-
1
-
-
77952867730
-
Targets of raf in tumorigenesis
-
doi:10.1093/carcin/bgp337
-
Niault TS, Baccarini M. Targets of raf in tumorigenesis. Carcinogenesis (2010) 31:1165-74. doi:10.1093/carcin/bgp337
-
(2010)
Carcinogenesis
, vol.31
, pp. 1165-1174
-
-
Niault, T.S.1
Baccarini, M.2
-
2
-
-
84868628069
-
Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response
-
McCubrey JA, Steelman LS, Chappell WH, Abrams SL, Montalto G, Cervello M, et al. Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades which alter therapy response. Oncotarget (2012) 3:954-87.
-
(2012)
Oncotarget
, vol.3
, pp. 954-987
-
-
McCubrey, J.A.1
Steelman, L.S.2
Chappell, W.H.3
Abrams, S.L.4
Montalto, G.5
Cervello, M.6
-
3
-
-
77956124562
-
RAF protein-serine/threonine kinases: structure and regulation
-
doi:10.1016/j.bbrc.2010.07.092
-
Roskoski R Jr. RAF protein-serine/threonine kinases: structure and regulation. Biochem Biophys Res Commun (2010) 399:313-7. doi:10.1016/j.bbrc.2010.07.092
-
(2010)
Biochem Biophys Res Commun
, vol.399
, pp. 313-317
-
-
Roskoski Jr., R.1
-
4
-
-
84879619977
-
Clinicopathological relevance of BRAF mutations in human cancer
-
doi:10.1097/PAT.0b013e328360b61d
-
Pakneshan S, Salajegheh A, Smith RA, Lam AK. Clinicopathological relevance of BRAF mutations in human cancer. Pathology (2013) 45:346-56. doi:10.1097/PAT.0b013e328360b61d
-
(2013)
Pathology
, vol.45
, pp. 346-356
-
-
Pakneshan, S.1
Salajegheh, A.2
Smith, R.A.3
Lam, A.K.4
-
5
-
-
79551595779
-
Targeting BRAF for patients with melanoma
-
doi:10.1038/sj.bjc.6606030
-
Arkenau HT, Kefford R, Long GV. Targeting BRAF for patients with melanoma. Br J Cancer (2011) 104:392-8. doi:10.1038/sj.bjc.6606030
-
(2011)
Br J Cancer
, vol.104
, pp. 392-398
-
-
Arkenau, H.T.1
Kefford, R.2
Long, G.V.3
-
6
-
-
84859471412
-
Targeting mutant BRAF in melanoma: current status and future development of combination therapy strategies
-
doi:10.1097/PPO.0b013e31824b436e
-
Kudchadkar R, Paraiso KH, Smalley KS. Targeting mutant BRAF in melanoma: current status and future development of combination therapy strategies. Cancer J (2012) 18:124-31. doi:10.1097/PPO.0b013e31824b436e
-
(2012)
Cancer J
, vol.18
, pp. 124-131
-
-
Kudchadkar, R.1
Paraiso, K.H.2
Smalley, K.S.3
-
7
-
-
67349219657
-
Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma
-
doi:10.1038/onc.2009.73
-
Jones DT, Kocialkowski S, Liu L, Pearson DM, Ichimura K, Collins VP. Oncogenic RAF1 rearrangement and a novel BRAF mutation as alternatives to KIAA1549:BRAF fusion in activating the MAPK pathway in pilocytic astrocytoma. Oncogene (2009) 28:2119-23. doi:10.1038/onc.2009.73
-
(2009)
Oncogene
, vol.28
, pp. 2119-2123
-
-
Jones, D.T.1
Kocialkowski, S.2
Liu, L.3
Pearson, D.M.4
Ichimura, K.5
Collins, V.P.6
-
8
-
-
77957275728
-
RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort
-
doi:10.1007/s00401-010-0693-y
-
Lawson AR, Tatevossian RG, Phipps KP, Picker SR, Michalski A, Sheer D, et al. RAF gene fusions are specific to pilocytic astrocytoma in a broad paediatric brain tumour cohort. Acta Neuropathol (2010) 120:271-3. doi:10.1007/s00401-010-0693-y
-
(2010)
Acta Neuropathol
, vol.120
, pp. 271-273
-
-
Lawson, A.R.1
Tatevossian, R.G.2
Phipps, K.P.3
Picker, S.R.4
Michalski, A.5
Sheer, D.6
-
10
-
-
84880799275
-
Validation of next generation sequencing technologies in comparison to current diagnostic gold standards for BRAF, EGFR and KRAS mutational analysis
-
doi:10.1371/journal.pone.0069604
-
McCourt CM, McArt DG, Mills K, Catherwood MA, Maxwell P, Waugh DJ, et al. Validation of next generation sequencing technologies in comparison to current diagnostic gold standards for BRAF, EGFR and KRAS mutational analysis. PLoS One (2013) 8:e69604. doi:10.1371/journal.pone.0069604
-
(2013)
PLoS One
, vol.8
-
-
McCourt, C.M.1
McArt, D.G.2
Mills, K.3
Catherwood, M.A.4
Maxwell, P.5
Waugh, D.J.6
-
11
-
-
79959580390
-
Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody
-
doi:10.1007/s00401-011-0841-z
-
Capper D, Preusser M, Habel A, Sahm F, Ackermann U, Schindler G, et al. Assessment of BRAF V600E mutation status by immunohistochemistry with a mutation-specific monoclonal antibody. Acta Neuropathol (2011) 122:11-9. doi:10.1007/s00401-011-0841-z
-
(2011)
Acta Neuropathol
, vol.122
, pp. 11-19
-
-
Capper, D.1
Preusser, M.2
Habel, A.3
Sahm, F.4
Ackermann, U.5
Schindler, G.6
-
12
-
-
84880265173
-
