu, Y.Q. Yin, L.F. Xu, J.W. Gao, H.Z. Guo, Y.H. Yu, H.Z. Sun, Chung Kuo I. Hsueh Ko Hsueh Yuan Hsueh Pao 9 (1987) 323-328.
- (1987) Hsueh Ko Hsueh Yuan Hsueh Pao , vol.9 , pp. 323-328
- Zheng, J.R.¹ Fang, J.L.² Gu, K.X.³ Yin, Y.Q.⁴ Xu, L.F.⁵ Gao, J.W.⁶ Guo, H.Z.⁷ Yu, Y.H.⁸ Sun, H.Z.⁹ Chung Kuo, I.¹⁰

11
- 0031024058
- L.A. Shamon, J.M. Pezzuto, J.M. Graves, R.R. Mehta, S. Wangcharoentrakul, R. Sangsuwan, S. Chaichana, P. Tuchinda, P. Cleason, and V. Reutrakul Cancer Lett. 112 1997 113 117
- (1997) Cancer Lett. , vol.112 , pp. 113-117
- Shamon, L.A.¹ Pezzuto, J.M.² Graves, J.M.³ Mehta, R.R.⁴ Wangcharoentrakul, S.⁵ Sangsuwan, R.⁶ Chaichana, S.⁷ Tuchinda, P.⁸ Cleason, P.⁹ Reutrakul, V.¹⁰

12
- 0031784541
- Y. Yang, Z. Liu, E. Tolosa, J. Yang, and L. Li Immunopharmacology 40 1998 139 149
- (1998) Immunopharmacology , vol.40 , pp. 139-149
- Yang, Y.¹ Liu, Z.² Tolosa, E.³ Yang, J.⁴ Li, L.⁵

13
- 0034909663
- B.J. Chen Leuk. Lymphoma 42 2001 253 256
- (2001) Leuk. Lymphoma , vol.42 , pp. 253-256
- Chen, B.J.¹

14
- 0141576565
- S. Yang, J. Chen, Z. Guo, X.M. Xu, L. Wang, X.F. Pei, J. Yang, C.B. Underhill, and L. Zhang Mol. Cancer Ther. 2 2003 65 72
- (2003) Mol. Cancer Ther. , vol.2 , pp. 65-72
- Yang, S.¹ Chen, J.² Guo, Z.³ Xu, X.M.⁴ Wang, L.⁵ Pei, X.F.⁶ Yang, J.⁷ Underhill, C.B.⁸ Zhang, L.⁹

15
- 0030939874
- P.E. Lipsky, and X.L. Tao Semin. Arthritis Rheum. 26 1997 713 723
- (1997) Semin. Arthritis Rheum. , vol.26 , pp. 713-723
- Lipsky, P.E.¹ Tao, X.L.²

16
- 0036023433
- T.M. Kiviharju, P.S. Lecane, R.G. Sellers, and D.M. Peehl Clin. Cancer Res. 8 2002 2666 26744
- (2002) Clin. Cancer Res. , vol.8 , pp. 2666-26744
- Kiviharju, T.M.¹ Lecane, P.S.² Sellers, R.G.³ Peehl, D.M.⁴

17
- 33745944185
- B.Z. Carter, D.H. Mak, W.D. Schober, T. McQueen, D. Harris, Z. Estrov, R.L. Evans, and M. Andreeff Blood 108 2006 630 637
- (2006) Blood , vol.108 , pp. 630-637
- Carter, B.Z.¹ Mak, D.H.² Schober, W.D.³ McQueen, T.⁴ Harris, D.⁵ Estrov, Z.⁶ Evans, R.L.⁷ Andreeff, M.⁸

