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Volumn 7, Issue 10, 2012, Pages

The Prognostic Value of BRAF Mutation in Colorectal Cancer and Melanoma: A Systematic Review and Meta-Analysis

Author keywords

[No Author keywords available]

Indexed keywords

B RAF KINASE;

EID: 84867298938     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0047054     Document Type: Article
Times cited : (185)

References (76)
  • 2
    • 0037805547 scopus 로고    scopus 로고
    • RAS oncogenes: the first 30 years
    • Malumbres M, Barbacid M, (2003) RAS oncogenes: the first 30 years. Nat Rev Cancer 3: 459-465.
    • (2003) Nat Rev Cancer , vol.3 , pp. 459-465
    • Malumbres, M.1    Barbacid, M.2
  • 4
    • 0036894746 scopus 로고    scopus 로고
    • BRAF and RAS mutations in human lung cancer and melanoma
    • Brose MS, Volpe P, Feldman M, Kumar M, Rishi I, et al. (2002) BRAF and RAS mutations in human lung cancer and melanoma. Cancer Res 62: 6997-7000.
    • (2002) Cancer Res , vol.62 , pp. 6997-7000
    • Brose, M.S.1    Volpe, P.2    Feldman, M.3    Kumar, M.4    Rishi, I.5
  • 6
    • 12144289677 scopus 로고    scopus 로고
    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF
    • Wan PT, Garnett MJ, Roe SM, Lee S, Niculescu-Duvaz D, et al. (2004) Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. Cell 116: 855-867.
    • (2004) Cell , vol.116 , pp. 855-867
    • Wan, P.T.1    Garnett, M.J.2    Roe, S.M.3    Lee, S.4    Niculescu-Duvaz, D.5
  • 8
    • 31544442670 scopus 로고    scopus 로고
    • Oncogenic BRAF is required for tumor growth and maintenance in melanoma models
    • Hoeflich KP, Gray DC, Eby MT, Tien JY, Wong L, et al. (2006) Oncogenic BRAF is required for tumor growth and maintenance in melanoma models. Cancer Res 66: 999-1006.
    • (2006) Cancer Res , vol.66 , pp. 999-1006
    • Hoeflich, K.P.1    Gray, D.C.2    Eby, M.T.3    Tien, J.Y.4    Wong, L.5
  • 9
    • 79956298812 scopus 로고    scopus 로고
    • Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status
    • Van Cutsem E, Kohne CH, Lang I, Folprecht G, Nowacki MP, et al. (2011) Cetuximab plus irinotecan, fluorouracil, and leucovorin as first-line treatment for metastatic colorectal cancer: updated analysis of overall survival according to tumor KRAS and BRAF mutation status. J Clin Oncol 29: 2011-2019.
    • (2011) J Clin Oncol , vol.29 , pp. 2011-2019
    • Van Cutsem, E.1    Kohne, C.H.2    Lang, I.3    Folprecht, G.4    Nowacki, M.P.5
  • 10
    • 79958064993 scopus 로고    scopus 로고
    • Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia
    • Stanojevic B, Dzodic R, Saenko V, Milovanovic Z, Pupic G, et al. (2011) Mutational and clinico-pathological analysis of papillary thyroid carcinoma in Serbia. Endocr J 58: 381-393.
    • (2011) Endocr J , vol.58 , pp. 381-393
    • Stanojevic, B.1    Dzodic, R.2    Saenko, V.3    Milovanovic, Z.4    Pupic, G.5
  • 11
    • 54249165951 scopus 로고    scopus 로고
    • Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases
    • Barault L, Charon-Barra C, Jooste V, de la Vega MF, Martin L, et al. (2008) Hypermethylator phenotype in sporadic colon cancer: study on a population-based series of 582 cases. Cancer Res 68: 8541-8546.
    • (2008) Cancer Res , vol.68 , pp. 8541-8546
    • Barault, L.1    Charon-Barra, C.2    Jooste, V.3    de la Vega, M.F.4    Martin, L.5
  • 12
    • 50349091081 scopus 로고    scopus 로고
    • Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer
    • French AJ, Sargent DJ, Burgart LJ, Foster NR, Kabat BF, et al. (2008) Prognostic significance of defective mismatch repair and BRAF V600E in patients with colon cancer. Clin Cancer Res 14: 3408-3415.
    • (2008) Clin Cancer Res , vol.14 , pp. 3408-3415
    • French, A.J.1    Sargent, D.J.2    Burgart, L.J.3    Foster, N.R.4    Kabat, B.F.5
  • 13
    • 77953688634 scopus 로고    scopus 로고
    • Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis
    • Zlobec I, Bihl MP, Schwarb H, Terracciano L, Lugli A, (2010) Clinicopathological and protein characterization of BRAF- and K-RAS-mutated colorectal cancer and implications for prognosis. Int J Cancer 127: 367-380.
