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Volumn 3 MAY, Issue , 2013, Pages

Targeting nuclear factor-kappa B to overcome resistance to chemotherapy

Author keywords

Apoptosis; Cancer; Chemotherapy; Cisplatin; NF B; Oncogene; Resistance

Indexed keywords

4 (2 AMINOETHYLAMINO) 1, 8 DIMETHYLIMIDAZO [1, 2 A] QUINOXALINE; 4 (2 AMINOETHYLAMINO) 1,8 DIMETHYLIMIDAZO[1,2 A]QUINOXALINE; BINDARIT; BIOPERINE; BLACK PEPPER EXTRACT; BORTEZOMIB; CARBOPLATIN; CASPASE 8; CD40 ANTIGEN; CISPLATIN; CURCUMIN; CYCLIN D; CYCLIN DEPENDENT KINASE 2; CYCLOHEXIMIDE; CYCLOOXYGENASE 2 INHIBITOR; DOCETAXEL; FAS ANTIGEN; FLICE INHIBITORY PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; PACLITAXEL; PARTHENOLIDE; PHOSPHATIDYLETHANOLAMINE BINDING PROTEIN; POLO LIKE KINASE 3; PROTEIN P100; PROTEIN P53; STRESS ACTIVATED PROTEIN KINASE; SYNAPTOTAGMIN I; TEMOZOLOMIDE; TUMOR NECROSIS FACTOR RECEPTOR; TUMOR NECROSIS FACTOR RELATED APOPTOSIS INDUCING LIGAND; UNCLASSIFIED DRUG; UNINDEXED DRUG;

EID: 84891139838     PISSN: None     EISSN: 2234943X     Source Type: Journal    
DOI: 10.3389/fonc.2013.00120     Document Type: Review
Times cited : (244)

References (133)
  • 1
    • 49649110459 scopus 로고    scopus 로고
    • Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells
    • Abedini, M. R., Muller, E. J., Brun, J., Bergeron, R., Gray, D. A., and Tsang, B. K. (2008). Cisplatin induces p53-dependent FLICE-like inhibitory protein ubiquitination in ovarian cancer cells. Cancer Res. 68, 4511-4517.
    • (2008) Cancer Res. , vol.68 , pp. 4511-4517
    • Abedini, M.R.1    Muller, E.J.2    Brun, J.3    Bergeron, R.4    Gray, D.A.5    Tsang, B.K.6
  • 2
    • 4844220794 scopus 로고    scopus 로고
    • Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro
    • Abedini, M. R., Qiu, Q., Yan, X., and Tsang, B. K. (2004). Possible role of FLICE-like inhibitory protein (FLIP) in chemoresistant ovarian cancer cells in vitro. Oncogene 23, 6997-7004.
    • (2004) Oncogene , vol.23 , pp. 6997-7004
    • Abedini, M.R.1    Qiu, Q.2    Yan, X.3    Tsang, B.K.4
  • 3
    • 3142745263 scopus 로고    scopus 로고
    • Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma
    • Amiri, K. I., Horton, L. W., Lafleur, B. J., Sosman, J. A., and Richmond, A. (2004). Augmenting chemosensitivity of malignant melanoma tumors via proteasome inhibition: implication for bortezomib (VELCADE, PS-341) as a therapeutic agent for malignant melanoma. Cancer Res. 64, 4912-4918.
    • (2004) Cancer Res. , vol.64 , pp. 4912-4918
    • Amiri, K.I.1    Horton, L.W.2    Lafleur, B.J.3    Sosman, J.A.4    Richmond, A.5
  • 4
    • 77954297744 scopus 로고    scopus 로고
    • Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer
    • Annunziata, C. M., Stavnes, H. T., Kleinberg, L., Berner, A., Hernandez, L. F., Birrer, M. J., et al. (2010). Nuclear factor kappaB transcription factors are coexpressed and convey a poor outcome in ovarian cancer. Cancer 116, 3276-3284.
    • (2010) Cancer , vol.116 , pp. 3276-3284
    • Annunziata, C.M.1    Stavnes, H.T.2    Kleinberg, L.3    Berner, A.4    Hernandez, L.F.5    Birrer, M.J.6
  • 5
    • 12844286907 scopus 로고    scopus 로고
    • cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B
    • Anrather, J., Racchumi, G., and Iadecola, C. (2005). cis-acting, element-specific transcriptional activity of differentially phosphorylated nuclear factor-kappa B. J. Biol. Chem. 280, 244-252.
    • (2005) J. Biol. Chem. , vol.280 , pp. 244-252
    • Anrather, J.1    Racchumi, G.2    Iadecola, C.3
  • 6
    • 0037025347 scopus 로고    scopus 로고
    • Inhibition of tumor necrosis factor-alpha-induced nuclear translocation and activation of NF-kappa B by dehydroxymethylepoxyquinomicin
    • Ariga, A., Namekawa, J., Matsumoto, N., Inoue, J., and Umezawa, K. (2002). Inhibition of tumor necrosis factor-alpha-induced nuclear translocation and activation of NF-kappa B by dehydroxymethylepoxyquinomicin. J. Biol. Chem. 277, 24625-24630.
    • (2002) J. Biol. Chem. , vol.277 , pp. 24625-24630
    • Ariga, A.1    Namekawa, J.2    Matsumoto, N.3    Inoue, J.4    Umezawa, K.5
  • 7
    • 0032575714 scopus 로고    scopus 로고
    • Death receptors: signaling and modulation
    • Ashkenazi, A., and Dixit, V. M. (1998). Death receptors: signaling and modulation. Science 281, 1305-1308.
    • (1998) Science , vol.281 , pp. 1305-1308
    • Ashkenazi, A.1    Dixit, V.M.2
  • 8
    • 70449091786 scopus 로고    scopus 로고
    • Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1
    • Barbie, D. A., Tamayo, P., Boehm, J. S., Kim, S. Y., Moody, S. E., Dunn, I. F., et al. (2009). Systematic RNA interference reveals that oncogenic KRAS-driven cancers require TBK1. Nature 462, 108-112.
    • (2009) Nature , vol.462 , pp. 108-112
    • Barbie, D.A.1    Tamayo, P.2    Boehm, J.S.3    Kim, S.Y.4    Moody, S.E.5    Dunn, I.F.6
  • 9
    • 54049115864 scopus 로고    scopus 로고
    • Identification of PP2A as a crucial regulator of the NF-kappaB feedback loop: its inhibition by UVB turns NF-kappaB into a pro-apoptotic factor
    • Barisic, S., Strozyk, E., Peters, N., Walczak, H., and Kulms, D. (2008). Identification of PP2A as a crucial regulator of the NF-kappaB feedback loop: its inhibition by UVB turns NF-kappaB into a pro-apoptotic factor. Cell Death Differ. 15, 1681-1690.
    • (2008) Cell Death Differ. , vol.15 , pp. 1681-1690
    • Barisic, S.1    Strozyk, E.2    Peters, N.3    Walczak, H.4    Kulms, D.5
  • 10
    • 70350554098 scopus 로고    scopus 로고
    • Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization
    • Baritaki, S., Yeung, K., Palladino, M., Berenson, J., and Bonavida, B. (2009). Pivotal roles of snail inhibition and RKIP induction by the proteasome inhibitor NPI-0052 in tumor cell chemoimmunosensitization. Cancer Res. 69, 8376-8385.
    • (2009) Cancer Res. , vol.69 , pp. 8376-8385
    • Baritaki, S.1    Yeung, K.2    Palladino, M.3    Berenson, J.4    Bonavida, B.5
  • 11
    • 84872530707 scopus 로고    scopus 로고
    • Generation and characterisation of Cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature
    • doi:10.1371/journal.pone.0054193
    • Barr, M. P., Gray, S. G., Hoffmann, A. C., Hilger, R. A., Thomale, J., O'Flaherty, J. D., et al. (2013). Generation and characterisation of Cisplatin-resistant non-small cell lung cancer cell lines displaying a stem-like signature. PLoS ONE 8:e54193. doi:10.1371/journal.pone.0054193
    • (2013) PLoS ONE , vol.8
    • Barr, M.P.1    Gray, S.G.2    Hoffmann, A.C.3    Hilger, R.A.4    Thomale, J.5    O'Flaherty, J.D.6
  • 12
    • 41649119370 scopus 로고    scopus 로고
    • Snail is a repressor of RKIP transcription in metastatic prostate cancer cells
    • Beach, S., Tang, H., Park, S., Dhillon, A. S., Keller, E. T., Kolch, W., et al. (2008). Snail is a repressor of RKIP transcription in metastatic prostate cancer cells. Oncogene 27, 2243-2248.
