메뉴 건너뛰기




Volumn 14, Issue 10, 2012, Pages 726-739

Guidelines for biomarker testing in colorectal carcinoma (CRC): A national consensus of the Spanish Society of Pathology (SEAP) and the Spanish Society of Medical Oncology (SEOM)

Author keywords

BRAF; EGFR; KRAS; MSI; PTEN

Indexed keywords

B RAF KINASE; BIOLOGICAL MARKER; CAPECITABINE; CETUXIMAB; EPIDERMAL GROWTH FACTOR RECEPTOR; FLUOROPYRIMIDINE; FLUOROURACIL; FOLINIC ACID; IRINOTECAN; K RAS PROTEIN; OXALIPLATIN; PANITUMUMAB; PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE;

EID: 84871273318     PISSN: 1699048X     EISSN: 16993055     Source Type: Journal    
DOI: 10.1007/s12094-012-0856-5     Document Type: Article
Times cited : (21)

References (71)
  • 1
    • 0034950515 scopus 로고    scopus 로고
    • American Gastroenterological Association medical position statement: Hereditary colorectal cancer and genetic testing
    • American Gastroenterological Association
    • American Gastroenterological Association (2001) American Gastroenterological Association medical position statement: hereditary colorectal cancer and genetic testing. Gastroenterology 121:195-197
    • (2001) Gastroenterology , vol.121 , pp. 195-197
  • 2
    • 0033063711 scopus 로고    scopus 로고
    • New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC
    • Vasen HF, Watson P, Mecklin JP et al (1999) New clinical criteria for hereditary nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the International Collaborative group on HNPCC. Gastroenterology 116:1453-1456
    • (1999) Gastroenterology , vol.116 , pp. 1453-1456
    • Vasen, H.F.1    Watson, P.2    Mecklin, J.P.3
  • 4
    • 10744233937 scopus 로고    scopus 로고
    • Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability
    • Umar A, Boland CR, Terdiman JP et al (2004) Revised Bethesda Guidelines for hereditary nonpolyposis colorectal cancer (Lynch syndrome) and microsatellite instability. J Natl Cancer Inst 96:261-268
    • (2004) J Natl Cancer Inst , vol.96 , pp. 261-268
    • Umar, A.1    Boland, C.R.2    Terdiman, J.P.3
  • 5
    • 33749040947 scopus 로고    scopus 로고
    • Prediction of MLH1 and MSH2 mutations in Lynch syndrome
    • Balmana J, Stockwell DH, Steyerberg EW et al (2006) Prediction of MLH1 and MSH2 mutations in Lynch syndrome. JAMA 296:1469-1478
    • (2006) JAMA , vol.296 , pp. 1469-1478
    • Balmana, J.1    Stockwell, D.H.2    Steyerberg, E.W.3
  • 6
    • 25144456860 scopus 로고    scopus 로고
    • A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis
    • Popat S, Houlston RS (2005) A systematic review and meta-analysis of the relationship between chromosome 18q genotype, DCC status and colorectal cancer prognosis. Eur J Cancer 41:2060-2070
    • (2005) Eur J Cancer , vol.41 , pp. 2060-2070
    • Popat, S.1    Houlston, R.S.2
  • 7
    • 0029955460 scopus 로고    scopus 로고
    • The DCC protein and prognosis in colorectal cancer
    • Shibata D, Reale MA, Lavin P et al (1996) The DCC protein and prognosis in colorectal cancer. N Engl J Med 335:1727-1732
    • (1996) N Engl J Med , vol.335 , pp. 1727-1732
    • Shibata, D.1    Reale, M.A.2    Lavin, P.3
  • 8
    • 20244365185 scopus 로고    scopus 로고
    • SMAD4 as a prognostic marker in colorectal cancer
    • Alazzouzi H, Alhopuro P, Salovaara R et al (2005) SMAD4 as a prognostic marker in colorectal cancer. Clin Cancer Res 11:2606-2611
    • (2005) Clin Cancer Res , vol.11 , pp. 2606-2611
    • Alazzouzi, H.1    Alhopuro, P.2    Salovaara, R.3
  • 9
    • 77949274921 scopus 로고    scopus 로고
    • Stage-specific prognostic value of molecular markers in colon cancer: Results of the translational study on the PETACC 3-EORTC 40993-SAKK 60-00 trial
    • Roth AD, Tejpar S, Yan P et al (2009) Stage-specific prognostic value of molecular markers in colon cancer: results of the translational study on the PETACC 3-EORTC 40993-SAKK 60-00 trial. ASCO Meeting Abstracts 27:4002
    • (2009) ASCO Meeting Abstracts , vol.27 , pp. 4002
    • Roth, A.D.1    Tejpar, S.2    Yan, P.3