BRAF V600E-specific immunohistochemistry for the exclusion of Lynch syndrome in MSI-H colorectal cancer
-
doi:10.1002/ijc.28183
-
Capper D, Voigt A, Bozukova G, Ahadova A, Kickingereder P, von Deimling A, et al. BRAF V600E-specific immunohistochemistry for the exclusion of Lynch syndrome in MSI-H colorectal cancer. Int J Cancer (2013) 133:1624-30. doi:10.1002/ijc.28183
-
(2013)
Int J Cancer
, vol.133
, pp. 1624-1630
-
-
Capper, D.1
Voigt, A.2
Bozukova, G.3
Ahadova, A.4
Kickingereder, P.5
von Deimling, A.6
-
13
-
-
84879254737
-
BRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma
-
doi:10.1002/gcc.22070
-
Affolter K, Samowitz W, Tripp S, Bronner MP. BRAF V600E mutation detection by immunohistochemistry in colorectal carcinoma. Genes Chromosomes Cancer (2013) 52:748-52. doi:10.1002/gcc.22070
-
(2013)
Genes Chromosomes Cancer
, vol.52
, pp. 748-752
-
-
Affolter, K.1
Samowitz, W.2
Tripp, S.3
Bronner, M.P.4
-
14
-
-
84880572740
-
Mutation-specific antibody detects mutant BRAF protein expression in human colon carcinomas
-
doi:10.1002/cncr.28133
-
Sinicrope FA, Smyrk TC, Tougeron D, Thibodeau SN, Singh S, Muranyi A, et al. Mutation-specific antibody detects mutant BRAF protein expression in human colon carcinomas. Cancer (2013) 119:2765-70. doi:10.1002/cncr.28133
-
(2013)
Cancer
, vol.119
, pp. 2765-2770
-
-
Sinicrope, F.A.1
Smyrk, T.C.2
Tougeron, D.3
Thibodeau, S.N.4
Singh, S.5
Muranyi, A.6
-
15
-
-
84884513645
-
BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndrome
-
doi:10.1097/PAS.0b013e31828f233d
-
Toon CW, Walsh MD, Chou A, Capper D, Clarkson A, Sioson L, et al. BRAFV600E immunohistochemistry facilitates universal screening of colorectal cancers for Lynch syndrome. Am J Surg Pathol (2013) 37:1592-602. doi:10.1097/PAS.0b013e31828f233d
-
(2013)
Am J Surg Pathol
, vol.37
, pp. 1592-1602
-
-
Toon, C.W.1
Walsh, M.D.2
Chou, A.3
Capper, D.4
Clarkson, A.5
Sioson, L.6
-
16
-
-
84889097025
-
BRAF mutation in sporadic colorectal cancer and Lynch syndrome
-
doi:10.1007/s00428-013-1470-9
-
Thiel A, Heinonen M, Kantonen J, Gylling A, Lahtinen L, Korhonen M, et al. BRAF mutation in sporadic colorectal cancer and Lynch syndrome. Virchows Arch (2013). doi:10.1007/s00428-013-1470-9
-
(2013)
Virchows Arch
-
-
Thiel, A.1
Heinonen, M.2
Kantonen, J.3
Gylling, A.4
Lahtinen, L.5
Korhonen, M.6
-
17
-
-
84880725363
-
Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 is not a useful surrogate for genotyping in colorectal adenocarcinoma
-
doi:10.1111/his.12154
-
Adackapara CA, Sholl LM, Barletta JA, Hornick JL. Immunohistochemistry using the BRAF V600E mutation-specific monoclonal antibody VE1 is not a useful surrogate for genotyping in colorectal adenocarcinoma. Histopathology (2013) 63:187-93. doi:10.1111/his.12154
-
(2013)
Histopathology
, vol.63
, pp. 187-193
-
-
Adackapara, C.A.1
Sholl, L.M.2
Barletta, J.A.3
Hornick, J.L.4
-
18
-
-
22244472992
-
Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
-
doi:10.1158/0008-5472.CAN-05-0404
-
Samowitz WS, Sweeney C, Herrick J, Albertsen H, Levin TR, Murtaugh MA, et al. Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. Cancer Res (2005) 65:6063-9. doi:10.1158/0008-5472.CAN-05-0404
-
(2005)
Cancer Res
, vol.65
, pp. 6063-6069
-
-
Samowitz, W.S.1
Sweeney, C.2
Herrick, J.3
Albertsen, H.4
Levin, T.R.5
Murtaugh, M.A.6
-
19
-
-
84891749141
-
Improved molecular classification of serrated lesions of the colon by immunohistochemical detection of BRAF V600E
-
doi:10.1038/modpathol.2013.126
-
Mesteri I, Bayer G, Meyer J, Capper D, Schoppmann SF, von Deimling A, et al. Improved molecular classification of serrated lesions of the colon by immunohistochemical detection of BRAF V600E. Mod Pathol (2013). doi:10.1038/modpathol.2013.126
-
(2013)
Mod Pathol
-
-
Mesteri, I.1
Bayer, G.2
Meyer, J.3
Capper, D.4
Schoppmann, S.F.5
von Deimling, A.6
-
20
-
-
77953688634
-
Clinicopathological and protein characterization of BRAF'and K-RAS-mutated colorectal cancer and implications for prognosis
-
doi:10.1002/ijc.25042
-
Zlobec I, Bihl MP, Schwarb H, Terracciano L, Lugli A. Clinicopathological and protein characterization of BRAF'and K-RAS-mutated colorectal cancer and implications for prognosis. Int JCancer (2010) 127:367-80. doi:10.1002/ijc.25042
-
(2010)
Int JCancer
, vol.127
, pp. 367-380
-
-
Zlobec, I.1
Bihl, M.P.2
Schwarb, H.3
Terracciano, L.4
Lugli, A.5
-
21
-
-
75749102647
-
Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
-
