In vivo effects of traditional Ayurvedic formulations in Drosophila melanogaster model relate with therapeutic applications

PLoS ONE

Volumn 7, Issue 5, 2012, Pages

  Dwivedi, Vibha ^a   Anandan, E M ^b   Mony, Rajesh S ^b   Muraleedharan, T S ^b   Valiathan, M S ^c   Mutsuddi, Mousumi ^a   Lakhotia, Subhash C ^a  

^a BANARAS HINDU UNIVERSITY   (India)

^b Arya Vaidya Sala ^*  (India)

^c MANIPAL UNIVERSITY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

AMALAKI RASAYANA; AYURVEDIC DRUG; HETEROGENEOUS NUCLEAR RIBONUCLEOPROTEIN; RASA SINDOOR; UNCLASSIFIED DRUG; AMALAKIRASAYANA; DROSOPHILA PROTEIN; ORGANOMERCURY COMPOUND; PLANT EXTRACT;

ANALYTICAL PARAMETERS; ARTICLE; AYURVEDA; CONTROLLED STUDY; DIET SUPPLEMENTATION; DROSOPHILA MELANOGASTER; EMBLICA OFFICINALIS; FERTILITY; HEAT TOLERANCE; IN VIVO STUDY; LIFESPAN; LONGEVITY; NONHUMAN; PROTEIN EXPRESSION; PROTEIN FUNCTION; STARVATION; STRESS; ANIMAL; DRUG EFFECT; FEMALE; GROWTH, DEVELOPMENT AND AGING; HUMAN; MALE; MEDICINAL PLANT; METABOLISM; PHYSIOLOGICAL STRESS; PHYSIOLOGY;

DROSOPHILA MELANOGASTER;

ANIMALS; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; FEMALE; FERTILITY; HETEROGENEOUS-NUCLEAR RIBONUCLEOPROTEINS; HUMANS; LONGEVITY; MALE; MEDICINE, AYURVEDIC; ORGANOMERCURY COMPOUNDS; PLANT EXTRACTS; PLANTS, MEDICINAL; STRESS, PHYSIOLOGICAL;

EID: 84861004630     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0037113     Document Type: Article

References (62)

