1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1-yl)ethanones as novel CCR1 antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 5, 2013, Pages 1228-1231

  Pennell, Andrew M K ^a   Aggen, James B ^a   Sen, Subhabrata ^a   Chen, Wei ^a   Xu, Yuan ^a   Sullivan, Edward ^a   Li, Lianfa ^a   Greenman, Kevin ^a   Charvat, Trevor ^a   Hansen, Derek ^a   Dairaghi, Daniel J ^a   Wright, J J Kim ^a   Zhang, Penglie ^a  

^a ChemoCentryx Inc   (United States)

Author keywords

CCR1; Chemokine receptor antagonists; Chemokines; Multiple myeloma; Pyrazoles; Rheumatoid arthritis

Indexed keywords

1 (4 PHENYLPIPERAZIN 1 YL) 2(1H PYRAZOL 1 YL)ETHANONE; CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR1; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; DRUG BIOAVAILABILITY; DRUG HALF LIFE; HIGH THROUGHPUT SCREENING; HUMAN; HUMAN CELL; NONHUMAN; RAT; RECEPTOR BINDING; STRUCTURE ACTIVITY RELATION;

CELL LINE; HUMANS; PIPERAZINES; PYRAZOLES; RECEPTORS, CCR1; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84873727207     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2013.01.005     Document Type: Article

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