doi:10.1200/JCO.2009.23.3452
-
Roth AD, Tejpar S, Delorenzi M, Yan P, Fiocca R, Klingbiel D, et al. Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol (2010) 28:466-74. doi:10.1200/JCO.2009.23.3452
-
(2010)
J Clin Oncol
, vol.28
, pp. 466-474
-
-
Roth, A.D.1
Tejpar, S.2
Delorenzi, M.3
Yan, P.4
Fiocca, R.5
Klingbiel, D.6
-
22
-
-
78649473910
-
The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients
-
doi:10.1093/annonc/mdq258
-
Farina-Sarasqueta A, van Lijnschoten G, Moerland E, Creemers GJ, Lemmens VE, Rutten HJ, et al. The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients. Ann Oncol (2010) 21:2396-402. doi:10.1093/annonc/mdq258
-
(2010)
Ann Oncol
, vol.21
, pp. 2396-2402
-
-
Farina-Sarasqueta, A.1
van Lijnschoten, G.2
Moerland, E.3
Creemers, G.J.4
Lemmens, V.E.5
Rutten, H.J.6
-
23
-
-
84856512550
-
Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803
-
doi:10.1158/1078-0432.CCR-11-2246
-
Ogino S, Shima K, Meyerhardt JA, McCleary NJ, Ng K, Hollis D, et al. Predictive and prognostic roles of BRAF mutation in stage III colon cancer: results from intergroup trial CALGB 89803. Clin Cancer Res (2012) 18:890-900. doi:10.1158/1078-0432.CCR-11-2246
-
(2012)
Clin Cancer Res
, vol.18
, pp. 890-900
-
-
Ogino, S.1
Shima, K.2
Meyerhardt, J.A.3
McCleary, N.J.4
Ng, K.5
Hollis, D.6
-
24
-
-
84859885193
-
BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features
-
doi:10.1097/PAS.0b013e31824430d7
-
Pai RK, Jayachandran P, Koong AC, Chang DT, Kwok S, Ma L, et al. BRAF-mutated, microsatellite-stable adenocarcinoma of the proximal colon: an aggressive adenocarcinoma with poor survival, mucinous differentiation, and adverse morphologic features. Am J Surg Pathol (2012) 36:744-52. doi:10.1097/PAS.0b013e31824430d7
-
(2012)
Am J Surg Pathol
, vol.36
, pp. 744-752
-
-
Pai, R.K.1
Jayachandran, P.2
Koong, A.C.3
Chang, D.T.4
Kwok, S.5
Ma, L.6
-
25
-
-
85047689482
-
BRAF mutations in colorectal cancer are associated with distinct clinical characteristics and worse prognosis
-
doi:10.1097/DCR.0b013e31823c08b3
-
Kalady MF, Dejulius KL, Sanchez JA, Jarrar A, Liu X, Manilich E, et al. BRAF mutations in colorectal cancer are associated with distinct clinical characteristics and worse prognosis. Dis Colon Rectum (2012) 55:128-33. doi:10.1097/DCR.0b013e31823c08b3
-
(2012)
Dis Colon Rectum
, vol.55
, pp. 128-133
-
-
Kalady, M.F.1
Dejulius, K.L.2
Sanchez, J.A.3
Jarrar, A.4
Liu, X.5
Manilich, E.6
-
26
-
-
84878558999
-
The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer
-
doi:10.1038/bjc.2013.212
-
Eklöf V, Wikberg ML, Edin S, Dahlin AM, Jonsson BA, Oberg A, et al. The prognostic role of KRAS, BRAF, PIK3CA and PTEN in colorectal cancer. Br J Cancer (2013) 108:2153-63. doi:10.1038/bjc.2013.212
-
(2013)
Br J Cancer
, vol.108
, pp. 2153-2163
-
-
Eklöf, V.1
Wikberg, M.L.2
Edin, S.3
Dahlin, A.M.4
Jonsson, B.A.5
Oberg, A.6
-
27
-
-
84860589077
-
Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum
-
doi:10.1136/gutjnl-2011-300865
-
Yamauchi M, Morikawa T, Kuchiba A, Imamura Y, Qian ZR, Nishihara R, et al. Assessment of colorectal cancer molecular features along bowel subsites challenges the conception of distinct dichotomy of proximal versus distal colorectum. Gut (2012) 61:847-54. doi:10.1136/gutjnl-2011-300865
-
(2012)
Gut
, vol.61
, pp. 847-854
-
-
Yamauchi, M.1
Morikawa, T.2
Kuchiba, A.3
Imamura, Y.4
Qian, Z.R.5
Nishihara, R.6
-
28
-
-
77956067587
-
Lymph node harvest in colon cancer: influence of microsatellite instability and proximal tumor location
-
doi:10.1007/s00268-009-02554
-
Soreide K, Nedrebo BS, Soreide JA, Slewa A, Korner H. Lymph node harvest in colon cancer: influence of microsatellite instability and proximal tumor location. World J Surg (2009) 33:2695-703. doi:10.1007/s00268-009-02554
-
(2009)
World J Surg
, vol.33
, pp. 2695-2703
-
-
Soreide, K.1
Nedrebo, B.S.2
Soreide, J.A.3
Slewa, A.4
Korner, H.5
-
29
-
-
74549215196
-
Association between a high number of isolated lymph nodes in T1 to T4 N0M0 colorectal cancer and the microsatellite instability phenotype
-
doi:10.1001/archsurg.2009.224
-
Eveno C, Nemeth J, Soliman H, Praz F, de The H, Valleur P, et al. Association between a high number of isolated lymph nodes in T1 to T4 N0M0 colorectal cancer and the microsatellite instability phenotype. Arch Surg (2010) 145:12-7. doi:10.1001/archsurg.2009.224
-
(2010)
Arch Surg
, vol.145
, pp. 12-17
-
-
Eveno, C.1
Nemeth, J.2
