SCOPUS 정보 검색 플랫폼

Bioorganic and Medicinal Chemistry Letters

Volumn 23, Issue 14, 2013, Pages 4026-4030

Design, synthesis and structure-activity relationships of zwitterionic spirocyclic compounds as potent CCR1 antagonists

(6) Hossain, Nafizal a Ivanova, Svetlana a Timén, Åsa Sjöholm a Bergare, Jonas a Mussie, Tesfaledet a Bergström, Lena a

a ASTRAZENECA R AND D (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

CHEMOKINE RECEPTOR ANTAGONIST; CHEMOKINE RECEPTOR CCR1 ANTAGONIST; UNCLASSIFIED DRUG; ZWITTERIONIC SPIROCYCLIC COMPOUND;

ANIMAL CELL; ARTICLE; CHEMOTAXIS; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN; HUMAN CELL; IN VITRO STUDY; NONHUMAN; RAT; STRUCTURE ACTIVITY RELATION;

CELL LINE, TUMOR; CHEMOTAXIS; DRUG DESIGN; HUMANS; PROTEIN BINDING; RECEPTORS, CCR1; SPIRO COMPOUNDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84879409938 PISSN: 0960894X EISSN: 14643405 Source Type: Journal
DOI: 10.1016/j.bmcl.2013.05.087 Document Type: Article

Times cited : (2)

References (21)

1
- 26844438935
- W.J. Karpus, and K.J. Kennedy J. Leukoc. Biol. 62 1997 691
- (1997) J. Leukoc. Biol. , vol.62 , pp. 691
- Karpus, W.J.¹ Kennedy, K.J.²

2
- 0029015342
- R. Godiska, D. Chantry, G.N. Dietsch, and P.N. gray J. Neuroimmunol. 58 1995 167
- (1995) J. Neuroimmunol. , vol.58 , pp. 167
- Godiska, R.¹ Chantry, D.² Dietsch, G.N.³ Gray, P.N.⁴

3
- 0035546057
- N. Godessart, and S.L. Kunkel Curr. Opin. Immunol. 13 2001 670
- (2001) Curr. Opin. Immunol. , vol.13 , pp. 670
- Godessart, N.¹ Kunkel, S.L.²

4
- 0035985805
- P. Loetscher, and B. Moser Arthritis Res. 4 2002 233
- (2002) Arthritis Res. , vol.4 , pp. 233
- Loetscher, P.¹ Moser, B.²

5
- 0029979617
- R.M. Strieter, T.J. Standiford, G.B. Huffnagle, L.M. Colletti, N.W. Lukacs, and S.L. Kunkle J. Immunol. 156 1996 3583
- (1996) J. Immunol. , vol.156 , pp. 3583
- Strieter, R.M.¹ Standiford, T.J.² Huffnagle, G.B.³ Colletti, L.M.⁴ Lukacs, N.W.⁵ Kunkle, S.L.⁶

6
- 0032509889
- A.D. Luster N. Eng. J. Med. 338 1998 436
- (1998) N. Eng. J. Med. , vol.338 , pp. 436
- Luster, A.D.¹

7
- 0035260881
- C. Gerard, and B.J. Rollins Nat. Immunol. 2 2001 108
- (2001) Nat. Immunol. , vol.2 , pp. 108
- Gerard, C.¹ Rollins, B.J.²

8
- 0036485214
- A.E.I. Proudfoot Nat. Rev. Immunol. 2 2002 106
- (2002) Nat. Rev. Immunol. , vol.2 , pp. 106
- Proudfoot, A.E.I.¹

9
- 0034705618
- M. Liang, C. Hallari, M. Rosser, H.P. Ng, K. May, S. Monahan, J.G. Baumann, I. Islam, A. Ghannam, B. Buckman, K. Shaw, G.P. Wei, W. Zu, Z. Zhao, E. Ho, J. Shen, H. Oanh, B. Subramanyam, R. Vergona, D. Taub, L. Dunning, S. Harvey, R.M. Snider, J. Hesselgeser, M.M. Morrissey, H.D. Perez, and R. Horuk J. Biol. Chem. 275 2000 19000
- (2000) J. Biol. Chem. , vol.275 , pp. 19000
- Liang, M.¹ Hallari, C.² Rosser, M.³ Ng, H.P.⁴ May, K.⁵ Monahan, S.⁶ Baumann, J.G.⁷ Islam, I.⁸ Ghannam, A.⁹ Buckman, B.¹⁰ Shaw, K.¹¹ Wei, G.P.¹² Zu, W.¹³ Zhao, Z.¹⁴ Ho, E.¹⁵ Shen, J.¹⁶ Oanh, H.¹⁷ Subramanyam, B.¹⁸ Vergona, R.¹⁹ Taub, D.²⁰ more..

