Anti-tumor activity of the X-linked inhibitor of apoptosis (XIAP) inhibitor embelin in gastric cancer cells

Molecular and Cellular Biochemistry

Volumn 386, Issue 1-2, 2014, Pages 143-152

  Wang, Da Guang ^a   Sun, Ya Bin ^a   Ye, Fei ^b   Li, Wei ^a   Kharbuja, Punyaram ^a   Gao, Ling ^a   Zhang, David Y ^b   Suo, Jian ^a  

^a JILIN UNIVERSITY   (China)

^b MOUNT SINAI SCHOOL OF MEDICINE   (United States)

Author keywords

Apoptosis; Embelin; Gastric cancer; Ingenuity pathway analysis; XIAP

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; CDC25B PROTEIN; CDC25C PROTEIN; CDK1 PROTEIN; CYCLIN B1; CYCLIN DEPENDENT KINASE 2; EMBELIN; FLUOROURACIL; JANUS KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; PHOSPHATIDYLINOSITOL 3 KINASE; PROTEIN; PROTEIN KINASE B; PROTEIN P53; STAT PROTEIN; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; APOPTOSIS; ARTICLE; CANCER CELL; CELL GROWTH; CELL VIABILITY; CELL VIABILITY ASSAY; CONTROLLED STUDY; DRUG MECHANISM; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; M PHASE CELL CYCLE CHECKPOINT; MTT ASSAY; PROTEIN EXPRESSION; S PHASE CELL CYCLE CHECKPOINT; STOMACH CANCER; WESTERN BLOTTING;

APOPTOSIS; BENZOQUINONES; BLOTTING, WESTERN; CELL LINE, TUMOR; FLOW CYTOMETRY; FLUOROURACIL; HUMANS; SIGNAL TRANSDUCTION; STOMACH NEOPLASMS; X-LINKED INHIBITOR OF APOPTOSIS PROTEIN;

EID: 84891507798     PISSN: 03008177     EISSN: 15734919     Source Type: Journal    
DOI: 10.1007/s11010-013-1853-x     Document Type: Article

References (43)

