메뉴 건너뛰기




Volumn 55, Issue 1, 2014, Pages 67-73

Methylenetetrahydrofolate reductase C677T and overall survival in pediatric acute lymphoblastic leukemia: A systematic review

Author keywords

Acute lymphoblastic leukemia; Mortality; MTHFR; Pediatric; Survival

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2);

EID: 84891368024     PISSN: 10428194     EISSN: 10292403     Source Type: Journal    
DOI: 10.3109/10428194.2013.792336     Document Type: Article
Times cited : (13)

References (62)
  • 1
    • 84865168175 scopus 로고    scopus 로고
    • Pediatric acute lymphoblastic leukemia: Where are we going and how do we get there?
    • Pul CH, Mullighan CG, Evans WE, et al. Pediatric acute lymphoblastic leukemia: Where are we going and how do we get there? Blood 2012; 120: 1165-1174.
    • (2012) Blood , vol.120 , pp. 1165-1174
    • Pul, C.H.1    Mullighan, C.G.2    Evans, W.E.3
  • 2
    • 84880203379 scopus 로고    scopus 로고
    • In search of targeted therapies for childhood cancer
    • Mackall CL. In search of targeted therapies for childhood cancer. Front Oncol 2011; 1: 18.
    • (2011) Front Oncol , vol.1 , pp. 18
    • Mackall, C.L.1
  • 3
    • 3142736052 scopus 로고    scopus 로고
    • P harmacogenetic determinants of outcome in acute lymphoblastic leukaemia
    • Aplenc R, Lange B. P harmacogenetic determinants of outcome in acute lymphoblastic leukaemia. Br J Haematol 2004; 125: 421-434.
    • (2004) Br J Haematol , vol.125 , pp. 421-434
    • Aplenc, R.1    Lange, B.2
  • 4
    • 72249086376 scopus 로고    scopus 로고
    • Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia
    • Koppen IJ, Hermans FJ, Kaspers G J. Folate related gene polymorphisms and susceptibility to develop childhood acute lymphoblastic leukaemia. Br J Haematol 2010; 148: 3-14.
    • (2010) Br J Haematol , vol.148 , pp. 3-14
    • Koppen, I.J.1    Hermans, F.J.2    Kaspers, G.J.3
  • 5
    • 33846661727 scopus 로고    scopus 로고
    • Do polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia?
    • Pereira TV, Rudnicki M, Pereira AC, et al. D o polymorphisms of 5,10-methylenetetrahydrofolate reductase (MTHFR) gene affect the risk of childhood acute lymphoblastic leukemia? Eur J Epidemiol 2006; 21: 885-886.
    • (2006) Eur J Epidemiol , vol.21 , pp. 885-886
    • Pereira, T.V.1    Rudnicki, M.2    Pereira, A.C.3
  • 6
    • 80053212404 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblastic leukemia risk: A meta-Analysis based on 28 case-control studies
    • Tong N, Sheng X, Wang M, et al. Methylenetetrahydrofolate reductase gene polymorphisms and acute lymphoblastic leukemia risk: A meta-Analysis based on 28 case-control studies. Leuk Lymphoma 2011; 52: 1949-1960.
    • (2011) Leuk Lymphoma , vol.52 , pp. 1949-1960
    • Tong, N.1    Sheng, X.2    Wang, M.3
  • 7
    • 78149357320 scopus 로고    scopus 로고
    • MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-Analysis
    • Wang J, Zhan P, Chen B, et al. MTHFR C677T polymorphisms and childhood acute lymphoblastic leukemia: A meta-Analysis. Leuk Res 2010; 34: 1596-1600.
    • (2010) Leuk Res , vol.34 , pp. 1596-1600
    • Wang, J.1    Zhan, P.2    Chen, B.3
  • 8
    • 84865620566 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-Analysis including 35 studies
    • Wang H, Wang J, Zhao L, et al. Methylenetetrahydrofolate reductase polymorphisms and risk of acute lymphoblastic leukemia-evidence from an updated meta-Analysis including 35 studies. BMC Med Genet 2012; 13: 77.