10
- 0035953316
- A. Naya, Y. Sagara, K. Ohwaki, T. Saeki, D. Ichikawa, Y. Iwasawa, K. Noguchi, and N. Ohtake J. Med. Chem. 44 2001 1429
- (2001) J. Med. Chem. , vol.44 , pp. 1429
- Naya, A.¹ Sagara, Y.² Ohwaki, K.³ Saeki, T.⁴ Ichikawa, D.⁵ Iwasawa, Y.⁶ Noguchi, K.⁷ Ohtake, N.⁸

11
- 0345533991
- P.H. Ng, K. May, J.G. Baumann, A. Ghannam, I. Islam, M. Liang, R. Horuk, J. Hesselgesser, R.M. Snider, H.D. Perez, and M. Morrissey J. Med. Chem. 42 1999 4680
- (1999) J. Med. Chem. , vol.42 , pp. 4680
- Ng, P.H.¹ May, K.² Baumann, J.G.³ Ghannam, A.⁴ Islam, I.⁵ Liang, M.⁶ Horuk, R.⁷ Hesselgesser, J.⁸ Snider, R.M.⁹ Perez, H.D.¹⁰ Morrissey, M.¹¹

12
- 11144355983
- J.C. Kath, W.H. Brissette, M.F. Brown, M. Conklyn, A.P. DiRico, P. Dorff, R.P. Gladue, B.M. Lillie, P.D. Lira, E.N. Mairs, W.H. Martin, E.B. McElroy, M.A. McGlynn, T.J. Paradis, C.S. Poss, I.A. Stock, L.A. Tylaska, and D. Zheng Bioorg. Med. Chem. Lett. 14 2004 2169
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 2169
- Kath, J.C.¹ Brissette, W.H.² Brown, M.F.³ Conklyn, M.⁴ Dirico, A.P.⁵ Dorff, P.⁶ Gladue, R.P.⁷ Lillie, B.M.⁸ Lira, P.D.⁹ Mairs, E.N.¹⁰ Martin, W.H.¹¹ McElroy, E.B.¹² McGlynn, M.A.¹³ Paradis, T.J.¹⁴ Poss, C.S.¹⁵ Stock, I.A.¹⁶ Tylaska, L.A.¹⁷ Zheng, D.¹⁸

13
- 11144355807
- M.F. Brown, M. Avery, W.H. Brissette, J.H. Chang, K. Colizza, M. Conklyn, A.P. DiRico, R.P. Glaude, J.C. Kath, S.S. Krueger, P.D. Lira, B.M. Lillie, G.D. Lundquist, E.N. Mairs, E.B. MaElroy, M.A. McGlynn, T.J. Paradis, C.S. Poss, M.I. Rossulek, R.M. Shepard, J. Sims, T.J. Strelevitz, S. Trusdell, L.A. Tylaska, K. Yoon, and D. Zheng Bioorg. Med. Chem. Lett. 14 2004 2175
- (2004) Bioorg. Med. Chem. Lett. , vol.14 , pp. 2175
- Brown, M.F.¹ Avery, M.² Brissette, W.H.³ Chang, J.H.⁴ Colizza, K.⁵ Conklyn, M.⁶ Dirico, A.P.⁷ Glaude, R.P.⁸ Kath, J.C.⁹ Krueger, S.S.¹⁰ Lira, P.D.¹¹ Lillie, B.M.¹² Lundquist, G.D.¹³ Mairs, E.N.¹⁴ Maelroy, E.B.¹⁵ McGlynn, M.A.¹⁶ Paradis, T.J.¹⁷ Poss, C.S.¹⁸ Rossulek, M.I.¹⁹ Shepard, R.M.²⁰ more..

14
- 26844562398
- L. Revesz, B. Bollbuck, T. Buhl, J. Eder, R. Esser, R. feifel, R. Heng, P. Hiestand, B. Jachez-Demange, P. Loeetscher, H. Sparrer, A. Schlapbach, and R. Waelchli Bioorg. Med. Chem. Lett. 15 2005 5160
- (2005) Bioorg. Med. Chem. Lett. , vol.15 , pp. 5160
- Revesz, L.¹ Bollbuck, B.² Buhl, T.³ Eder, J.⁴ Esser, R.⁵ Feifel, R.⁶ Heng, R.⁷ Hiestand, P.⁸ Jachez-Demange, B.⁹ Loeetscher, P.¹⁰ Sparrer, H.¹¹ Schlapbach, A.¹² Waelchli, R.¹³

