Safety and toxicity issues associated with lead-based traditional herbo-metallic preparations

Journal of Ethnopharmacology

Volumn 151, Issue 1, 2014, Pages 1-11

  Nagarajan, Surya ^a   Sivaji, Kalaiarasi ^a   Krishnaswamy, Sridharan ^a   Pemiah, Brindha ^a   Rajan, Kalpoondi Sekar ^a   Krishnan, Uma Maheswari ^a   Sethuraman, Swaminathan ^a  

^a SASTRA UNIVERSITY   (India)

Author keywords

Ayurveda (knowledge of life); Heavy metals; Herbo metallic preparation; Naga bhasma (lead sulphide ash); Toxicity

Indexed keywords

HERBACEOUS AGENT; LEAD; MINERAL;

AYURVEDA; BIOLOGY; CHEMICAL ENGINEERING; DATA BASE; DRUG SAFETY; DRUG TOXICITY; NONHUMAN; REVIEW; TRADITIONAL MEDICINE;

SCOPUS;

AYURVEDA (KNOWLEDGE OF LIFE); HEAVY METALS; HERBO-METALLIC PREPARATION; NAGA BHASMA (LEAD SULPHIDE ASH); TOXICITY;

HUMANS; LEAD; LEAD POISONING; MEDICINE, TRADITIONAL; PLANT PREPARATIONS;

EID: 84891484195     PISSN: 03788741     EISSN: 18727573     Source Type: Journal    
DOI: 10.1016/j.jep.2013.10.037     Document Type: Review

References (65)