Soliman, H.3
Praz, F.4
de The, H.5
Valleur, P.6
-
30
-
-
84883791516
-
Influence of microsatellite instability, KRAS and BRAF mutations on lymph node harvest in stage I-III colon cancers
-
doi:10.2119/molmed.2013.00049
-
Berg M, Guriby M, Nordgard O, Nedrebo BS, Ahlquist TC, Smaaland R, et al. Influence of microsatellite instability, KRAS and BRAF mutations on lymph node harvest in stage I-III colon cancers. Mol Med (2013). doi:10.2119/molmed.2013.00049
-
(2013)
Mol Med
-
-
Berg, M.1
Guriby, M.2
Nordgard, O.3
Nedrebo, B.S.4
Ahlquist, T.C.5
Smaaland, R.6
-
31
-
-
84877087305
-
Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase 3 study of metastatic colorectal cancer
-
doi:10.1158/1078-0432.CCR-12-1913
-
Peeters M, Oliner K, Parker A, Siena S, Van Cutsem E, Huang J, et al. Massively parallel tumor multigene sequencing to evaluate response to panitumumab in a randomized phase 3 study of metastatic colorectal cancer. Clin Cancer Res (2013) 19:1902-12. doi:10.1158/1078-0432.CCR-12-1913
-
(2013)
Clin Cancer Res
, vol.19
, pp. 1902-1912
-
-
Peeters, M.1
Oliner, K.2
Parker, A.3
Siena, S.4
Van Cutsem, E.5
Huang, J.6
-
32
-
-
84881640407
-
Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication
-
doi:10.1093/jnci/djt173
-
Lochhead P, Kuchiba A, Imamura Y, Liao X, Yamauchi M, Nishihara R, et al. Microsatellite instability and BRAF mutation testing in colorectal cancer prognostication. J Natl Cancer Inst (2013) 105:1151-6. doi:10.1093/jnci/djt173
-
(2013)
J Natl Cancer Inst
, vol.105
, pp. 1151-1156
-
-
Lochhead, P.1
Kuchiba, A.2
Imamura, Y.3
Liao, X.4
Yamauchi, M.5
Nishihara, R.6
-
33
-
-
73349114941
-
KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial
-
doi:10.1200/JCO.2009.22.4295
-
Richman SD, Seymour MT, Chambers P, Elliott F, Daly CL, Meade AM, et al. KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J Clin Oncol (2009) 27:5931-7. doi:10.1200/JCO.2009.22.4295
-
(2009)
J Clin Oncol
, vol.27
, pp. 5931-5937
-
-
Richman, S.D.1
Seymour, M.T.2
Chambers, P.3
Elliott, F.4
Daly, C.L.5
Meade, A.M.6
-
34
-
-
50349091081
-
Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer
-
doi:10.1158/1078-0432.CCR-07-1489
-
French AJ, Sargent DJ, Burgart LJ, Foster NR, Kabat BF, Goldberg R, et al. Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer. Clin Cancer Res (2008) 14:3408-15. doi:10.1158/1078-0432.CCR-07-1489
-
(2008)
Clin Cancer Res
, vol.14
, pp. 3408-3415
-
-
French, A.J.1
Sargent, D.J.2
Burgart, L.J.3
Foster, N.R.4
Kabat, B.F.5
Goldberg, R.6
-
35
-
-
84887231621
-
Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations
-
doi:10.1038/ajg.2013.292
-
Mouradov D, Domingo E, Gibbs P, Jorissen RN, Li S, Soo PY, et al. Survival in stage II/III colorectal cancer is independently predicted by chromosomal and microsatellite instability, but not by specific driver mutations. Am J Gastroenterol (2013) 108:1785-93. doi:10.1038/ajg.2013.292
-
(2013)
Am J Gastroenterol
, vol.108
, pp. 1785-1793
-
-
Mouradov, D.1
Domingo, E.2
Gibbs, P.3
Jorissen, R.N.4
Li, S.5
Soo, P.Y.6
-
36
-
-
84867298938
-
The prognostic value of BRAF mutation in colorectal cancer and melanoma: a systematic review and meta-analysis
-
doi:10.1371/journal.pone.0047054
-
Safaee Ardekani G, Jafarnejad SM, Tan L, Saeedi A, Li G. The prognostic value of BRAF mutation in colorectal cancer and melanoma: a systematic review and meta-analysis. PLoS One (2012) 7:e47054. doi:10.1371/journal.pone.0047054
-
(2012)
PLoS One
, vol.7
-
-
Safaee Ardekani, G.1
Jafarnejad, S.M.2
Tan, L.3
Saeedi, A.4
Li, G.5
-
37
-
-
57449095367
-
Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer
-
doi:10.1200/JCO.2008.18.0786
-
Di Nicolantonio F, Martini M, Molinari F, Sartore-Bianchi A, Arena S, Saletti P, et al. Wild-type BRAF is required for response to panitumumab or cetuximab in metastatic colorectal cancer. J Clin Oncol (2008) 26:5705-12. doi:10.1200/JCO.2008.18.0786
-
(2008)
J Clin Oncol
, vol.26
, pp. 5705-5712
-
-
Di Nicolantonio, F.1
Martini, M.2
Molinari, F.3
Sartore-Bianchi, A.4
Arena, S.5
Saletti, P.6
-
38
-
-
77955277111
-
Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
-
doi:10.1016/S1470-2045(10)70130-3
-
De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, Fountzilas G, et al. Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol (2010) 11:753-62. doi:10.1016/S1470-2045(10)70130-3
-
(2010)
Lancet Oncol
, vol.11
, pp. 753-762
-
-
De Roock, W.1
Claes, B.2
