-
2
-
-
0030941458
-
p53, the cellular gatekeeper for growth and division
-
DOI 10.1016/S0092-8674(00)81871-1
-
A.J. Levine p53, the cellular gatekeeper for growth and division Cell 88 1997 323 331 (Pubitemid 27131374)
-
(1997)
Cell
, vol.88
, Issue.3
, pp. 323-331
-
-
Levine, A.J.1
-
4
-
-
77956186383
-
Drug discovery and mutant p53
-
M.M. Maslon, and T.R. Hupp Drug discovery and mutant p53 Trends Cell Biol 20 2010 542 555
-
(2010)
Trends Cell Biol
, vol.20
, pp. 542-555
-
-
Maslon, M.M.1
Hupp, T.R.2
-
6
-
-
0026649648
-
The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation
-
J. Momand, G.P. Zambetti, D.C. Olson, D. George, and A.J. Levine The mdm-2 oncogene product forms a complex with the p53 protein and inhibits p53-mediated transactivation Cell 69 1992 1237 1245
-
(1992)
Cell
, vol.69
, pp. 1237-1245
-
-
Momand, J.1
Zambetti, G.P.2
Olson, D.C.3
George, D.4
Levine, A.J.5
-
7
-
-
0034708458
-
Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53
-
DOI 10.1074/jbc.275.12.8945
-
S. Fang, J.P. Jensen, R.L. Ludwig, K.H. Vousden, and A.M. Weissman Mdm2 is a RING finger-dependent ubiquitin protein ligase for itself and p53 J Biol Chem 275 2000 8945 8951 (Pubitemid 30180252)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.12
, pp. 8945-8951
-
-
Fang, S.1
Jensen, J.P.2
Ludwig, R.L.3
Vousden, K.H.4
Weissman, A.M.5
-
8
-
-
0034282220
-
The MDM2 RING-finger domain is required to promote p53 nuclear export
-
R.K. Geyer, Z.K. Yu, and C.G. Maki The MDM2 RING-finger domain is required to promote p53 nuclear export Nat Cell Biol 2 2000 569 573
-
(2000)
Nat Cell Biol
, vol.2
, pp. 569-573
-
-
Geyer, R.K.1
Yu, Z.K.2
Maki, C.G.3
-
9
-
-
0842325666
-
Inhibition of the p53-MDM2 Interaction: Targeting a Protein-Protein Interface
-
P. Chene Inhibition of the p53-MDM2 interaction: targeting a protein-protein interface Mol Cancer Res 2 2004 20 28 (Pubitemid 38167104)
-
(2004)
Molecular Cancer Research
, vol.2
, Issue.1
, pp. 20-28
-
-
Chene, P.1
-
10
-
-
76149111139
-
Patented inhibitors of p53-Mdm2 interaction (2006-2008)
-
L. Weber Patented inhibitors of p53-Mdm2 interaction (2006-2008) Expert Opin Ther Pat 20 2010 179 191
-
(2010)
Expert Opin Ther Pat
, vol.20
, pp. 179-191
-
-
Weber, L.1
-
11
-
-
76249126943
-
Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX
-
J. Phan, Z. Li, A. Kasprzak, B. Li, S. Sebti, and W. Guida Structure-based design of high affinity peptides inhibiting the interaction of p53 with MDM2 and MDMX J Biol Chem 285 2010 2174 2183
-
(2010)
J Biol Chem
, vol.285
, pp. 2174-2183
-
-
Phan, J.1
Li, Z.2
Kasprzak, A.3
Li, B.4
Sebti, S.5
Guida, W.6
-
12
-
-
79953655080
-
Recent advances in the therapeutic perspectives of Nutlin-3
-
P. Secchiero, R. Bosco, C. Celeghini, and G. Zauli Recent advances in the therapeutic perspectives of Nutlin-3 Curr Pharm Des 17 2011 569 577
-
(2011)
Curr Pharm des
, vol.17
, pp. 569-577
-
-
Secchiero, P.1
Bosco, R.2
Celeghini, C.3
Zauli, G.4
-
13
-
-
79952523293
-
The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious
-
G.M. Popowicz, A. Domling, and T.A. Holak The structure-based design of Mdm2/Mdmx-p53 inhibitors gets serious Angew Chem Int Ed Engl 50 2011 2680 2688
-
(2011)
Angew Chem Int Ed Engl
, vol.50
, pp. 2680-2688
-
-
Popowicz, G.M.1
Domling, A.2
Holak, T.A.3
-
14
-
-
84874109542
-
First Clinical Trial Looks at RG7112 As A Way to Disable MDM2 in Leukemia
-
9 Dec. 2010. Web. 29 Dec. 2012
-
First Clinical Trial Looks At RG7112 As A Way To Disable MDM2 In Leukemia. Medical News Today. MediLexicon, Intl., 9 Dec. 2010. Web. 29 Dec. 2012 in < http://www.medicalnewstoday.com/releases/210729.php >.