1. The Ayurvedic Formulary of India, Part 1, 2003. second ed. Department of Indian Systems of Medicine & Homoeopathy, Government of India, New Delhi.
2. D.D. Alasia Lead nephropathy: revisiting an overlooked cause of kidney disease Nephrol. Rev. 2 2010 1 8
3. C. Anjana, T.N. Nagaraja, S.K. Dixit, J.K. Agrawal, Mohan Kumar, and Bhanu Prakash A novel ayurvedic anti diabetic medicine Ancient Sci. Life 15 1995 153 155
4. A. Bansal, M. Sairam, D. Prasad, S.K. Sharma, G. Ilavazhagan, D. Kumar, and W. Selvamurthy Cytoprotective and immunomodulatory properties of Geriforte, a herbomineral preparation in lymphocytes Phytomedicine 8 2001 438 444
5. K. Balaji, P. Brindha, K. Sridharan, K. Uma Maheswari, S. Swaminathan, and K.S. Rajan Elucidation of a core-shell model for Lauha bhasma through physicochemical characterization Int. J. Pharm. Pharm. Sci. 4 2012 644 649
6. K. Balaji, R. Narendran, P. Brindha, K. Sridharan, K. Uma Maheswari, S. Swaminathan, and K.S. Rajan Scientific validation of the different purification steps involved in the preparation of an Indian ayurvedic medicine, Lauha bhasma J. Ethnopharmacol. 142 2012 98 104
7. K. Balaji, K.P. Arun, P Brindha, K. Sridharan, K. Uma Maheswari, S. Swaminathan, and K.S. Rajan Bhanupaka: a green process in the preparation of an Indian ayurvedic medicine, Lauha bhasma J. Chem. 2013 2013 951951
8. P. Bhavana et al. Whole genome expression and biochemical correlates of extreme constitutional types defined in ayurveda J. Transl. Med. 6 2008 48
9. P. Bhushan, W. Dnyaneshwar, P. Pushpangadan, and Narendra Bhatt Ayurveda and traditional Chinese medicine: a comparative overview Evidence-based Complement. Altern. Med. 2 2005 465 473
10. Y.W. Chi, S.L Chen, M.H Yang, R.C Hwang, and M.L. Chu Heavy metals in traditional Chinese medicine: ba-pao-neu-hwang-san Zhonghua Min Guo Xiao Er Ke Yi Xue Hui Za Zhi 34 1993 181 190
11. Barry Clark The Quintessence Tantras of Tibetan Medicine 1995 Snow Lion Publications New York
12. R. Cornelis Handbook of Elemental Speciation II: Species in the Environment, Food, Medicine & Occupational Health 2005 Wiley Publications
13. S.M. Deshmukh, C.L. Bhingare, and S.J. Kshirsagar Screening of antidiabetic effect of Naga bhasma in alloxan induced hyperglycemic rats Int. J. Res. Ayurveda Pharm 4 2012 240 242
14. Yeshi. Donden Healing from the Source 2000 Snow Lion Publications New York
15. N. Ercal, H. Gurer-Orhan, and N. Aykin-Burns Toxic metals and oxidative stress part I: mechanisms involved in metal-induced oxidative damage Curr. Top. Med. Chem. 1 2001 529 539
16. S.J.S. Flora Arsenic induced oxidative stress and its reversibility Free Radical Biol. Med. 51 2011 257 281
17. G. Flora, D. Gupta, and A. Tiwari Toxicity of lead: a review with recent updates Interdisciplin. Toxicol. 5 2012 47 58
18. T.L. Guidotti, J. McNamara, and M.S. Moses The interpretation of trace element analysis in body fluids Indian J. Med. Res. 128 2008 524 532
19. W. Huang, J. Zhang, and D.D. Moore A traditional herbal medicine enhances bilirubin clearance by activating the nuclear receptor CAR J. Clin. Invest. 113 2004 137 143
20. R.R. John, and S. Muttaiya Lead ion binding and RNA chain hydrolysis in phenylalanine tRNA J. Biomol. Struct. Dyn. 1 1983 639 646
21. B. Joseph, K. Kyung-ah, C. Tamal, and G. Gary Molecular mechanisms of lead neurotoxicity Neurochemical. Res. 24 1999 595 600
22. C. Jisong, H. Li, Z. Annie, L.L. Jane, Y. Jinghua, S. Soumaya, M. Peter, R. Immaculada, P. Fernado, and D.W. Samuel Guggulsterone is a farnesoid x receptor antagonist in coactivator association assays but acts to enhance transcription of bile salt export pump J. Biochem. Chem. 278 2003 10214 10220
23. S.N. Kales, C.A. Christophi, and R.B. Saper Hematopoietic toxicity from lead-containing ayurvedic medications Med. Sci. Monit. 13 2007 295 298
24. M. Kara, B.B. Hasinoff, D.W. McKay, and N.R. Campbel Clinical and chemical interactions between iron preparations and ciprofloxacin Br. J. Clin. Pharmacol. 31 1991 257 261
25. S.K. Karri, R.B. Saper, and N.S. Kales Lead encephalopathy due to traditional medicines Curr. Drug Saf. 3 2008 54 59
26. A. Kumar, A.G Nair, A.V. Reddy, and A.N. Garg Bhasmas: unique ayurvedic metallic-herbal preparations, chemical characterization Biol. Trace Elem. Res. 109 2006 231 254
27. T. Lisa et al. Differential stability of lead sulfide nanoparticles influences biological responses in embryonic zebra fish Arch. Toxicol. 85 2011 787 798
28. J.K. Michael, P.W. Richard, J.R. Stephen, L.H. Karen, L.M. Barbara, S.S Brian, Howard Hu, and W. Alan Recommendations for medical management of adult lead exposure Environ. Health Perspect. 115 2007 463 471
29. S.A. Nasim, and B. Dhir Heavy metals alter potency of medicinal plants Rev. Environ. Contam. Toxicol. 203 2010 139 149
30. H. Needleman Lead poisoning Ann. Rev. Med. 55 2004 209 222
31. R.C. Patra, D. Swarup, and S.K. Dwivedi Antioxidant effects of α tocopherol, ascorbic acid and l-methionine on lead induced oxidative stress to the liver, kidney and brain in rats Toxicology 162 2001 81 88
32. L. Patrick Lead toxicity, a review of the literature. Part 1: Exposure, evaluation, and treatment Altern. Med. Rev. 11 2006 2 22
33. I.D. Paul et al. Heavy metal poisoning from ayurvedic traditional medicines: an emerging problem Int. J. Environ. Health 2 2008 463 474