    • (2008) Oncogene , vol.27 , pp. 2243-2248
    • Beach, S.1    Tang, H.2    Park, S.3    Dhillon, A.S.4    Keller, E.T.5    Kolch, W.6
  • 13
    • 0035502956 scopus 로고    scopus 로고
    • Activation of nuclear factor kappa B through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells
    • Bottero, V., Busuttil, V., Loubat, A., Magné, N., Fischel, J. L., Milano, G., et al. (2001). Activation of nuclear factor kappa B through the IKK complex by the topoisomerase poisons SN38 and doxorubicin: a brake to apoptosis in HeLa human carcinoma cells. Cancer Res. 61, 7785-7791.
    • (2001) Cancer Res. , vol.61 , pp. 7785-7791
    • Bottero, V.1    Busuttil, V.2    Loubat, A.3    Magné, N.4    Fischel, J.L.5    Milano, G.6
  • 14
    • 33750586523 scopus 로고    scopus 로고
    • Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells
    • Braeuer, S. J., Buneker, C., Mohr, A., and Zwacka, R. M. (2006). Constitutively activated nuclear factor-kappaB, but not induced NF-kappaB, leads to TRAIL resistance by up-regulation of X-linked inhibitor of apoptosis protein in human cancer cells. Mol. Cancer Res. 4, 715-728.
    • (2006) Mol. Cancer Res. , vol.4 , pp. 715-728
    • Braeuer, S.J.1    Buneker, C.2    Mohr, A.3    Zwacka, R.M.4
  • 15
    • 0036251154 scopus 로고    scopus 로고
    • Stat proteins and oncogenesis
    • Bromberg, J. (2002). Stat proteins and oncogenesis. J. Clin. Invest. 109, 1139-1142.
    • (2002) J. Clin. Invest. , vol.109 , pp. 1139-1142
    • Bromberg, J.1
  • 16
    • 33751203592 scopus 로고    scopus 로고
    • Morphoproteomic demonstration of constitutive nuclear factor-kappaB activation in glioblastoma multiforme with genomic correlates and therapeutic implications
    • Brown, R. E., and Law, A. (2006). Morphoproteomic demonstration of constitutive nuclear factor-kappaB activation in glioblastoma multiforme with genomic correlates and therapeutic implications. Ann. Clin. Lab. Sci. 36, 421-426.
    • (2006) Ann. Clin. Lab. Sci. , vol.36 , pp. 421-426
    • Brown, R.E.1    Law, A.2
  • 17
    • 0035842333 scopus 로고    scopus 로고
    • Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53
    • Bush, J. A., Cheung, K. J. Jr., and Li, G. (2001). Curcumin induces apoptosis in human melanoma cells through a Fas receptor/caspase-8 pathway independent of p53. Exp. Cell Res. 271, 305-314.
    • (2001) Exp. Cell Res. , vol.271 , pp. 305-314
    • Bush, J.A.1    Cheung Jr., K.J.2    Li, G.3
  • 18
    • 1842526076 scopus 로고    scopus 로고
    • Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B
    • Campbell, K. J., Rocha, S., and Perkins, N. D. (2004). Active repression of antiapoptotic gene expression by RelA(p65) NF-kappa B. Mol. Cell 13, 853-865.
    • (2004) Mol. Cell , vol.13 , pp. 853-865
    • Campbell, K.J.1    Rocha, S.2    Perkins, N.D.3
  • 19
    • 5344266052 scopus 로고    scopus 로고
    • Protein interactions with platinum-DNA adducts: from structure to function
    • Chaney, S. G., Campbell, S. L., Temple, B., Bassett, E., Wu, Y., and Faldu, M. (2004). Protein interactions with platinum-DNA adducts: from structure to function. J. Inorg. Biochem. 98, 1551-1559.
    • (2004) J. Inorg. Biochem. , vol.98 , pp. 1551-1559
    • Chaney, S.G.1    Campbell, S.L.2    Temple, B.3    Bassett, E.4    Wu, Y.5    Faldu, M.6
  • 20
    • 2342435822 scopus 로고    scopus 로고
    • RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis
    • Chatterjee, D., Bai, Y., Wang, Z., Beach, S., Mott, S., Roy, R., et al. (2004). RKIP sensitizes prostate and breast cancer cells to drug-induced apoptosis. J. Biol. Chem. 279, 17515-17523.
    • (2004) J. Biol. Chem. , vol.279 , pp. 17515-17523
    • Chatterjee, D.1    Bai, Y.2    Wang, Z.3    Beach, S.4    Mott, S.5    Roy, R.6
  • 21
    • 33846828787 scopus 로고    scopus 로고
    • NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2
    • Chua, H. L., Bhat-Nakshatri, P., Clare, S. E., Morimiya, A., Badve, S., and Nakshatri, H. (2007). NF-kappaB represses E-cadherin expression and enhances epithelial to mesenchymal transition of mammary epithelial cells: potential involvement of ZEB-1 and ZEB-2. Oncogene 26, 711-724.
    • (2007) Oncogene , vol.26 , pp. 711-724
    • Chua, H.L.1    Bhat-Nakshatri, P.2    Clare, S.E.3    Morimiya, A.4    Badve, S.5    Nakshatri, H.6
  • 22
    • 0036569563 scopus 로고    scopus 로고
    • Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells
    • Chuang, S. E., Yeh, P. Y., Lu, Y. S., Lai, G. M., Liao, C. M., Gao, M., et al. (2002). Basal levels and patterns of anticancer drug-induced activation of nuclear factor-kappaB (NF-kappaB), and its attenuation by tamoxifen, dexamethasone, and curcumin in carcinoma cells. Biochem. Pharmacol. 63, 1709-1716.
    • (2002) Biochem. Pharmacol. , vol.63 , pp. 1709-1716
    • Chuang, S.E.1    Yeh, P.Y.2    Lu, Y.S.3    Lai, G.M.4    Liao, C.M.5    Gao, M.6
  • 23
    • 51649119590 scopus 로고    scopus 로고
    • Proapoptotic effects of NF-kappaB on cisplatin-induced cell death in auditory cell line
    • Chung, W. H., Boo, S. H., Chung, M. K., Lee, H. S., Cho, Y. S., and Hong, S. H. (2008). Proapoptotic effects of NF-kappaB on cisplatin-induced cell death in auditory cell line. Acta Otolaryngol. 128, 1063-1070.
    • (2008) Acta Otolaryngol. , vol.128 , pp. 1063-1070
    • Chung, W.H.1    Boo, S.H.2    Chung, M.K.3    Lee, H.S.4    Cho, Y.S.5    Hong, S.H.6
  • 24
    • 38849208347 scopus 로고    scopus 로고
    • Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma
    • doi:10.1371/journal.pmed.0050008
    • Cloughesy, T. F., Yoshimoto, K., Nghiemphu, P., Brown, K., Dang, J., Zhu, S., et al. (2008). Antitumor activity of rapamycin in a Phase I trial for patients with recurrent PTEN-deficient glioblastoma. PLoS Med. 5:e8. doi:10.1371/journal.pmed.0050008
    • (2008) PLoS Med. , vol.5
    • Cloughesy, T.F.1    Yoshimoto, K.2    Nghiemphu, P.3    Brown, K.4    Dang, J.5    Zhu, S.6
  • 25
    • 77954897621 scopus 로고    scopus 로고
    • A study of paclitaxel, carboplatin, and bortezomib in the treatment of metastatic malignant melanoma: a phase 2 consortium study
    • Croghan, G. A., Suman, V. J., Maples, W. J., Albertini, M., Linette, G., Flaherty, L., et al. (2010). A study of paclitaxel, carboplatin, and bortezomib in the treatment of metastatic malignant melanoma: a phase 2 consortium study. Cancer 116, 3463-3468.
    • (2010) Cancer , vol.116 , pp. 3463-3468
    • Croghan, G.A.1    Suman, V.J.2    Maples, W.J.3    Albertini, M.4    Linette, G.5    Flaherty, L.6
  • 26
    • 16844373775 scopus 로고    scopus 로고
    • Homeostatic niche specification among naive and activated B cells: a growing role for the BLyS family of receptors and ligands
    • Crowley, J. E., Treml, L. S., Stadanlick, J. E., Carpenter, E., and Cancro, M. P. (2005). Homeostatic niche specification among naive and activated B cells: a growing role for the BLyS family of receptors and ligands. Semin. Immunol. 17, 193-199.
    • (2005) Semin. Immunol. , vol.17 , pp. 193-199
    • Crowley, J.E.1    Treml, L.S.2    Stadanlick, J.E.3    Carpenter, E.4    Cancro, M.P.5
  • 27
    • 0028141961 scopus 로고
    • Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy
    • Dabholkar, M., Vionnet, J., Bostick-Bruton, F., Yu, J. J., and Reed, E. (1994). Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy. J. Clin. Invest. 94, 703-708.
    • (1994) J. Clin. Invest. , vol.94 , pp. 703-708
    • Dabholkar, M.1    Vionnet, J.2    Bostick-Bruton, F.3    Yu, J.J.4    Reed, E.5
  • 28
    • 0036782706 scopus 로고    scopus 로고
    • Transcription factors as targets for cancer therapy
    • Darnell, J. E. Jr. (2002). Transcription factors as targets for cancer therapy. Nat. Rev. Cancer 2, 740-749.