    • (2012) BMC Med Genet , vol.13 , pp. 77
    • Wang, H.1    Wang, J.2    Zhao, L.3
  • 9
    • 84856812366 scopus 로고    scopus 로고
    • A meta-Analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children
    • Yan J, Yin M, Dreyer ZE, et al. A meta-Analysis of MTHFR C677T and A1298C polymorphisms and risk of acute lymphoblastic leukemia in children. Pediatr Blood Cancer 2012; 58: 513-518.
    • (2012) Pediatr Blood Cancer , vol.58 , pp. 513-518
    • Yan, J.1    Yin, M.2    Dreyer, Z.E.3
  • 10
    • 84858798304 scopus 로고    scopus 로고
    • Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: A synthesis of genetic association studies
    • Zintzaras E, Doxani C, Rodopoulou P, et al. Variants of the MTHFR gene and susceptibility to acute lymphoblastic leukemia in children: A synthesis of genetic association studies. Cancer Epidemiol 2012; 36: 169-176.
    • (2012) Cancer Epidemiol , vol.36 , pp. 169-176
    • Zintzaras, E.1    Doxani, C.2    Rodopoulou, P.3
  • 12
    • 28044447631 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase polymorphisms and pharmacogenetics: A new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and disease
    • Kim YI. 5,10-Methylenetetrahydrofolate reductase polymorphisms and pharmacogenetics: A new role of single nucleotide polymorphisms in the folate metabolic pathway in human health and disease. Nutr Rev 2005; 63: 398-407.
    • (2005) Nutr Rev , vol.63 , pp. 398-407
    • Kim, Y.I.1
  • 13
    • 67651167100 scopus 로고    scopus 로고
    • Treatment of acute lymphoblastic leukemia in children and adolescents: Peaks and pitfalls
    • Seibel N L. Treatment of acute lymphoblastic leukemia in children and adolescents: Peaks and pitfalls. Hematology Am Soc Hematol Educ Program 2008: 374-380.
    • (2008) Hematology Am Soc Hematol Educ Program , pp. 374-380
    • Seibel, N.L.1
  • 14
    • 84868148325 scopus 로고    scopus 로고
    • Impact of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on methotrexate-induced toxicities in acute lymphoblastic leukemia: A meta-Analysis
    • Yang L, Hu X, Xu L. Impact of methylenetetrahydrofolate reductase (MTHFR) polymorphisms on methotrexate-induced toxicities in acute lymphoblastic leukemia: A meta-Analysis. Tumour Biol 2012; 33: 1445-1454.
    • (2012) Tumour Biol , vol.33 , pp. 1445-1454
    • Yang, L.1    Hu, X.2    Xu, L.3
  • 15
    • 84891359119 scopus 로고    scopus 로고
    • A systematic review and meta-Analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia
    • Oct 23. [Epub ahead of print]
    • Lopez-Lopez E, Martin-Guerrero I, Ballesteros J, et al. A systematic review and meta-Analysis of MTHFR polymorphisms in methotrexate toxicity prediction in pediatric acute lymphoblastic leukemia. Pharmacogenomics J 2012 Oct 23. [Epub ahead of print].
    • (2012) Pharmacogenomics J
    • Lopez-Lopez, E.1    Martin-Guerrero, I.2    Ballesteros, J.3
  • 16
    • 84864004759 scopus 로고    scopus 로고
    • Overall survival: Patient outcome, therapeutic objective, clinical trial end point, or public health measure?
    • Saad ED, Buyse M. Overall survival: Patient outcome, therapeutic objective, clinical trial end point, or public health measure? J. Clin Oncol 2012; 30: 1750-1754.
    • (2012) J. Clin Oncol , vol.30 , pp. 1750-1754
    • Saad, E.D.1    Buyse, M.2
  • 17
    • 84965181896 scopus 로고    scopus 로고
    • Meta-Analysis
    • In: Rothman KJ. Greenland S. Lash TL editors Philadelphia, PA: Lippincott Williams & Wilkins
    • Greenland S, O ' Rourke K. Meta-Analysis. In: Rothman KJ, Greenland S, Lash TL, editors. Modern epidemiology. Philadelphia, PA: Lippincott Williams & Wilkins; 2008. pp. 652-682.
