Design and synthesis of novel C14-hydroxyl substituted triptolide derivatives as potential selective antitumor agents

Journal of Medicinal Chemistry

Volumn 52, Issue 16, 2009, Pages 5115-5123

  Li, Zheng ^a   Zhou, Zhao Li ^b   Miao, Ze Hong ^a   Lin, Li Ping ^a   Feng, Hui Jin ^a   Tong, Lin Jiang ^a   Ding, Jian ^a,b   Li, Yuan Chao ^a  

^a SHANGHAI INSTITUTE OF MATERIA MEDICA   (China)

^b SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

12BETA CHLORO 13ALPHA HYDROXY 14,21 EPOXYTRIPTOLIDE; 14 SPIRO 14ALPHA,21 SULFINYLDIOXYTRIPTOLIDE; 14,21 EPOXYTRIPTOLIDE; 14BETA HYDROXYMETHYLEPITRIPTOLIDE; 5ALPHA HYDROXY 14,21 EPOXYTRIPTOLIDE; ANTINEOPLASTIC AGENT; DELTA 5,6 DEHYDRO 14,21 EPOXYTRIPTOLIDE; HYDROXYL GROUP; TRIPTOLIDE; TRIPTOLIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CHEMICAL MODIFICATION; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DRUG DESIGN; DRUG EFFICACY; DRUG POTENCY; DRUG SELECTIVITY; DRUG SYNTHESIS; DRUG TOLERABILITY; HUMAN; HUMAN CELL; HYDROGEN BOND; IC 50; IN VITRO STUDY; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; STRUCTURE ACTIVITY RELATION; STRUCTURE ANALYSIS; SUBSTITUTION REACTION;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CRYSTALLOGRAPHY, X-RAY; DITERPENES; DRUG DESIGN; DRUG RESISTANCE, MULTIPLE; DRUG RESISTANCE, NEOPLASM; DRUG SCREENING ASSAYS, ANTITUMOR; EPOXY COMPOUNDS; HUMANS; MICE; MICE, NUDE; PHENANTHRENES; PHENANTHROLINES; STEREOISOMERISM; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 69049086659     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm900342g     Document Type: Article

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