    • (2002) Nat. Rev. Cancer , vol.2 , pp. 740-749
    • Darnell Jr., J.E.1
  • 29
    • 0028234529 scopus 로고
    • Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins
    • Darnell, J. E. Jr., Kerr, I. M., and Stark, G. R. (1994). Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science 264, 1415-1421.
    • (1994) Science , vol.264 , pp. 1415-1421
    • Darnell Jr., J.E.1    Kerr, I.M.2    Stark, G.R.3
  • 30
    • 2342489456 scopus 로고    scopus 로고
    • eIF-4E expression and its role in malignancies and metastases
    • De Benedetti, A., and Graff, J. R. (2004). eIF-4E expression and its role in malignancies and metastases. Oncogene 23, 3189-3199.
    • (2004) Oncogene , vol.23 , pp. 3189-3199
    • De Benedetti, A.1    Graff, J.R.2
  • 32
    • 14944353807 scopus 로고    scopus 로고
    • Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation
    • di Meglio, P., Ianaro, A., and Ghosh, S. (2005). Amelioration of acute inflammation by systemic administration of a cell-permeable peptide inhibitor of NF-kappaB activation. Arthritis Rheum. 52, 951-958.
    • (2005) Arthritis Rheum. , vol.52 , pp. 951-958
    • di Meglio, P.1    Ianaro, A.2    Ghosh, S.3
  • 33
    • 84866718513 scopus 로고    scopus 로고
    • Cell-selective inhibition of NF-kappaB signaling improves therapeutic index in a melanoma chemotherapy model
    • Enzler, T., Sano, Y., Choo, M. K., Cottam, H. B., Karin, M., Tsao, H., et al. (2011). Cell-selective inhibition of NF-kappaB signaling improves therapeutic index in a melanoma chemotherapy model. Cancer Discov. 1, 496-507.
    • (2011) Cancer Discov. , vol.1 , pp. 496-507
    • Enzler, T.1    Sano, Y.2    Choo, M.K.3    Cottam, H.B.4    Karin, M.5    Tsao, H.6
  • 34
    • 78249286547 scopus 로고    scopus 로고
    • Curcumin and gemcitabine in patients with advanced pancreatic cancer
    • Epelbaum, R., Schaffer, M., Vizel, B., Badmaev, V., and Bar-Sela, G. (2010). Curcumin and gemcitabine in patients with advanced pancreatic cancer. Nutr. Cancer 62, 1137-1141.
    • (2010) Nutr. Cancer , vol.62 , pp. 1137-1141
    • Epelbaum, R.1    Schaffer, M.2    Vizel, B.3    Badmaev, V.4    Bar-Sela, G.5
  • 36
    • 0035902115 scopus 로고    scopus 로고
    • Proliferation, cell cycle and apoptosis in cancer
    • Evan, G. I., and Vousden, K. H. (2001). Proliferation, cell cycle and apoptosis in cancer. Nature 411, 342-348.
    • (2001) Nature , vol.411 , pp. 342-348
    • Evan, G.I.1    Vousden, K.H.2
  • 38
    • 0347362802 scopus 로고    scopus 로고
    • Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein
    • Fu, J., Jin, Y., and Arend, L. J. (2003). Smac3, a novel Smac/DIABLO splicing variant, attenuates the stability and apoptosis-inhibiting activity of X-linked inhibitor of apoptosis protein. J. Biol. Chem. 278, 52660-52672.
    • (2003) J. Biol. Chem. , vol.278 , pp. 52660-52672
    • Fu, J.1    Jin, Y.2    Arend, L.J.3
  • 39
    • 3042591332 scopus 로고    scopus 로고
    • Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB
    • Fujioka, S., Schmidt, C., Sclabas, G. M., Li, Z., Pelicano, H., Peng, B., et al. (2004). Stabilization of p53 is a novel mechanism for proapoptotic function of NF-kappaB. J. Biol. Chem. 279, 27549-27559.
    • (2004) J. Biol. Chem. , vol.279 , pp. 27549-27559
    • Fujioka, S.1    Schmidt, C.2    Sclabas, G.M.3    Li, Z.4    Pelicano, H.5    Peng, B.6
  • 40
    • 84867334724 scopus 로고    scopus 로고
    • A phase 2 study of bevacizumab with cisplatin plus intensity-modulated radiation therapy for stage III/IVB head and neck squamous cell cancer
    • Fury, M. G., Lee, N. Y., Sherman, E., Lisa, D., Kelly, K., Lipson, B., et al. (2012). A phase 2 study of bevacizumab with cisplatin plus intensity-modulated radiation therapy for stage III/IVB head and neck squamous cell cancer. Cancer 118, 5008-5014.
    • (2012) Cancer , vol.118 , pp. 5008-5014
    • Fury, M.G.1    Lee, N.Y.2    Sherman, E.3    Lisa, D.4    Kelly, K.5    Lipson, B.6
  • 41
    • 0031897632 scopus 로고    scopus 로고
    • NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses
    • Ghosh, S., May, M. J., and Kopp, E. B. (1998). NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu. Rev. Immunol. 16, 225-260.
    • (1998) Annu. Rev. Immunol. , vol.16 , pp. 225-260
    • Ghosh, S.1    May, M.J.2    Kopp, E.B.3
  • 42
    • 3042824992 scopus 로고    scopus 로고
    • Epidermal growth factor and trail interactions in epithelial-derived cells
    • Gibson, S. B. (2004). Epidermal growth factor and trail interactions in epithelial-derived cells. Vitam. Horm. 67, 207-227.
    • (2004) Vitam. Horm. , vol.67 , pp. 207-227
    • Gibson, S.B.1
  • 43
    • 33845897636 scopus 로고    scopus 로고
    • A phase II study of PS-341 (Bortezomib) in advanced or metastatic urothelial cancer. A trial of the Princess Margaret Hospital and University of Chicago phase II consortia
    • Gomez-Abuin, G., Winquist, E., Stadler, W. M., Pond, G., Degendorfer, P., Wright, J., et al. (2007). A phase II study of PS-341 (Bortezomib) in advanced or metastatic urothelial cancer. A trial of the Princess Margaret Hospital and University of Chicago phase II consortia. Invest. New Drugs 25, 181-185.
    • (2007) Invest. New Drugs , vol.25 , pp. 181-185
    • Gomez-Abuin, G.1    Winquist, E.2    Stadler, W.M.3    Pond, G.4    Degendorfer, P.5    Wright, J.6
  • 44
    • 26444538871 scopus 로고    scopus 로고
    • The two faces of NFkappaB in cell survival responses
    • Graham, B., and Gibson, S. B. (2005). The two faces of NFkappaB in cell survival responses. Cell Cycle 4, 1342-1345.
    • (2005) Cell Cycle , vol.4 , pp. 1342-1345
    • Graham, B.1    Gibson, S.B.2
  • 45
    • 17144387901 scopus 로고    scopus 로고
    • PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways
    • Grandage, V. L., Gale, R. E., Linch, D. C., and Khwaja, A. (2005). PI3-kinase/Akt is constitutively active in primary acute myeloid leukaemia cells and regulates survival and chemoresistance via NF-kappaB, Mapkinase and p53 pathways. Leukemia 19, 586-594.
    • (2005) Leukemia , vol.19 , pp. 586-594
    • Grandage, V.L.1    Gale, R.E.2    Linch, D.C.3    Khwaja, A.4
  • 46
    • 0028071555 scopus 로고
    • Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis
    • Greenblatt, M. S., Bennett, W. P., Hollstein, M., and Harris, C. C. (1994). Mutations in the p53 tumor suppressor gene: clues to cancer etiology and molecular pathogenesis. Cancer Res. 54, 4855-4878.
    • (1994) Cancer Res. , vol.54 , pp. 4855-4878
    • Greenblatt, M.S.1    Bennett, W.P.2    Hollstein, M.3    Harris, C.C.4
  • 47
    • 68149096799 scopus 로고    scopus 로고
    • The pharmacology of mTOR inhibition
    • Guertin, D. A., and Sabatini, D. M. (2009). The pharmacology of mTOR inhibition. Sci. Signal. 2, e24.