-
Medical News Today. MediLexicon, Intl.
-
-
-
15
-
-
79955054710
-
Gain of function of mutant p53 by coaggregation with multiple tumor suppressors
-
J. Xu, J. Reumers, J.R. Couceiro, F. De Smet, R. Gallardo, and S. Rudyak Gain of function of mutant p53 by coaggregation with multiple tumor suppressors Nat Chem Biol 7 2011 285 295
-
(2011)
Nat Chem Biol
, vol.7
, pp. 285-295
-
-
Xu, J.1
Reumers, J.2
Couceiro, J.R.3
De Smet, F.4
Gallardo, R.5
Rudyak, S.6
-
16
-
-
84864999268
-
Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: Implications for cancer
-
A.P. Ano Bom, L.P. Rangel, D.C. Costa, G.A. de Oliveira, D. Sanches, and C.A. Braga Mutant p53 aggregates into prion-like amyloid oligomers and fibrils: implications for cancer J Biol Chem 287 2012 28152 28162
-
(2012)
J Biol Chem
, vol.287
, pp. 28152-28162
-
-
Ano Bom, A.P.1
Rangel, L.P.2
Costa, D.C.3
De Oliveira, G.A.4
Sanches, D.5
Braga, C.A.6
-
17
-
-
0032553485
-
2 arrest after DNA damage
-
F. Bunz, A. Dutriaux, C. Lengauer, T. Waldman, S. Zhou, and J.P. Brown Requirement for p53 and p21 to sustain G2 arrest after DNA damage Science 282 1998 1497 1501 (Pubitemid 28538613)
-
(1998)
Science
, vol.282
, Issue.5393
, pp. 1497-1501
-
-
Bunz, F.1
Dutriaux, A.2
Lengauer, C.3
Waldman, T.4
Zhou, S.5
Brown, J.P.6
Sedivy, J.M.7
Kinzler, K.W.8
Vogelstein, B.9
-
18
-
-
0026535237
-
P53: A transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer
-
T. Unger, M.M. Nau, S. Segal, and J.D. Minna p53: a transdominant regulator of transcription whose function is ablated by mutations occurring in human cancer EMBO J 11 1992 1383 1390
-
(1992)
EMBO J
, vol.11
, pp. 1383-1390
-
-
Unger, T.1
Nau, M.M.2
Segal, S.3
Minna, J.D.4
-
19
-
-
3142580336
-
Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-β1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes
-
DOI 10.1021/bi049781x
-
S. Solá, R.E. Castro, B.T. Kren, C.J. Steer, and C.M. Rodrigues Modulation of nuclear steroid receptors by ursodeoxycholic acid inhibits TGF-beta1-induced E2F-1/p53-mediated apoptosis of rat hepatocytes Biochemistry 43 2004 8429 8438 (Pubitemid 38902521)
-
(2004)
Biochemistry
, vol.43
, Issue.26
, pp. 8429-8438
-
-
Sola, S.1
Castro, R.E.2
Kren, B.T.3
Steer, C.J.4
Rodrigues, C.M.P.5
-
20
-
-
0036138908
-
A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications
-
DOI 10.1038/nbt0102-87
-
T. Nagai, K. Ibata, E.S. Park, M. Kubota, K. Mikoshiba, and A. Miyawaki A variant of yellow fluorescent protein with fast and efficient maturation for cell-biological applications Nat Biotechnol 20 2002 87 90 (Pubitemid 34044921)
-
(2002)
Nature Biotechnology
, vol.20
, Issue.1
, pp. 87-90
-
-
Nagai, T.1
Ibata, K.2
Park, E.S.3
Kubota, M.4
Mikoshiba, K.5
Miyawaki, A.6
-
21
-
-
34547634446
-
Quaternary structures of tumor suppressor p53 and a specific p53-DNA complex