1. Hohenberger P, Gretschel S (2003) Gastric cancer. Lancet 26:305-315
2. Yu GZ, Chen Y, Wang JJ (2009) Overexpression of Grb2/HER2 signaling in Chinese gastric cancer: their relationship with clinicopathological parameters and prognostic significance. J Cancer Res Clin Oncol 135:1331-1339
3. Ooi CH, Ivanova T, Wu J, Lee M, Tan IB, Tao J, Ward L, Koo JH, Gopalakrishnan V, Zhu Y, Cheng LL, Lee J, et al. (2009) Oncogenic pathway combinations predict clinical prognosis in gastric cancer. PLoS Genet 5:e1000676
4. Fang JS, Gillies RD, Gatenby RA (2008) Adaptation to hypoxia and acidosis in carcinogenesis and tumor progression. Semin Cancer Biol 18:330-337
5. Choi JH, Lim HY, Joo HJ, Kim HS, Yi JW, Kim HC, Cho YK, Kim MW, Lee KB (2002) Expression of multidrug resistance-associated protein1, P-glycoprotein, and thymidylate synthase in gastric cancer patients treated with 5-fluorouracil and doxorubicin-based adjuvant chemotherapy after curative resection. Br J Cancer 20(86):1578-1585
6. Suzuki Y, Imai Y, Nakayama H, Takahashi K, Takio K, Takahashi R (2001) A serine protease, HtrA2, is released from the mitochondria and interacts with XIAP, inducing cell death. Mol Cell 8:613-621
7. Notarbartolo M, Cervello M, Poma P, Dusonchet L, Meli M, D'Alessandro N (2004) Expression of the IAPs in multidrug resistant tumor cells. Oncol Rep 11:133-136
8. Nikolovska-Coleska Z, Xu L, Hu Z, Tomita Y, Li P, Roller PP, Wang R, Fang X, Guo R, Zhang M, Lippman ME, Yang D, et al. (2004) Discovery of embelin as a cell-permeable, small-molecular weight inhibitor of XIAP through structure-based computational screening of a traditional herbal medicine three-dimensional structure database. J Med Chem 47:2430-2440
9. Podolak I, Galanty A, Janeczko Z (2005) Cytotoxic activity of embelin from lysimachia punctata. Fitoterapia 76:333-335
10. Siegelin MD, Gaiser T, Siegelin Y (2009) The XIAP inhibitor embelin enhances TRAIL-mediated apoptosis in malignant glioma cells by down-regulation of the short isoform of FLIP. Neurochem Int 55:423-430
11. Mori T, Doi R, Kida A, Nagai K, Kami K, Ito D, Toyoda E, Kawaguchi Y, Uemoto S (2007) Effect of the XIAP inhibitor embelin on TRAIL-induced apoptosis of pancreatic cancer cells. J Surg Res 142:281-286
12. Salvesen GS, Duckett CS (2002) IAP proteins: blocking the road to death's door. Nat Rev Mol Cell Biol 3:401-410
13. Srinivasula SM, Ashwell JD (2008) IAPs: what's in a name? Mol Cell 25(30):123-135
14. Yan Y, Mahotka C, Heikaus S, Shibata T, Wethkamp N, Liebmann J, Suschek CV, Guo Y, Gabbert HE, Gerharz CD, Ramp U (2004) Disturbed balance of expression between XIAP and Smac/DIABLO during tumour progression in renal cell carcinomas. Br J Cancer 91:1349-1357
15. Asselin E, Mills GB, Tsang BK (2001) XIAP regulates Akt activity and caspase-3-dependent cleavage during cisplatin-induced apoptosis in human ovarian epithelial cancer cells. Cancer Res 61:1862-1868
16. Zhang J, Li Y, Shen B (2002) Up-regulation of XIAP by M-CSF is associated with resistance of myeloid leukemia cells to apoptosis. Leukemia 16:2163-2165
17. Hu Y, Cherton-Horvat G, Dragowska V, Baird S, Korneluk RG, Durkin JP, Mayer LD, LaCasse EC (2003) Antisense oligonucleotides targeting XIAP induce apoptosis and enhance chemotherapeutic activity against human lung cancer cells in vitro and in vivo. Clin Cancer Res 9:2826-2836
18. Cummins JM, Kohli M, Rago C, Kinzler KW, Vogelstein B, Bunz F (2004) X-linked inhibitor of apoptosis protein (XIAP) is a nonredundant modulator of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL)-mediated apoptosis in human cancer cells. Cancer Res 64:3006-3008
19. Xu M, Cui J, Fu H, Proksch P, Lin W, Li M (2005) Embelin derivatives and their anticancer activity through microtubule disassembly. Planta Med 71:944-948
20. Dai Y, Qiao L, Chan KW, Yang M, Ye J, Ma J, Zou B, Gu Q, Wang J, Pang R, Lan HY, Wong BC (2009) Peroxisome proliferator-activated receptor-gamma contributes to the inhibitory effects of embelin on colon carcinogenesis. Cancer Res 69:4776-4783