    • (2009) Sci. Signal. , vol.2
    • Guertin, D.A.1    Sabatini, D.M.2
  • 48
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: the next generation
    • Hanahan, D., and Weinberg, R. A. (2011). Hallmarks of cancer: the next generation. Cell 144, 646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 50
    • 84866394311 scopus 로고    scopus 로고
    • Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-kappaB signaling
    • doi:10.1371/journal.pone.0044259
    • Hwang, S. G., Park, J., Park, J. Y., Park, C. H., Lee, K. H., Cho, J. W., et al. (2012). Anti-cancer activity of a novel small molecule compound that simultaneously activates p53 and inhibits NF-kappaB signaling. PLoS ONE 7:e44259. doi:10.1371/journal.pone.0044259
    • (2012) PLoS ONE , vol.7
    • Hwang, S.G.1    Park, J.2    Park, J.Y.3    Park, C.H.4    Lee, K.H.5    Cho, J.W.6
  • 52
    • 0036713778 scopus 로고    scopus 로고
    • TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling
    • Inoki, K., Li, Y., Zhu, T., Wu, J., and Guan, K. L. (2002). TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell Biol. 4, 648-657.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 648-657
    • Inoki, K.1    Li, Y.2    Zhu, T.3    Wu, J.4    Guan, K.L.5
  • 53
    • 84858337114 scopus 로고    scopus 로고
    • Identification of a novel pro-apoptotic role of NF-kappaB in the regulation of TRAIL-and CD95-mediated apoptosis of glioblastoma cells
    • Jennewein, C., Karl, S., Baumann, B., Micheau, O., Debatin, K. M., and Fulda, S. (2012). Identification of a novel pro-apoptotic role of NF-kappaB in the regulation of TRAIL-and CD95-mediated apoptosis of glioblastoma cells. Oncogene 31, 1468-1474.
    • (2012) Oncogene , vol.31 , pp. 1468-1474
    • Jennewein, C.1    Karl, S.2    Baumann, B.3    Micheau, O.4    Debatin, K.M.5    Fulda, S.6
  • 54
    • 36349011403 scopus 로고    scopus 로고
    • Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition
    • Julien, S., Puig, I., Caretti, E., Bonaventure, J., Nelles, L., Van Roy, F., et al. (2007). Activation of NF-kappaB by Akt upregulates Snail expression and induces epithelium mesenchyme transition. Oncogene 26, 7445-7456.
    • (2007) Oncogene , vol.26 , pp. 7445-7456
    • Julien, S.1    Puig, I.2    Caretti, E.3    Bonaventure, J.4    Nelles, L.5    Van Roy, F.6
  • 55
    • 0344393606 scopus 로고    scopus 로고
    • Up-regulation of FLIP in cisplatin-selected HeLa cells causes cross-resistance to CD95/Fas death signalling
    • Kamarajan, P., Sun, N. K., and Chao, C. C. (2003). Up-regulation of FLIP in cisplatin-selected HeLa cells causes cross-resistance to CD95/Fas death signalling. Biochem. J. 376, 253-260.
    • (2003) Biochem. J. , vol.376 , pp. 253-260
    • Kamarajan, P.1    Sun, N.K.2    Chao, C.C.3
  • 56
    • 33744832401 scopus 로고    scopus 로고
    • United States Food and Drug Administration approval summary: bortezomib for the treatment of progressive multiple myeloma after one prior therapy
    • Kane, R. C., Farrell, A. T., Sridhara, R., and Pazdur, R. (2006). United States Food and Drug Administration approval summary: bortezomib for the treatment of progressive multiple myeloma after one prior therapy. Clin. Cancer Res. 12, 2955-2960.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2955-2960
    • Kane, R.C.1    Farrell, A.T.2    Sridhara, R.3    Pazdur, R.4
  • 57
    • 0035400270 scopus 로고    scopus 로고
    • Mechanisms of resistance to cisplatin
    • Kartalou, M., and Essigmann, J. M. (2001). Mechanisms of resistance to cisplatin. Mutat. Res. 478, 23-43.
    • (2001) Mutat. Res. , vol.478 , pp. 23-43
    • Kartalou, M.1    Essigmann, J.M.2
  • 58
    • 0242298578 scopus 로고    scopus 로고
    • CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response
    • Kato, T. Jr., Delhase, M., Hoffmann, A., and Karin, M. (2003). CK2 Is a C-Terminal IkappaB Kinase Responsible for NF-kappaB Activation during the UV Response. Mol. Cell 12, 829-839.
    • (2003) Mol. Cell , vol.12 , pp. 829-839
    • Kato Jr., T.1    Delhase, M.2    Hoffmann, A.3    Karin, M.4
  • 59
    • 34547226194 scopus 로고    scopus 로고
    • Regulation of MAPKs by growth factors and receptor tyrosine kinases
    • Katz, M., Amit, I., and Yarden, Y. (2007). Regulation of MAPKs by growth factors and receptor tyrosine kinases. Biochim. Biophys. Acta 1773, 1161-1176.
    • (2007) Biochim. Biophys. Acta , vol.1773 , pp. 1161-1176
    • Katz, M.1    Amit, I.2    Yarden, Y.3
  • 60
    • 0037031848 scopus 로고    scopus 로고
    • p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation
    • Kim, S. J., Hwang, S. G., Shin, D. Y., Kang, S. S., and Chun, J. S. (2002). p38 kinase regulates nitric oxide-induced apoptosis of articular chondrocytes by accumulating p53 via NFkappa B-dependent transcription and stabilization by serine 15 phosphorylation. J. Biol. Chem. 277, 33501-33508.
    • (2002) J. Biol. Chem. , vol.277 , pp. 33501-33508
    • Kim, S.J.1    Hwang, S.G.2    Shin, D.Y.3    Kang, S.S.4    Chun, J.S.5
  • 61
    • 67649233847 scopus 로고    scopus 로고
    • CAGE, a cancer/testis antigen, induces c-FLIP(L) and Snail to enhance cell motility and increase resistance to an anti-cancer drug
    • Kim, Y., Park, H., and Jeoung, D. (2009). CAGE, a cancer/testis antigen, induces c-FLIP(L) and Snail to enhance cell motility and increase resistance to an anti-cancer drug. Biotechnol. Lett. 31, 945-952.
    • (2009) Biotechnol. Lett. , vol.31 , pp. 945-952
    • Kim, Y.1    Park, H.2    Jeoung, D.3
  • 62
    • 12444255106 scopus 로고    scopus 로고
    • TNF combined with IFN-alpha accelerates NF-kappaB-mediated apoptosis through enhancement of Fas expression in colon cancer cells
    • Kimura, M., Haisa, M., Uetsuka, H., Takaoka, M., Ohkawa, T., Kawashima, R., et al. (2003). TNF combined with IFN-alpha accelerates NF-kappaB-mediated apoptosis through enhancement of Fas expression in colon cancer cells. Cell Death Differ. 10, 718-728.
    • (2003) Cell Death Differ. , vol.10 , pp. 718-728
    • Kimura, M.1    Haisa, M.2    Uetsuka, H.3    Takaoka, M.4    Ohkawa, T.5    Kawashima, R.6
  • 63
    • 0034744033 scopus 로고    scopus 로고
    • NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling
    • Kreuz, S., Siegmund, D., Scheurich, P., and Wajant, H. (2001). NF-kappaB inducers upregulate cFLIP, a cycloheximide-sensitive inhibitor of death receptor signaling. Mol. Cell. Biol. 21, 3964-3973.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 3964-3973
    • Kreuz, S.1    Siegmund, D.2    Scheurich, P.3    Wajant, H.4
  • 64
    • 0033621839 scopus 로고    scopus 로고
    • NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis
    • Kuhnel, F., Zender, L., Paul, Y., Tietze, M. K., Trautwein, C., Manns, M., et al. (2000). NFkappaB mediates apoptosis through transcriptional activation of Fas (CD95) in adenoviral hepatitis. J. Biol. Chem. 275, 6421-6427.
    • (2000) J. Biol. Chem. , vol.275 , pp. 6421-6427
    • Kuhnel, F.1    Zender, L.2    Paul, Y.3    Tietze, M.K.4    Trautwein, C.5    Manns, M.6
  • 65
    • 84875490171 scopus 로고    scopus 로고
    • Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFalpha-and NK cytotoxicity
    • Kulesza, D. W., Carre, T., Chouaib, S., and Kaminska, B. (2013). Silencing of the transcription factor STAT3 sensitizes lung cancer cells to DNA damaging drugs, but not to TNFalpha-and NK cytotoxicity. Exp. Cell Res. 319, 506-516.
    • (2013) Exp. Cell Res. , vol.319 , pp. 506-516
    • Kulesza, D.W.1    Carre, T.2    Chouaib, S.3    Kaminska, B.4
  • 66
    • 71549142886 scopus 로고    scopus 로고
    • Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells
    • Kuroda, H., Takeno, M., Murakami, S., Miyazawa, N., Kaneko, T., and Ishigatsubo, Y. (2010). Inhibition of heme oxygenase-1 with an epidermal growth factor receptor inhibitor and cisplatin decreases proliferation of lung cancer A549 cells. Lung Cancer 67, 31-36.