-
DOI 10.1073/pnas.0705069104
-
H. Tidow, R. Melero, E. Mylonas, S.M. Freund, J.G. Grossmann, and J.M. Carazo Quaternary structures of tumor suppressor p53 and a specific p53 DNA complex Proc Natl Acad Sci USA 104 2007 12324 12329 (Pubitemid 47206136)
-
(2007)
Proceedings of the National Academy of Sciences of the United States of America
, vol.104
, Issue.30
, pp. 12324-12329
-
-
Tidow, H.1
Melero, R.2
Mylonas, E.3
Freund, S.M.V.4
Grossmann, J.G.5
Carazo, J.M.6
Svergun, D.I.7
Valle, M.8
Fersht, A.R.9
-
22
-
-
37149035299
-
Genetic analysis of p53 nuclear importation
-
DOI 10.1038/sj.onc.1210597, PII 1210597
-
Q. Li, R.R. Falsey, S. Gaitonde, V. Sotello, K. Kislin, and J.D. Martinez Genetic analysis of p53 nuclear importation Oncogene 26 2007 7885 7893 (Pubitemid 350261791)
-
(2007)
Oncogene
, vol.26
, Issue.57
, pp. 7885-7893
-
-
Li, Q.1
Falsey, R.R.2
Gaitonde, S.3
Sotello, V.4
Kislin, K.5
Martinez, J.D.6
-
23
-
-
11844252081
-
Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: Scope and mechanism
-
DOI 10.1021/ja046699g
-
T.J. Magliery, C.G. Wilson, W. Pan, D. Mishler, I. Ghosh, and A.D. Hamilton Detecting protein-protein interactions with a green fluorescent protein fragment reassembly trap: scope and mechanism J Am Chem Soc 127 2005 146 157 (Pubitemid 40094379)
-
(2005)
Journal of the American Chemical Society
, vol.127
, Issue.1
, pp. 146-157
-
-
Magliery, T.J.1
Wilson, C.G.M.2
Pan, W.3
Mishler, D.4
Ghosh, I.5
Hamilton, A.D.6
Regan, L.7
-
24
-
-
10744221485
-
In Vivo Activation of the p53 Pathway by Small-Molecule Antagonists of MDM2
-
DOI 10.1126/science.1092472
-
L.T. Vassilev, B.T. Vu, B. Graves, D. Carvajal, F. Podlaski, and Z. Filipovic In vivo activation of the p53 pathway by small-molecule antagonists of MDM2 Science 303 2004 844 848 (Pubitemid 38174664)
-
(2004)
Science
, vol.303
, Issue.5659
, pp. 844-848
-
-
Vassilev, L.T.1
Vu, B.T.2
Graves, B.3
Carvajal, D.4
Podlaski, F.5
Filipovic, Z.6
Kong, N.7
Kammlott, U.8
Lukacs, C.9
Klein, C.10
Fotouhi, N.11
Liu, E.A.12
-
26
-
-
0028883179
-
Tumor suppressor p53 is a direct transcriptional activator of the human bax gene
-
T. Miyashita, and J.C. Reed Tumor suppressor p53 is a direct transcriptional activator of the human bax gene Cell 80 1995 293 299
-
(1995)
Cell
, vol.80
, pp. 293-299
-
-
Miyashita, T.1
Reed, J.C.2
-
27
-
-
0034640281
-
Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis
-
DOI 10.1126/science.288.5468.1053
-
E. Oda, R. Ohki, H. Murasawa, J. Nemoto, T. Shibue, and T. Yamashita Noxa, a BH3-only member of the Bcl-2 family and candidate mediator of p53-induced apoptosis Science 288 2000 1053 1058 (Pubitemid 30324238)
-
(2000)
Science
, vol.288
, Issue.5468
, pp. 1053-1058
-
-
Oda, E.1
Ohki, R.2
Murasawa, H.3
Nemoto, J.4