1. Sharma P, (1999) Sushruta Samhita (Sanskrit with English Translation). Varanasi Chaukhambha Visvabharati.
2. Singh RH, (2003) The holistic principles of Ayurvedic medicine. Delhi, India Chaukhamba Sanskrit Pratishthan.
3. Sharma PV, (1994) Charaka Samhita (Sanskrit with English Translation). Varanasi, India Chaukhambha Orientalia.
4. Valiathan S, (2006) Ayurveda - putting the house in order (Guest Editorial). Curr Sci 90: 5-6.
5. Bier E, (2005) Drosophila, the golden bug, emerges as a tool for human genetics. Nat Rev Genet 6: 9-23.
6. Bilen J, Bonini NM, (2005) Drosophila as a model for human neurodegenerative disease. Annu Rev Genet 39: 153-171.
7. Brumby AM, Richardson HE, (2005) Using Drosophila melanogaster to map human cancer pathways. Nat Rev Cancer 5: 626-639.
8. Restifo LL, (2005) Mental retardation genes in drosophila: New approaches to understanding and treating developmental brain disorders. Ment Retard Dev Disabil Res Rev 11: 286-294.
9. Wolf MJ, Amrein H, Izatt JA, Choma MA, Reedy MC, et al. (2006) Drosophila as a model for the identification of genes causing adult human heart disease. Proc Natl Acad Sci U S A 103: 1394-1399.
10. Mallik M, Lakhotia SC, (2010) Modifiers and mechanisms of multi-system polyglutamine neurodegenerative disorders: lessons from fly models. J Genetics 89: 497-526.
11. Murthy KRS, (2000) Ashtanga Hridaya (Sanskrit with English Translation). Varanasi, India Krishnadas Academy.
12. Sharma S, (1979) Rastarangini (Sanskrit with Hindi translation). In: K Sastri, editors. editor Varanasi, India Motilal Benarasidas.
13. Patel NG, (1986) India's Traditional Medicine: Ayurveda. In: Steiner RP, editors. Folk Medicine: The Art and the Science Washington DC American Chemical Society.
14. Singh SK, Chaudhary AK, Rai DK, Rai SB, (2009) Preparation and characterization of a mercury based Indian traditional drug Ras-sindoor. Indian J Traditional Knowledge 8: 346-357.
15. Sarkar PK, Chaudhary AK, (2010) Ayurvedic Bhasma: the most ancient application of nanomedicine. J Sci Industr Res 69: 901-915.
16. Demerec M, (1950) Biology of Drosophila. New York John Wiley and Sons.
17. Roy S, Lakhotia SC, (1977) Synchrony of replication in sister salivary glands of Drosophila kikkawai. Indian J Exp Biol 15: 794-796.
18. Zhimulev IF, Koryakov DE, (2009) Polytene chromosomes. Encyclopedia of Life Sciences (ELS). Chichester John Wiley and Sons, Ltd.
19. Tapadia MG, Lakhotia SC, (1997) Specific induction of the hsr omega locus of Drosophila melanogaster by amides. Chromosome Res 5: 359-362.
20. Huey RB, Crill WD, Kingsolver JG, Weber KE, (1992) A method for rapid measurement of heat or cold resistance of small insects. Funct Ecol 6: 489-494.
21. Sorensen JG, Kristensen TN, Loeschcke V, (2003) The evolutionary and ecological role of heat shock proteins. Ecology Letters 6: 1025-1037.
22. Feder ME, Hofmann GE, (1999) Heat-shock proteins, molecular chaperones, and the stress response: evolutionary and ecological physiology. Annu Rev Physiol 61: 243-282.
23. Lakhotia SC, Ray P, Rajendra TK, Prasanth KV, (1999) he noncoding transcripts of hsr-omega gene in Drosophila: do they regulate trafficking and availability of nuclear RNA-processing factors? Curr Sci 77: 553-563.
24. Jolly C, Lakhotia SC, (2006) Human sat III and Drosophila hsr omega transcripts: a common paradigm for regulation of nuclear RNA processing in stressed cells. Nucleic Acids Res 34: 5508-5514.
25. Lakhotia SC, Mallik M, Singh AK, Ray M, (2012) The large noncoding hsromega-n transcripts are essential for thermotolerance and remobilization of hnRNPs, HP1 and RNA polymerase II during recovery from heat shock in Drosophila. Chromosoma 121: 49-70.
26. Han SP, Tang YH, Smith R, (2010) Functional diversity of the hnRNPs: past, present and perspectives. Biochem J 430: 379-392.
27. Prasanth KV, Rajendra TK, Lal AK, Lakhotia SC, (2000) Omega speckles - a novel class of nuclear speckles containing hnRNPs associated with noncoding hsr-omega RNA in Drosophila. J Cell Sci 113 Pt 19: 3485-3497.
28. Saumweber H, Symmons P, Kabisch R, Will H, Bonhoeffer F, (1980) Monoclonal antibodies against chromosomal proteins of Drosophila melanogaster: establishment of antibody producing cell lines and partial characterization of corresponding antigens. Chromosoma 80: 253-275.
29. Ashburner M, (1972) Puffing patterns in Drosophila melanogaster and related species. In: Beermann W, editors. Developmental Studies on Giant Chromosomes Berlin Springer-Verlag pp. 101-151.
30. Amero SA, Matunis MJ, Matunis EL, Hockensmith JW, Raychaudhuri G, et al. (1993) A unique ribonucleoprotein complex assembles preferentially on ecdysone-responsive sites in Drosophila melanogaster. Mol Cell Biol 13: 5323-5330.
31. Poltanov EA, Shikov AN, Dorman HJ, Pozharitskaya ON, Makarov VG, et al. (2009) Chemical and antioxidant evaluation of Indian gooseberry (Emblica officinalis Gaertn., syn. Phyllanthus emblica L.) supplements. Phytother Res 23: 1309-1315.
32. Govindarajan R, Vijayakumar M, Pushpangadan P, (2005) Antioxidant approach to disease management and the role of 'Rasayana' herbs of Ayurveda. J Ethnopharmacol 99: 165-178.
