Sequential platelet-derived growth factor-simvastatin release promotes dentoalveolar regeneration

Tissue Engineering - Part A

Volumn 20, Issue 1-2, 2014, Pages 356-364

  Chang, Po Chun ^a,b   Chong, Li Yen ^b   Dovban, Alex S M ^b   Lim, Lum Peng ^b   Lim, Jason C ^c   Kuo, Mark Yen Ping ^a   Wang, Chi Hwa ^d  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

^c AGENCY FOR SCIENCE   (Singapore)

^d NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

[No Author keywords available]

Indexed keywords

BONE; COMPUTERIZED TOMOGRAPHY; MOLECULES; ORGANIC POLYMERS; PLATELETS; REPAIR;

BOVINE SERUM ALBUMINS; ELECTROHYDRODYNAMIC ATOMIZATION; MICROCOMPUTED TOMOGRAPHY; OSTEOGENIC DIFFERENTIATION; PLATELET-DERIVED GROWTH FACTORS; POLY(D ,L-LACTIDE-CO- GLYCOLIDE); REGENERATION PROCESS; SCANNING ELECTRONIC MICROSCOPY;

MICROSPHERES;

BOVINE SERUM ALBUMIN; MICROSPHERE; POLYGLACTIN; POLYLACTIDE; RECOMBINANT PLATELET DERIVED GROWTH FACTOR BB; SIMVASTATIN;

ALVEOLAR BONE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BONE DEVELOPMENT; BONE REGENERATION; CHEMICAL PROCEDURES; COAXIAL ELECTROHYDRODYNAMIC ATOMIZATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DENTOALVEOLAR; HISTOLOGY; HUMAN; HYDRODYNAMICS; MALE; MICRO-COMPUTED TOMOGRAPHY; MICROENCAPSULATION; MICROTECHNOLOGY; MORPHOMETRICS; NEBULIZATION; NONHUMAN; OSTEOBLAST; OUTCOME ASSESSMENT; PARTICLE SIZE; PRIORITY JOURNAL; RAT; SCANNING ELECTRON MICROSCOPY; TRABECULAR BONE;

ALVEOLAR PROCESS; ANIMALS; HUMANS; LACTIC ACID; MALE; MICROSPHERES; PARTICLE SIZE; PLATELET-DERIVED GROWTH FACTOR; POLYGLYCOLIC ACID; RATS; RATS, SPRAGUE-DAWLEY; REGENERATION; SIMVASTATIN; X-RAY MICROTOMOGRAPHY;

EID: 84891520943     PISSN: 19373341     EISSN: 1937335X     Source Type: Journal    
DOI: 10.1089/ten.tea.2012.0687     Document Type: Article

References (44)

