Identification of existing and emerging chemical residue contamination concerns in milk

Irish Journal of Agricultural and Food Research

Volumn 52, Issue 2 SPEC. ISSUE 2, 2013, Pages 173-183

  Danaher, Martin ^a   Jordan, Kieran ^a  

^a TEAGASC FOOD RESEARCH CENTRE   (Ireland)

Author keywords

Banned substances; Biocides; Economic adulterants; Milk and dairy products; Persistent organic pollutants; Phthalates; Quaternary ammonium compounds; Veterinary drugs

Indexed keywords

EID: 84890905193     PISSN: 07916833     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (62)

1. Abernethy, G. and Higgs, K. 2013. Rapid detection of economic adulterants in fresh milk by liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 1288: 10-20.
2. Anonymous. 2008. Perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA) and their salts Scientific Opinion of the Panel on Contaminants in the Food Chain. The EFSA Journal. 653: 1-131.
3. Anonymous. 2010a. Commission Regulation (EU) No. 37/2010 of 22nd December 2009 on pharmacologically active substances and their classification regarding maximum residue limits in foodstuffs of animal origin. Official Journal of the European Union L15: 1-72.
4. Anonymous. 2010b. Scientific opinion on polybrominated biphenyls (PBBs) in food. The EFSA Journal 8: 1789-1940.
5. Anonymous. 2011a. "National Food Residue Database - Residue Testing Plan for Ireland (Targeted Samples), 2010". Available online: http://nfrd.teagasc.ie/study_main.asp?Year=2011&SType=5&FCat=&FSCat=&Food=&ResCat=&ResSCat=&Res=&NoFiltF=&NoFiltNC=&NoPreFilter=1&filt=1&filtF=&filtS=310&filtC=&page=&CountryID=&FoodID=&ResultID=&ResID=&caller2=&ColHead=&ColData=&StudyID=269&caller=2 [accessed October 31 2013].
6. Anonymous. 2011b. Scientific opinion on polybrominated diphenyl ethers (PBDEs) in food. The EFSA Journal 9: 2156-2430.
7. Anonymous. 2012a. CVMP assessment report under Article 30(3) of Regulation (EC) No. 726/2004 for dapsone as an impurity in veterinary medicinal products containing sulphamethoxazole or other sulphonamides. London, EMA, 15 pages.
8. Anonymous. 2012b. Health assessment of benzalkonium chloride residues in food. Berlin, BfR.
9. Anonymous. 2012c. "National Food Residue Database - Residue Testing Plan for Ireland (Targeted Samples), 2011". Available online: http://nfrd.teagasc.ie/study_main.asp?Year=2011&SType=5&FCat=&FSCat=&NoFiltF=&NoFiltNC=&NoPreFilter=1&Food=&ResCat=&ResSCat=&Res=&filt=1&filtS=310&StudyID=310&caller=2. [accessed October 31 2013].
10. Anonymous. 2012d. Scientific opinion on brominated flame retardants (BFRs) in food: brominated phenols and their derivatives. The EFSA Journal 10: 2634-2678.
11. Anonymous. 2012e. Scientific opinion on emerging and novel brominated flame retardants (BFRs) in food. The EFSA Journal 10: 2908-3033.
12. Anonymous. 2013. "Factsheet on the Irish Agriculture and Food & Drink Sector" Available online: http://www.bordbia.ie/industryinfo/agri/pages/default.aspx [accessed October 31 2013].
13. Baliukoniene, V., Bakutis, B., Vaivadaite, T., Bartkiene, E. and Jovaisiene, J. 2012. Prevalence of fungi and mycotoxins in silage and milk in Lithuania. Veterinarija Ir Zootechnika 59: 3-9.
14. Berendsen, B., Pikkemaat, M., Romkens, P., Wegh, R., van Sisseren, M., Stolker, L. and Nielen, M. 2013. Occurrence of chloramphenicol in crops through natural production by bacteria in soil. Journal of Agricultural and Food Chemistry 61: 4004-4010.
15. Berendsen, B., Stolker, L., de Jong, J., Nielen, M., Tserendorj, E., Sodnomdarjaa, R., Cannavan, A. and Elliott, C. 2010. Evidence of natural occurrence of the banned antibiotic chloramphenicol in herbs and grass. Analytical and Bioanalytical Chemistry 397: 1955-1963.
16. Berendsen, B.J.A., Zuidema, T., de Jong, J., Stolker, L.A.M. and Nielen, M.W.F. 2011. Discrimination of eight chloramphenicol isomers by liquid chromatography tandem mass spectrometry in order to investigate the natural occurrence of chloramphenicol. Analytica Chimica Acta 700: 78-85.