34. H. Ping-Chi, and L.G. Yueliang Antioxidant nutrients and lead toxicity Toxicology 180 2002 33 34
35. M.T. Pravin, B.J. Patgiri, and P.K. Prajapati Pharmaceutical standardization of Naga bhasma Ayu 30 2009 300 309
36. D. Prochazkova, I. Bousava, and N. Wihelmova Antioxidant and prooxidant properties of flavanoids Fitoterapia 82 2011 513 523
37. K.S. Rajan, K. Dhasandhan, S.N. Srivastava, and B. Pitchumani Studies on gas-solid heat transfer during pneumatic conveying Int. J. Heat Mass Transfer 51 2008 2801 2813
38. K.S. Rajan, B. Pitchumani, S.N Srivastava, and B. Mohanty Two-dimensional simulation of gas-solid heat transfer in pneumatic conveying Int. J. Heat Mass Transfer 50 2007 967 976
39. K.S. Rajan, S.N. Srivastava, B. Pitchumani, and B. Mohanty Simulation of gas-solid heat transfer during pneumatic conveying: use of multiple gas inlets along the duct Int. Commun. Heat Mass Transfer 33 2006 1234 1242
40. K.S. Rajan, S.N. Srivastava, B. Pitchumani, and B. Mohanty Simulation of countercurrent gas-solid heat exchanger: effect of solid loading ratio and particle size Appl. Therm. Eng. 27 2007 1345 1351
41. S. Rajat, J. Deepinder, and D.J. Kiran Lipoperoxidative damage on lead exposure in rat brain and its implications on membrane bound enzymes Pharmacol. Toxicol. 74 1994 66 71
42. S.K. Rastogi Renal effects of environmental and occupational lead exposure Indian J. Occup. Environ. Med. 12 2008 103 106
43. A. Raviraja, G.N. Vishal Babu, A. Sehgal, and R.B. Saper Three cases of lead toxicity associated with consumption of ayurvedic medicines Indian J. Clin. Biochem. 25 2010 326 329
44. R. Renner Exposure on tap: drinking water as an overlooked source of lead Environ. Health Perspect. 118 2010 A68 A74
45. F.O. Robert et al. Phase III trial of carboplatin and paclitaxel compared with cisplatin and paclitaxel in patients with optimally resected stage III ovarian cancer: a gynecologic oncology group study J. Clin. Oncol. 21 2003 3194 3200
46. 2+ homeostasis in cultured osteoclastic bone cells Toxicol. Appl. Pharmacol. 98 1989 530 543
47. H.A. Saleh, G.A. El-Aziz, M.M. El-Fark, and M. El-Gohary Effect of maternal lead exposure on craniofacial ossification in rat foetuses and the role of antioxidant therapy Anat. Histol. Embryol. 38 2009 392 399
48. R.B. Saper, S.N. Kales, and J. Paquin Heavy metal content of ayurvedic herbal medicine products J. Am. Med. Assoc. 292 2004 2868 2873
49. R.B. Saper, R.S. Phillips, and A. Sehgal Lead, mercury and arsenic in US-and Indian-manufactured ayurvedic medicines sold via the internet J. Am. Med. Assoc. 300 2008 915 923
50. A. Schoen, B. Beck, R. Sharma, and E. Dube Arsenic toxicity at low doses: epidemiological and mode of action considerations Toxicol. Appl. Pharmacol. 198 2004 253 267
51. Shyamsundaracharyavaishya Rasayanasara 1997 Krishna Das Academy Varanasi
52. E.K. Silbergeld et al. Lead in bone: storage site, exposure source, and target organ Neurotoxicology 14 1993 225 236
53. M. Singh, D. Josh, and N.C. Arya Studies on testicular regenerative potential of Naga bhasma Ancient Sci. Life 9 1989 95 98
54. S.K. Singh, D.N.S. Gautam, M. Kumar, and S.B. Rai Synthesis, characterization and histopathological study of a lead-based traditional drug: Naga bhasma Indian J. Pharm. Sci. 72 2010 24 30
55. J. Sun, M. Zhu, K. Fu, N. Lewinski, and R.A. Drezek Lead sulfide near-infrared quantum dot bioconjugates for targeted molecular imaging Int. J. Nanomed. 2 2007 235 240
56. N. Surya, P. Brindha, K. Uma Maheswari, K.S. Rajan, K. Sridharan, and S. Swaminathan Physico chemical characterization of lead based Indian traditional medicine-Naga bhasma Int. J. Pharm. Pharm. Sci. 4 2012 69 74
57. U.K. Sushant, P. Brindha, K.S. Rajan, K. Sridharan, S. Swaminathan, and K. Uma Maheswari Mercury-based traditional herbo-metallic preparations: a toxicological perspective Arch. Toxicol. 86 2012 831 838
58. V. Sushil Kumar, P. Rajalakshimi, P. Brindha, K. Sridharan, K. Uma Maheswari, S. Swaminathan, and K.S. Rajan Preparation & characterization of Vanga bhasma, a tin-based herbo-metallic preparation Int. J. Pharm. Pharm. Sci. 4 2012 49 54
59. G.C. Tenore et al. Antioxidant profile and in vitro cardiac radical-scavenging versus pro-oxidant effects of commercial red grape juices (Vitis vinifera L. cv. Aglianico N.) J. Agric. Food Chem. 60 2012 9680 9687
60. K.H.C. Thomas Activation of pregnane X receptor (pxr) and constitutive androstane receptor (CAR) by herbal medicines Am. Assoc. Pharm. Scientists J. 11 2009 590 601
61. H.J. Ullmann Colloidal lead and irradiation in the treatment of cancer report of two years experience J. Am. Med. Assoc. 92 1929 18 20
62. N.D. Vaziri, and H.C. Gonick Cardiovascular effects of lead exposure Indian J. Med. Res. 128 2008 426 435
63. D. Vibha, E.M. Anandan, S.M. Rajesh, T.S. Muraleedharan, M.S. Valiathan, M. Mousumi, and C. Subhash Lakhotia In vivo effects of traditional ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications PLoS One 7 2012 1 25
64. Virupaksha Gupta, K.L. Pallavi, G. Patgiri, B.J. Galib, and P.K. Prajapati Critical review on the pharmaceutical vistas of Lauha kalpas (iron formulations) J. Ayurveda Integr. Med. 3 2012 21 28
65. T.K. Wilson, F. Phyllis, and D.S. Richard Interactions between iron deficiency and lead poisoning: epidemiology and pathogenesis Sci. Total Environ. 330 2004 21 37