1. Retzepi, M., and Donos, N. Guided Bone Regeneration: biological principle and therapeutic applications. Clin Oral Implants Res 21, 567, 2010.
2. Kaigler, D., Avila, G., Wisner-Lynch, L., Nevins, M.L., Nevins, M., Rasperini, G., et al. Platelet-derived growth factor applications in periodontal and peri-implant bone regeneration. Expert Opin Biol Ther 11, 375, 2011.
3. Chang, P.C., Lang, N.P., and Giannobile, W.V. Evaluation of functional dynamics during osseointegration and regeneration associated with oral implants. Clin Oral Implants Res 21, 1, 2010.
4. Wikesjo, U.M., Qahash, M., Huang, Y.H., Xiropaidis, A., Polimeni, G., and Susin, C. Bone morphogenetic proteins for periodontal and alveolar indications; biological observations - clinical implications. Orthod Craniofac Res 12, 263, 2009.
5. Dereka, X.E., Markopoulou, C.E., and Vrotsos, I.A. Role of growth factors on periodontal repair. Growth Factors 24, 260, 2006.
6. Schilephake, H. Bone growth factors in maxillofacial skeletal reconstruction. Int J Oral Maxillofac Surg 31, 469, 2002.
7. Chen, L., Jiang, W., Huang, J., He, B.C., Zuo, G.W., Zhang, W., et al. Insulin-like growth factor 2 (IGF-2) potentiates BMP-9-induced osteogenic differentiation and bone formation. J Bone Miner Res 25, 2447, 2010.
8. Patel, Z.S., Young, S., Tabata, Y., Jansen, J.A., Wong, M.E., and Mikos, A.G. Dual delivery of an angiogenic and an osteogenic growth factor for bone regeneration in a critical size defect model. Bone 43, 931, 2008.
9. Hernandez, A., Reyes, R., Sanchez, E., Rodriguez-Evora, M., Delgado, A., and Evora, C. In vivo osteogenic response to different ratios of BMP-2 and VEGF released from a biodegradable porous system. J Biomed Mater Res A 100, 2382, 2012.
10. Holland, T.A., Tabata, Y., and Mikos, A.G. Dual growth factor delivery from degradable oligo(poly(ethylene glycol) fumarate) hydrogel scaffolds for cartilage tissue engineering. J Control Release 101, 111, 2005.
11. Raiche, A.T., and Puleo, D.A. In vitro effects of combined and sequential delivery of two bone growth factors. Biomaterials 25, 677, 2004.
12. Chang, P.C., Chung, M.C., Lei, C., Chong, L.Y., and Wang, C.H. Biocompatibility of PDGF-simvastatin double-walled PLGA (PDLLA) microspheres for dentoalveolar regeneration: a preliminary study. J Biomed Mater Res A 100, 2970, 2012.
13. Shah, P., Keppler, L., and Rutkowski, J. A review of platelet derived growth factor playing pivotal role in bone regeneration. J Oral Implantol 2012 [Epub ahead of print]; DOI: 10.1563/AAID-JOI-D-11-00173.1.
14. Mukozawa, A., Ueki, K., Marukawa, K., Okabe, K., Moroi, A., and Nakagawa, K. Bone healing of critical-sized nasal defects in rabbits by statins in two different carriers. Clin Oral Implants Res 22, 1327, 2011.
15. Chang, P.C., Lim, L.P., Chong, L.Y., Dovban, A.S., Chien, L.Y., Chung, M.C., et al. PDGF-simvastatin delivery stimulates osteogenesis in heat-induced osteonecrosis. J Dent Res 91, 618, 2012.
16. Burghardt, A.J., Kazakia, G.J., Laib, A., and Majumdar, S. Quantitative assessment of bone tissue mineralization with polychromatic micro-computed tomography. Calcif Tissue Int 83, 129, 2008.
17. Bernhardt, A., Thieme, S., Domaschke, H., Springer, A., Rosen-Wolff, A., and Gelinsky, M. Crosstalk of osteoblast and osteoclast precursors on mineralized collagen - towards an in vitro model for bone remodeling. J Biomed Mater Res A 95, 848, 2010.
18. Dimitriou, R., Tsiridis, E., and Giannoudis, P.V. Current concepts of molecular aspects of bone healing. Injury 36, 1392, 2005.
19. Mistry, A.S., and Mikos, A.G. Tissue engineering strategies for bone regeneration. Adv Biochem Eng Biotechnol 94, 1, 2005.
20. Cooke, J.W., Sarment, D.P., Whitesman, L.A., Miller, S.E., Jin, Q., Lynch, S.E., et al. Effect of rhPDGF-BB delivery on mediators of periodontal wound repair. Tissue Eng 12, 1441, 2006.
21. Schipani, E., Maes, C., Carmeliet, G., and Semenza, G.L. Regulation of osteogenesis-angiogenesis coupling by HIFs and VEGF. J Bone Miner Res 24, 1347, 2009.
22. Bradley, J.D., Cleverly, D.G., Burns, A.M., Helm, N.B., Schmid, M.J., Marx, D.B., et al. Cyclooxygenase-2 inhibitor reduces simvastatin-induced bone morphogenetic protein-2 and bone formation in vivo. J Periodontal Res 42, 267, 2007.