Bernasconi, D.3
De Schutter, J.4
Biesmans, B.5
Fountzilas, G.6
-
39
-
-
84878901220
-
The prognostic role of BRAF mutation in metastatic colorectal cancer receiving anti-EGFR monoclonal antibodies: a meta-analysis
-
doi:10.1371/journal.pone.0065995
-
Yuan ZX, Wang XY, Qin QY, Chen DF, Zhong QH, Wang L, et al. The prognostic role of BRAF mutation in metastatic colorectal cancer receiving anti-EGFR monoclonal antibodies: a meta-analysis. PLoS One (2013) 8:e65995. doi:10.1371/journal.pone.0065995
-
(2013)
PLoS One
, vol.8
-
-
Yuan, Z.X.1
Wang, X.Y.2
Qin, Q.Y.3
Chen, D.F.4
Zhong, Q.H.5
Wang, L.6
-
40
-
-
84871273318
-
Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish society of pathology (SEAP) and the Spanish society of medical oncology (SEOM)
-
doi:10.1007/s12094-012-0856-5
-
Garcia-Alfonso P, Salazar R, Garcia-Foncillas J, Musulen E, Garcia-Carbonero R, Paya A, et al. Guidelines for biomarker testing in colorectal carcinoma (CRC): a national consensus of the Spanish society of pathology (SEAP) and the Spanish society of medical oncology (SEOM). Clin Transl Oncol (2012) 14:726-39. doi:10.1007/s12094-012-0856-5
-
(2012)
Clin Transl Oncol
, vol.14
, pp. 726-739
-
-
Garcia-Alfonso, P.1
Salazar, R.2
Garcia-Foncillas, J.3
Musulen, E.4
Garcia-Carbonero, R.5
Paya, A.6
-
41
-
-
77954215850
-
Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
-
doi:10.1016/j.ejca.2010.03.036
-
Tol J, Dijkstra JR, Klomp M, Teerenstra S, Dommerholt M, Vink-Borger ME, et al. Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. Eur J Cancer (2010) 46:1997-2009. doi:10.1016/j.ejca.2010.03.036
-
(2010)
Eur J Cancer
, vol.46
, pp. 1997-2009
-
-
Tol, J.1
Dijkstra, J.R.2
Klomp, M.3
Teerenstra, S.4
Dommerholt, M.5
Vink-Borger, M.E.6
-
42
-
-
79956298812
-
Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status
-
doi:10.1200/JCO.2010.33.5091
-
Van Cutsem E, Kohne CH, Lang I, Folprecht G, Nowacki MP, Cascinu S, et al. Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol (2011) 29:2011-9. doi:10.1200/JCO.2010.33.5091
-
(2011)
J Clin Oncol
, vol.29
, pp. 2011-2019
-
-
Van Cutsem, E.1
Kohne, C.H.2
Lang, I.3
Folprecht, G.4
Nowacki, M.P.5
Cascinu, S.6
-
43
-
-
84862026304
-
Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials
-
doi:10.1016/j.ejca.2012.02.057
-
Bokemeyer C, Van Cutsem E, Rougier P, Ciardiello F, Heeger S, Schlichting M, et al. Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomised clinical trials. Eur J Cancer (2012) 48:1466-75. doi:10.1016/j.ejca.2012.02.057
-
(2012)
Eur J Cancer
, vol.48
, pp. 1466-1475
-
-
Bokemeyer, C.1
Van Cutsem, E.2
Rougier, P.3
Ciardiello, F.4
Heeger, S.5
Schlichting, M.6
-
44
-
-
84891067274
-
Evaluation of KRAS, NRAS, and BRAF mutations in PRIME: panitumumab with FOLFOX4 as first-line treatment in metastatic colorectal cancer (mCRC)
-
doi:10.1093/annonc/mdt201.31
-
Oliner K, Douillard J, Siena S, Tabernero J, Burkes R, Barugel M, et al. Evaluation of KRAS, NRAS, and BRAF mutations in PRIME: panitumumab with FOLFOX4 as first-line treatment in metastatic colorectal cancer (mCRC). Ann Oncol (2013) 24(Suppl 4):iv23-4. doi:10.1093/annonc/mdt201.31
-
(2013)
Ann Oncol
, vol.24
, Issue.SUPPL. 4
-
-
Oliner, K.1
Douillard, J.2
Siena, S.3
Tabernero, J.4
Burkes, R.5
Barugel, M.6
-
45
-
-
79953856354
-
Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer
-
doi:10.1200/JCO.2010.30.1366
-
Hutchins G, Southward K, Handley K, Magill L, Beaumont C, Stahlschmidt J, et al. Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer. J Clin Oncol (2011) 29:1261-70. doi:10.1200/JCO.2010.30.1366
-
(2011)
J Clin Oncol
, vol.29
, pp. 1261-1270
-
-
Hutchins, G.1
Southward, K.2
Handley, K.3
Magill, L.4
Beaumont, C.5
Stahlschmidt, J.6
-
46
-
-
84876900933
-
Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts
-
doi:10.1136/gutjnl-2012-304356
-
Vasen HF, Blanco I, Aktan-Collan K, Gopie JP, Alonso A, Aretz S, et al. Revised guidelines for the clinical management of Lynch syndrome (HNPCC): recommendations by a group of European experts. Gut (2013) 62:812-23. doi:10.1136/gutjnl-2012-304356
-
(2013)
Gut
, vol.62
, pp. 812-823
-
-
Vasen, H.F.1
Blanco, I.2
Aktan-Collan, K.3
Gopie, J.P.4
Alonso, A.5
Aretz, S.6
-
47
-
-
84863609627
-
Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National society of genetic counselors and the collaborative group of the Americans on inherited colorectal cancer joint practice guideline
-