17. Bussche, J.V., Kiebooms, J.A.L., De Clercq, N., Deceuninck, Y., Le Bizec, B., De Brabander, H.F. and Vanhaecke, L. 2011a. Feed or food responsible for the presence of low-level thiouracil in urine of livestock and humans? Journal of Agricultural and Food Chemistry 59: 5786-5792.
18. Bussche, J.V., Vanhaecke, L., Deceuninck, Y., Wille, K., Bekaert, K., Le Bizec, B. and De Brabander, H.F. 2011b. Ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry detection of naturally occurring thiouracil in urine of untreated livestock, domesticated animals and humans. Food Additives and Contaminants Part A - Chemistry Analysis Control Exposure & Risk Assessment 28: 166-172.
19. Cao, X.L. 2010. Phthalate esters in foods: Sources, occurrence, and analytical methods. Comprehensive Reviews in Food Science and Food Safety 9: 21-43.
20. Casajuana, N. and Lacorte, S. 2004. New methodology for the determination of phthalate esters, bisphenol A, bisphenol A diglycidyl ether, and nonylphenol in commercial whole milk samples. Journal of Agricultural and Food Chemistry 52: 3702-3707.
21. Clarke, L., Moloney, M., O'Mahony, J., O'Kennedy, R. and Danaher, M. 2013. Determination of 20 coccidiostats in milk, duck muscle and nonavian muscle tissue using ultra high pressure liquid chromatography - tandem mass spectrometry. Food Additives & Contaminants: Part A 30: 958-969.
22. Cooper, K.M., Whelan, M., Danaher, M. and Kennedy, D.G. 2011. Stability during cooking of anthelmintic veterinary drug residues in beef. Food Additives and Contaminants Part A - Chemistry Analysis Control Exposure & Risk Assessment 28: 155-165.
23. Cooper, K.M., Whelan, M., Kennedy, D.G., Trigueros, G., Cannavan, A., Boon, P.E., Wapperom, D. and Danaher, M. 2012a. Anthelmintic drug residues in beef: UPLC-MS/MS method validation, European retail beef survey, and associated exposure and risk assessments. Food Additives and Contaminants Part A - Chemistry Analysis Control Exposure & Risk Assessment 29: 746-760.
24. Cooper, K.M., Whyte, M., Danaher, M. and Kennedy, D.G. 2012b. Emergency slaughter of casualty cattle increases the prevalence of anthelmintic drug residues in muscle. Food Additives and Contaminants Part A - Chemistry Analysis Control Exposure & Risk Assessment 29: 1263-1271.
25. Cordewener, J.H.G., Luykx, D.M.A.M., Frankhuizen, R., Bremer, M.G.E.G., Hooijerink, H. and America, A.H.P. 2009. Untargeted LC-Q-TOF mass spectrometry method for the detection of adulterations in skimmed-milk powder. Journal of Separation Science 32: 1216-1223.
26. de Souza, S.V.C., Junqueira, R.G. and Ginn, R. 2005. Analysis of semicarbazide in baby food by liquid chromatography tandem mass spectrometry (LC-MS-MS) - In-house method validation. Journal of Chromatography A 1077: 151-158.
27. Dowling, G., Malone, E., Harbison, T. and Martin, S. 2010. Analytical strategy for the determination of non-steroidal anti-inflammatory drugs in plasma and improved analytical strategy for the determination of authorised and non-authorised non-steroidal anti-inflammatory drugs in milk by LC-MS/MS. Food Additives and Contaminants Part A - Chemistry Analysis Control Exposure & Risk Assessment 27: 962-982.
28. Farajzadeh, M.A., Goushjuii, L., Djozan, D. and Mohammadi, J.K. 2012. Dispersive liquid-liquid microextraction combined with gas chromatography for extraction and determination of class 1 residual solvents in pharmaceuticals. Journal of Separation Science 35: 1027-1035.
29. Fierens, T., Van Holderbeke, M., Willems, H., De Henauw, S. and Sioen, I. 2012. Phthalates in Belgian cow's milk and the role of feed and other contamination pathways at farm level. Food and Chemical Toxicology 50: 2945-2953.
30. Fierens, T., Van Holderbeke, M., Willems, H., De Henauw, S. and Sioen, I. 2013. Transfer of eight phthalates through the milk chain - A case study. Environment International 51: 1-7.