  • 10
    • 63049111794 scopus 로고    scopus 로고
    • PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer
    • Ogino S, Nosho K, Kirkner GJ et al (2009) PIK3CA mutation is associated with poor prognosis among patients with curatively resected colon cancer. J Clin Oncol 27:1477-1484
    • (2009) J Clin Oncol , vol.27 , pp. 1477-1484
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3
  • 11
    • 14544300998 scopus 로고    scopus 로고
    • Systematic review of microsatellite instability and colorectal cancer prognosis
    • Popat S, Hubner R, Houlston RS (2005) Systematic review of microsatellite instability and colorectal cancer prognosis. J Clin Oncol 23:609-618
    • (2005) J Clin Oncol , vol.23 , pp. 609-618
    • Popat, S.1    Hubner, R.2    Houlston, R.S.3
  • 12
    • 77954748953 scopus 로고    scopus 로고
    • Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer
    • Sargent DJ, Marsoni S, Monges G et al (2010) Defective mismatch repair as a predictive marker for lack of efficacy of fluorouracil-based adjuvant therapy in colon cancer. J Clin Oncol 28:3219-3226
    • (2010) J Clin Oncol , vol.28 , pp. 3219-3226
    • Sargent, D.J.1    Marsoni, S.2    Monges, G.3
  • 13
    • 79953856354 scopus 로고    scopus 로고
    • Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer
    • Hutchins G, Southward K, Handley K et al (2011) Value of mismatch repair, KRAS, and BRAF mutations in predicting recurrence and benefits from chemotherapy in colorectal cancer. J Clin Oncol 29:1261-1270
    • (2011) J Clin Oncol , vol.29 , pp. 1261-1270
    • Hutchins, G.1    Southward, K.2    Handley, K.3
  • 14
    • 79958828886 scopus 로고    scopus 로고
    • DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracilbased adjuvant therapy
    • Sinicrope FA, Foster NR, Thibodeau SN et al (2011) DNA mismatch repair status and colon cancer recurrence and survival in clinical trials of 5-fluorouracilbased adjuvant therapy. J Natl Cancer Inst 103:863-875
    • (2011) J Natl Cancer Inst , vol.103 , pp. 863-875
    • Sinicrope, F.A.1    Foster, N.R.2    Thibodeau, S.N.3
  • 15
    • 79958807898 scopus 로고    scopus 로고
    • Microsatellite instability, prognosis and drug sensitivity of stage II and III colorectal cancer: More complexity to the puzzle
    • Tejpar S, Saridaki Z, Delorenzi M et al (2011) Microsatellite instability, prognosis and drug sensitivity of stage II and III colorectal cancer: more complexity to the puzzle. J Natl Cancer Inst 103:841-844
    • (2011) J Natl Cancer Inst , vol.103 , pp. 841-844
    • Tejpar, S.1    Saridaki, Z.2    Delorenzi, M.3
  • 16
    • 1442308342 scopus 로고    scopus 로고
    • Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters
    • Bertucci F, Salas S, Eysteries S et al (2004) Gene expression profiling of colon cancer by DNA microarrays and correlation with histoclinical parameters. Oncogene 23:1377-1391
    • (2004) Oncogene , vol.23 , pp. 1377-1391
    • Bertucci, F.1    Salas, S.2    Eysteries, S.3
  • 17
    • 2442684455 scopus 로고    scopus 로고
    • Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer
    • Wang Y, Jatkoe T, Zhang Y et al (2004) Gene expression profiles and molecular markers to predict recurrence of Dukes' B colon cancer. J Clin Oncol 22:1564-1571
    • (2004) J Clin Oncol , vol.22 , pp. 1564-1571
    • Wang, Y.1    Jatkoe, T.2    Zhang, Y.3
  • 18
    • 20144387414 scopus 로고    scopus 로고
    • Right-and left-sided colorectal cancers display distinct expression profiles and the anatomical stratification allows a high accuracy prediction of lymph node metastasis
    • Komuro K, Tada M, Tamoto E et al (2005) Right-and left-sided colorectal cancers display distinct expression profiles and the anatomical stratification allows a high accuracy prediction of lymph node metastasis. J Surg Res 124:216-224
    • (2005) J Surg Res , vol.124 , pp. 216-224
    • Komuro, K.1    Tada, M.2    Tamoto, E.3
  • 19
    • 20644443287 scopus 로고    scopus 로고