doi:10.1007/s10897-011-9465-7
-
Weissman SM, Burt R, Church J, Erdman S, Hampel H, Holter S, et al. Identification of individuals at risk for Lynch syndrome using targeted evaluations and genetic testing: National society of genetic counselors and the collaborative group of the Americans on inherited colorectal cancer joint practice guideline. J Genet Couns (2012) 21:484-93. doi:10.1007/s10897-011-9465-7
-
(2012)
J Genet Couns
, vol.21
, pp. 484-493
-
-
Weissman, S.M.1
Burt, R.2
Church, J.3
Erdman, S.4
Hampel, H.5
Holter, S.6
-
48
-
-
84867499525
-
Identification of Lynch syndrome among patients with colorectal cancer
-
doi:10.1001/jama.2012.13088
-
Moreira L, Balaguer F, Lindor N, de la Chapelle A, Hampel H, Aaltonen LA, et al. Identification of Lynch syndrome among patients with colorectal cancer. JAMA (2012) 308:1555-65. doi:10.1001/jama.2012.13088
-
(2012)
JAMA
, vol.308
, pp. 1555-1565
-
-
Moreira, L.1
Balaguer, F.2
Lindor, N.3
de la Chapelle, A.4
Hampel, H.5
Aaltonen, L.A.6
-
49
-
-
84860314426
-
Correlation of tumour BRAF mutations and MLH1 methylation with germline mismatch repair (MMR) gene mutation status: a literature review assessing utility of tumour features for MMR variant classification
-
doi:10.1136/jmedgenet-2011-100714
-
Parsons MT, Buchanan DD, Thompson B, Young JP, Spurdle AB. Correlation of tumour BRAF mutations and MLH1 methylation with germline mismatch repair (MMR) gene mutation status: a literature review assessing utility of tumour features for MMR variant classification. J Med Genet (2012) 49:151-7. doi:10.1136/jmedgenet-2011-100714
-
(2012)
J Med Genet
, vol.49
, pp. 151-157
-
-
Parsons, M.T.1
Buchanan, D.D.2
Thompson, B.3
Young, J.P.4
Spurdle, A.B.5
-
50
-
-
84881668573
-
Targeting BRAF in melanoma: biological and clinical challenges
-
doi:10.1016/j.critrevonc.2013.01.003
-
Mandala M, Voit C. Targeting BRAF in melanoma: biological and clinical challenges. Crit Rev Oncol Hematol (2013) 87:239-55. doi:10.1016/j.critrevonc.2013.01.003
-
(2013)
Crit Rev Oncol Hematol
, vol.87
, pp. 239-255
-
-
Mandala, M.1
Voit, C.2
-
51
-
-
67649909568
-
Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
-
doi:10.1200/JCO.2007.15.7636
-
Hauschild A, Agarwala SS, Trefzer U, Hogg D, Robert C, Hersey P, et al. Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol (2009) 27:2823-30. doi:10.1200/JCO.2007.15.7636
-
(2009)
J Clin Oncol
, vol.27
, pp. 2823-2830
-
-
Hauschild, A.1
Agarwala, S.S.2
Trefzer, U.3
Hogg, D.4
Robert, C.5
Hersey, P.6
-
52
-
-
84873346707
-
Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma
-
doi:10.1200/JCO.2012.42.1529
-
Flaherty KT, Lee SJ, Zhao F, Schuchter LM, Flaherty L, Kefford R, et al. Phase III trial of carboplatin and paclitaxel with or without sorafenib in metastatic melanoma. J Clin Oncol (2013) 31:373-9. doi:10.1200/JCO.2012.42.1529
-
(2013)
J Clin Oncol
, vol.31
, pp. 373-379
-
-
Flaherty, K.T.1
Lee, S.J.2
Zhao, F.3
Schuchter, L.M.4
Flaherty, L.5
Kefford, R.6
-
53
-
-
84883016265
-
BRAF in melanoma: current strategies and future directions
-
doi:10.1158/1078-0432.CCR-13-0779
-
Salama AK, Flaherty KT. BRAF in melanoma: current strategies and future directions. Clin Cancer Res (2013) 19:4326-34. doi:10.1158/1078-0432.CCR-13-0779
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4326-4334
-
-
Salama, A.K.1
Flaherty, K.T.2
-
54
-
-
47949116252
-
Sorafenib in advanced hepatocellular carcinoma
-
SHARP Investigators Study Group. doi:10.1056/NEJMoa0708857
-
Llovet JM, Ricci S, Mazzaferro V, Hilgard P, Gane E, Blanc JF, et al. SHARP Investigators Study Group. Sorafenib in advanced hepatocellular carcinoma. N Engl J Med (2008) 359:378-90. doi:10.1056/NEJMoa0708857
-
(2008)
N Engl J Med
, vol.359
, pp. 378-390
-
-
Llovet, J.M.1
Ricci, S.2
Mazzaferro, V.3
Hilgard, P.4
Gane, E.5
Blanc, J.F.6
-
55
-
-
84861852381
-
Receptor tyrosine kinases in cancer escape from BRAF inhibitors
-
doi:10.1038/cr.2012.78
-
Lo RS. Receptor tyrosine kinases in cancer escape from BRAF inhibitors. Cell Res (2012) 22:945-7. doi:10.1038/cr.2012.78
-
(2012)
Cell Res
, vol.22
, pp. 945-947
-
-
Lo, R.S.1
-
56
-
-
78649723255
-
PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors [abstract]
-
Kopetz S, Desai J, Chan E, Hecht JR, O'Dwyer PJ, Lee RJ, et al. PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors [abstract]. J Clin Oncol (2010) 28(Suppl):3534.
-
(2010)
J Clin Oncol
, vol.28
, Issue.SUPPL.