31. Gallo, P., Vinci, F., Fusco, G. and Serpe, L. 2009. An analytical strategy for identification of a somatotropin- like bioactive peptide by ion trap liquid chromatography/electrospray ionization tandem mass spectrometry after immuno-affinity purification from buffalo serum. Rapid Communications in Mass Spectrometry 23: 395-402.
32. Gleeson, D., O'Brien, B., Flynn, J., O'Callaghan, E. and Galli, F. 2009. Effect of pre-milking teat preparation procedures on the microbial count on teats prior to cluster application. Irish Veterinary Journal 62: 461-467.
33. Hoenicke, K., Gatermann, R., Hartig, L., Mandix, M. and Otte, S. 2004. Formation of semicarbazide (SEM) in food by hypochlorite treatment: is SEM a specific marker for nitrofurazone abuse? Food Additives and Contaminants 21: 526-537.
34. Hoogenboom, L.A.P., Mulder, P.P.J., Zeilmaker, M.J., van den Top, H.J., Remmelink, G.J., Brandon, E.F.A., Klijnstra, M., Meijer, G.A.L., Schothorst, R. and Van Egmond, H.P. 2011. Carryover of pyrrolizidine alkaloids from feed to milk in dairy cows. Food Additives and Contaminants Part A - Chemistry Analysis Control Exposure & Risk Assessment 28: 359-372.
35. Keegan, J., O'Kennedy, R., Crooks, S., Elliott, C., Brandon, D. and Danaher, M. 2011. Detection of benzimidazole carbamates and amino metabolites in liver by surface plasmon resonance-biosensor. Analytica Chimica Acta 700: 41-48.
36. Keegan, J., Whelan, M., Danaher, M., Crooks, S., Sayers, R., Anastasio, A., Elliott, C., Brandon, D., Furey, A. and O'Kennedy, R. 2009. Benzimidazole carbamate residues in milk: Detection by surface plasmon resonance-biosensor, using a modified QuEChERS (Quick, Easy, Cheap, Effective, Rugged and Safe) method for extraction. Analytica Chimica Acta 654: 111-119.
37. Kesler, E.M., Watrous, G.H., Knodt, C.B. and Williams, P.S. 1948. The value of hypochlorite and quaternary ammonium compounds, when used in udder washes, in reducing the plate count of milk. Journal of Dairy Science 31: 179-182.
38. Kim, M., Yun, S.J. and Chung, G.S. 2009.Determination of phthalates in raw bovine milk by gas chromatography/time-of-flight mass spectrometry (GC/TOF-MS) and dietary intakes. Food Additives and Contaminants Part A - Chemistry Analysis Control Exposure & Risk Assessment 26: 134-138.
39. Kinsella, B., Byrne, P., Cantwell, H., McCormack, M., Furey, A. and Danaher, M. 2011. Determination of the new anthelmintic monepantel and its sulfone metabolite in milk and muscle using a UHPLC-MS/MS and QuEChERS method. Journal of Chromatography B - Analytical Technologies in the Biomedical and Life Sciences 879: 3707-3713.
40. Kinsella, B., Lehotay, S.J., Mastovska, K., Lightfield, A.R., Furey, A. and Danaher, M. 2009. New method for the analysis of flukicide and other anthelmintic residues in bovine milk and liver using liquid chromatography-tandem mass spectrometry. Analytica Chimica Acta 637: 196-207.
41. Latini, G., De Felice, C. and Verrotti, A. 2004. Plasticizers, infant nutrition and reproductive health. Reproductive Toxicology 19: 27-33.
42. Lavis, J.N., Robertson, D., Woodside, J.M., McLeod, C.B. and Abelson, J. 2003. How can research organizations more effectively transfer research knowledge to decision makers? Milbank Quarterly 81: 221-248.
43. Le Breton, M.H., Beck-Henzelin, A., Richoz-Payot, J., Rochereau-Roulet, S., Pinel, G., Delatour, T. and Le Bizec, B. 2010. Detection of recombinant bovine somatotropin in milk and effect of industrial processes on its stability. Analytica Chimica Acta 672: 45-49.
44. Malone, E.M., Elliott, C.T., Kennedy, D.G. and Regan, L. 2010. Screening and quantitative confirmatory method for the analysis of glucocorticoids in bovine milk using liquid chromatography- tandem mass spectrometry. Journal of AOAC International 93: 1656-1665.
45. Moloney, M., Clarke, L., O'Mahony, J., Gadaj, A., O'Kennedy, R. and Danaher, M. 2012. Determination of 20 coccidiostats in egg and avian muscle tissue using ultra high performance liquid chromatography-tandem mass spectrometry. Journal of Chromatography A 1253: 94-104.