23. Takahashi, S., Nakamura, H., Seki, M., Shiraishi, Y., Yamamoto, M., Furuuchi, M., et al. Reversal of elastase-induced pulmonary emphysema and promotion of alveolar epithelial cell proliferation by simvastatin in mice. Am J Physiol Lung Cell Mol Physiol 294, L882, 2008.
24. Wu, H., Jiang, H., Lu, D., Qu, C., Xiong, Y., Zhou, D., et al. Induction of angiogenesis and modulation of vascular endothelial growth factor receptor-2 by simvastatin after traumatic brain injury. Neurosurgery 68, 1363, 2011; discussion 71.
25. Caceres,M.,Romero,A.,Copaja,M.,Diaz-Araya, G.,Martinez, J., and Smith, P.C. Simvastatin alters fibroblastic cell responses involved in tissue repair. J Periodontal Res 46, 456, 2011.
26. Ali, O.F., Growcott, E.J., Butrous, G.S., and Wharton, J. Pleiotropic effects of statins in distal human pulmonary artery smooth muscle cells. Respir Res 12, 137, 2011.
27. Hsieh, S.C., and Graves, D.T. Pulse application of plateletderived growth factor enhances formation of a mineralizing matrix while continuous application is inhibitory. J Cell Biochem 69, 169, 1998.
28. Marzouk, K.M., Gamal, A.Y., Al-Awady, A.A., and Sharawy, M.M. Platelet-derived growth factor BB treated osteoprogenitors inhibit bone regeneration. J Oral Implantol 34, 242, 2008.
29. Alberich-Bayarri, A., Marti-Bonmati, L., Sanz-Requena, R., Belloch, E., and Moratal, D. In vivo trabecular bone morphologic and mechanical relationship using high-resolution 3-T MRI. AJR Am J Roentgenol 191, 721, 2008.
30. Frost, H.M. On the trabecular "thickness"-number problem. J Bone Miner Res 14, 1816, 1999.
31. Berglundh, T., Abrahamsson, I., Lang, N.P., and Lindhe, J. De novo alveolar bone formation adjacent to endosseous implants. Clin Oral Implants Res 14, 251, 2003.
32. Cardaropoli, G., Araujo, M., and Lindhe, J. Dynamics of bone tissue formation in tooth extraction sites. An experimental study in dogs. J Clin Periodontol 30, 809, 2003.
33. Anderson, J.M., and Shive, M.S. Biodegradation and biocompatibility of PLA and PLGA microspheres. Adv Drug Deliv Rev 28, 5, 1997.
34. Nie, H., Fu, Y., and Wang, C.H. Paclitaxel and suraminloaded core/shell microspheres in the treatment of brain tumors. Biomaterials 31, 8732, 2010.
35. Xu, Q., Xia, Y., Wang, C.H., and Pack, D.W. Monodisperse double-walled microspheres loaded with chitosan-p53 nanoparticles and doxorubicin for combined gene therapy and chemotherapy. J Control Release 163, 130, 2012.
36. Pradeep, A.R., Rao, N.S., Bajaj, P., and Kumari, M. Efficacy of subgingivally delivered simvastatin in the treatment of patients with type 2 diabetes and chronic periodontitis: a randomized double-masked controlled clinical trial. J Periodontol 84, 24, 2013.
37. Nevins, M., Kao, R.T., McGuire, M.K., McClain, P.K., Hinrichs, J.E., McAllister, B.S., et al. Platelet-derived growth factor promotes periodontal regeneration in localized osseous defects: 36-month extension results from a randomized, controlled, double-masked clinical trial. J Periodontol 84, 456, 2013.
38. Smith, D.M., Cooper, G.M., Mooney, M.P., Marra, K.G., and Losee, J.E. Bone morphogenetic protein 2 therapy for craniofacial surgery. J Craniofac Surg 19, 1244, 2008.
39. Lauzon, M.A., Bergeron, E., Marcos, B., and Faucheux, N. Bone repair: new developments in growth factor delivery systems and their mathematical modeling. J Control Release 162, 502, 2012.
40. Nicolete, R., dos Santos, D.F., and Faccioli, L.H. The uptake of PLGA micro or nanoparticles by macrophages provokes distinct in vitro inflammatory response. Int Immunopharmacol 11, 1557, 2011.
41. Ji, W., Yang, F., Seyednejad, H., Chen, Z., Hennink, W.E., Anderson, J.M., et al. Biocompatibility and degradation characteristics of PLGA-based electrospun nanofibrous scaffolds with nanoapatite incorporation. Biomaterials 33, 6604, 2012.
42. Subramani, T., Rathnavelu, V., and Alitheen, N.B. The possible potential therapeutic targets for drug induced gingival overgrowth. Mediators Inflamm 2013, 639468, 2013.
43. Alla, V.M., Agrawal, V., Denazareth, A., Mohiuddin, S., Ravilla, S., and Rendell, M. A reappraisal of the risks and benefits of treating to target with cholesterol lowering drugs. Drugs 73, 1025, 2013.
44. Larsen, S., Stride, N., Hey-Mogensen, M., Hansen, C.N., Bang, L.E., Bundgaard, H., et al. Simvastatin effects on skeletal muscle: relation to decreased mitochondrial function and glucose intolerance. J Am Coll Cardiol 61, 44, 2013.