21. Hu R, Zhu K, Li Y, Yao K, Zhang R, Wang H, Yang W, Liu Z (2011) Embelin induces apoptosis through down-regulation of XIAP in human leukemia cells. Med Oncol 28(4):1584-1588
22. Roshak AK, Capper EA, Imburgia C, Fornwald J, Scott G, Marshall LA (2000) The human polo-like kinase, PLK, regulates cdc2/cyclin B through phosphorylation and activation of the cdc25C phosphatase. Cell Signal 12:405-411
23. Kitagawa M, Higashi H, Jung HK, Suzuki-Takahashi I, Ikeda M, Tamai K, Kato J, Segawa K, Yoshida E, Nishimura S, Taya Y (1996) The consensus motif for phosphorylation by cyclin D1-Cdk4 is different from that for phosphorylation by cyclin A/E-Cdk2. EMBO J 15:7060-7069
24. Sapi E, Alvero AB, Chen W, O'Malley D, Hao XY, Dwipoyono B, Garg M, Kamsteeg M, Rutherford T, Mor G (2004) Resistance of ovarian carcinoma cells to docetaxel is XIAP dependent and reversible by phenoxodiol. Oncol Res 14:567-578
25. Muris JJ, Cillessen SA, Vos W, van Houdt IS, Kummer JA, van Krieken JH, Jiwa NM, Jansen PM, Kluin-Nelemans HC, Ossenkoppele GJ, Gundy C, Meijer CJ, et al. (2005) Immunohistochemical profiling of caspase signaling pathways predicts clinical response to chemotherapy in primary nodal diffuse large B-cell lymphomas. Blood 5:2916-2923
26. Alvero AB, O'Malley D, Brown D, Kelly G, Garg M, Chen W, Rutherford T, Mor G (2006) Molecular mechanism of phenoxodiol-induced apoptosis in ovarian carcinoma cells. Cancer 106:599-608
27. Cao C, Mu Y, Hallahan DE, Lu B (2004) XIAP and survivin as therapeutic targets for radiation sensitization in preclinical models of lung cancer. Oncogene 42:7047-7052
28. Holcik M, Yeh C, Korneluk RG, Chow T (2000) Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death. Oncogene 19:4174-4177
29. Cantley LC, Neel BG (1999) New insights into tumor suppression: PTEN suppresses tumor formation by restraining the phosphoinositide 3-kinase/AKT pathway. Proc Natl Acad Sci USA 96:4240-4245
30. Li Y, Sarkar FH (2002) Inhibition of nuclear factor kappaB activation in PC3 cells by genistein is mediated via akt signaling pathway. Clin Cancer Res 8:2369-2377
31. Kane LP, Shapiro VS, Stokoe D, Weiss A (1999) Induction of NF-κB by the Akt/PKB kinase. Curr Biol 9:601-604
32. Gottlieb TM, Leal JF, Seger R, Taya Y, Oren M (2002) Cross-talk between akt, p53 and Mdm2: possible implications for the regulation of apoptosis. Oncogene 21:1299-1303
33. Yu H, Jove R (2004) The STATs of cancer-new molecular targets come of age. Nat Rev Cancer 4:97-105
34. Song H, Wang R, Wang S, Lin J (2005) A low-molecular-weight compound discovered through virtual database screening inhibits Stat3 function in breast cancer cells. Proc Natl Acad Sci USA 102:4700-4705
35. Schust J, Sperl B, Hollis A, Mayer TU, Berg T (2006) Stattic: a small-molecule inhibitor of STAT3 activation and dimerization. Chem Biol 13:1235-1242
36. Deng J, Grande F, Neamati N (2007) Small molecule inhibitors of Stat3 signaling pathway. Curr Cancer Drug Targets 7:91-107
37. Siddiquee K, Zhang S, Guida WC, Blaskovich MA, Greedy B, Lawrence HR, Yip ML, Jove R, McLaughlin MM, Lawrence NJ, Sebti SM, Turkson J (2007) Selective chemical probe inhibitor of Stat3, identified through structure-based virtual screening, induces antitumor activity. Proc Natl Acad Sci USA 104:7391-7396
38. Foster FM, Traer CJ, Abraham SM, Fry MJ (2003) The phosphoinositide (PI) 3-kinase family. J Cell Sci 116:3037-3040
39. Bulavin DV, Fornace AJ Jr (2004) p38 MAP kinase's emerging role as a tumor suppressor. Adv Cancer Res 92:95-118
40. Vazquez A, Bond EE, Levine AJ, Bond GL (2008) The genetics of the p53 pathway, apoptosis and cancer therapy. Nat Rev Drug Discov 7:979-987
41. Chen X, Bargonetti J, Prives C (1995) p53, through p21 (WAF1/CIP1), induces cyclin D1 synthesis. Cancer Res 55:4257-4263
42. Flatt PM, Tang LJ, Scatena CD, Szak ST, Pietenpol JA (2000) p53 regulation of G(2) checkpoint is retinoblastoma protein dependent. Mol Cell Biol 20:4210-4223
43. Taylor WR, DePrimo SE, Agarwal A, Agarwal ML, Schonthal AH, Katula KS, Stark GR (1999) Mechanisms of G2 arrest in response to overexpression of p53. Mol Biol Cell 10:3607-3622