Shibue, T.5
Yamashita, T.6
Tokino, T.7
Taniguchi, T.8
Tanaka, N.9
-
28
-
-
0035265686
-
PUMA, a novel proapoptotic gene, is induced by p53
-
DOI 10.1016/S1097-2765(01)00214-3
-
K. Nakano, and K.H. Vousden PUMA. a novel proapoptotic gene, is induced by p53 Mol Cell 7 2001 683 694 (Pubitemid 32706359)
-
(2001)
Molecular Cell
, vol.7
, Issue.3
, pp. 683-694
-
-
Nakano, K.1
Vousden, K.H.2
-
29
-
-
0037039319
-
Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo
-
DOI 10.1073/pnas.012283399
-
M.D. Kaeser, and R.D. Iggo Chromatin immunoprecipitation analysis fails to support the latency model for regulation of p53 DNA binding activity in vivo Proc Natl Acad Sci USA 99 2002 95 100 (Pubitemid 34060322)
-
(2002)
Proceedings of the National Academy of Sciences of the United States of America
, vol.99
, Issue.1
, pp. 95-100
-
-
Kaeser, M.D.1
Iggo, R.D.2
-
30
-
-
0037452759
-
PUMA mediates the apoptotic response to p53 in colorectal cancer cells
-
DOI 10.1073/pnas.2627984100
-
J. Yu, Z. Wang, K.W. Kinzler, B. Vogelstein, and L. Zhang PUMA mediates the apoptotic response to p53 in colorectal cancer cells Proc Natl Acad Sci USA 100 2003 1931 1936 (Pubitemid 36254551)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.4
, pp. 1931-1936
-
-
Yu, J.1
Wang, Z.2
Kinzler, K.W.3
Vogelstein, B.4
Zhang, L.5
-
31
-
-
77957102879
-
Nutlin's two roads toward apoptosis
-
Q. Zhang, and H. Lu Nutlin's two roads toward apoptosis Cancer Biol Ther 10 2010 579 581
-
(2010)
Cancer Biol Ther
, vol.10
, pp. 579-581
-
-
Zhang, Q.1
Lu, H.2
-
32
-
-
70449109071
-
P53 and the regulation of hepatocyte apoptosis: Implications for disease pathogenesis
-
J.D. Amaral, R.E. Castro, C.J. Steer, and C.M. Rodrigues p53 and the regulation of hepatocyte apoptosis: implications for disease pathogenesis Trends Mol Med 15 2009 531 541
-
(2009)
Trends Mol Med
, vol.15
, pp. 531-541
-
-
Amaral, J.D.1
Castro, R.E.2
Steer, C.J.3
Rodrigues, C.M.4
-
33
-
-
70350371736
-
Nutlin-3 affects expression and function of retinoblastoma protein: Role of retinoblastoma protein in cellular response to nutlin-3
-
W. Du, J. Wu, E.M. Walsh, Y. Zhang, C.Y. Chen, and Z.X. Xiao Nutlin-3 affects expression and function of retinoblastoma protein: role of retinoblastoma protein in cellular response to nutlin-3 J Biol Chem 284 2009 26315 26321
-
(2009)
J Biol Chem
, vol.284
, pp. 26315-26321
-
-
Du, W.1
Wu, J.2
Walsh, E.M.3
Zhang, Y.4
Chen, C.Y.5
Xiao, Z.X.6
-
34
-
-
32444449180
-
Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: Implications for therapy
-
DOI 10.1073/pnas.0507493103
-
C. Tovar, J. Rosinski, Z. Filipovic, B. Higgins, K. Kolinsky, and H. Hilton Small-molecule MDM2 antagonists reveal aberrant p53 signaling in cancer: implications for therapy Proc Natl Acad Sci USA 103 2006 1888 1893 (Pubitemid 43228788)