    • (2010) Int J Cancer , vol.127 , pp. 367-380
    • Zlobec, I.1    Bihl, M.P.2    Schwarb, H.3    Terracciano, L.4    Lugli, A.5
  • 14
    • 24344490303 scopus 로고    scopus 로고
    • BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival
    • Akslen LA, Angelini S, Straume O, Bachmann IM, Molven A, et al. (2005) BRAF and NRAS mutations are frequent in nodular melanoma but are not associated with tumor cell proliferation or patient survival. J Invest Dermatol 125: 312-317.
    • (2005) J Invest Dermatol , vol.125 , pp. 312-317
    • Akslen, L.A.1    Angelini, S.2    Straume, O.3    Bachmann, I.M.4    Molven, A.5
  • 16
    • 0002384074 scopus 로고    scopus 로고
    • Meta-analysis
    • In: Rothman KJ, Greenland, S., editor, 2nd ed. Philadelphia: Lippincott-Raven
    • Greenland S (1998) Meta-analysis. In: Rothman KJ, Greenland, S., editor. Modern epidemiology. 2nd ed. Philadelphia: Lippincott-Raven. 643-673.
    • (1998) Modern epidemiology , pp. 643-673
    • Greenland, S.1
  • 17
    • 0032583387 scopus 로고    scopus 로고
    • Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints
    • Parmar MK, Torri V, Stewart L, (1998) Extracting summary statistics to perform meta-analyses of the published literature for survival endpoints. Stat Med 17: 2815-2834.
    • (1998) Stat Med , vol.17 , pp. 2815-2834
    • Parmar, M.K.1    Torri, V.2    Stewart, L.3
  • 18
    • 83255191650 scopus 로고    scopus 로고
    • Prevalence of BRAF V600E mutation in Chinese melanoma patients: large scale analysis of BRAF and NRAS mutations in a 432-case cohort
    • Si L, Kong Y, Xu X, Flaherty KT, Sheng X, et al. (2012) Prevalence of BRAF V600E mutation in Chinese melanoma patients: large scale analysis of BRAF and NRAS mutations in a 432-case cohort. Eur J Cancer 48: 94-100.
    • (2012) Eur J Cancer , vol.48 , pp. 94-100
    • Si, L.1    Kong, Y.2    Xu, X.3    Flaherty, K.T.4    Sheng, X.5
  • 19
    • 78149407730 scopus 로고    scopus 로고
    • Impact of pathognomonic genetic alterations on the prognosis of papillary thyroid carcinoma. ESES vienna presentation
    • Musholt TJ, Schonefeld S, Schwarz CH, Watzka FM, Musholt PB, et al. (2010) Impact of pathognomonic genetic alterations on the prognosis of papillary thyroid carcinoma. ESES vienna presentation. Langenbecks Arch Surg 395: 877-883.
    • (2010) Langenbecks Arch Surg , vol.395 , pp. 877-883
    • Musholt, T.J.1    Schonefeld, S.2    Schwarz, C.H.3    Watzka, F.M.4    Musholt, P.B.5
  • 20
    • 53749086690 scopus 로고    scopus 로고
    • BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study
    • Elisei R, Ugolini C, Viola D, Lupi C, Biagini A, et al. (2008) BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study. J Clin Endocrinol Metab 93: 3943-3949.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 3943-3949
    • Elisei, R.1    Ugolini, C.2    Viola, D.3    Lupi, C.4    Biagini, A.5
  • 21
    • 70449535638 scopus 로고    scopus 로고
    • Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study
    • Board RE, Ellison G, Orr MC, Kemsley KR, McWalter G, et al. (2009) Detection of BRAF mutations in the tumour and serum of patients enrolled in the AZD6244 (ARRY-142886) advanced melanoma phase II study. Br J Cancer 101: 1724-1730.
    • (2009) Br J Cancer , vol.101 , pp. 1724-1730
    • Board, R.E.1    Ellison, G.2    Orr, M.C.3    Kemsley, K.R.4    McWalter, G.5
  • 22
    • 73349121946 scopus 로고    scopus 로고
    • Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain Metastases
    • Amaravadi RK, Schuchter LM, McDermott DF, Kramer A, Giles L, et al. (2009) Phase II Trial of Temozolomide and Sorafenib in Advanced Melanoma Patients with or without Brain Metastases. Clin Cancer Res 15: 7711-7718.
    • (2009) Clin Cancer Res , vol.15 , pp. 7711-7718
    • Amaravadi, R.K.1    Schuchter, L.M.2    McDermott, D.F.3    Kramer, A.4    Giles, L.5
  • 24
    • 78649952872 scopus 로고    scopus 로고
    • BRAF(V600E) mutation is associated with an increased risk of nodal recurrence requiring reoperative surgery in patients with papillary thyroid cancer
    • discussion 1145-1136
    • O'Neill CJ, Bullock M, Chou A, Sidhu SB, Delbridge LW, et al. (2010) BRAF(V600E) mutation is associated with an increased risk of nodal recurrence requiring reoperative surgery in patients with papillary thyroid cancer. Surgery 148: 1139-1145; discussion 1145-1136.