, pp. 3534
-
-
Kopetz, S.1
Desai, J.2
Chan, E.3
Hecht, J.R.4
O'Dwyer, P.J.5
Lee, R.J.6
-
57
-
-
84863012433
-
Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer
-
doi:10.1158/0008-5472.CAN-11-2941
-
Yang H, Higgins B, Kolinsky K, Packman K, Bradley WD, Lee RJ, et al. Antitumor activity of BRAF inhibitor vemurafenib in preclinical models of BRAF-mutant colorectal cancer. Cancer Res (2012) 72:779-89. doi:10.1158/0008-5472.CAN-11-2941
-
(2012)
Cancer Res
, vol.72
, pp. 779-789
-
-
Yang, H.1
Higgins, B.2
Kolinsky, K.3
Packman, K.4
Bradley, W.D.5
Lee, R.J.6
-
58
-
-
84861863158
-
EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib
-
doi:10.1158/2159-8290.CD-11-0341
-
Corcoran RB, Ebi H, Turke AB, Coffee EM, Nishino M, Cogdill AP, et al. EGFR-mediated re-activation of MAPK signaling contributes to insensitivity of BRAF mutant colorectal cancers to RAF inhibition with vemurafenib. Cancer Discov (2012) 2:227-35. doi:10.1158/2159-8290.CD-11-0341
-
(2012)
Cancer Discov
, vol.2
, pp. 227-235
-
-
Corcoran, R.B.1
Ebi, H.2
Turke, A.B.3
Coffee, E.M.4
Nishino, M.5
Cogdill, A.P.6
-
59
-
-
84864285794
-
Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion
-
doi:10.1038/nature11183
-
Straussman R, Morikawa T, Shee K, Barzily-Rokni M, Qian ZR, Du J, et al. Tumour micro-environment elicits innate resistance to RAF inhibitors through HGF secretion. Nature (2012) 487:500-4. doi:10.1038/nature11183
-
(2012)
Nature
, vol.487
, pp. 500-504
-
-
Straussman, R.1
Morikawa, T.2
Shee, K.3
Barzily-Rokni, M.4
Qian, Z.R.5
Du, J.6
-
60
-
-
80053307869
-
Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers
-
Corcoran RB, Settleman J, Engelman JA. Potential therapeutic strategies to overcome acquired resistance to BRAF or MEK inhibitors in BRAF mutant cancers. Oncotarget (2011) 2:336-46.
-
(2011)
Oncotarget
, vol.2
, pp. 336-346
-
-
Corcoran, R.B.1
Settleman, J.2
Engelman, J.A.3
-
61
-
-
73949083834
-
MEK1 mutations confer resistance to MEK and B-RAF inhibition
-
doi:10.1073/pnas.0905833106
-
Emery CM, Vijayendran KG, Zipser MC, Sawyer AM, Niu L, Kim JJ, et al. MEK1 mutations confer resistance to MEK and B-RAF inhibition. Proc Natl Acad Sci U S A (2009) 106:20411-6. doi:10.1073/pnas.0905833106
-
(2009)
Proc Natl Acad Sci U S A
, vol.106
, pp. 20411-6
-
-
Emery, C.M.1
Vijayendran, K.G.2
Zipser, M.C.3
Sawyer, A.M.4
Niu, L.5
Kim, J.J.6
-
62
-
-
78650303507
-
Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation
-
doi:10.1038/nature09626
-
Nazarian R, Shi H, Wang Q, Kong X, Koya RC, Lee H, et al. Melanomas acquire resistance to B-RAF(V600E) inhibition by RTK or N-RAS upregulation. Nature (2010) 468:973-7. doi:10.1038/nature09626
-
(2010)
Nature
, vol.468
, pp. 973-977
-
-
Nazarian, R.1
Shi, H.2
Wang, Q.3
Kong, X.4
Koya, R.C.5
Lee, H.6
-
63
-
-
78650309875
-
COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
-
doi:10.1038/nature09627
-
Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, Johnson LA, et al. COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature (2010) 468:968-72. doi:10.1038/nature09627
-
(2010)
Nature
, vol.468
, pp. 968-972
-
-
Johannessen, C.M.1
Boehm, J.S.2
Kim, S.Y.3
Thomas, S.R.4
Wardwell, L.5
Johnson, L.A.6
-
64
-
-
74849109743
-
Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF
-
doi:10.1016/j.cell.2009.12.040
-
Heidorn SJ, Milagre C, Whittaker S, Nourry A, Niculescu-Duvas I, Dhomen N, et al. Kinase-dead BRAF and oncogenic RAS cooperate to drive tumor progression through CRAF. Cell (2010) 140:209-21. doi:10.1016/j.cell.2009.12.040
-
(2010)
Cell
, vol.140
, pp. 209-221
-
-
Heidorn, S.J.1
Milagre, C.2
Whittaker, S.3
Nourry, A.4
Niculescu-Duvas, I.5
Dhomen, N.6
-
65
-
-
83455254767
-
RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
-
doi:10.1038/nature10662
-
Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, Moriceau G, et al. RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature (2011) 480:387-90. doi:10.1038/nature10662
-
(2011)
Nature
, vol.480
, pp. 387-390
-
-
Poulikakos, P.I.1
Persaud, Y.2
Janakiraman, M.3
Kong, X.4
Ng, C.5
Moriceau, G.6
-
66
-
-
79953325104
-
PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression
-
doi:10.1158/0008-5472.CAN-10-2954
-
Paraiso KH, Xiang Y, Rebecca VW, Abel EV, Chen YA, Munko AC, et al. PTEN loss confers BRAF inhibitor resistance to melanoma cells through the suppression of BIM expression. Cancer Res (2011) 71:2750-60. doi:10.1158/0008-5472.CAN-10-2954
-
(2011)
Cancer Res
, vol.71
, pp. 2750-2760
-
-
Paraiso, K.H.1
Xiang, Y.2
Rebecca, V.W.3
Abel, E.V.4
Chen, Y.A.5
Munko, A.C.6
-