15
- 34249275319
- Y.F. Xie, K. Lake, K. Ligsay, M. Komanda, I. Sircar, G. Nagarajan, J. Li, K. Xu, J. Parise, L. Schneider, D. Huang, J. Liu, K. Dines, N. Sakurai, M. Barbose, and R. Jack Bioorg. Med. Chem. Lett. 17 2007 3367
- (2007) Bioorg. Med. Chem. Lett. , vol.17 , pp. 3367
- Xie, Y.F.¹ Lake, K.² Ligsay, K.³ Komanda, M.⁴ Sircar, I.⁵ Nagarajan, G.⁶ Li, J.⁷ Xu, K.⁸ Parise, J.⁹ Schneider, L.¹⁰ Huang, D.¹¹ Liu, J.¹² Dines, K.¹³ Sakurai, N.¹⁴ Barbose, M.¹⁵ Jack, R.¹⁶

16
- 40749128432
- Y.F. Xie, I. Sircar, K. Lake, M. Komandla, K. Ligsay, J. Li, K. Xu, J. Parise, L. Schneider, D. Huang, J. Liu, N. Sakurai, M. Barbose, and R. Jack Bioorg. Med. Chem. Lett. 18 2008 2215
- (2008) Bioorg. Med. Chem. Lett. , vol.18 , pp. 2215
- Xie, Y.F.¹ Sircar, I.² Lake, K.³ Komandla, M.⁴ Ligsay, K.⁵ Li, J.⁶ Xu, K.⁷ Parise, J.⁸ Schneider, L.⁹ Huang, D.¹⁰ Liu, J.¹¹ Sakurai, N.¹² Barbose, M.¹³ Jack, R.¹⁴

17
- 84873727207
- A.M.K. Pernell, J.B. Aggen, S. Sen, W. Chen, Y. Xu, E. Sullivan, L. Li, K. Greenman, T. Charvat, D. Hansen, D.J. Dairaghi, J.J.K. Wright, and P. Zhang Bioorg. Med. Chem. Lett. 23 2013 1228
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 1228
- Pernell, A.M.K.¹ Aggen, J.B.² Sen, S.³ Chen, W.⁴ Xu, Y.⁵ Sullivan, E.⁶ Li, L.⁷ Greenman, K.⁸ Charvat, T.⁹ Hansen, D.¹⁰ Dairaghi, D.J.¹¹ Wright, J.J.K.¹² Zhang, P.¹³

18
- 80054777639
- G. Bhaley, B. Albrecht, M. Akhlaq, U. Baettig, D. Beer, Z. Brown, S. Charlton, A. Dunstan, M. Bradley, P. Gedeck, A. Glen, T. Howe, T. Keller, J.L. Davies, A. Li, C. McCarthy, C. Mocquet, C. Owen, P. Nicklin, and E. Rosethorne Bioorg. Med. Chem. Lett. 21 2011 6249
- (2011) Bioorg. Med. Chem. Lett. , vol.21 , pp. 6249
- Bhaley, G.¹ Albrecht, B.² Akhlaq, M.³ Baettig, U.⁴ Beer, D.⁵ Brown, Z.⁶ Charlton, S.⁷ Dunstan, A.⁸ Bradley, M.⁹ Gedeck, P.¹⁰ Glen, A.¹¹ Howe, T.¹² Keller, T.¹³ Davies, J.L.¹⁴ Li, A.¹⁵ McCarthy, C.¹⁶ Mocquet, C.¹⁷ Owen, C.¹⁸ Nicklin, P.¹⁹ Rosethorne, E.²⁰ more..

19
- 84874655840
- N. Hossain, S. Ivanova, J. Bergare, and T. Eriksson Bioorg. Med. Chem. Lett 23 2013 1883
- (2013) Bioorg. Med. Chem. Lett , vol.23 , pp. 1883
- Hossain, N.¹ Ivanova, S.² Bergare, J.³ Eriksson, T.⁴

20
- 84878106101
- N. Hossain, I. Ivanova, J. Bergare, M. Mensonides-Harsema, and M.E. Cooper Bioorg. Med. Chem. Lett. 23 2013 3500
- (2013) Bioorg. Med. Chem. Lett. , vol.23 , pp. 3500
- Hossain, N.¹ Ivanova, I.² Bergare, J.³ Mensonides-Harsema, M.⁴ Cooper, M.E.⁵

21
- 84879418515
- 50 was determined in human embryonic kidney cells via ion flux electrophysiology, for detail see Ref. 15b
- 50 was determined in human embryonic kidney cells via ion flux electrophysiology, for detail see Ref. 15b.

* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.