33. Khan KH, (2009) Roles of Emblica officinalis in Medicine-A Review. Botany Research International 2: 218-228.
34. Krishnaveni M, Mirunalini S, (2010) Therapeutic potential of Phyllanthus emblica (amla): the ayurvedic wonder. J Basic Clin Physiol Pharmacol 21: 93-105.
35. Chatterjee UR, Bandyopadhyay SS, Ghosh D, Ghosal PK, Ray B, (2011) In vitro anti-oxidant activity, fluorescence quenching study and structural features of carbohydrate polymers from Phyllanthus emblica. Int J Biol Macromol 49: 637-642.
36. Scartezzini P, Speroni E, (2000) Review on some plants of Indian traditional medicine with antioxidant activity. Journal of Ethnopharmacology 71: 23-43.
37. Priyadarshini S, Ashadevi JS, Nagarjun V, Prasanna KS, (2010) Increase in Drosophila melanogaster longevity due to rasayana diet: Preliminary results. J Ayurveda Integr Med 1: 114-119.
38. Guru Prasad BR, Mokshith MC, Pankaj P, (2011) Investigation of Emblica officinalis diet on Longevity, behavior and fitness characters in a Drosophilid: Phorticella striata. Munis Entomology & Zoology 6: 785-795.
39. Lakhotia SC, (2010) Validation of Ayurvedic formulations in animal models requires stringent scientific rigor. J Ayurveda Integr Med 1: 171-172.
40. Swain U, Sindhu KK, Boda U, Pothani S, Giridharan NV, et al. (2011) Studies on the molecular correlates of genomic stability in rat brain cells following Amalakirasayana therapy. Mech. Ageing Develop.http://dx.doi.org/10.1016/j.mad.2011.10.006.
41. Boffetta P, Merler E, Vainio H, (1993) Carcinogenicity of mercury and mercury compounds. Scand J Work Environ Health 19: 1-7.
42. Guzzi G, La Porta CA, (2008) Molecular mechanisms triggered by mercury. Toxicology 244: 1-12.
43. Vallee BL, Ulmer DD, (1972) Biochemical effects of mercury, cadmium, and lead. Annu Rev Biochem 41: 91-128.
44. Liu J, Shi JZ, Yu LM, Goyer RA, Waalkes MP, (2008) Mercury in traditional medicines: is cinnabar toxicologically similar to common mercurials? Exp Biol Med (Maywood) 233: 810-817.
45. Zhou X, Wang L, Sun X, Yang X, Chen C, et al. (2011) Cinnabar is not converted into methylmercury by human intestinal bacteria. Journal of ethnopharmacology 135: 110-115.
46. Chippindale AK, Chu TJE, Rose MR, (1996) Complex trade-offs and the evolution of starvation resistance in Drosophila melanogaster. Evolution 50: 753-766.
47. Prasad NG, Joshi A, (2003) What have two decades of laboratory life-history evolution studies on Drosophila melanogaster taught us? J Genet 82: 45-76.
48. Eric LB, Philippe V, Patrice L, François P, (2001) Effects of mild heat shocks at young age on aging and longevity in Drosophila melanogaster. Biogerontology 2: 155-164.
49. Kristensen TN, Sorensen V, Loeschcke V, (2003) Mild heat stress at a young age in Drosophila melanogaster leads to increased Hsp70 synthesis after stress exposure later in life. J Genet 82: 89-94.
50. Lakhotia SC, (2011) Forty years of the 93D puff of Drosophila melanogaster. Journal of Biosciences 36: 399-423.
51. Dreyfuss G, Matunis MJ, Pinol-Roma S, Burd CG, (1993) hnRNP proteins and the biogenesis of mRNA. Annu Rev Biochem 62: 289-321.
52. Blanchette M, Green RE, MacArthur S, Brooks AN, Brenner SE, et al. (2009) Genome-wide analysis of alternative pre-mRNA splicing and RNA-binding specificities of the Drosophila hnRNP A/B family members. Molecular Cell 33: 438-449.
53. Zu K, Sikes ML, Beyer AL, (1998) Separable roles in vivo for the two RNA binding domains of Drosophila A1-hnRNP homolog. Rna 4: 1585-1598.
54. Zu K, Sikes ML, Haynes SR, Beyer AL, (1996) Altered levels of the Drosophila HRB87F/hrp36 hnRNP protein have limited effects on alternative splicing in vivo. Mol Biol Cell 7: 1059-1073.
55. Borah S, Wong AC, Steitz JA, (2009) Drosophila hnRNP A1 homologs Hrp36/Hrp38 enhance U2-type versus U12-type splicing to regulate alternative splicing of the prospero twintron. Proc Natl Acad Sci U S A 106: 2577-2582.
56. Wayne ML, Soundararajan U, Harshman LG, (2006) Environmental stress and reproduction in Drosophila melanogaster: starvation resistance, ovariole numbers and early age egg production. BMC evolutionary biology 6: 57.
57. Norry FM, Larsen PF, Liu Y, Loeschcke V, (2009) Combined expression patterns of QTL-linked candidate genes best predict thermotolerance in Drosophila melanogaster. J Insect Physiol 55: 1050-1057.
58. Morin X, Daneman R, Zavortink M, Chia W, (2001) A protein trap strategy to detect GFP-tagged proteins expressed from their endogenous loci in Drosophila. Proc Natl Acad Sci U S A 98: 15050-15055.
59. Buszczak M, Paterno S, Lighthouse D, Bachman J, Planck J, et al. (2007) The Carnegie protein trap library: a versatile tool for Drosophila developmental studies. Genetics 175: 1505-1531.
60. Lakhotia SC, Tapadia MG, (1998) Genetic mapping of the amide response element(s) of the hsr omega locus of Drosophila melanogaster. Chromosoma 107: 127-135.
61. Hao X, Zhang S, Timakov B, Zhang P, (2007) The Hsp27 gene is not required for Drosophila development but its activity is associated with starvation resistance. Cell Stress Chaperones 12: 364-372.
62. Haynes SR, Johnson D, Raychaudhuri G, Beyer AL, (1991) The Drosophila Hrb87F gene encodes a new member of the A and B hnRNP protein group. Nucleic Acids Res 19: 25-31.