    • (2010) Surgery , vol.148 , pp. 1139-1145
    • O'Neill, C.J.1    Bullock, M.2    Chou, A.3    Sidhu, S.B.4    Delbridge, L.W.5
  • 25
    • 62549101651 scopus 로고    scopus 로고
    • BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease-free survival of patients
    • Ito Y, Yoshida H, Maruo R, Morita S, Takano T, et al. (2009) BRAF mutation in papillary thyroid carcinoma in a Japanese population: its lack of correlation with high-risk clinicopathological features and disease-free survival of patients. Endocr J 56: 89-97.
    • (2009) Endocr J , vol.56 , pp. 89-97
    • Ito, Y.1    Yoshida, H.2    Maruo, R.3    Morita, S.4    Takano, T.5
  • 26
    • 39049169179 scopus 로고    scopus 로고
    • Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population
    • Abubaker J, Jehan Z, Bavi P, Sultana M, Al-Harbi S, et al. (2008) Clinicopathological analysis of papillary thyroid cancer with PIK3CA alterations in a Middle Eastern population. J Clin Endocrinol Metab 93: 611-618.
    • (2008) J Clin Endocrinol Metab , vol.93 , pp. 611-618
    • Abubaker, J.1    Jehan, Z.2    Bavi, P.3    Sultana, M.4    Al-Harbi, S.5
  • 27
    • 40749104889 scopus 로고    scopus 로고
    • BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma
    • Costa AM, Herrero A, Fresno MF, Heymann J, Alvarez JA, et al. (2008) BRAF mutation associated with other genetic events identifies a subset of aggressive papillary thyroid carcinoma. Clin Endocrinol (Oxf) 68: 618-634.
    • (2008) Clin Endocrinol (Oxf) , vol.68 , pp. 618-634
    • Costa, A.M.1    Herrero, A.2    Fresno, M.F.3    Heymann, J.4    Alvarez, J.A.5
  • 28
    • 84856684811 scopus 로고    scopus 로고
    • Poorer Prognosis and Higher Prevalence of BRAF (V600E) Mutation in Synchronous Bilateral Papillary Thyroid Carcinoma
    • Wang W, Zhao W, Wang H, Teng X, Chen X, et al. (2012) Poorer Prognosis and Higher Prevalence of BRAF (V600E) Mutation in Synchronous Bilateral Papillary Thyroid Carcinoma. Ann Surg Oncol 19: 31-36.
    • (2012) Ann Surg Oncol , vol.19 , pp. 31-36
    • Wang, W.1    Zhao, W.2    Wang, H.3    Teng, X.4    Chen, X.5
  • 29
    • 16844362816 scopus 로고    scopus 로고
    • Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors
    • Sharma A, Trivedi NR, Zimmerman MA, Tuveson DA, Smith CD, et al. (2005) Mutant V599EB-Raf regulates growth and vascular development of malignant melanoma tumors. Cancer Res 65: 2412-2421.
    • (2005) Cancer Res , vol.65 , pp. 2412-2421
    • Sharma, A.1    Trivedi, N.R.2    Zimmerman, M.A.3    Tuveson, D.A.4    Smith, C.D.5
  • 30
    • 67649909568 scopus 로고    scopus 로고
    • Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma
    • Hauschild A, Agarwala SS, Trefzer U, Hogg D, Robert C, et al. (2009) Results of a phase III, randomized, placebo-controlled study of sorafenib in combination with carboplatin and paclitaxel as second-line treatment in patients with unresectable stage III or stage IV melanoma. J Clin Oncol 27: 2823-2830.
    • (2009) J Clin Oncol , vol.27 , pp. 2823-2830
    • Hauschild, A.1    Agarwala, S.S.2    Trefzer, U.3    Hogg, D.4    Robert, C.5
  • 31
    • 77956513286 scopus 로고    scopus 로고
    • Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma
    • Bollag G, Hirth P, Tsai J, Zhang J, Ibrahim PN, et al. (2010) Clinical efficacy of a RAF inhibitor needs broad target blockade in BRAF-mutant melanoma. Nature 467: 596-599.
    • (2010) Nature , vol.467 , pp. 596-599
    • Bollag, G.1    Hirth, P.2    Tsai, J.3    Zhang, J.4    Ibrahim, P.N.5
  • 32
    • 84864285704 scopus 로고    scopus 로고
    • Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial
    • Hauschild A, Grob JJ, Demidov LV, Jouary T, Gutzmer R, et al. (2012) Dabrafenib in BRAF-mutated metastatic melanoma: a multicentre, open-label, phase 3 randomised controlled trial. Lancet 380: 358-365.