    • (2010) Lung Cancer , vol.67 , pp. 31-36
    • Kuroda, H.1    Takeno, M.2    Murakami, S.3    Miyazawa, N.4    Kaneko, T.5    Ishigatsubo, Y.6
  • 67
    • 0033957264 scopus 로고    scopus 로고
    • p53 gene status modulates the chemosensitivity of non-small cell lung cancer cells
    • Lai, S. L., Perng, R. P., and Hwang, J. (2000). p53 gene status modulates the chemosensitivity of non-small cell lung cancer cells. J. Biomed. Sci. 7, 64-70.
    • (2000) J. Biomed. Sci. , vol.7 , pp. 64-70
    • Lai, S.L.1    Perng, R.P.2    Hwang, J.3
  • 69
    • 63249092765 scopus 로고    scopus 로고
    • Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors
    • Lee, H., Herrmann, A., Deng, J. H., Kujawski, M., Niu, G., Li, Z., et al. (2009). Persistently activated Stat3 maintains constitutive NF-kappaB activity in tumors. Cancer Cell 15, 283-293.
    • (2009) Cancer Cell , vol.15 , pp. 283-293
    • Lee, H.1    Herrmann, A.2    Deng, J.H.3    Kujawski, M.4    Niu, G.5    Li, Z.6
  • 70
    • 84877627415 scopus 로고    scopus 로고
    • The Role of c-FLIP in Cisplatin Resistance of Human Bladder Cancer Cells
    • Lee, S., Yoon, C. Y., Byun, S. S., Lee, E., and Lee, S. E. (2013). The Role of c-FLIP in Cisplatin Resistance of Human Bladder Cancer Cells. J. Urol. 189, 2329-2336.
    • (2013) J. Urol. , vol.189 , pp. 2329-2336
    • Lee, S.1    Yoon, C.Y.2    Byun, S.S.3    Lee, E.4    Lee, S.E.5
  • 71
    • 0036781052 scopus 로고    scopus 로고
    • NF-kappaB regulation in the immune system
    • Li, Q., and Verma, I. M. (2002). NF-kappaB regulation in the immune system. Nat. Rev. Immunol. 2, 725-734.
    • (2002) Nat. Rev. Immunol. , vol.2 , pp. 725-734
    • Li, Q.1    Verma, I.M.2
  • 72
    • 23044498269 scopus 로고    scopus 로고
    • Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells
    • Li, Y., Ahmed, F., Ali, S., Philip, P. A., Kucuk, O., and Sarkar, F. H. (2005a). Inactivation of nuclear factor kappaB by soy isoflavone genistein contributes to increased apoptosis induced by chemotherapeutic agents in human cancer cells. Cancer Res. 65, 6934-6942.
    • (2005) Cancer Res. , vol.65 , pp. 6934-6942
    • Li, Y.1    Ahmed, F.2    Ali, S.3    Philip, P.A.4    Kucuk, O.5    Sarkar, F.H.6
  • 73
    • 20444444295 scopus 로고    scopus 로고
    • Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response
    • Li, Z., Niu, J., Uwagawa, T., Peng, B., and Chiao, P. J. (2005b). Function of polo-like kinase 3 in NF-kappaB-mediated proapoptotic response. J. Biol. Chem. 280, 16843-16850.
    • (2005) J. Biol. Chem. , vol.280 , pp. 16843-16850
    • Li, Z.1    Niu, J.2    Uwagawa, T.3    Peng, B.4    Chiao, P.J.5
  • 74
    • 0032589089 scopus 로고    scopus 로고
    • NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type
    • Lin, B., Williams-Skipp, C., Tao, Y., Schleicher, M. S., Cano, L. L., Duke, R. C., et al. (1999). NF-kappaB functions as both a proapoptotic and antiapoptotic regulatory factor within a single cell type. Cell Death Differ. 6, 570-582.
    • (1999) Cell Death Differ. , vol.6 , pp. 570-582
    • Lin, B.1    Williams-Skipp, C.2    Tao, Y.3    Schleicher, M.S.4    Cano, L.L.5    Duke, R.C.6
  • 75
    • 66949142175 scopus 로고    scopus 로고
    • The role of Bcl-x(L) protein in nucleotide excision repair-facilitated cell protection against cisplatin-induced apoptosis
    • Lomonaco, S. L., Xu, X. S., and Wang, G. (2009). The role of Bcl-x(L) protein in nucleotide excision repair-facilitated cell protection against cisplatin-induced apoptosis. DNA Cell Biol. 28, 285-294.
    • (2009) DNA Cell Biol. , vol.28 , pp. 285-294
    • Lomonaco, S.L.1    Xu, X.S.2    Wang, G.3
  • 77
    • 77951026717 scopus 로고    scopus 로고
    • Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis
    • Lu, Z. H., Shvartsman, M. B., Lee, A. Y., Shao, J. M., Murray, M. M., Kladney, R. D., et al. (2010). Mammalian target of rapamycin activator RHEB is frequently overexpressed in human carcinomas and is critical and sufficient for skin epithelial carcinogenesis. Cancer Res. 70, 3287-3298.
    • (2010) Cancer Res. , vol.70 , pp. 3287-3298
    • Lu, Z.H.1    Shvartsman, M.B.2    Lee, A.Y.3    Shao, J.M.4    Murray, M.M.5    Kladney, R.D.6
  • 78
    • 53249087846 scopus 로고    scopus 로고
    • Short hairpin RNA targeting c-FLIP sensitizes human cervical adenocarcinoma Hela cells to chemotherapy and radiotherapy
    • Luo, A., Wang, W., Sima, N., Lu, Y., Zhou, J., Xu, G., et al. (2008). Short hairpin RNA targeting c-FLIP sensitizes human cervical adenocarcinoma Hela cells to chemotherapy and radiotherapy. Cancer Lett. 271, 323-332.
    • (2008) Cancer Lett. , vol.271 , pp. 323-332
    • Luo, A.1    Wang, W.2    Sima, N.3    Lu, Y.4    Zhou, J.5    Xu, G.6
  • 79
    • 0029860159 scopus 로고    scopus 로고
    • DNA-damaging agents induce both p53-dependent and p53-independent apoptosis in immature thymocytes
    • MacFarlane, M., Jones, N. A., Dive, C., and Cohen, G. M. (1996). DNA-damaging agents induce both p53-dependent and p53-independent apoptosis in immature thymocytes. Mol. Pharmacol. 50, 900-911.
    • (1996) Mol. Pharmacol. , vol.50 , pp. 900-911
    • MacFarlane, M.1    Jones, N.A.2    Dive, C.3    Cohen, G.M.4
  • 80
    • 65549167833 scopus 로고    scopus 로고
    • Targeting the mTOR signaling network for cancer therapy
    • Meric-Bernstam, F., and Gonzalez-Angulo, A. M. (2009). Targeting the mTOR signaling network for cancer therapy. J. Clin. Oncol. 27, 2278-2287.
    • (2009) J. Clin. Oncol. , vol.27 , pp. 2278-2287
    • Meric-Bernstam, F.1    Gonzalez-Angulo, A.M.2
  • 81
    • 70449109147 scopus 로고    scopus 로고
    • Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma
    • Meylan, E., Dooley, A. L., Feldser, D. M., Shen, L., Turk, E., Ouyang, C., et al. (2009). Requirement for NF-kappaB signalling in a mouse model of lung adenocarcinoma. Nature 462, 104-107.
    • (2009) Nature , vol.462 , pp. 104-107
    • Meylan, E.1    Dooley, A.L.2    Feldser, D.M.3    Shen, L.4    Turk, E.5    Ouyang, C.6
  • 83
    • 0033583191 scopus 로고    scopus 로고
    • Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs
    • Micheau, O., Solary, E., Hammann, A., and Dimanche-Boitrel, M. T. (1999). Fas ligand-independent, FADD-mediated activation of the Fas death pathway by anticancer drugs. J. Biol. Chem. 274, 7987-7992.
    • (1999) J. Biol. Chem. , vol.274 , pp. 7987-7992
    • Micheau, O.1    Solary, E.2    Hammann, A.3    Dimanche-Boitrel, M.T.4
  • 84
    • 77649189887 scopus 로고    scopus 로고
    • Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action
    • Miller, S. C., Huang, R., Sakamuru, S., Shukla, S. J., Attene-Ramos, M. S., Shinn, P., et al. (2010). Identification of known drugs that act as inhibitors of NF-kappaB signaling and their mechanism of action. Biochem. Pharmacol. 79, 1272-1280.
    • (2010) Biochem. Pharmacol. , vol.79 , pp. 1272-1280
    • Miller, S.C.1    Huang, R.2    Sakamuru, S.3    Shukla, S.J.4    Attene-Ramos, M.S.5    Shinn, P.6
  • 85
    • 1842421811 scopus 로고    scopus 로고
    • RelA life and death decisions
    • Miyamoto, S. (2004). RelA life and death decisions. Mol. Cell 13, 763-764.