    • (2008) Modern epidemiology , pp. 652-682
    • Greenland, S.1    O'Rourke, K.2
  • 19
    • 58949100713 scopus 로고    scopus 로고
    • Additional genetic risk factor for death in children with acute lymphoblastic leukemia: A common polymorphism of the MTHFR gene
    • Pietrzyk JJ, Bik-Multanowski M, Balwierz W, et al. Additional genetic risk factor for death in children with acute lymphoblastic leukemia: A common polymorphism of the MTHFR gene. Pediatr Blood Cancer 2009; 52: 364-368.
    • (2009) Pediatr Blood Cancer , vol.52 , pp. 364-368
    • Pietrzyk, J.J.1    Bik-Multanowski, M.2    Balwierz, W.3
  • 20
    • 82455209055 scopus 로고    scopus 로고
    • Methotrexate toxicity and efficacy during the consolidation phase in paediatric acute lymphoblastic leukaemia and MTHFR polymorphisms as pharmacogenetic determinants
    • D'Angelo V, Ramaglia M, Iannotta A, et al. Methotrexate toxicity and efficacy during the consolidation phase in paediatric acute lymphoblastic leukaemia and MTHFR polymorphisms as pharmacogenetic determinants. Cancer Chemother Pharmacol 2011; 68: 1339-1346.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 1339-1346
    • D'Angelo, V.1    Ramaglia, M.2    Iannotta, A.3
  • 21
    • 75649124222 scopus 로고    scopus 로고
    • Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia
    • Tantawy AA, El-Bostany EA, Adly AA, et al. Methylene tetrahydrofolate reductase gene polymorphism in Egyptian children with acute lymphoblastic leukemia. Blood Coagul Fibrinolysis 2010; 21: 28-34.
    • (2010) Blood Coagul Fibrinolysis , vol.21 , pp. 28-34
    • Tantawy, A.A.1    El-Bostany, E.A.2    Adly, A.A.3
  • 22
    • 84891364980 scopus 로고    scopus 로고
    • Influence of methylenetetrahydrofolate reductase C677T, A1298C, and G80A polymorphisms on the survival of pediatric patients with acute lymphoblastic leukemia
    • De Deus DM, de Lima EL, Seabra Silva RM, et al. Influence of methylenetetrahydrofolate reductase C677T, A1298C, and G80A polymorphisms on the survival of pediatric patients with acute lymphoblastic leukemia. Leuk Res Treatment 2012; 2012: 292043.
    • (2012) Leuk Res Treatment , vol.2012 , pp. 292043
    • De Deus, D.M.1    De Lima, E.L.2    Seabra Silva, R.M.3
  • 23
    • 84861355815 scopus 로고    scopus 로고
    • Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia
    • Erculj N, Kotnik BF, Debeljak M, et al. Influence of folate pathway polymorphisms on high-dose methotrexate-related toxicity and survival in childhood acute lymphoblastic leukemia. Leuk Lymphoma 2012; 53: 1096-1104.
    • (2012) Leuk Lymphoma , vol.53 , pp. 1096-1104
    • Erculj, N.1    Kotnik, B.F.2    Debeljak, M.3
  • 24
    • 84872827371 scopus 로고    scopus 로고
    • Study of the pharmacokinetic and pharmacogenetic contribution to the toxicity of high-dose methotrexate in children with acute lymphoblastic leukemia
    • El-Khodary NM, El-Haggar SM, Eid MA, et al. Study of the pharmacokinetic and pharmacogenetic contribution to the toxicity of high-dose methotrexate in children with acute lymphoblastic leukemia. Med Oncol 2012; 29: 2053-2062.
    • (2012) Med Oncol , vol.29 , pp. 2053-2062
    • El-Khodary, N.M.1    El-Haggar, S.M.2    Eid, M.A.3
  • 25
    • 3843072366 scopus 로고    scopus 로고
    • Model-based estimation of relative risks and other epidemiologic measures in studies of common outcomes and in casecontrol studies
    • Greenland S. M odel-based estimation of relative risks and other epidemiologic measures in studies of common outcomes and in casecontrol studies. Am J. Epidemiol 2004; 160: 301-305.
