Structure-activity relationship and antitumor activity of thio-benzodiazepines as p53-MDM2 protein-protein interaction inhibitors

European Journal of Medicinal Chemistry

Volumn 56, Issue , 2012, Pages 10-16

  Guo, Zizhao ^a   Zhuang, Chunlin ^a   Zhu, Lingjian ^a   Zhang, Yongqiang ^a   Yao, Jianzhong ^a   Dong, Guoqiang ^a   Wang, Shengzheng ^a   Liu, Yang ^a   Chen, Hai ^a   Sheng, Chunquan ^a   Miao, Zhenyuan ^a   Zhang, Wannian ^a  

^a SECOND MILITARY MEDICAL UNIVERSITY   (China)

Author keywords

Antitumor activity; p53 MDM2; SAR; Thio benzodiazepine

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; BENZENE; BENZODIAZEPINE DERIVATIVE; ELECTROPHILE; METHYL 2 (4 CHLOROPHENYL) 2 [3 (4 CHLOROPHENYL) 5 OXO 2 THIOXO 8 (TRIFLUOROMETHYL) 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 4(5H) YL]ACETATE; METHYL 2 (4 CHLOROPHENYL) 2 [3 (4 CHLOROPHENYL) 7 FLUORO 5 OXO 2 THIOXO 2,3 DIHYDRO 1H BENZO[E][1,4]DIAZEPIN 4(5H) YL]ACETATE; NUCLEOPHILE; NUTLIN 3; PROTEIN MDM2; PROTEIN P53; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BINDING AFFINITY; CANCER CELL CULTURE; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG PROTEIN BINDING; DRUG SCREENING; DRUG SELECTIVITY; HUMAN; HUMAN CELL; IN VITRO STUDY; MOLECULAR DOCKING; PROTEIN PROTEIN INTERACTION; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; BENZODIAZEPINES; CELL LINE, TUMOR; CELL PROLIFERATION; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; LIGANDS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; PROTEIN BINDING; PROTO-ONCOGENE PROTEINS C-MDM2; STRUCTURE-ACTIVITY RELATIONSHIP; SULFHYDRYL COMPOUNDS; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84865561339     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2012.08.003     Document Type: Article

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