-
(2006)
Proceedings of the National Academy of Sciences of the United States of America
, vol.103
, Issue.6
, pp. 1888-1893
-
-
Tovar, C.1
Rosinski, J.2
Filipovic, Z.3
Higgins, B.4
Kolinsky, K.5
Hilton, H.6
Zhao, X.7
Vu, B.T.8
Qing, W.9
Packman, K.10
Myklebost, O.11
Heimbrook, D.C.12
Vassilev, L.T.13
-
35
-
-
84862888097
-
Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas
-
A. Kunkele, K. De Preter, L. Heukamp, T. Thor, K.W. Pajtler, and W. Hartmann Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas Neuro Oncol 14 2012 859 869
-
(2012)
Neuro Oncol
, vol.14
, pp. 859-869
-
-
Kunkele, A.1
De Preter, K.2
Heukamp, L.3
Thor, T.4
Pajtler, K.W.5
Hartmann, W.6
-
36
-
-
34347374044
-
Universal strategies in research and drug discovery based on protein-fragment complementation assays
-
DOI 10.1038/nrd2311, PII NRD2311
-
S.W. Michnick, P.H. Ear, E.N. Manderson, I. Remy, and E. Stefan Universal strategies in research and drug discovery based on protein-fragment complementation assays Nat Rev Drug Discov 6 2007 569 582 (Pubitemid 47019445)
-
(2007)
Nature Reviews Drug Discovery
, vol.6
, Issue.7
, pp. 569-582
-
-
Michnick, S.W.1
Ear, P.H.2
Manderson, E.N.3
Remy, I.4
Stefan, E.5
-
37
-
-
33745785300
-
Visualization of molecular interactions by fluorescence complementation
-
DOI 10.1038/nrm1929, PII NRM1929
-
T.K. Kerppola Visualization of molecular interactions by fluorescence complementation Nat Rev Mol Cell Biol 7 2006 449 456 (Pubitemid 44050098)
-
(2006)
Nature Reviews Molecular Cell Biology
, vol.7
, Issue.6
, pp. 449-456
-
-
Kerppola, T.K.1
-
38
-
-
77950653875
-
Using BRET to study chemical compound-induced disruptions of the p53-HDM2 interactions in live cells
-
A. Mazars, and R. Fahraeus Using BRET to study chemical compound-induced disruptions of the p53-HDM2 interactions in live cells Biotechnol J 5 2010 377 384
-
(2010)
Biotechnol J
, vol.5
, pp. 377-384
-
-
Mazars, A.1
Fahraeus, R.2
-
39
-
-
51349160681
-
High-throughput screening assays to discover small-molecule inhibitors of protein interactions
-
P. Colas High-throughput screening assays to discover small-molecule inhibitors of protein interactions Curr Drug Discov Technol 5 2008 190 199
-
(2008)
Curr Drug Discov Technol
, vol.5
, pp. 190-199
-
-
Colas, P.1
-
40
-
-
84857351293
-
Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation
-
F. Herrera, S. Goncalves, and T.F. Outeiro Imaging protein oligomerization in neurodegeneration using bimolecular fluorescence complementation Methods Enzymol 506 2012 157 174
-
(2012)
Methods Enzymol
, vol.506
, pp. 157-174
-
-
Herrera, F.1
Goncalves, S.2
Outeiro, T.F.3
-
41
-
-
70349601671
-
New GATEWAY vectors for high throughput analyses of protein-protein interactions by bimolecular fluorescence complementation
