Fluorination of triptolide and its analogues and their cytotoxicity

Bioorganic and Medicinal Chemistry Letters

Volumn 18, Issue 7, 2008, Pages 2459-2463

  Aoyagi, Yutaka ^a   Hitotsuyanagi, Yukio ^a   Hasuda, Tomoyo ^a   Matsuyama, Saki ^a   Fukaya, Haruhiko ^a   Takeya, Koichi ^a   Aiyama, Ritsuo ^b   Matsuzaki, Takeshi ^b   Hashimoto, Shusuke ^b  

^a TOKYO UNIVERSITY OF PHARMACY AND LIFE SCIENCES   (Japan)

^b YAKULT CENTRAL INSTITUTE FOR MICROBIOLOGICAL RESEARCH   (Japan)

Author keywords

Cytotoxicity; Fluorination; SAR; Semisynthesis; Tripterygium wilfordii; Triptolide

Indexed keywords

(DIETHYLAMINO)SULFUR TRIFLUORIDE; 14BETA DEHYDROXY 14BETA FLUOROTRIPTOLIDE; BIS(2 METHOXYETHYL)AMINOSULFUR TRIFLUORIDE; FLUORINE DERIVATIVE; TERPENOID DERIVATIVE; TRIPTOLIDE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CHEMICAL REACTION; CONTROLLED STUDY; CYTOTOXICITY; DRUG SCREENING; DRUG SYNTHESIS; FLUORINATION; HUMAN; HUMAN CELL; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; DIETHYLAMINES; DITERPENES; EPOXY COMPOUNDS; FLUORIDES; FLUORINE; HT29 CELLS; HUMANS; HYDROCARBONS, FLUORINATED; MODELS, CHEMICAL; PHENANTHRENES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP; SULFUR COMPOUNDS;

TRIPTERYGIUM WILFORDII;

EID: 41149159746     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2008.02.039     Document Type: Article

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