67
-
-
78650008177
-
Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K
-
doi:10.1016/j.ccr.2010.11.023
-
Villanueva J, Vultur A, Lee JT, Somasundaram R, Fukunaga-Kalabis M, Cipolla AK, et al. Acquired resistance to BRAF inhibitors mediated by a RAF kinase switch in melanoma can be overcome by cotargeting MEK and IGF-1R/PI3K. Cancer Cell (2010) 18:683-95. doi:10.1016/j.ccr.2010.11.023
-
(2010)
Cancer Cell
, vol.18
, pp. 683-695
-
-
Villanueva, J.1
Vultur, A.2
Lee, J.T.3
Somasundaram, R.4
Fukunaga-Kalabis, M.5
Cipolla, A.K.6
-
68
-
-
84886385231
-
Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression
-
doi:10.1158/1078-0432.CCR-13-0661
-
Romano E, Pradervand S, Paillusson A, Weber J, Harshman K, Muehlethaler K, et al. Identification of multiple mechanisms of resistance to vemurafenib in a patient with BRAFV600E-mutated cutaneous melanoma successfully rechallenged after progression. Clin Cancer Res (2013) 19:5749-57. doi:10.1158/1078-0432.CCR-13-0661
-
(2013)
Clin Cancer Res
, vol.19
, pp. 5749-5757
-
-
Romano, E.1
Pradervand, S.2
Paillusson, A.3
Weber, J.4
Harshman, K.5
Muehlethaler, K.6
-
69
-
-
78649436372
-
BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation
-
ra84. doi:10.1126/scisignal.2001148
-
Corcoran RB, Dias-Santagata D, Bergethon K, Iafrate AJ, Settleman J, Engelman JA. BRAF gene amplification can promote acquired resistance to MEK inhibitors in cancer cells harboring the BRAF V600E mutation. Sci Signal (2010) 3:ra84. doi:10.1126/scisignal.2001148
-
(2010)
Sci Signal
, vol.3
-
-
Corcoran, R.B.1
Dias-Santagata, D.2
Bergethon, K.3
Iafrate, A.J.4
Settleman, J.5
Engelman, J.A.6
-
70
-
-
84863230465
-
Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
-
doi:10.1038/nature10868
-
Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, Zecchin D, et al. Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature (2012) 483:100-3. doi:10.1038/nature10868
-
(2012)
Nature
, vol.483
, pp. 100-103
-
-
Prahallad, A.1
Sun, C.2
Huang, S.3
Di Nicolantonio, F.4
Salazar, R.5
Zecchin, D.6
-
71
-
-
84882992810
-
Vemurafenib synergizes with nutlin-3 to deplete survivin and suppress melanoma viability and tumor growth
-
doi:10.1158/1078-0432.CCR-13-0074
-
Ji Z, Kumar R, Taylor M, Rajadurai A, Marzuka-Alcala A, Chen YE, et al. Vemurafenib synergizes with nutlin-3 to deplete survivin and suppress melanoma viability and tumor growth. Clin Cancer Res (2013) 19:4383-91. doi:10.1158/1078-0432.CCR-13-0074
-
(2013)
Clin Cancer Res
, vol.19
, pp. 4383-4391
-
-
Ji, Z.1
Kumar, R.2
Taylor, M.3
Rajadurai, A.4
Marzuka-Alcala, A.5
Chen, Y.E.6
-
72
-
-
84873360893
-
Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents
-
doi:10.1158/1078-0432.CCR-11-1446
-
Mao M, Tian F, Mariadason JM, Tsao CC, Lemos R Jr, Dayyani F, et al. Resistance to BRAF inhibition in BRAF-mutant colon cancer can be overcome with PI3K inhibition or demethylating agents. Clin Cancer Res (2013) 19:657-67. doi:10.1158/1078-0432.CCR-11-1446
-
(2013)
Clin Cancer Res
, vol.19
, pp. 657-667
-
-
Mao, M.1
Tian, F.2
Mariadason, J.M.3
Tsao, C.C.4
Lemos Jr., R.5
Dayyani, F.6
-
73
-
-
84878066430
-
Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer
-
doi:10.1158/1078-0432.CCR-12-2556
-
Coffee EM, Faber AC, Roper J, Sinnamon MJ, Goel G, Keung L, et al. Concomitant BRAF and PI3K/mTOR blockade is required for effective treatment of BRAF(V600E) colorectal cancer. Clin Cancer Res (2013) 19:2688-98. doi:10.1158/1078-0432.CCR-12-2556
-
(2013)
Clin Cancer Res
, vol.19
, pp. 2688-2698
-
-
Coffee, E.M.1
Faber, A.C.2
Roper, J.3
Sinnamon, M.J.4
Goel, G.5
Keung, L.6
-
74
-
-
84880020762
-
A genetic progression model of braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention
-
doi:10.1016/j.ccr.2013.05.014
-
Rad R, Cadinanos J, Rad L, Varela I, Strong A, Kriegl L, et al. A genetic progression model of braf(V600E)-induced intestinal tumorigenesis reveals targets for therapeutic intervention. Cancer Cell (2013) 24:15-29. doi:10.1016/j.ccr.2013.05.014
-
(2013)
Cancer Cell
, vol.24
, pp. 15-29
-
-
Rad, R.1
Cadinanos, J.2
Rad, L.3
Varela, I.4
Strong, A.5
Kriegl, L.6
-
75
-
-
84868224906
-
Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations
-
doi:10.1056/NEJMoa1210093
-
Flaherty KT, Infante JR, Daud A, Gonzalez R, Kefford RF, Sosman J, et al. Combined BRAF and MEK inhibition in melanoma with BRAF V600 mutations. N Engl J Med (2012) 367:1694-703. doi:10.1056/NEJMoa1210093
-
(2012)
N Engl J Med
, vol.367
, pp. 1694-1703
-
-
Flaherty, K.T.1
Infante, J.R.2
Daud, A.3
Gonzalez, R.4
Kefford, R.F.5
Sosman, J.6
|