    • Molecular staging for survival prediction of colorectal cancer patients
    • Eschrich S, Yang I, Bloom G et al (2005) Molecular staging for survival prediction of colorectal cancer patients. J Clin Oncol 23:3526-3535
    • (2005) J Clin Oncol , vol.23 , pp. 3526-3535
    • Eschrich, S.1    Yang, I.2    Bloom, G.3
  • 20
    • 22244441099 scopus 로고    scopus 로고
    • Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma
    • Croner RS, Peters A, Brueckl WM et al (2005) Microarray versus conventional prediction of lymph node metastasis in colorectal carcinoma. Cancer 104:395-404
    • (2005) Cancer , vol.104 , pp. 395-404
    • Croner, R.S.1    Peters, A.2    Brueckl, W.M.3
  • 21
    • 33750593381 scopus 로고    scopus 로고
    • Stage II colon cancer prognosis prediction by tumor gene expression profiling
    • Barrier A, Boelle PY, Roser F et al (2006) Stage II colon cancer prognosis prediction by tumor gene expression profiling. J Clin Oncol 24:4685-4691
    • (2006) J Clin Oncol , vol.24 , pp. 4685-4691
    • Barrier, A.1    Boelle, P.Y.2    Roser, F.3
  • 22
    • 34247392921 scopus 로고    scopus 로고
    • Prognosis of stage II colon cancer by non-neoplastic mucosa gene expression profiling
    • Barrier A, Roser F, Boelle PY et al (2007) Prognosis of stage II colon cancer by non-neoplastic mucosa gene expression profiling. Oncogene 26:2642-2648
    • (2007) Oncogene , vol.26 , pp. 2642-2648
    • Barrier, A.1    Roser, F.2    Boelle, P.Y.3
  • 23
    • 33846889777 scopus 로고    scopus 로고
    • Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer
    • Lin YH, Friederichs J, Black MA et al (2007) Multiple gene expression classifiers from different array platforms predict poor prognosis of colorectal cancer. Clin Cancer Res 13:498-507
    • (2007) Clin Cancer Res , vol.13 , pp. 498-507
    • Lin, Y.H.1    Friederichs, J.2    Black, M.A.3
  • 24
    • 34447310077 scopus 로고    scopus 로고
    • Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients
    • Vendrell E, Ribas M, Valls J et al (2007) Genomic and transcriptomic prognostic factors in R0 Dukes B and C colorectal cancer patients. Int J Oncol 30:1099-1107
    • (2007) Int J Oncol , vol.30 , pp. 1099-1107
    • Vendrell, E.1    Ribas, M.2    Valls, J.3
  • 25
    • 77957582401 scopus 로고    scopus 로고
    • Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin
    • O'Connell MJ, Lavery I, Yothers G et al (2010) Relationship between tumor gene expression and recurrence in four independent studies of patients with stage II/III colon cancer treated with surgery alone or surgery plus adjuvant fluorouracil plus leucovorin. J Clin Oncol 28:3937-3944
    • (2010) J Clin Oncol , vol.28 , pp. 3937-3944
    • O'Connell, M.J.1    Lavery, I.2    Yothers, G.3
  • 26
    • 83355166957 scopus 로고    scopus 로고
    • Validation study of a quantitative multigene reverse transcriptase- polymerase chain reaction assay for assessment of recurrence risk in patients with stage II colon cancer
    • Gray RG, Quirke P, Handley K et al (2011) Validation study of a quantitative multigene reverse transcriptase-polymerase chain reaction assay for assessment of recurrence risk in patients with stage II colon cancer. J Clin Oncol 29:4611-4619
    • (2011) J Clin Oncol , vol.29 , pp. 4611-4619
    • Gray, R.G.1    Quirke, P.2    Handley, K.3
  • 27
    • 77953292791 scopus 로고    scopus 로고
    • Development and validation of a robust prognostic and predictive signature for colorectal cancer (CRC) patients
    • Glas AM, Roepman P, Salazar R et al (2009) Development and validation of a robust prognostic and predictive signature for colorectal cancer (CRC) patients. ASCO Meet Abstr 27:4036
    • (2009) ASCO Meet Abstr , vol.27 , pp. 4036
    • Glas, A.M.1    Roepman, P.2    Salazar, R.3
  • 28
    • 79951506562 scopus 로고    scopus 로고
    • Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer
    • Salazar R, Roepman P, Capella G et al (2011) Gene expression signature to improve prognosis prediction of stage II and III colorectal cancer. J Clin Oncol 29:17-24