18
- 0032433899
- T. Tengchaisri, R. Chawengkirttikul, N. Rachaphaew, V. Reutrakul, R. Sangsuwan, and S. Sirisinha Cancer Lett. 133 1998 169 175
- (1998) Cancer Lett. , vol.133 , pp. 169-175
- Tengchaisri, T.¹ Chawengkirttikul, R.² Rachaphaew, N.³ Reutrakul, V.⁴ Sangsuwan, R.⁵ Sirisinha, S.⁶

19
- 0035910420
- W.T. Chang, J.J. Kang, K.Y. Lee, K. Wei, E. Anderson, S. Gotmare, J.A. Ross, and G.D. Rosen J. Biol. Chem. 276 2001 2221 2227
- (2001) J. Biol. Chem. , vol.276 , pp. 2221-2227
- Chang, W.T.¹ Kang, J.J.² Lee, K.Y.³ Wei, K.⁴ Anderson, E.⁵ Gotmare, S.⁶ Ross, J.A.⁷ Rosen, G.D.⁸

20
- 0041333929
- S. Frese, F. Pirnia, D. Miescher, S. Krajewski, M.M. Borner, J.C. Reed, and R.A. Schmid Oncogene 22 2003 5427 5435
- (2003) Oncogene , vol.22 , pp. 5427-5435
- Frese, S.¹ Pirnia, F.² Miescher, D.³ Krajewski, S.⁴ Borner, M.M.⁵ Reed, J.C.⁶ Schmid, R.A.⁷

21
- 0642287879
- J.M. Fidler, K. Li, C. Chung, K. Wei, J.A. Ross, M. Gao, and G.D. Rosen Mol. Cancer Ther. 2 2003 855 862
- (2003) Mol. Cancer Ther. , vol.2 , pp. 855-862
- Fidler, J.M.¹ Li, K.² Chung, C.³ Wei, K.⁴ Ross, J.A.⁵ Gao, M.⁶ Rosen, G.D.⁷

22
- 84867793735
- R. Chugh, V. Sangwan, S.P. Patil, V. Dudeja, R.K. Dawra, S. Banerjee, R.J. Schumacher, B.R. Blazar, G.I. Georg, S.M. Vickers, and A.K. Saluja Sci. Transl. Med. 4 2012 156ra139
- (2012) Sci. Transl. Med. , vol.4
- Chugh, R.¹ Sangwan, V.² Patil, S.P.³ Dudeja, V.⁴ Dawra, R.K.⁵ Banerjee, S.⁶ Schumacher, R.J.⁷ Blazar, B.R.⁸ Georg, G.I.⁹ Vickers, S.M.¹⁰ Saluja, A.K.¹¹

23
- 33646900838
- S.D. Westerheide, T.L. Kawahara, K. Orton, and R.I. Morimoto J. Biol. Chem. 281 2006 9616 9622
- (2006) J. Biol. Chem. , vol.281 , pp. 9616-9622
- Westerheide, S.D.¹ Kawahara, T.L.² Orton, K.³ Morimoto, R.I.⁴

24
- 41149159746
- A. Yutaka, H. Yukio, H. Tomoyo, M. Saki, F. Haruhiko, T. Koichi, A. Ritsuo, M. Takeshi, and H. Shusuke Bioorg. Med. Chem. Lett. 18 2008 2459 2463
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 2459-2463
- Yutaka, A.¹ Yukio, H.² Tomoyo, H.³ Saki, M.⁴ Haruhiko, F.⁵ Koichi, T.⁶ Ritsuo, A.⁷ Takeshi, M.⁸ Shusuke, H.⁹

25
- 69049086659
- Z. Li, Z.L. Zhou, Z.H. Miao, L.P. Lin, H.J. Feng, L.J. Tong, J. Ding, and Y.C. Li J. Med. Chem. 52 2009 5115 5123
- (2009) J. Med. Chem. , vol.52 , pp. 5115-5123
- Li, Z.¹ Zhou, Z.L.² Miao, Z.H.³ Lin, L.P.⁴ Feng, H.J.⁵ Tong, L.J.⁶ Ding, J.⁷ Li, Y.C.⁸