    • (2012) Lancet , vol.380 , pp. 358-365
    • Hauschild, A.1    Grob, J.J.2    Demidov, L.V.3    Jouary, T.4    Gutzmer, R.5
  • 33
    • 84861745961 scopus 로고    scopus 로고
    • BRIM-1, -2 and -3 trials: improved survival with vemurafenib in metastatic melanoma patients with a BRAF(V600E) mutation
    • Young K, Minchom A, Larkin J, (2012) BRIM-1,-2 and-3 trials: improved survival with vemurafenib in metastatic melanoma patients with a BRAF(V600E) mutation. Future Oncol 8: 499-507.
    • (2012) Future Oncol , vol.8 , pp. 499-507
    • Young, K.1    Minchom, A.2    Larkin, J.3
  • 34
    • 73349114941 scopus 로고    scopus 로고
    • KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial
    • Richman SD, Seymour MT, Chambers P, Elliott F, Daly CL, et al. (2009) KRAS and BRAF mutations in advanced colorectal cancer are associated with poor prognosis but do not preclude benefit from oxaliplatin or irinotecan: results from the MRC FOCUS trial. J Clin Oncol 27: 5931-5937.
    • (2009) J Clin Oncol , vol.27 , pp. 5931-5937
    • Richman, S.D.1    Seymour, M.T.2    Chambers, P.3    Elliott, F.4    Daly, C.L.5
  • 35
    • 79959795786 scopus 로고    scopus 로고
    • Improved survival with vemurafenib in melanoma with BRAF V600E mutation
    • Chapman PB, Hauschild A, Robert C, Haanen JB, Ascierto P, et al. (2011) Improved survival with vemurafenib in melanoma with BRAF V600E mutation. N Engl J Med 364: 2507-2516.
    • (2011) N Engl J Med , vol.364 , pp. 2507-2516
    • Chapman, P.B.1    Hauschild, A.2    Robert, C.3    Haanen, J.B.4    Ascierto, P.5
  • 36
    • 77953276524 scopus 로고    scopus 로고
    • Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy
    • Paraiso KH, Fedorenko IV, Cantini LP, Munko AC, Hall M, et al. (2010) Recovery of phospho-ERK activity allows melanoma cells to escape from BRAF inhibitor therapy. Br J Cancer 102: 1724-1730.
    • (2010) Br J Cancer , vol.102 , pp. 1724-1730
    • Paraiso, K.H.1    Fedorenko, I.V.2    Cantini, L.P.3    Munko, A.C.4    Hall, M.5
  • 37
    • 78650309875 scopus 로고    scopus 로고
    • COT drives resistance to RAF inhibition through MAP kinase pathway reactivation
    • Johannessen CM, Boehm JS, Kim SY, Thomas SR, Wardwell L, et al. (2010) COT drives resistance to RAF inhibition through MAP kinase pathway reactivation. Nature 468: 968-972.
    • (2010) Nature , vol.468 , pp. 968-972
    • Johannessen, C.M.1    Boehm, J.S.2    Kim, S.Y.3    Thomas, S.R.4    Wardwell, L.5
  • 38
    • 83455254767 scopus 로고    scopus 로고
    • RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E)
    • Poulikakos PI, Persaud Y, Janakiraman M, Kong X, Ng C, et al. (2011) RAF inhibitor resistance is mediated by dimerization of aberrantly spliced BRAF(V600E). Nature 480: 387-390.
    • (2011) Nature , vol.480 , pp. 387-390
    • Poulikakos, P.I.1    Persaud, Y.2    Janakiraman, M.3    Kong, X.4    Ng, C.5
  • 39
    • 80051625929 scopus 로고    scopus 로고
    • Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling
    • Wagle N, Emery C, Berger MF, Davis MJ, Sawyer A, et al. (2011) Dissecting therapeutic resistance to RAF inhibition in melanoma by tumor genomic profiling. J Clin Oncol 29: 3085-3096.
    • (2011) J Clin Oncol , vol.29 , pp. 3085-3096
    • Wagle, N.1    Emery, C.2    Berger, M.F.3    Davis, M.J.4    Sawyer, A.5
  • 40
    • 78649723255 scopus 로고    scopus 로고
    • PLX4032 in metastatic colon cancer patients with mutant BRAF tumors
    • abstract 3534
    • Kopetz S, Desai J, Chan E, Hecht JR, O'Dwyer PJ, et al. (2010) PLX4032 in metastatic colon cancer patients with mutant BRAF tumors. J Clin Oncol 28: abstract 3534.
    • (2010) J Clin Oncol , vol.28
    • Kopetz, S.1    Desai, J.2    Chan, E.3    Hecht, J.R.4    O'Dwyer, P.J.5
  • 41
    • 75749102647 scopus 로고    scopus 로고
    • Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial
    • Roth AD, Tejpar S, Delorenzi M, Yan P, Fiocca R, et al. (2010) Prognostic role of KRAS and BRAF in stage II and III resected colon cancer: results of the translational study on the PETACC-3, EORTC 40993, SAKK 60-00 trial. J Clin Oncol 28: 466-474.