    • (2004) Am J. Epidemiol , vol.160 , pp. 301-305
    • Greenland, S.1
  • 26
    • 24144458327 scopus 로고    scopus 로고
    • Easy SAS calculations for risk or prevalence ratios and differences
    • Spiegelman D, Hertzmark E. Easy SAS calculations for risk or prevalence ratios and differences. Am J. Epidemiol 2005; 162: 199-200.
    • (2005) Am J. Epidemiol , vol.162 , pp. 199-200
    • Spiegelman, D.1    Hertzmark, E.2
  • 29
    • 0028152471 scopus 로고
    • Why sources of heterogeneity in meta-Analysis should be investigated
    • Thompson SG. Why sources of heterogeneity in meta-Analysis should be investigated. BMJ 1994; 309: 1351-1355.
    • (1994) BMJ , vol.309 , pp. 1351-1355
    • Thompson, S.G.1
  • 30
    • 0028048042 scopus 로고
    • Meta-Analysis and its problems
    • Eysenck HJ. Meta-Analysis and its problems. BMJ 1994; 309: 789-792.
    • (1994) BMJ , vol.309 , pp. 789-792
    • Eysenck, H.J.1
  • 31
    • 0036277684 scopus 로고    scopus 로고
    • Point: Population stratification: A problem for case-control studies of candidate-gene associations?
    • Thomas DC, Witte JS. Point: Population stratification: A problem for case-control studies of candidate-gene associations? Cancer Epidemiol Biomarkers Prev 2002; 11: 505-512.
    • (2002) Cancer Epidemiol Biomarkers Prev , vol.11 , pp. 505-512
    • Thomas, D.C.1    Witte, J.S.2
  • 33
    • 84873408800 scopus 로고    scopus 로고
    • C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: Effect on methotrexaterelated toxicity in adult acute lymphoblastic leukaemia
    • Eissa DS, Ahmed TM. C677T and A1298C polymorphisms of the methylenetetrahydrofolate reductase gene: Effect on methotrexaterelated toxicity in adult acute lymphoblastic leukaemia. Blood Coagul Fibrinolysis 2013; 24: 181-188.
    • (2013) Blood Coagul Fibrinolysis , vol.24 , pp. 181-188
    • Eissa, D.S.1    Ahmed, T.M.2
  • 34
    • 84859737779 scopus 로고    scopus 로고
    • The role of MTHFR and RFC1 polymorphisms on toxicity and outcome of adult patients with hematological malignancies treated with high-dose methotrexate followed by leucovorin rescue
    • Chiusolo P, Giammarco S, Bellesi S, et al. The role of MTHFR and RFC1 polymorphisms on toxicity and outcome of adult patients with hematological malignancies treated with high-dose methotrexate followed by leucovorin rescue. Cancer Chemother Pharmacol 2012; 69: 691-696.
    • (2012) Cancer Chemother Pharmacol , vol.69 , pp. 691-696
    • Chiusolo, P.1    Giammarco, S.2    Bellesi, S.3
  • 35
    • 84866631524 scopus 로고    scopus 로고
    • Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia
    • De Beaumais TA, Jacqz-Aigrain E. Pharmacogenetic determinants of mercaptopurine disposition in children with acute lymphoblastic leukemia. Eur J. Clin Pharmacol 2012; 68: 1233-1242.
    • (2012) Eur J. Clin Pharmacol , vol.68 , pp. 1233-1242
    • De Beaumais, T.A.1    Jacqz-Aigrain, E.2
  • 36
    • 84891358941 scopus 로고    scopus 로고
    • Characterizing rare variants in drug metabolism genes in refractory pediatric high-risk pre-B ALL
    • Abstract 879
    • Hughes A, Giacalone J, Druley T E. Characterizing rare variants in drug metabolism genes in refractory pediatric high-risk pre-B ALL. Blood 2012; 120(Suppl. 1): Abstract 879.
    • (2012) Blood , vol.120 , Issue.SUPPL. 1
    • Hughes, A.1    Giacalone, J.2    Druley, T.E.3
  • 37
    • 84866722399 scopus 로고    scopus 로고
    • Pharmacogenetic analysis of pediatric patients with acute lymphoblastic leukemia: A possible association between survival rate and ITPA polymorphism
    • Kim H, Kang HJ, Kim HJ, et al. Pharmacogenetic analysis of pediatric patients with acute lymphoblastic leukemia: A possible association between survival rate and ITPA polymorphism. PLoS One 2012; 7: E45558.