26
- 79955563183
- A. Yutaka, H. Yukio, H. Tomoyo, F. Haruhiko, T. Koichi, A. Ritsuo, M. Takeshi, and H. Shusuke Bioorg. Med. Chem. Lett. 21 2011 3046 3049
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 3046-3049
- Yutaka, A.¹ Yukio, H.² Tomoyo, H.³ Haruhiko, F.⁴ Koichi, T.⁵ Ritsuo, A.⁶ Takeshi, M.⁷ Shusuke, H.⁸

27
- 33646947952
- R. Hili, and A.K. Yudin Nat. Chem. Biol. 6 2006 284 287
- (2006) Nat. Chem. Biol. , vol.6 , pp. 284-287
- Hili, R.¹ Yudin, A.K.²

28
- 0037208308
- M. Feher, and J.M. Schmidt J. Chem. Inf. Comput. Sci. 43 2003 218 227
- (2003) J. Chem. Inf. Comput. Sci. , vol.43 , pp. 218-227
- Feher, M.¹ Schmidt, J.M.²

29
- 0033104653
- T. Henkel, R.M. Brunne, H. Muller, and F. Reichel Angew. Chem., Int. Ed. 38 1999 643 647
- (1999) Angew. Chem., Int. Ed. , vol.38 , pp. 643-647
- Henkel, T.¹ Brunne, R.M.² Muller, H.³ Reichel, F.⁴

30
- 69249129394
- F. Collet, R.H. Dodd, and P. Dauban Chem. Commun. 34 2009 5061 5074
- (2009) Chem. Commun. , vol.34 , pp. 5061-5074
- Collet, F.¹ Dodd, R.H.² Dauban, P.³

31
- 4243159924
- R.W. De Simone, K.S. Currie, S.A. Mitchell, J.W. Darrow, and D.A. Pippin Comb. Chem. High Throughput Screen. 7 2004 473 494
- (2004) Comb. Chem. High Throughput Screen. , vol.7 , pp. 473-494
- De Simone, R.W.¹ Currie, K.S.² Mitchell, S.A.³ Darrow, J.W.⁴ Pippin, D.A.⁵

32
- 35748934487
- P.D. Leeson, and B. Springthorpe Nat. Rev. Drug Discov. 6 2007 881 890
- (2007) Nat. Rev. Drug Discov. , vol.6 , pp. 881-890
- Leeson, P.D.¹ Springthorpe, B.²

33
- 0342446557
- K. Tamao, and N. Ishida Tetrahedron Lett. 25 1984 4245 4248
- (1984) Tetrahedron Lett. , vol.25 , pp. 4245-4248
- Tamao, K.¹ Ishida, N.²

34
- 0025367455
- L.V. Rubinstein, R.H. Shoemaker, K.D. Paull, R.M. Simon, S. Tosini, P. Skehan, D.A. Scudiero, A. Monks, and M.R. Boyd J. Natl. Cancer Inst. 82 1990 1113 1118
- (1990) J. Natl. Cancer Inst. , vol.82 , pp. 1113-1118
- Rubinstein, L.V.¹ Shoemaker, R.H.² Paull, K.D.³ Simon, R.M.⁴ Tosini, S.⁵ Skehan, P.⁶ Scudiero, D.A.⁷ Monks, A.⁸ Boyd, M.R.⁹

35
- 34548228429
- W. Li, Y. Shao, L. Hu, X. Zhang, Y. Chen, L. Tong, C. Li, X. Shen, and J. Ding Cancer Biol. Ther. 6 2007 787 794
- (2007) Cancer Biol. Ther. , vol.6 , pp. 787-794
- Li, W.¹ Shao, Y.² Hu, L.³ Zhang, X.⁴ Chen, Y.⁵ Tong, L.⁶ Li, C.⁷ Shen, X.⁸ Ding, J.⁹

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