    • (2010) J Clin Oncol , vol.28 , pp. 466-474
    • Roth, A.D.1    Tejpar, S.2    Delorenzi, M.3    Yan, P.4    Fiocca, R.5
  • 42
    • 84863230465 scopus 로고    scopus 로고
    • Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR
    • Prahallad A, Sun C, Huang S, Di Nicolantonio F, Salazar R, et al. (2012) Unresponsiveness of colon cancer to BRAF(V600E) inhibition through feedback activation of EGFR. Nature 483: 100-103.
    • (2012) Nature , vol.483 , pp. 100-103
    • Prahallad, A.1    Sun, C.2    Huang, S.3    Di Nicolantonio, F.4    Salazar, R.5
  • 43
    • 77149176231 scopus 로고    scopus 로고
    • KRAS mutation and microsatellite instability: two genetic markers of early tumor development that influence the prognosis of colorectal cancer
    • Nash GM, Gimbel M, Cohen AM, Zeng ZS, Ndubuisi MI, et al. (2010) KRAS mutation and microsatellite instability: two genetic markers of early tumor development that influence the prognosis of colorectal cancer. Ann Surg Oncol 17: 416-424.
    • (2010) Ann Surg Oncol , vol.17 , pp. 416-424
    • Nash, G.M.1    Gimbel, M.2    Cohen, A.M.3    Zeng, Z.S.4    Ndubuisi, M.I.5
  • 44
    • 77950790383 scopus 로고    scopus 로고
    • Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers
    • Rampazzo E, Bertorelle R, Serra L, Terrin L, Candiotto C, et al. (2010) Relationship between telomere shortening, genetic instability, and site of tumour origin in colorectal cancers. Br J Cancer 102: 1300-1305.
    • (2010) Br J Cancer , vol.102 , pp. 1300-1305
    • Rampazzo, E.1    Bertorelle, R.2    Serra, L.3    Terrin, L.4    Candiotto, C.5
  • 45
    • 78649473910 scopus 로고    scopus 로고
    • The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients
    • Farina-Sarasqueta A, van Lijnschoten G, Moerland E, Creemers GJ, Lemmens VE, et al. (2010) The BRAF V600E mutation is an independent prognostic factor for survival in stage II and stage III colon cancer patients. Ann Oncol 21: 2396-2402.
    • (2010) Ann Oncol , vol.21 , pp. 2396-2402
    • Farina-Sarasqueta, A.1    van Lijnschoten, G.2    Moerland, E.3    Creemers, G.J.4    Lemmens, V.E.5
  • 46
    • 79251595305 scopus 로고    scopus 로고
    • Colon carcinoma-classification into right and left sided cancer or according to colonic subsite?-Analysis of 29,568 patients
    • Benedix F, Schmidt U, Mroczkowski P, Gastinger I, Lippert H, et al. (2011) Colon carcinoma-classification into right and left sided cancer or according to colonic subsite?-Analysis of 29,568 patients. Eur J Surg Oncol 37: 134-139.
    • (2011) Eur J Surg Oncol , vol.37 , pp. 134-139
    • Benedix, F.1    Schmidt, U.2    Mroczkowski, P.3    Gastinger, I.4    Lippert, H.5
  • 47
    • 84867628245 scopus 로고    scopus 로고
    • Influence of anatomical subsite on the incidence of microsatellite instability, and KRAS and BRAF mutation rates in patients with colon carcinoma
    • (in press)
    • Benedix F, Meyer F, Kube R, Kropf S, Kuester D, et al. (2012) Influence of anatomical subsite on the incidence of microsatellite instability, and KRAS and BRAF mutation rates in patients with colon carcinoma. Pathol Res Pract (in press).
    • (2012) Pathol Res Pract
    • Benedix, F.1    Meyer, F.2    Kube, R.3    Kropf, S.4    Kuester, D.5
  • 48
    • 68749119351 scopus 로고    scopus 로고
    • KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer
    • Loupakis F, Ruzzo A, Cremolini C, Vincenzi B, Salvatore L, et al. (2009) KRAS codon 61, 146 and BRAF mutations predict resistance to cetuximab plus irinotecan in KRAS codon 12 and 13 wild-type metastatic colorectal cancer. Br J Cancer 101: 715-721.