    • (2011) J Clin Oncol , vol.29 , pp. 17-24
    • Salazar, R.1    Roepman, P.2    Capella, G.3
  • 29
    • 80052762485 scopus 로고    scopus 로고
    • Independent validation of a prognostic genomic profile (ColoPrint) for stage II colon cancer (CC) patients
    • Rosenberg R, Maak M, Simon I et al Independent validation of a prognostic genomic profile (ColoPrint) for stage II colon cancer (CC) patients. ASCO Meeting Abstracts 29:358
    • ASCO Meeting Abstracts , vol.29 , pp. 358
    • Rosenberg, R.1    Maak, M.2    Simon, I.3
  • 30
    • 83355174077 scopus 로고    scopus 로고
    • Development and independent validation of a prognostic assay for stage ii colon cancer using formalin-fixed paraffin-embedded tissue
    • Kennedy RD, Bylesjo M, Kerr P et al (2011) Development and independent validation of a prognostic assay for stage ii colon cancer using formalin-fixed paraffin-embedded tissue. J Clin Oncol 29:4620-4626
    • (2011) J Clin Oncol , vol.29 , pp. 4620-4626
    • Kennedy, R.D.1    Bylesjo, M.2    Kerr, P.3
  • 31
    • 75749102647 scopus 로고    scopus 로고
    • Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: Results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
    • Roth AD, Tejpar S, Delorenzi M et al (2010) Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol 28:466-474
    • (2010) J Clin Oncol , vol.28 , pp. 466-474
    • Roth, A.D.1    Tejpar, S.2    Delorenzi, M.3
  • 32
    • 63849088630 scopus 로고    scopus 로고
    • Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer
    • Van Cutsem E, Kohne CH, Hitre E et al (2009) Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer. N Engl J Med 360:1408-1417
    • (2009) N Engl J Med , vol.360 , pp. 1408-1417
    • Van Cutsem, E.1    Kohne, C.H.2    Hitre, E.3
  • 33
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorecta cancer: Updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Kohne CH, Lang I et al (2011) Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorecta cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 29:2011-2019
    • (2011) J Clin Oncol , vol.29 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3
  • 34
    • 79956310674 scopus 로고    scopus 로고
    • Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: The OPUS study
    • Bokemeyer C, Bondarenko I, Hartmann JT et al (2011) Efficacy according to biomarker status of cetuximab plus FOLFOX-4 as first-line treatment for metastatic colorectal cancer: the OPUS study. Ann Oncol 22:1535-1546
    • (2011) Ann Oncol , vol.22 , pp. 1535-1546
    • Bokemeyer, C.1    Bondarenko, I.2    Hartmann, J.T.3
  • 35
    • 59949091448 scopus 로고    scopus 로고
    • Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer
    • Bokemeyer C, Bondarenko I, Makhson A et al (2009) Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer. J Clin Oncol 27:663-671
    • (2009) J Clin Oncol , vol.27 , pp. 663-671
    • Bokemeyer, C.1    Bondarenko, I.2    Makhson, A.3
  • 36
    • 73249130298 scopus 로고    scopus 로고
    • Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: The CELIM randomised phase 2 trial
    • Folprecht G, Gruenberger T, Bechstein WO et al (2010) Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial. Lancet Oncol 11:38-47
    • (2010) Lancet Oncol , vol.11 , pp. 38-47
    • Folprecht, G.1    Gruenberger, T.2    Bechstein, W.O.3
  • 37
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: Results of the randomised phase 3 MRC COIN trial
    • Maughan TS, Adams RA, Smith CG et al (2011) Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 377:2103-2114
    • (2011) Lancet , vol.377 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3
  • 38
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: A retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D et al (2010) Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 11:753-762
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3
  • 39
    • 78049341541 scopus 로고    scopus 로고
