BM6, a new semi-synthetic Vinca alkaloid, exhibits its potent in vivo anti-tumor activities via its high binding affinity for tubulin and improved pharmacokinetic profiles

Cancer Biology and Therapy

Volumn 6, Issue 5, 2007, Pages 787-794

  Li, Weihong ^a   Shao, Yong ^a   Hu, Lihong ^a   Zhang, Xiongwen ^a   Chen, Yi ^a   Tong, Linjiang ^a   Li, Chuan ^a   Shen, Xu ^a   Ding, Jian ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

Author keywords

Anti tumor; BM6; Cytoskeleton; Mitotic arrest; Pharmacokinetics; Tubulin binding; Vinca alkaloids

Indexed keywords

3 DECARBOXYL ACETYLOXYLMETHYL ANHYDROVINBLASTINE; ANTINEOPLASTIC AGENT; BM 6; COLCHICINE; DOXORUBICIN; NAVELBINE; TUBULIN; UNCLASSIFIED DRUG; VINBLASTINE; VINCA ALKALOID; VINCRISTINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; AREA UNDER THE CURVE; ARTICLE; BINDING AFFINITY; BINDING SITE; CELL CYCLE ARREST; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSKELETON; CYTOTOXICITY; DRUG DISTRIBUTION; DRUG MECHANISM; DRUG STRUCTURE; FEMALE; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN CELL; LETHAL DOSE; MALE; MITOSIS; MOUSE; NONHUMAN; RAT;

EID: 34548228429     PISSN: 15384047     EISSN: 15558576     Source Type: Journal    
DOI: 10.4161/cbt.6.5.4006     Document Type: Article

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