    • (2004) Mol. Cell , vol.13 , pp. 763-764
    • Miyamoto, S.1
  • 86
    • 84855643283 scopus 로고    scopus 로고
    • Bindarit: an anti-inflammatory small molecule that modulates the NFkappaB pathway
    • Mora, E., Guglielmotti, A., Biondi, G., and Sassone-Corsi, P. (2012). Bindarit: an anti-inflammatory small molecule that modulates the NFkappaB pathway. Cell Cycle 11, 159-169.
    • (2012) Cell Cycle , vol.11 , pp. 159-169
    • Mora, E.1    Guglielmotti, A.2    Biondi, G.3    Sassone-Corsi, P.4
  • 87
    • 16844366650 scopus 로고    scopus 로고
    • Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs
    • Nakanishi, C., and Toi, M. (2005). Nuclear factor-kappaB inhibitors as sensitizers to anticancer drugs. Nat. Rev. Cancer 5, 297-309.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 297-309
    • Nakanishi, C.1    Toi, M.2
  • 88
    • 33646388647 scopus 로고    scopus 로고
    • Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ
    • Namba, R., Young, L. J., Abbey, C. K., Kim, L., Damonte, P., Borowsky, A. D., et al. (2006). Rapamycin inhibits growth of premalignant and malignant mammary lesions in a mouse model of ductal carcinoma in situ. Clin. Cancer Res. 12, 2613-2621.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 2613-2621
    • Namba, R.1    Young, L.J.2    Abbey, C.K.3    Kim, L.4    Damonte, P.5    Borowsky, A.D.6
  • 90
    • 33644823859 scopus 로고    scopus 로고
    • Expression of the inhibitors of apoptosis proteins in cisplatin-resistant prostate cancer cells
    • Nomura, T., Yamasaki, M., Nomura, Y., and Mimata, H. (2005). Expression of the inhibitors of apoptosis proteins in cisplatin-resistant prostate cancer cells. Oncol. Rep. 14, 993-997.
    • (2005) Oncol. Rep. , vol.14 , pp. 993-997
    • Nomura, T.1    Yamasaki, M.2    Nomura, Y.3    Mimata, H.4
  • 91
    • 84863616518 scopus 로고    scopus 로고
    • Activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway overcomes cisplatin resistance in ovarian carcinoma cells
    • Non-aka, M., Itamochi, H., Kawaguchi, W., Kudoh, A., Sato, S., Uegaki, K., et al. (2012). Activation of the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase pathway overcomes cisplatin resistance in ovarian carcinoma cells. Int. J. Gynecol. Cancer 22, 922-929.
    • (2012) Int. J. Gynecol. Cancer , vol.22 , pp. 922-929
    • Non-aka, M.1    Itamochi, H.2    Kawaguchi, W.3    Kudoh, A.4    Sato, S.5    Uegaki, K.6
  • 92
    • 3242876938 scopus 로고    scopus 로고
    • In vitro and in vivo anti-tumoral effect of curcumin against melanoma cells
    • Odot, J., Albert, P., Carlier, A., Tarpin, M., Devy, J., and Madoulet, C. (2004). In vitro and in vivo anti-tumoral effect of curcumin against melanoma cells. Int J Cancer 111, 381-387.
    • (2004) Int J Cancer , vol.111 , pp. 381-387
    • Odot, J.1    Albert, P.2    Carlier, A.3    Tarpin, M.4    Devy, J.5    Madoulet, C.6
  • 93
    • 77950923924 scopus 로고    scopus 로고
    • Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer
    • Oliver, T. G., Mercer, K. L., Sayles, L. C., Burke, J. R., Mendus, D., Lovejoy, K. S., et al. (2010). Chronic cisplatin treatment promotes enhanced damage repair and tumor progression in a mouse model of lung cancer. Genes Dev. 24, 837-852.
    • (2010) Genes Dev. , vol.24 , pp. 837-852
    • Oliver, T.G.1    Mercer, K.L.2    Sayles, L.C.3    Burke, J.R.4    Mendus, D.5    Lovejoy, K.S.6
  • 94
    • 0033596121 scopus 로고    scopus 로고
    • Activators and target genes of Rel/NF-kappaB transcription factors
    • Pahl, H. L. (1999). Activators and target genes of Rel/NF-kappaB transcription factors. Oncogene 18, 6853-6866.
    • (1999) Oncogene , vol.18 , pp. 6853-6866
    • Pahl, H.L.1
  • 95
    • 0034710539 scopus 로고    scopus 로고
    • Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappa B is enhanced by I kappa B alpha super-repressor and parthenolide
    • Patel, N. M., Nozaki, S., Shortle, N. H., Bhat-Nakshatri, P., Newton, T. R., Rice, S., et al. (2000). Paclitaxel sensitivity of breast cancer cells with constitutively active NF-kappa B is enhanced by I kappa B alpha super-repressor and parthenolide. Oncogene 19, 4159-4169.
    • (2000) Oncogene , vol.19 , pp. 4159-4169
    • Patel, N.M.1    Nozaki, S.2    Shortle, N.H.3    Bhat-Nakshatri, P.4    Newton, T.R.5    Rice, S.6
  • 96
    • 33646488626 scopus 로고    scopus 로고
    • NF-kappaB inhibition: a double-edged sword in cancer?
    • Pikarsky, E., and Ben-Neriah, Y. (2006). NF-kappaB inhibition: a double-edged sword in cancer? Eur. J. Cancer 42, 779-784.
    • (2006) Eur. J. Cancer , vol.42 , pp. 779-784
    • Pikarsky, E.1    Ben-Neriah, Y.2
  • 97
    • 33746829168 scopus 로고    scopus 로고
    • Pro-apoptotic role of NF-kappaB: implications for cancer therapy
    • Radhakrishnan, S. K., and Kamalakaran, S. (2006). Pro-apoptotic role of NF-kappaB: implications for cancer therapy. Biochim. Biophys. Acta 1766, 53-62.
    • (2006) Biochim. Biophys. Acta , vol.1766 , pp. 53-62
    • Radhakrishnan, S.K.1    Kamalakaran, S.2
  • 98
    • 34547896623 scopus 로고    scopus 로고
    • Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis
    • Rae, C., Langa, S., Tucker, S. J., and Macewan, D. J. (2007). Elevated NF-kappaB responses and FLIP levels in leukemic but not normal lymphocytes: reduction by salicylate allows TNF-induced apoptosis. Proc. Natl. Acad. Sci. U.S.A. 104, 12790-12795.
    • (2007) Proc. Natl. Acad. Sci. U.S.A. , vol.104 , pp. 12790-12795
    • Rae, C.1    Langa, S.2    Tucker, S.J.3    Macewan, D.J.4
  • 99
    • 0035067368 scopus 로고    scopus 로고
    • Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB
    • Ravi, R., Bedi, G. C., Engstrom, L. W., Zeng, Q., Mookerjee, B., Gelinas, C., et al. (2001). Regulation of death receptor expression and TRAIL/Apo2L-induced apoptosis by NF-kappaB. Nat. Cell Biol. 3, 409-416.
    • (2001) Nat. Cell Biol. , vol.3 , pp. 409-416
    • Ravi, R.1    Bedi, G.C.2    Engstrom, L.W.3    Zeng, Q.4    Mookerjee, B.5    Gelinas, C.6
  • 100
    • 55949095821 scopus 로고    scopus 로고
    • Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells
    • Reuter, S., Eifes, S., Dicato, M., Aggarwal, B. B., and Diederich, M. (2008). Modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells. Biochem. Pharmacol. 76, 1340-1351.
    • (2008) Biochem. Pharmacol. , vol.76 , pp. 1340-1351
    • Reuter, S.1    Eifes, S.2    Dicato, M.3    Aggarwal, B.B.4    Diederich, M.5
  • 101
    • 0035555653 scopus 로고    scopus 로고
    • relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells
    • Ricca, A., Biroccio, A., Trisciuoglio, D., Cippitelli, M., Zupi, G., and Del Bufalo, D. (2001). relA over-expression reduces tumorigenicity and activates apoptosis in human cancer cells. Br. J. Cancer 85, 1914-1921.
    • (2001) Br. J. Cancer , vol.85 , pp. 1914-1921
    • Ricca, A.1    Biroccio, A.2    Trisciuoglio, D.3    Cippitelli, M.4    Zupi, G.5    Del Bufalo, D.6
  • 102
    • 0035798624 scopus 로고    scopus 로고
    • NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death
    • Rivera-Walsh, I., Waterfield, M., Xiao, G., Fong, A., and Sun, S. C. (2001). NF-kappaB signaling pathway governs TRAIL gene expression and human T-cell leukemia virus-I Tax-induced T-cell death. J. Biol. Chem. 276, 40385-40388.
    • (2001) J. Biol. Chem. , vol.276 , pp. 40385-40388
    • Rivera-Walsh, I.1    Waterfield, M.2    Xiao, G.3    Fong, A.4    Sun, S.C.5
  • 103
    • 34250730846 scopus 로고    scopus 로고
    • Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells
    • Rogers, K. M., Thomas, M., Galligan, L., Wilson, T. R., Allen, W. L., Sakai, H., et al. (2007). Cellular FLICE-inhibitory protein regulates chemotherapy-induced apoptosis in breast cancer cells. Mol. Cancer Ther. 6, 1544-1551.