-
C. Gehl, R. Waadt, J. Kudla, R.R. Mendel, and R. Hansch New GATEWAY vectors for high throughput analyses of protein-protein interactions by bimolecular fluorescence complementation Mol Plant 2 2009 1051 1058
-
(2009)
Mol Plant
, vol.2
, pp. 1051-1058
-
-
Gehl, C.1
Waadt, R.2
Kudla, J.3
Mendel, R.R.4
Hansch, R.5
-
42
-
-
78049259996
-
Zooming into protein oligomerization in neurodegeneration using BiFC
-
S.A. Goncalves, J.E. Matos, and T.F. Outeiro Zooming into protein oligomerization in neurodegeneration using BiFC Trends Biochem Sci 35 2010 643 651
-
(2010)
Trends Biochem Sci
, vol.35
, pp. 643-651
-
-
Goncalves, S.A.1
Matos, J.E.2
Outeiro, T.F.3
-
43
-
-
77956175013
-
NFAT, immunity and cancer: A transcription factor comes of age
-
M.R. Muller, and A. Rao NFAT, immunity and cancer: a transcription factor comes of age Nat Rev Immunol 10 2010 645 656
-
(2010)
Nat Rev Immunol
, vol.10
, pp. 645-656
-
-
Muller, M.R.1
Rao, A.2
-
44
-
-
70350514636
-
NFAT proteins: Emerging roles in cancer progression
-
M. Mancini, and A. Toker NFAT proteins: emerging roles in cancer progression Nat Rev Cancer 9 2009 810 820
-
(2009)
Nat Rev Cancer
, vol.9
, pp. 810-820
-
-
Mancini, M.1
Toker, A.2
-
45
-
-
84865734269
-
Transcription factor NFAT1 activates the mdm2 oncogene independent of p53
-
X. Zhang, Z. Zhang, J. Cheng, M. Li, W. Wang, and W. Xu Transcription factor NFAT1 activates the mdm2 oncogene independent of p53 J Biol Chem 287 2012 30468 30476
-
(2012)
J Biol Chem
, vol.287
, pp. 30468-30476
-
-
Zhang, X.1
Zhang, Z.2
Cheng, J.3
Li, M.4
Wang, W.5
Xu, W.6
-
46
-
-
76649113100
-
Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells
-
S.R. Volate, B.T. Kawasaki, E.M. Hurt, J.A. Milner, Y.S. Kim, and J. White Gossypol induces apoptosis by activating p53 in prostate cancer cells and prostate tumor-initiating cells Mol Cancer Ther 9 2010 461 470
-
(2010)
Mol Cancer Ther
, vol.9
, pp. 461-470
-
-
Volate, S.R.1
Kawasaki, B.T.2
Hurt, E.M.3
Milner, J.A.4
Kim, Y.S.5
White, J.6
-
47
-
-
41649102468
-
Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition
-
DOI 10.1073/pnas.0708917105
-
S. Shangary, D. Qin, D. McEachern, M. Liu, R.S. Miller, and S. Qiu Temporal activation of p53 by a specific MDM2 inhibitor is selectively toxic to tumors and leads to complete tumor growth inhibition Proc Natl Acad Sci USA 105 2008 3933 3938 (Pubitemid 351723502)
-
(2008)
Proceedings of the National Academy of Sciences of the United States of America
, vol.105
, Issue.10
, pp. 3933-3938
-
-
Shangary, S.1
Qin, D.2
McEachern, D.3
Liu, M.4
Miller, R.S.5
Qiu, S.6
Nikolovska-Coleska, Z.7
Ding, K.8
Wang, G.9
Chen, J.10
Bernard, D.11
Zhang, J.12
Lu, Y.13
Gu, Q.14
Shah, R.B.15
Pienta, K.J.16
Ling, X.17
Kang, S.18
Guo, M.19
Sun, Y.20
Yang, D.21
Wang, S.22
more..
|