    • Association of KRAS p. G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab
    • De Roock W, Jonker DJ, Di Nicolantonio F et al (2010) Association of KRAS p. G13D mutation with outcome in patients with chemotherapy-refractory metastatic colorectal cancer treated with cetuximab. JAMA 304:1812-1820
    • (2010) JAMA , vol.304 , pp. 1812-1820
    • De Roock, W.1    Jonker, D.J.2    Di Nicolantonio, F.3
  • 40
    • 78149250536 scopus 로고    scopus 로고
    • Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: The PRIME study
    • Douillard JY, Siena S, Cassidy J et al (2010) Randomized, phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study. J Clin Oncol 28:4697-4705
    • (2010) J Clin Oncol , vol.28 , pp. 4697-4705
    • Douillard, J.Y.1    Siena, S.2    Cassidy, J.3
  • 41
    • 81055135355 scopus 로고    scopus 로고
    • Final results from PRIME: Randomized phase III study of panitumumab (pmab) with FOLFOX4 for first line metastatic colorectal cancer (mCRC)
    • Douillard J, Siena S, Cassidy J et al (2011) Final results from PRIME: Randomized phase III study of panitumumab (pmab) with FOLFOX4 for first line metastatic colorectal cancer (mCRC). ASCO Meet Abstr 29:3510
    • (2011) ASCO Meet Abstr , vol.29 , pp. 3510
    • Douillard, J.1    Siena, S.2    Cassidy, J.3
  • 42
    • 79952702311 scopus 로고    scopus 로고
    • KRAS mutation analysis: A comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients
    • Knijn N, Mekenkamp LJ, Klomp M et al (2011) KRAS mutation analysis: a comparison between primary tumours and matched liver metastases in 305 colorectal cancer patients. Br J Cancer 104:1020-1026
    • (2011) Br J Cancer , vol.104 , pp. 1020-1026
    • Knijn, N.1    Mekenkamp, L.J.2    Klomp, M.3
  • 43
    • 73349114941 scopus 로고    scopus 로고
    • KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: Results from the MRC FOCUS trial
    • Richman SD, Seymour MT, Chambers P et al (2009) KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J Clin Oncol 27:5931-5937
    • (2009) J Clin Oncol , vol.27 , pp. 5931-5937
    • Richman, S.D.1    Seymour, M.T.2    Chambers, P.3
  • 44
    • 34548238762 scopus 로고    scopus 로고
    • Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab
    • Khambata-Ford S, Garrett CR, Meropol NJ et al (2007) Expression of epiregulin and amphiregulin and K-ras mutation status predict disease control in metastatic colorectal cancer patients treated with cetuximab. J Clin Oncol 25:3230-3237
    • (2007) J Clin Oncol , vol.25 , pp. 3230-3237
    • Khambata-Ford, S.1    Garrett, C.R.2    Meropol, N.J.3
  • 45
    • 77949613568 scopus 로고    scopus 로고
    • EGF61A[G polymorphism as predictive marker of clinical outcome to first-line capecitabine and oxaliplatin in metastatic colorectal cancer
    • Spindler KL, Andersen RF, Jensen LH et al (2010) EGF61A[G polymorphism as predictive marker of clinical outcome to first-line capecitabine and oxaliplatin in metastatic colorectal cancer. Ann Oncol 21:535-539
    • (2010) Ann Oncol , vol.21 , pp. 535-539
    • Spindler, K.L.1    Andersen, R.F.2    Jensen, L.H.3
  • 46
    • 17844362179 scopus 로고    scopus 로고
    • Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: A cohort study
    • Moroni M, Veronese S, Benvenuti S et al (2005) Gene copy number for epidermal growth factor receptor (EGFR) and clinical response to antiEGFR treatment in colorectal cancer: a cohort study. Lancet Oncol 6:279-286
    • (2005) Lancet Oncol , vol.6 , pp. 279-286
    • Moroni, M.1    Veronese, S.2    Benvenuti, S.3
  • 47
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • Laurent-Puig P, Cayre A, Manceau G et al (2009) Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol 27:5924-5930
    • (2009) J Clin Oncol , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3
  • 48
    • 74249093155 scopus 로고    scopus 로고
    • PTEN status in advanced colorectal cancer treated with cetuximab
