Coexposure of mice to trovafloxacin and lipopolysaccharide, a model of idiosyncratic hepatotoxicity, results in a unique gene expression profile and interferon gamma-dependent liver injury

Toxicological Sciences

Volumn 107, Issue 1, 2009, Pages 270-280

  Shaw, Patrick J ^a   Ditewig, Amy C ^b   Waring, Jeffrey F ^b   Liguori, Michael J ^b   Blomme, Eric A ^b   Ganey, Patricia E ^a   Roth, Robert A ^a  

^a MICHIGAN STATE UNIVERSITY   (United States)

^b ABBOTT LABORATORIES   (United States)

Author keywords

Hepatotoxicity; Idiosyncratic toxicity; Inflammation; Interferon gamma; Liver injury; Trovafloxacin

Indexed keywords

BETA 2 MICROGLOBULIN; CXCL2 CHEMOKINE; GAMMA INTERFERON; HLA A ANTIGEN; INTERCELLULAR ADHESION MOLECULE 1; INTERLEUKIN 17 RECEPTOR; INTERLEUKIN 1BETA; INTERLEUKIN 8; JANUS KINASE; LEVOFLOXACIN; LIPOPOLYSACCHARIDE; MANGANESE SUPEROXIDE DISMUTASE; MYELOID DIFFERENTIATION FACTOR 88; STAT PROTEIN; SUPPRESSOR OF CYTOKINE SIGNALING 2; SUPPRESSOR OF CYTOKINE SIGNALING 3; TROVAFLOXACIN; TUMOR NECROSIS FACTOR ALPHA; VASCULOTROPIN A;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; GENE CLUSTER; GENE EXPRESSION PROFILING; GENE PROBE; GENETIC ANALYSIS; GENETIC RISK; LIVER NECROSIS; LIVER TOXICITY; MALE; MOUSE; NONHUMAN; PROTEIN BLOOD LEVEL; RISK FACTOR; SIGNAL TRANSDUCTION; TOXICOGENETICS; WILD TYPE;

ANALYSIS OF VARIANCE; ANIMALS; FEMALE; FLUOROQUINOLONES; GENE EXPRESSION; HEPATOCYTES; INFLAMMATION; INTERFERON-GAMMA; INTERLEUKIN-18; JANUS KINASES; LIPOPOLYSACCHARIDES; LIVER; LIVER DISEASES; MALE; MICE; MICE, INBRED BALB C; NAPHTHYRIDINES; NECROSIS; OFLOXACIN; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; STAT TRANSCRIPTION FACTORS; TRANSCRIPTIONAL ACTIVATION;

MUS;

EID: 58049194180     PISSN: 10966080     EISSN: 10960929     Source Type: Journal    
DOI: 10.1093/toxsci/kfn205     Document Type: Article

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