    • (2009) Br J Cancer , vol.101 , pp. 715-721
    • Loupakis, F.1    Ruzzo, A.2    Cremolini, C.3    Vincenzi, B.4    Salvatore, L.5
  • 49
    • 79960149283 scopus 로고    scopus 로고
    • Impact of KRAS and BRAF Gene Mutation Status on Outcomes From the Phase III AGITG MAX Trial of Capecitabine Alone or in Combination With Bevacizumab and Mitomycin in Advanced Colorectal Cancer
    • Price TJ, Hardingham JE, Lee CK, Weickhardt A, Townsend AR, et al. (2011) Impact of KRAS and BRAF Gene Mutation Status on Outcomes From the Phase III AGITG MAX Trial of Capecitabine Alone or in Combination With Bevacizumab and Mitomycin in Advanced Colorectal Cancer. J Clin Oncol 29: 2675-2682.
    • (2011) J Clin Oncol , vol.29 , pp. 2675-2682
    • Price, T.J.1    Hardingham, J.E.2    Lee, C.K.3    Weickhardt, A.4    Townsend, A.R.5
  • 51
    • 2942607408 scopus 로고    scopus 로고
    • Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis
    • Houben R, Becker JC, Kappel A, Terheyden P, Brocker EB, et al. (2004) Constitutive activation of the Ras-Raf signaling pathway in metastatic melanoma is associated with poor prognosis. J Carcinog 3: 6.
    • (2004) J Carcinog , vol.3 , pp. 6
    • Houben, R.1    Becker, J.C.2    Kappel, A.3    Terheyden, P.4    Brocker, E.B.5
  • 52
    • 1442323605 scopus 로고    scopus 로고
    • BRAF mutations are common somatic events in melanocytic nevi
    • Kumar R, Angelini S, Snellman E, Hemminki K, (2004) BRAF mutations are common somatic events in melanocytic nevi. J Invest Dermatol 122: 342-348.
    • (2004) J Invest Dermatol , vol.122 , pp. 342-348
    • Kumar, R.1    Angelini, S.2    Snellman, E.3    Hemminki, K.4
  • 53
    • 78651457445 scopus 로고    scopus 로고
    • Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A
    • Arozarena I, Sanchez-Laorden B, Packer L, Hidalgo-Carcedo C, Hayward R, et al. (2011) Oncogenic BRAF induces melanoma cell invasion by downregulating the cGMP-specific phosphodiesterase PDE5A. Cancer Cell 19: 45-57.
    • (2011) Cancer Cell , vol.19 , pp. 45-57
    • Arozarena, I.1    Sanchez-Laorden, B.2    Packer, L.3    Hidalgo-Carcedo, C.4    Hayward, R.5
  • 55
    • 77955277111 scopus 로고    scopus 로고
    • Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis
    • De Roock W, Claes B, Bernasconi D, De Schutter J, Biesmans B, et al. (2010) Effects of KRAS, BRAF, NRAS, and PIK3CA mutations on the efficacy of cetuximab plus chemotherapy in chemotherapy-refractory metastatic colorectal cancer: a retrospective consortium analysis. Lancet Oncol 11: 753-762.
    • (2010) Lancet Oncol , vol.11 , pp. 753-762
    • De Roock, W.1    Claes, B.2    Bernasconi, D.3    De Schutter, J.4    Biesmans, B.5
  • 56
    • 41649093940 scopus 로고    scopus 로고
    • The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile
    • Ferracin M, Gafa R, Miotto E, Veronese A, Pultrone C, et al. (2008) The methylator phenotype in microsatellite stable colorectal cancers is characterized by a distinct gene expression profile. J Pathol 214: 594-602.
    • (2008) J Pathol , vol.214 , pp. 594-602
    • Ferracin, M.1    Gafa, R.2    Miotto, E.3    Veronese, A.4    Pultrone, C.5
  • 57
    • 73349094741 scopus 로고    scopus 로고
    • Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer
    • Laurent-Puig P, Cayre A, Manceau G, Buc E, Bachet JB, et al. (2009) Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer. J Clin Oncol 27: 5924-5930.
    • (2009) J Clin Oncol , vol.27 , pp. 5924-5930
    • Laurent-Puig, P.1    Cayre, A.2    Manceau, G.3    Buc, E.4    Bachet, J.B.5
  • 58
    • 77956610320 scopus 로고    scopus 로고
    • Gene mutations in epidermal growth factor receptor signaling network and their association with survival in Chinese patients with metastatic colorectal cancers
    • Liao W, Liao Y, Zhou JX, Xie J, Chen J, et al. (2010) Gene mutations in epidermal growth factor receptor signaling network and their association with survival in Chinese patients with metastatic colorectal cancers. Anat Rec (Hoboken) 293: 1506-1511.
    • (2010) Anat Rec (Hoboken) , vol.293 , pp. 1506-1511
    • Liao, W.1    Liao, Y.2    Zhou, J.X.3    Xie, J.4    Chen, J.5
  • 59
    • 80755132294 scopus 로고    scopus 로고
    • Mutations in BRAF correlate with poor survival of colorectal cancers in Chinese population
    • Liou JM, Wu MS, Shun CT, Chiu HM, Chen MJ, et al. (2011) Mutations in BRAF correlate with poor survival of colorectal cancers in Chinese population. Int J Colorectal Dis 26: 1387-1395.