    • Negri FV, Bozzetti C, Lagrasta CA et al (2010) PTEN status in advanced colorectal cancer treated with cetuximab. Br J Cancer 102:162-164
    • (2010) Br J Cancer , vol.102 , pp. 162-164
    • Negri, F.V.1    Bozzetti, C.2    Lagrasta, C.A.3
  • 51
    • 80054052229 scopus 로고    scopus 로고
    • KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications
    • Balschun K, Haag J, Wenke AK et al (2011) KRAS, NRAS, PIK3CA exon 20, and BRAF genotypes in synchronous and metachronous primary colorectal cancers diagnostic and therapeutic implications. J Mol Diagn 13:436-445
    • (2011) J Mol Diagn , vol.13 , pp. 436-445
    • Balschun, K.1    Haag, J.2    Wenke, A.K.3
  • 52
    • 77954668198 scopus 로고    scopus 로고
    • Acquired KRAS mutations during progression of colorectal cancer metastases: Possible implications for therapy and prognosis
    • Bouchahda M, Karaboue A, Saffroy R et al (2010) Acquired KRAS mutations during progression of colorectal cancer metastases: possible implications for therapy and prognosis. Cancer Chemother Pharmacol 66:605-609
    • (2010) Cancer Chemother Pharmacol , vol.66 , pp. 605-609
    • Bouchahda, M.1    Karaboue, A.2    Saffroy, R.3
  • 53
    • 77952092674 scopus 로고    scopus 로고
    • KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: Biological and clinical implications
    • Italiano A, Hostein I, Soubeyran I et al (2010) KRAS and BRAF mutational status in primary colorectal tumors and related metastatic sites: biological and clinical implications. Ann Surg Oncol 17:1429-1434
    • (2010) Ann Surg Oncol , vol.17 , pp. 1429-1434
    • Italiano, A.1    Hostein, I.2    Soubeyran, I.3
  • 54
    • 78650236616 scopus 로고    scopus 로고
    • Concordant analysis of KRAS status in primary colon carcinoma and matched metastasis
    • Mariani P, Lae M, Degeorges A et al (2010) Concordant analysis of KRAS status in primary colon carcinoma and matched metastasis. Anticancer Res 30:4229-4235
    • (2010) Anticancer Res , vol.30 , pp. 4229-4235
    • Mariani, P.1    Lae, M.2    Degeorges, A.3
  • 55
    • 84859445133 scopus 로고    scopus 로고
    • Recomendaciones para la determinación de mutaciones de K-RAS en cáncer de colon
    • in press
    • Hernández-Losa J, Sanz J, Landolfi S et al (2012) Recomendaciones para la determinación de mutaciones de K-RAS en cáncer de colon. Rev Esp Patol (In press)
    • (2012) Rev Esp Patol
    • Hernández-Losa, J.1    Sanz, J.2    Landolfi, S.3
  • 56
    • 0035447953 scopus 로고    scopus 로고
    • Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: Implications for a standardized scoring system
    • Goldstein NS, Armin M (2001) Epidermal growth factor receptor immunohistochemical reactivity in patients with American Joint Committee on Cancer Stage IV colon adenocarcinoma: implications for a standardized scoring system. Cancer 92:1331-1346
    • (2001) Cancer , vol.92 , pp. 1331-1346
    • Goldstein, N.S.1    Armin, M.2
  • 57
    • 68849106333 scopus 로고    scopus 로고
    • Immunohistochemical expression of EGFR in colorectal carcinoma correlates with high but not low level gene amplification, as demonstrated by CISH
    • Hemmings C, Broomfield A, Bean E et al (2009) Immunohistochemical expression of EGFR in colorectal carcinoma correlates with high but not low level gene amplification, as demonstrated by CISH. Pathology 41:356-360
    • (2009) Pathology , vol.41 , pp. 356-360
    • Hemmings, C.1    Broomfield, A.2    Bean, E.3
  • 58
    • 74249092482 scopus 로고    scopus 로고
    • Prognostic effect of activated EGFR expression in human colon carcinomas: Comparison with EGFR status
    • Rego RL, Foster NR, Smyrk TC et al (2010) Prognostic effect of activated EGFR expression in human colon carcinomas: comparison with EGFR status. Br J Cancer 102:165-172
    • (2010) Br J Cancer , vol.102 , pp. 165-172
    • Rego, R.L.1    Foster, N.R.2    Smyrk, T.C.3
  • 60
    • 35348908314 scopus 로고    scopus 로고
    • PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients
    • Frattini M, Saletti P, Romagnani E et al (2007) PTEN loss of expression predicts cetuximab efficacy in metastatic colorectal cancer patients. Br J Cancer 97:1139-1145
    • (2007) Br J Cancer , vol.97 , pp. 1139-1145
    • Frattini, M.1    Saletti, P.2    Romagnani, E.3
  • 61
    • 40949135397 scopus 로고    scopus 로고
    • PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab
    • Jhawer M, Goel S, Wilson AJ et al (2008) PIK3CA mutation/PTEN expression status predicts response of colon cancer cells to the epidermal growth factor receptor inhibitor cetuximab. Cancer Res 68:1953-1961
    • (2008) Cancer Res , vol.68 , pp. 1953-1961
    • Jhawer, M.1    Goel, S.2    Wilson, A.J.3
  • 62
    • 59049089201 scopus 로고    scopus 로고
    • PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients
    • Perrone F, Lampis A, Orsenigo M et al (2009) PI3KCA/PTEN deregulation contributes to impaired responses to cetuximab in metastatic colorectal cancer patients. Ann Oncol 20:84-90
    • (2009) Ann Oncol , vol.20 , pp. 84-90
    • Perrone, F.1    Lampis, A.2    Orsenigo, M.3
  • 63
    • 73449138781 scopus 로고    scopus 로고
    • Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma
    • Jang KS, Song YS, Jang SH et al (2010) Clinicopathological significance of nuclear PTEN expression in colorectal adenocarcinoma. Histopathology 56:229-239
    • (2010) Histopathology , vol.56 , pp. 229-239
    • Jang, K.S.1    Song, Y.S.2    Jang, S.H.3
  • 64
    • 79251596989 scopus 로고    scopus 로고
    • Clinical significance of tumor suppressor PTEN in colorectal carcinoma
    • Hsu CP, Kao TY, Chang WL et al (2011) Clinical significance of tumor suppressor PTEN in colorectal carcinoma. Eur J Surg Oncol 37:140-147
    • (2011) Eur J Surg Oncol , vol.37 , pp. 140-147
    • Hsu, C.P.1    Kao, T.Y.2    Chang, W.L.3
  • 65
    • 79951958340 scopus 로고    scopus 로고
    • A robust immunohistochemical assay for detecting PTEN expression in human tumors
    • Sangale Z, Prass C, Carlson A et al (2011) A robust immunohistochemical assay for detecting PTEN expression in human tumors. Appl Immunohistochem Mol Morphol 19:173-183
    • (2011) Appl Immunohistochem Mol Morphol , vol.19 , pp. 173-183
    • Sangale, Z.1    Prass, C.2    Carlson, A.3
  • 66
    • 84860634396 scopus 로고    scopus 로고
    • PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wildtype metastatic colorectal cancer: A systematic review and meta-analysis
    • Mao C, Yang ZY, Hu XF et al (2011) PIK3CA exon 20 mutations as a potential biomarker for resistance to anti-EGFR monoclonal antibodies in KRAS wildtype metastatic colorectal cancer: a systematic review and meta-analysis. Ann Oncol 23(6):1518-1525
    • (2011) Ann Oncol , vol.23 , Issue.6 , pp. 1518-1525
    • Mao, C.1    Yang, Z.Y.2    Hu, X.F.3
  • 67
    • 39749127809 scopus 로고    scopus 로고
    • Current overview of the role of Akt in cancer studies via applied immunohistochemistry
    • Shtilbans V, Wu M, Burstein DE (2008) Current overview of the role of Akt in cancer studies via applied immunohistochemistry. Ann Diagn Pathol 12:153-160
    • (2008) Ann Diagn Pathol , vol.12 , pp. 153-160
    • Shtilbans, V.1    Wu, M.2    Burstein, D.E.3
  • 68
    • 70349634800 scopus 로고    scopus 로고
    • Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum
    • Washington MK, Berlin J, Branton P et al (2009) Protocol for the examination of specimens from patients with primary carcinoma of the colon and rectum. Arch Pathol Lab Med 133:1539-1551
    • (2009) Arch Pathol Lab Med , vol.133 , pp. 1539-1551
    • Washington, M.K.1    Berlin, J.2    Branton, P.3
  • 69
    • 77952115282 scopus 로고    scopus 로고
    • Colorectal Cancer OncoGuia: Surgical pathology report guidelines
    • Sanjuan X, Salas A, Lloreta J et al (2010) Colorectal Cancer OncoGuia: surgical pathology report guidelines. Clin Transl Oncol 12:211-213
    • (2010) Clin Transl Oncol , vol.12 , pp. 211-213
    • Sanjuan, X.1    Salas, A.2    Lloreta, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.