    • (2007) Mol. Cancer Ther. , vol.6 , pp. 1544-1551
    • Rogers, K.M.1    Thomas, M.2    Galligan, L.3    Wilson, T.R.4    Allen, W.L.5    Sakai, H.6
  • 104
    • 0034689773 scopus 로고    scopus 로고
    • Role of NF-kappaB in p53-mediated programmed cell death
    • Ryan, K. M., Ernst, M. K., Rice, N. R., and Vousden, K. H. (2000). Role of NF-kappaB in p53-mediated programmed cell death. Nature 404, 892-897.
    • (2000) Nature , vol.404 , pp. 892-897
    • Ryan, K.M.1    Ernst, M.K.2    Rice, N.R.3    Vousden, K.H.4
  • 105
    • 0036679169 scopus 로고    scopus 로고
    • Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability
    • Sanchez-Perez, I., Benitah, S. A., Martinez-Gomariz, M., Lacal, J. C., and Perona, R. (2002). Cell stress and MEKK1-mediated c-Jun activation modulate NFkappaB activity and cell viability. Mol. Biol. Cell 13, 2933-2945.
    • (2002) Mol. Biol. Cell , vol.13 , pp. 2933-2945
    • Sanchez-Perez, I.1    Benitah, S.A.2    Martinez-Gomariz, M.3    Lacal, J.C.4    Perona, R.5
  • 106
    • 13844312400 scopus 로고    scopus 로고
    • Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
    • Sarbassov, D. D., Guertin, D. A., Ali, S. M., and Sabatini, D. M. (2005). Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex. Science 307, 1098-1101.
    • (2005) Science , vol.307 , pp. 1098-1101
    • Sarbassov, D.D.1    Guertin, D.A.2    Ali, S.M.3    Sabatini, D.M.4
  • 107
    • 28044469866 scopus 로고    scopus 로고
    • Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance
    • Silke, J., Kratina, T., Chu, D., Ekert, P. G., Day, C. L., Pakusch, M., et al. (2005). Determination of cell survival by RING-mediated regulation of inhibitor of apoptosis (IAP) protein abundance. Proc. Natl. Acad. Sci. U.S.A. 102, 16182-16187.
    • (2005) Proc. Natl. Acad. Sci. U.S.A. , vol.102 , pp. 16182-16187
    • Silke, J.1    Kratina, T.2    Chu, D.3    Ekert, P.G.4    Day, C.L.5    Pakusch, M.6
  • 108
    • 27744553033 scopus 로고    scopus 로고
    • X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling
    • Takeuchi, H., Kim, J., Fujimoto, A., Umetani, N., Mori, T., Bilchik, A., et al. (2005). X-Linked inhibitor of apoptosis protein expression level in colorectal cancer is regulated by hepatocyte growth factor/C-met pathway via Akt signaling. Clin. Cancer Res. 11, 7621-7628.
    • (2005) Clin. Cancer Res. , vol.11 , pp. 7621-7628
    • Takeuchi, H.1    Kim, J.2    Fujimoto, A.3    Umetani, N.4    Mori, T.5    Bilchik, A.6
  • 109
    • 0036172154 scopus 로고    scopus 로고
    • Proteasome inhibitor PS-341, a potential therapeutic agent for adult T-cell leukemia
    • Tan, C., and Waldmann, T. A. (2002). Proteasome inhibitor PS-341, a potential therapeutic agent for adult T-cell leukemia. Cancer Res. 62, 1083-1086.
    • (2002) Cancer Res. , vol.62 , pp. 1083-1086
    • Tan, C.1    Waldmann, T.A.2
  • 110
    • 84860816141 scopus 로고    scopus 로고
    • Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance
    • Tanaka, K., Babic, I., Nathanson, D., Akhavan, D., Guo, D., Gini, B., et al. (2011). Oncogenic EGFR signaling activates an mTORC2-NF-kappaB pathway that promotes chemotherapy resistance. Cancer Discov. 1, 524-538.
    • (2011) Cancer Discov. , vol.1 , pp. 524-538
    • Tanaka, K.1    Babic, I.2    Nathanson, D.3    Akhavan, D.4    Guo, D.5    Gini, B.6
  • 111
    • 38149140259 scopus 로고    scopus 로고
    • SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma
    • Tew, G. W., Lorimer, E. L., Berg, T. J., Zhi, H., Li, R., and Williams, C. L. (2008). SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma. J. Biol. Chem. 283, 963-976.
    • (2008) J. Biol. Chem. , vol.283 , pp. 963-976
    • Tew, G.W.1    Lorimer, E.L.2    Berg, T.J.3    Zhi, H.4    Li, R.5    Williams, C.L.6
  • 112
    • 0034695660 scopus 로고    scopus 로고
    • Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappa B activation protects kidney proximal tubule cells from cadmium-and reactive oxygen species-induced apoptosis
    • Thevenod, F., Friedmann, J. M., Katsen, A. D., and Hauser, I. A. (2000). Up-regulation of multidrug resistance P-glycoprotein via nuclear factor-kappa B activation protects kidney proximal tubule cells from cadmium-and reactive oxygen species-induced apoptosis. J. Biol. Chem. 275, 1887-1896.
    • (2000) J. Biol. Chem. , vol.275 , pp. 1887-1896
    • Thevenod, F.1    Friedmann, J.M.2    Katsen, A.D.3    Hauser, I.A.4
  • 113
    • 33748311907 scopus 로고    scopus 로고
    • Inhibition of tumor growth by NF-kappaB inhibitors
    • Umezawa, K. (2006). Inhibition of tumor growth by NF-kappaB inhibitors. Cancer Sci. 97, 990-995.
    • (2006) Cancer Sci. , vol.97 , pp. 990-995
    • Umezawa, K.1
  • 114
    • 0037206564 scopus 로고    scopus 로고
    • Molecular design and biological activities of NF-kappaB inhibitors
    • Umezawa, K., and Chaicharoenpong, C. (2002). Molecular design and biological activities of NF-kappaB inhibitors. Mol. Cells 14, 163-167.
    • (2002) Mol. Cells , vol.14 , pp. 163-167
    • Umezawa, K.1    Chaicharoenpong, C.2
  • 115
    • 33846048039 scopus 로고    scopus 로고
    • Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia
    • Vilimas, T., Mascarenhas, J., Palomero, T., Mandal, M., Buonamici, S., Meng, F., et al. (2007). Targeting the NF-kappaB signaling pathway in Notch1-induced T-cell leukemia. Nat. Med. 13, 70-77.
    • (2007) Nat. Med. , vol.13 , pp. 70-77
    • Vilimas, T.1    Mascarenhas, J.2    Palomero, T.3    Mandal, M.4    Buonamici, S.5    Meng, F.6
  • 116
    • 34250770091 scopus 로고    scopus 로고
    • A parallel dose-escalation study of weekly and twice-weekly bortezomib in combination with gemcitabine and cisplatin in the first-line treatment of patients with advanced solid tumors
    • Voortman, J., Smit, E. F., Honeywell, R., Kuenen, B. C., Peters, G. J., Van De Velde, H., et al. (2007). A parallel dose-escalation study of weekly and twice-weekly bortezomib in combination with gemcitabine and cisplatin in the first-line treatment of patients with advanced solid tumors. Clin. Cancer Res. 13, 3642-3651.
    • (2007) Clin. Cancer Res. , vol.13 , pp. 3642-3651
    • Voortman, J.1    Smit, E.F.2    Honeywell, R.3    Kuenen, B.C.4    Peters, G.J.5    Van De Velde, H.6
  • 117
    • 0032588317 scopus 로고    scopus 로고
    • NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis
    • Wang, C. Y., Guttridge, D. C., Mayo, M. W., and Baldwin, A. S. Jr. (1999). NF-kappaB induces expression of the Bcl-2 homologue A1/Bfl-1 to preferentially suppress chemotherapy-induced apoptosis. Mol. Cell. Biol. 19, 5923-5929.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 5923-5929
    • Wang, C.Y.1    Guttridge, D.C.2    Mayo, M.W.3    Baldwin Jr., A.S.4
  • 118
    • 0032508414 scopus 로고    scopus 로고
    • NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation
    • Wang, C. Y., Mayo, M. W., Korneluk, R. G., Goeddel, D. V., and Baldwin, A. S. Jr. (1998). NF-kappaB antiapoptosis: induction of TRAF1 and TRAF2 and c-IAP1 and c-IAP2 to suppress caspase-8 activation. Science 281, 1680-1683.