    • (2012) PLoS One , vol.7
    • Kim, H.1    Kang, H.J.2    Kim, H.J.3
  • 38
    • 84863255278 scopus 로고    scopus 로고
    • Germline genetic variation and treatment response on CCG-1891
    • Sepe DM, McWilliams T, Chen J, et al. Germline genetic variation and treatment response on CCG-1891. Pediatr Blood Cancer 2012; 58: 695-700.
    • (2012) Pediatr Blood Cancer , vol.58 , pp. 695-700
    • Sepe, D.M.1    McWilliams, T.2    Chen, J.3
  • 39
    • 84866173015 scopus 로고    scopus 로고
    • Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin
    • Tiseo M, Giovannetti E, Tibaldi C, et al. Pharmacogenetic study of patients with advanced non-small cell lung cancer (NSCLC) treated with second-line pemetrexed or pemetrexed-carboplatin. Lung Cancer 2012; 78: 92-99.
    • (2012) Lung Cancer , vol.78 , pp. 92-99
    • Tiseo, M.1    Giovannetti, E.2    Tibaldi, C.3
  • 40
    • 84858706750 scopus 로고    scopus 로고
    • Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: A pilot study
    • Windsor RE, Strauss SJ, Kallis C, et al. Germline genetic polymorphisms may influence chemotherapy response and disease outcome in osteosarcoma: A pilot study. Cancer 2012; 118: 1856-1867.
    • (2012) Cancer , vol.118 , pp. 1856-1867
    • Windsor, R.E.1    Strauss, S.J.2    Kallis, C.3
  • 41
    • 84866740024 scopus 로고    scopus 로고
    • Methotrexate consolidation treatment according to pharmacogenetics of MTHFR ameliorates event-free survival in childhood acute lymphoblastic leukaemia
    • Salazar J, Altes A, Del Rio E, et al. Methotrexate consolidation treatment according to pharmacogenetics of MTHFR ameliorates event-free survival in childhood acute lymphoblastic leukaemia. Pharmacogenomics J. 2012; 12: 379-385.
    • (2012) Pharmacogenomics J. , vol.12 , pp. 379-385
    • Salazar, J.1    Altes, A.2    Del Rio, E.3
  • 42
    • 77955102782 scopus 로고    scopus 로고
    • Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma
    • Horinouchi M, Yagi M, Imanishi H, et al. Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma. Pediatr Hematol Oncol 2010; 27: 344-354.
    • (2010) Pediatr Hematol Oncol , vol.27 , pp. 344-354
    • Horinouchi, M.1    Yagi, M.2    Imanishi, H.3
  • 43
    • 84859387335 scopus 로고    scopus 로고
    • Meta-Analyzing the link between MTHFR C677T genotype and susceptibility to childhood ALL
    • Goyal RK, Cooper JD. Meta-Analyzing the link between MTHFR C677T genotype and susceptibility to childhood ALL. Pediatr Blood Cancer 2012; 58: 483-484.
    • (2012) Pediatr Blood Cancer , vol.58 , pp. 483-484
    • Goyal, R.K.1    Cooper, J.D.2
  • 44
    • 67649331653 scopus 로고    scopus 로고
    • 5,10-Methylenetetrahydrofolate reductase (MTHFR) low activity genotypes reduce the risk of relapse-related acute lymphoblastic leukemia (ALL)
    • Karas Kuzelicki N, Milek M, Jazbec J, et al. 5,10- Methylenetetrahydrofolate reductase (MTHFR) low activity genotypes reduce the risk of relapse-related acute lymphoblastic leukemia (ALL). Leuk Res 2009; 33: 1344-1348.
    • (2009) Leuk Res , vol.33 , pp. 1344-1348
    • Karas Kuzelicki, N.1    Milek, M.2    Jazbec, J.3
  • 46
    • 67651229706 scopus 로고    scopus 로고
    • Role of the MTHFR polymorphisms in cancer risk modification and treatment
    • Kim Y I. Role of the MTHFR polymorphisms in cancer risk modification and treatment. Future Oncol 2009; 5: 523-542.