    • (2011) Int J Colorectal Dis , vol.26 , pp. 1387-1395
    • Liou, J.M.1    Wu, M.S.2    Shun, C.T.3    Chiu, H.M.4    Chen, M.J.5
  • 60
    • 34250201891 scopus 로고    scopus 로고
    • Role of the BRAF mutations in the microsatellite instability genetic pathway in sporadic colorectal cancer
    • Maestro ML, Vidaurreta M, Sanz-Casla MT, Rafael S, Veganzones S, et al. (2007) Role of the BRAF mutations in the microsatellite instability genetic pathway in sporadic colorectal cancer. Ann Surg Oncol 14: 1229-1236.
    • (2007) Ann Surg Oncol , vol.14 , pp. 1229-1236
    • Maestro, M.L.1    Vidaurreta, M.2    Sanz-Casla, M.T.3    Rafael, S.4    Veganzones, S.5
  • 61
    • 79959337678 scopus 로고    scopus 로고
    • Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial
    • Maughan TS, Adams RA, Smith CG, Meade AM, Seymour MT, et al. (2011) Addition of cetuximab to oxaliplatin-based first-line combination chemotherapy for treatment of advanced colorectal cancer: results of the randomised phase 3 MRC COIN trial. Lancet 377: 2103-2114.
    • (2011) Lancet , vol.377 , pp. 2103-2114
    • Maughan, T.S.1    Adams, R.A.2    Smith, C.G.3    Meade, A.M.4    Seymour, M.T.5
  • 62
    • 58249089525 scopus 로고    scopus 로고
    • CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer
    • Ogino S, Nosho K, Kirkner GJ, Kawasaki T, Meyerhardt JA, et al. (2009) CpG island methylator phenotype, microsatellite instability, BRAF mutation and clinical outcome in colon cancer. Gut 58: 90-96.
    • (2009) Gut , vol.58 , pp. 90-96
    • Ogino, S.1    Nosho, K.2    Kirkner, G.J.3    Kawasaki, T.4    Meyerhardt, J.A.5
  • 63
    • 80054760645 scopus 로고    scopus 로고
    • Analysis of KRAS, BRAF, PTEN, IGF1R, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer
    • Park JH, Han SW, Oh DY, Im SA, Jeong SY, et al. (2011) Analysis of KRAS, BRAF, PTEN, IGF1R, EGFR intron 1 CA status in both primary tumors and paired metastases in determining benefit from cetuximab therapy in colon cancer. Cancer Chemother Pharmacol 68: 1045-1055.
    • (2011) Cancer Chemother Pharmacol , vol.68 , pp. 1045-1055
    • Park, J.H.1    Han, S.W.2    Oh, D.Y.3    Im, S.A.4    Jeong, S.Y.5
  • 64
    • 22244472992 scopus 로고    scopus 로고
    • Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers
    • Samowitz WS, Sweeney C, Herrick J, Albertsen H, Levin TR, et al. (2005) Poor survival associated with the BRAF V600E mutation in microsatellite-stable colon cancers. Cancer Res 65: 6063-6069.
    • (2005) Cancer Res , vol.65 , pp. 6063-6069
    • Samowitz, W.S.1    Sweeney, C.2    Herrick, J.3    Albertsen, H.4    Levin, T.R.5
  • 65
    • 79251633445 scopus 로고    scopus 로고
    • Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in >/ = 2 line cetuximab-based therapy of colorectal cancer patients
    • Saridaki Z, Tzardi M, Papadaki C, Sfakianaki M, Pega F, et al. (2011) Impact of KRAS, BRAF, PIK3CA mutations, PTEN, AREG, EREG expression and skin rash in >/ = 2 line cetuximab-based therapy of colorectal cancer patients. PLoS One 6: e15980.
    • (2011) PLoS One , vol.6
    • Saridaki, Z.1    Tzardi, M.2    Papadaki, C.3    Sfakianaki, M.4    Pega, F.5
  • 67
    • 68149165771 scopus 로고    scopus 로고
    • Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer
    • Souglakos J, Philips J, Wang R, Marwah S, Silver M, et al. (2009) Prognostic and predictive value of common mutations for treatment response and survival in patients with metastatic colorectal cancer. Br J Cancer 101: 465-472.
    • (2009) Br J Cancer , vol.101 , pp. 465-472
    • Souglakos, J.1    Philips, J.2    Wang, R.3    Marwah, S.4    Silver, M.5
  • 68
    • 79952463028 scopus 로고    scopus 로고
    • Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation
    • Tie J, Gibbs P, Lipton L, Christie M, Jorissen RN, et al. (2011) Optimizing targeted therapeutic development: analysis of a colorectal cancer patient population with the BRAF(V600E) mutation. Int J Cancer 128: 2075-2084.