    • (1998) Science , vol.281 , pp. 1680-1683
    • Wang, C.Y.1    Mayo, M.W.2    Korneluk, R.G.3    Goeddel, D.V.4    Baldwin Jr., A.S.5
  • 119
    • 0036850143 scopus 로고    scopus 로고
    • NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function
    • Wang, Y., Cui, H., Schroering, A., Ding, J. L., Lane, W. S., Mcgill, G., et al. (2002). NF-kappa B2 p100 is a pro-apoptotic protein with anti-oncogenic function. Nat. Cell Biol. 4, 888-893.
    • (2002) Nat. Cell Biol. , vol.4 , pp. 888-893
    • Wang, Y.1    Cui, H.2    Schroering, A.3    Ding, J.L.4    Lane, W.S.5    Mcgill, G.6
  • 120
    • 0037025173 scopus 로고    scopus 로고
    • Cancer. Addiction to oncogenes-the Achilles heal of cancer
    • Weinstein, I. B. (2002). Cancer. Addiction to oncogenes-the Achilles heal of cancer. Science 297, 63-64.
    • (2002) Science , vol.297 , pp. 63-64
    • Weinstein, I.B.1
  • 121
    • 54049086233 scopus 로고    scopus 로고
    • Interleukin-8 signaling attenuates TRAIL-and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells
    • Wilson, C., Wilson, T., Johnston, P. G., Longley, D. B., and Waugh, D. J. (2008). Interleukin-8 signaling attenuates TRAIL-and chemotherapy-induced apoptosis through transcriptional regulation of c-FLIP in prostate cancer cells. Mol. Cancer Ther. 7, 2649-2661.
    • (2008) Mol. Cancer Ther. , vol.7 , pp. 2649-2661
    • Wilson, C.1    Wilson, T.2    Johnston, P.G.3    Longley, D.B.4    Waugh, D.J.5
  • 122
    • 47949129452 scopus 로고    scopus 로고
    • Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress
    • Wu, Z. H., and Miyamoto, S. (2008). Induction of a pro-apoptotic ATM-NF-kappaB pathway and its repression by ATR in response to replication stress. EMBO J. 27, 1963-1973.
    • (2008) EMBO J. , vol.27 , pp. 1963-1973
    • Wu, Z.H.1    Miyamoto, S.2
  • 123
    • 33846783142 scopus 로고    scopus 로고
    • NF-kappaB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage
    • Wuerzberger-Davis, S. M., Nakamura, Y., Seufzer, B. J., and Miyamoto, S. (2007). NF-kappaB activation by combinations of NEMO SUMOylation and ATM activation stresses in the absence of DNA damage. Oncogene 26, 641-651.
    • (2007) Oncogene , vol.26 , pp. 641-651
    • Wuerzberger-Davis, S.M.1    Nakamura, Y.2    Seufzer, B.J.3    Miyamoto, S.4
  • 124
    • 33646186160 scopus 로고    scopus 로고
    • Bortezomib (VELCADE) in metastatic breast cancer: pharmacodynamics, biological effects, and prediction of clinical benefits
    • Yang, C. H., Gonzalez-Angulo, A. M., Reuben, J. M., Booser, D. J., Pusztai, L., Krishnamurthy, S., et al. (2006a). Bortezomib (VELCADE) in metastatic breast cancer: pharmacodynamics, biological effects, and prediction of clinical benefits. Ann. Oncol. 17, 813-817.
    • (2006) Ann. Oncol. , vol.17 , pp. 813-817
    • Yang, C.H.1    Gonzalez-Angulo, A.M.2    Reuben, J.M.3    Booser, D.J.4    Pusztai, L.5    Krishnamurthy, S.6
  • 125
    • 32944468414 scopus 로고    scopus 로고
    • BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways
    • Yang, J., Amiri, K. I., Burke, J. R., Schmid, J. A., and Richmond, A. (2006b). BMS-345541 targets inhibitor of kappaB kinase and induces apoptosis in melanoma: involvement of nuclear factor kappaB and mitochondria pathways. Clin. Cancer Res. 12, 950-960.
    • (2006) Clin. Cancer Res. , vol.12 , pp. 950-960
    • Yang, J.1    Amiri, K.I.2    Burke, J.R.3    Schmid, J.A.4    Richmond, A.5
  • 126
    • 79954612742 scopus 로고    scopus 로고
    • The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer
    • Yang, G., Xiao, X., Rosen, D. G., Cheng, X., Wu, X., Chang, B., et al. (2011). The biphasic role of NF-kappaB in progression and chemoresistance of ovarian cancer. Clin. Cancer Res. 17, 2181-2194.
    • (2011) Clin. Cancer Res. , vol.17 , pp. 2181-2194
    • Yang, G.1    Xiao, X.2    Rosen, D.G.3    Cheng, X.4    Wu, X.5    Chang, B.6
  • 127
    • 34249868449 scopus 로고    scopus 로고
    • Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB
    • Yang, J., Liao, X., Agarwal, M. K., Barnes, L., Auron, P. E., and Stark, G. R. (2007). Unphosphorylated STAT3 accumulates in response to IL-6 and activates transcription by binding to NFkappaB. Genes Dev. 21, 1396-1408.
    • (2007) Genes Dev. , vol.21 , pp. 1396-1408
    • Yang, J.1    Liao, X.2    Agarwal, M.K.3    Barnes, L.4    Auron, P.E.5    Stark, G.R.6
  • 128
    • 84863233878 scopus 로고    scopus 로고
    • XIAP is a predictor of cisplatin-based chemotherapy response and prognosis for patients with advanced head and neck cancer
    • doi:10.1371/journal.pone.0031601
    • Yang, X. H., Feng, Z. E., Yan, M., Hanada, S., Zuo, H., Yang, C. Z., et al. (2012). XIAP is a predictor of cisplatin-based chemotherapy response and prognosis for patients with advanced head and neck cancer. PLoS ONE 7:e31601. doi:10.1371/journal.pone.0031601
    • (2012) PLoS ONE , vol.7
    • Yang, X.H.1    Feng, Z.E.2    Yan, M.3    Hanada, S.4    Zuo, H.5    Yang, C.Z.6
  • 129
    • 0033539167 scopus 로고    scopus 로고
    • Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP
    • Yeung, K., Seitz, T., Li, S., Janosch, P., Mcferran, B., Kaiser, C., et al. (1999). Suppression of Raf-1 kinase activity and MAP kinase signalling by RKIP. Nature 401, 173-177.
    • (1999) Nature , vol.401 , pp. 173-177
    • Yeung, K.1    Seitz, T.2    Li, S.3    Janosch, P.4    Mcferran, B.5    Kaiser, C.6
  • 130
    • 0034791116 scopus 로고    scopus 로고
    • Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation
    • Yeung, K. C., Rose, D. W., Dhillon, A. S., Yaros, D., Gustafsson, M., Chatterjee, D., et al. (2001). Raf kinase inhibitor protein interacts with NF-kappaB-inducing kinase and TAK1 and inhibits NF-kappaB activation. Mol. Cell. Biol. 21, 7207-7217.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 7207-7217
    • Yeung, K.C.1    Rose, D.W.2    Dhillon, A.S.3    Yaros, D.4    Gustafsson, M.5    Chatterjee, D.6
  • 131
    • 79952293503 scopus 로고    scopus 로고
    • Activation of mTORC2 by association with the ribosome
    • Zinzalla, V., Stracka, D., Oppliger, W., and Hall, M. N. (2011). Activation of mTORC2 by association with the ribosome. Cell 144, 757-768.
    • (2011) Cell , vol.144 , pp. 757-768
    • Zinzalla, V.1    Stracka, D.2    Oppliger, W.3    Hall, M.N.4
  • 132
    • 84863724938 scopus 로고    scopus 로고
    • Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models
    • Zollo, M., Di Dato, V., Spano, D., De Martino, D., Liguori, L., Marino, N., et al. (2012). Targeting monocyte chemotactic protein-1 synthesis with bindarit induces tumor regression in prostate and breast cancer animal models. Clin. Exp. Metastasis 29, 585-601.
    • (2012) Clin. Exp. Metastasis , vol.29 , pp. 585-601
    • Zollo, M.1    Di Dato, V.2    Spano, D.3    De Martino, D.4    Liguori, L.5    Marino, N.6
  • 133
    • 35348878567 scopus 로고    scopus 로고
    • Bortezomib induces apoptosis of Epstein-Barr virus (EBV)-transformed B cells and prolongs survival of mice inoculated with EBV-transformed B cells
    • Zou, P., Kawada, J., Pesnicak, L., and Cohen, J. I. (2007). Bortezomib induces apoptosis of Epstein-Barr virus (EBV)-transformed B cells and prolongs survival of mice inoculated with EBV-transformed B cells. J. Virol. 81, 10029-10036.
    • (2007) J. Virol. , vol.81 , pp. 10029-10036
    • Zou, P.1    Kawada, J.2    Pesnicak, L.3    Cohen, J.I.4


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