    • (2009) Future Oncol , vol.5 , pp. 523-542
    • Kim, Y.I.1
  • 47
    • 84891351219 scopus 로고    scopus 로고
    • Integrated molecular and pharmacogenetic profi les in prediction of early response to therapy in children with acute lymphoblastic leukemia (all): A report from malaysia-singapore all study group
    • Lu Y, Kham SKY, AriffinH, et al. Integrated molecular and pharmacogenetic profi les in prediction of early response to therapy in children with acute lymphoblastic leukemia (ALL): A report from Malaysia-Singapore ALL Study Group. Blood 2009; 114: 1029-1030.
    • (2009) Blood , vol.114 , pp. 1029-1030
    • Lu, Y.1    Kham, S.K.Y.2    Ariffin, H.3
  • 48
    • 67749114009 scopus 로고    scopus 로고
    • Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: Effects on methotrexate-related toxicity and survival
    • Ongaro A, De Mattei M, Della Porta MG, et al. Gene polymorphisms in folate metabolizing enzymes in adult acute lymphoblastic leukemia: Effects on methotrexate-related toxicity and survival. Haematologica 2009; 94: 1391-1398.
    • (2009) Haematologica , vol.94 , pp. 1391-1398
    • Ongaro, A.1    De Mattei, M.2    Della Porta, M.G.3
  • 49
    • 38949175429 scopus 로고    scopus 로고
    • Thymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients
    • Sharma R, Hoskins JM, Rivory LP, et al. Th ymidylate synthase and methylenetetrahydrofolate reductase gene polymorphisms and toxicity to capecitabine in advanced colorectal cancer patients. Clin Cancer Res 2008; 14: 817-825.
    • (2008) Clin Cancer Res , vol.14 , pp. 817-825
    • Sharma, R.1    Hoskins, J.M.2    Rivory, L.P.3
  • 50
    • 36549065249 scopus 로고    scopus 로고
    • Pharmacogenomics of acute lymphoblastic leukemia
    • Ansari M, St-Onge G, Krajinovic M. [ Pharmacogenomics of acute lymphoblastic leukemia]. Med Sci (Paris) 2007; 23: 961-967.
    • (2007) Med Sci (Paris) , vol.23 , pp. 961-967
    • Ansari, M.1    St-Onge, G.2    Krajinovic, M.3
  • 51
    • 35748970501 scopus 로고    scopus 로고
    • MTHFR polymorphisms ' influence on outcome and toxicity in acute lymphoblastic leukemia patients
    • Chiusolo P, Reddiconto G, Farina G, et al. MTHFR polymorphisms ' influence on outcome and toxicity in acute lymphoblastic leukemia patients. Leuk Res 2007; 31: 1669-1674.
    • (2007) Leuk Res , vol.31 , pp. 1669-1674
    • Chiusolo, P.1    Reddiconto, G.2    Farina, G.3
  • 52
    • 34547699409 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: Association with toxicity and survival
    • Gemmati D, Ongaro A, Tognazzo S, et al. Methylenetetrahydrofolate reductase C677T and A1298C gene variants in adult non-Hodgkin's lymphoma patients: Association with toxicity and survival. Haematologica 2007; 92: 478-485.
    • (2007) Haematologica , vol.92 , pp. 478-485
    • Gemmati, D.1    Ongaro, A.2    Tognazzo, S.3
  • 53
    • 34047109223 scopus 로고    scopus 로고
    • The epidemiology of childhood leukemia with a focus on birth weight and diet
    • Tower RL, Spector L G. The epidemiology of childhood leukemia with a focus on birth weight and diet. Crit Rev Clin Lab Sci 2007; 44: 203-242.
    • (2007) Crit Rev Clin Lab Sci , vol.44 , pp. 203-242
    • Tower, R.L.1    Spector, L.G.2
  • 54
    • 33646677710 scopus 로고    scopus 로고
    • MTHFR 677 (C-T) polymorphism is not relevant for prognosis or therapy-Associated toxicity in pediatric NHL: Results from 484 patients of multicenter trial NHL-BFM 95
    • Seidemann K, Book M, Zimmermann M, et al. MTHFR 677 (C-T) polymorphism is not relevant for prognosis or therapy-Associated toxicity in pediatric NHL: Results from 484 patients of multicenter trial NHL-BFM 95. Ann Hematol 2006; 85: 291-300.
