New insights into molecular recognition of 1,1-bisphosphonic acids by farnesyl diphosphate synthase

Bioorganic and Medicinal Chemistry

Volumn 22, Issue 1, 2014, Pages 398-405

  Ferrer Casal, Mariana ^a   Li, Catherine ^b   Galizzi, Melina ^b   Stortz, Carlos A ^a   Szajnman, Sergio H ^a   Docampo, Roberto ^b   Moreno, Silvia N J ^b   Rodriguez, Juan B ^a  

^a UNIVERSIDAD DE BUENOS AIRES   (Argentina)

^b UNIVERSITY OF GEORGIA   (United States)

Author keywords

Antiparasitic agents; Bisphosphonates; Farnesyl pyrophosphate synthase; Toxoplasma gondii; Trypanosoma cruzi

Indexed keywords

1 [(N ALKYLAMINO)ETHYL] 1 HYDROXY 1,1 BISPHOSPHONIC ACID; 1 [(N DECYLAMINO)ETHYL] 1 HYDROXY 1,1 BISPHOSPHONIC ACID; 1 [(N HEPTYLAMINO)ETHYL] 1 HYDROXY 1,1 BISPHOSPHONIC ACID; 1 [(N HEXYLAMINO)ETHYL] 1 HYDROXY 1,1 BISPHOSPHONIC ACID; 1 [(N OCTYLAMINO)ETHYL] 1 HYDROXY 1,1 BISPHOSPHONIC ACID; 1 [(N PENTYLAMINO)ETHYL] 1 HYDROXY 1,1 BISPHOSPHONIC ACID; 2 (DECYLAMINO)ACETIC ACID; 2 (HEXYLAMINO)ACETIC ACID; 2 (N HEPTYLAMINO)ACETIC ACID; 2 (N PENTYLAMINO)ACETIC ACID; 2 (OCTYLAMINO)ACETIC ACID; 2 ALKYLAMINOETHYL 1 HYDROXY 1,1 BISPHOSPHONIC ACID DERIVATIVE; BENZNIDAZOLE; BISPHOSPHONIC ACID DERIVATIVE; GERANYLTRANSFERASE; RISEDRONIC ACID; UNCLASSIFIED DRUG;

ARTICLE; BINDING SITE; CONTROLLED STUDY; DENSITY FUNCTIONAL THEORY; DRUG ACTIVITY; DRUG CONFORMATION; DRUG POTENCY; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS; GROWTH INHIBITION; HYDROGEN BOND; LEISHMANIA DONOVANI; MOLECULAR RECOGNITION; NONHUMAN; PLASMODIUM FALCIPARUM; TOXOPLASMA GONDII; TRYPANOSOMA CRUZI;

TOXOPLASMA GONDII; TRYPANOSOMA CRUZI;

ANTIPARASITIC AGENTS; BISPHOSPHONATES; FARNESYL PYROPHOSPHATE SYNTHASE; TOXOPLASMA GONDII; TRYPANOSOMA CRUZI;

ANTIPARASITIC AGENTS; DIPHOSPHONATES; DRUG DESIGN; GERANYLTRANSTRANSFERASE; STRUCTURE-ACTIVITY RELATIONSHIP; TOXOPLASMA; TRYPANOSOMA CRUZI;

EID: 84891496145     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2013.11.010     Document Type: Article

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