46. Mousavi, Z., Butler, F. and Danaher, M. 2013. Validation of a simple spectrophotometric method for the measurement of quaternary ammonium compound residue concentrations in food production facility. Food Analytical Methods 6: 1265-1270.
47. O'Connor, P.J., Hennessy, D., Lynch, M.B., Slattery, H. and Lewis, E. 2013. The effect of dicyandiamide on rumen and blood metabolites, diet digestibility and urinary excretion. Livestock Science 155: 30-37.
48. O'Keeffe, M. and Kennedy, O. 1998. Residues - a food safety problem? Journal of Food Safety 18: 297-319.
49. Pinel, G., Mathieu, S., Cesbron, N., Maume, D., De Brabander, H.F., Andre, F. and Le Bizec, B. 2006. Evidence that urinary excretion of thiouracil in adult bovine submitted to a cruciferous diet can give erroneous indications of the possible illegal use of thyrostats in meat production. Food Additives and Contaminants 23: 974-980.
50. Power, C., Danaher, M., Sayers, R., O'Brien, B., Whelan, M., Furey, A. and Jordan, K. 2013a. Investigation of the persistence of rafoxanide residues in bovine milk and fate during processing. Food Additives & Contaminants: Part A 30: 1087-1095.
51. Power, C., Whelan, M., Danaher, M., Bloemhoff, Y., Sayers, R., O'Brien, B., Furey, A. and Jordan, K. 2013b. Investigation of the persistence of triclabendazole residues in bovine milk following lactating-cow and dry-cow treatments. Food Additives & Contaminants: Part A 30: 1080-1086.
52. Radovnikovic, A., Moloney, M., Byrne, P. and Danaher, M. 2011. Detection of banned nitrofuran metabolites in animal plasma samples using UHPLC-MS/MS. Journal of Chromatography B 879: 159-166.
53. Rochereau-Roulet, S., Gaudin, I., Chereau, S., Prevost, S., Andre-Fontaine, G., Pinel, G. and Le Bizec, B. 2011. Development and validation of an enzyme-linked immunosorbent assay for the detection of circulating antibodies raised against growth hormone as a consequence of rbST treatment in cows. Analytica Chimica Acta 700: 189-193.
54. Ryan, S., Gleeson, D., Jordan, K., Furey, A. and O'Brien, B. 2012. Evaluation of trichloromethane formation from chlorine-based cleaning and disinfection agents in cow's milk. International Journal of Dairy Technology 65: 498-502.
55. Ryan, S., Gleeson, D., Jordan, K., Furey, A., O'Sullivan, K. and O'Brien, B. 2013. Strategy for the reduction of trichloromethane residue levels in farm bulk milk. Journal of Dairy Research 80: 184-189.
56. Schettler, T. 2006. Human exposure to phthalates via consumer products. International Journal of Andrology 29: 134-139.
57. Shen, Y., Han, C., Zhou, X., Chen, X., Huang, F. and Zhu, Z. 2013. Microwave-assisted extraction and determination of dicyandiamide residue in infant formula samples by liquid chromatographytandem mass spectrometry. Journal of Dairy Science 96: 6877-6882.
58. Stolker, A.A.M., Rutgers, P., Oosterink, E., Lasaroms, J.J.P., Peters, R.J.B., van Rhijn, J.A. and Nielen, M.W.F. 2008. Comprehensive screening and quantification of veterinary drugs in milk using UPLC-ToF-MS. Analytical and Bioanalytical Chemistry 391: 2309-2322.
59. Whelan, M., Bloemhoff, Y., Furey, A., Sayers, R. and Danaher, M. 2011. Investigation of the persistence of nitroxynil residues in milk from lactating dairy cows by ultra performance liquid chromatography tandem mass spectrometry. Journal of Agricultural and Food Chemistry 59: 7793-7797.
60. Whelan, M., Kinsella, B., Furey, A., Moloney, M., Cantwell, H., Lehotay, S.J. and Danaher, M. 2010. Determination of anthelmintic drug residues in milk using ultra high performance liquid chromatography- tandem mass spectrometry with rapid polarity switching. Journal of Chromatography A 1217: 4612-4622.
61. Xin, H. and Stone, R. 2008. Tainted milk scandal Chinese probe unmasks high-tech adulteration with melamine. Science 322: 1310-1311.
62. Yano, K., Hirosawa, N., Sakamoto, Y., Katayama, H., Moriguchi, T. and Asaoka, K. 2005. Phthalate levels in baby milk powders sold in several countries. Bulletin of Environmental Contamination and Toxicology 74: 373-379.