    • (2006) Ann Hematol , vol.85 , pp. 291-300
    • Seidemann, K.1    Book, M.2    Zimmermann, M.3
  • 55
    • 84891350164 scopus 로고    scopus 로고
    • Pharmacogenetics of minimal residual disease response in children with acute lymphoblastic leukemia (ALL)
    • Abstract 451
    • Davies SM, Borowitz M, Devidas M, et al. Pharmacogenetics of minimal residual disease response in children with acute lymphoblastic leukemia (ALL). Blood 2004; 104(Suppl. 1): Abstract 451.
    • (2004) Blood , vol.104 , Issue.SUPPL. 1
    • Davies, S.M.1    Borowitz, M.2    Devidas, M.3
  • 56
    • 1342268390 scopus 로고    scopus 로고
    • Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia
    • Krajinovic M, Lemieux-Blanchard E, Chiasson S, et al. Role of polymorphisms in MTHFR and MTHFD1 genes in the outcome of childhood acute lymphoblastic leukemia. Pharmacogenomics J. 2004; 4: 66-72.
    • (2004) Pharmacogenomics J , vol.4 , pp. 66-72
    • Krajinovic, M.1    Lemieux-Blanchard, E.2    Chiasson, S.3
  • 57
    • 84891362143 scopus 로고    scopus 로고
    • Thrombophilic genetic mutations have no impact in the pathogenesis of thromboembolism in gastro-intestinal cancer patients
    • Abstract 3518
    • Olimpieri OM, Schiavon G, Giannetti B, et al. Th rombophilic genetic mutations have no impact in the pathogenesis of thromboembolism in gastro-intestinal cancer patients. Blood 2004; 104(Suppl. 1): Abstract 3518.
    • (2004) Blood , vol.104 , Issue.SUPPL. 1
    • Olimpieri, O.M.1    Schiavon, G.2    Giannetti, B.3
  • 58
    • 0346308307 scopus 로고    scopus 로고
    • Methylenetetrahydrofolate reductase gene polymorphism and glucocorticoid intake in children with ALL and aseptic osteonecrosis
    • Bernbeck B, Mauz-Korholz C, Zotz RB, et al. Methylenetetrahydrofolate reductase gene polymorphism and glucocorticoid intake in children with ALL and aseptic osteonecrosis. Klin Padiatr 2003; 215: 327-331.
    • (2003) Klin Padiatr , vol.215 , pp. 327-331
    • Bernbeck, B.1    Mauz-Korholz, C.2    Zotz, R.B.3
  • 60
    • 0344196932 scopus 로고    scopus 로고
    • Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors
    • Nowak-Gottl U, Wermes C, Junker R, et al. Prospective evaluation of the thrombotic risk in children with acute lymphoblastic leukemia carrying the MTHFR TT 677 genotype, the prothrombin G20210A variant, and further prothrombotic risk factors. Blood 1999; 93: 1595-1599.
    • (1999) Blood , vol.93 , pp. 1595-1599
    • Nowak-Gottl, U.1    Wermes, C.2    Junker, R.3
  • 61
    • 0032840953 scopus 로고    scopus 로고
    • Cerebral venous sinus thrombosis in children with acute lymphoblastic leukemia carrying the MTHFR TT677 genotype and further prothrombotic risk factors
    • Wermes C, Fleischhack G, Junker R, et al. Cerebral venous sinus thrombosis in children with acute lymphoblastic leukemia carrying the MTHFR TT677 genotype and further prothrombotic risk factors. Klin Padiatr 1999; 211: 211-214.
    • (1999) Klin Padiatr , vol.211 , pp. 211-214
    • Wermes, C.1    Fleischhack, G.2    Junker, R.3
  • 62
    • 4644240756 scopus 로고    scopus 로고
    • E vidence for gradients of human genetic diversity within and among continents
    • Serre D, Paabo S. E vidence for gradients of human genetic diversity within and among continents. Genome Res 2004; 14: 1679-1685.
    • (2004) Genome Res , vol.14 , pp. 1679-1685
    • Serre, D.1    Paabo, S.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.