    • (2011) Int J Cancer , vol.128 , pp. 2075-2084
    • Tie, J.1    Gibbs, P.2    Lipton, L.3    Christie, M.4    Jorissen, R.N.5
  • 69
    • 77954215850 scopus 로고    scopus 로고
    • Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab
    • Tol J, Dijkstra JR, Klomp M, Teerenstra S, Dommerholt M, et al. (2010) Markers for EGFR pathway activation as predictor of outcome in metastatic colorectal cancer patients treated with or without cetuximab. Eur J Cancer 46: 1997-2009.
    • (2010) Eur J Cancer , vol.46 , pp. 1997-2009
    • Tol, J.1    Dijkstra, J.R.2    Klomp, M.3    Teerenstra, S.4    Dommerholt, M.5
  • 70
    • 84878364164 scopus 로고    scopus 로고
    • Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer
    • (in press)
    • Tran B, Kopetz S, Tie J, Gibbs P, Jiang ZQ, et al. (2012) Impact of BRAF mutation and microsatellite instability on the pattern of metastatic spread and prognosis in metastatic colorectal cancer. Cancer (in press).
    • (2012) Cancer
    • Tran, B.1    Kopetz, S.2    Tie, J.3    Gibbs, P.4    Jiang, Z.Q.5
  • 71
    • 79952282994 scopus 로고    scopus 로고
    • BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer
    • Yokota T, Ura T, Shibata N, Takahari D, Shitara K, et al. (2011) BRAF mutation is a powerful prognostic factor in advanced and recurrent colorectal cancer. Br J Cancer 104: 856-862.
    • (2011) Br J Cancer , vol.104 , pp. 856-862
    • Yokota, T.1    Ura, T.2    Shibata, N.3    Takahari, D.4    Shitara, K.5
  • 72
    • 0041333110 scopus 로고    scopus 로고
    • BRAF mutations in metastatic melanoma: a possible association with clinical outcome
    • Kumar R, Angelini S, Czene K, Sauroja I, Hahka-Kemppinen M, et al. (2003) BRAF mutations in metastatic melanoma: a possible association with clinical outcome. Clin Cancer Res 9: 3362-3368.
    • (2003) Clin Cancer Res , vol.9 , pp. 3362-3368
    • Kumar, R.1    Angelini, S.2    Czene, K.3    Sauroja, I.4    Hahka-Kemppinen, M.5
  • 73
    • 84978034236 scopus 로고    scopus 로고
    • Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma
    • Long GV, Menzies AM, Nagrial AM, Haydu LE, Hamilton AL, et al. (2011) Prognostic and clinicopathologic associations of oncogenic BRAF in metastatic melanoma. J Clin Oncol 29: 1239-1246.
    • (2011) J Clin Oncol , vol.29 , pp. 1239-1246
    • Long, G.V.1    Menzies, A.M.2    Nagrial, A.M.3    Haydu, L.E.4    Hamilton, A.L.5
  • 74
    • 84856363696 scopus 로고    scopus 로고
    • First-line temozolomide combined with bevacizumab in metastatic melanoma: a multicentre phase II trial (SAKK 50/07)
    • von Moos R, Seifert B, Simcock M, Goldinger SM, Gillessen S, et al. (2012) First-line temozolomide combined with bevacizumab in metastatic melanoma: a multicentre phase II trial (SAKK 50/07). Ann Oncol 23: 531-536.
    • (2012) Ann Oncol , vol.23 , pp. 531-536
    • von Moos, R.1    Seifert, B.2    Simcock, M.3    Goldinger, S.M.4    Gillessen, S.5
  • 75
    • 61449109161 scopus 로고    scopus 로고
    • High prevalence of BRAF mutation in a Brazilian cohort of patients with sporadic papillary thyroid carcinomas: correlation with more aggressive phenotype and decreased expression of iodide-metabolizing genes
    • Oler G, Cerutti JM, (2009) High prevalence of BRAF mutation in a Brazilian cohort of patients with sporadic papillary thyroid carcinomas: correlation with more aggressive phenotype and decreased expression of iodide-metabolizing genes. Cancer 115: 972-980.
    • (2009) Cancer , vol.115 , pp. 972-980
    • Oler, G.1    Cerutti, J.M.2
  • 76
    • 28744442816 scopus 로고    scopus 로고
    • BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer
    • Xing M, Westra WH, Tufano RP, Cohen Y, Rosenbaum E, et al. (2005) BRAF mutation predicts a poorer clinical prognosis for papillary thyroid cancer. J Clin Endocrinol Metab 90: 6373-6379.
    • (2005) J Clin Endocrinol Metab , vol.90 , pp. 6373-6379
    • Xing, M.1    Westra, W.H.2    Tufano, R.P.3    Cohen, Y.4    Rosenbaum, E.5


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