Ultra-high performance liquid chromatography coupled to triple quadrupole mass spectrometry detection of naturally occurring thiouracil in urine of untreated livestock, domesticated animals and humans

Food Additives and Contaminants - Part A

Volumn 28, Issue 2, 2011, Pages 166-172

  Vanden Bussche, J ^a   Vanhaecke, L ^a   Deceuninck, Y ^b   Wille, K ^a   Bekaert, K ^a   Le Bizec, B ^b   de Brabander, H F ^a  

^a GHENT UNIVERSITY   (Belgium)

^b LUNAM UNIVERSITÉ   (France)

Author keywords

Animal feed; Animal feedingstuffs; Clean up; Drug residues; Exposure; Extraction; Hormones; Liquid chromatography mass spectrometry; Processed foods; Vegetables

Indexed keywords

AGRICULTURE; DRUG PRODUCTS; EXTRACTION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HORMONES; LIQUIDS; MASS SPECTROMETRY; PROCESSED FOODS; VEGETABLES;

ANIMAL FEED; ANIMAL FEEDINGSTUFFS; DRUG RESIDUE; EXPOSURE; LIQUID CHROMATOGRAPHY/MASS SPECTROMETRY;

ANIMALS;

PROPYLTHIOURACIL; THIOURACIL;

ADULT; ARTICLE; BRASSICACEAE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DIETARY INTAKE; DOMESTIC ANIMAL; FEMALE; HUMAN; LIVESTOCK; MALE; MEDICAL RESEARCH; NONHUMAN; NORMAL HUMAN; PRIORITY JOURNAL; QUADRUPOLE MASS SPECTROMETRY; TRIPLE QUADRUPOLE MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY; URINALYSIS; URINE;

ANIMALIA; BRASSICACEAE;

EID: 79951471719     PISSN: 19440049     EISSN: 14645122     Source Type: Journal    
DOI: 10.1080/19440049.2010.544681     Document Type: Article

References (18)

1. Courtheyn D, Le Bizec B, Brambilla G, De Brabander HF, Cobbaert E, de Wiele AV, Vercammen J, De Wasch K. 2002. Recent developments in the use and abuse of growth promoters. Anal Chim Acta. 473:71-82.
2. De Brabander HF. 1984. Bepalingsmethoden voor thyreostatica in biologisch materiaal [thesis]. [Ghent]: Ghent University.
3. Derblom H, Johansson H, Nylander G. 1963. Thyroid hormone activity and gastrointestinal function, an experimental study in the rat. Acta Chir Scand. 10:1-5.
4. European Community. 1981. Council Directive 81/602/EC. Off J Eur Comm. L. 222:32-33.
5. European Community. 2002. Council Decision (2002)/657/EC. Off J Eur Comm. L. 221:8-36.
6. European Union of Reference Laboratory (EURL) 2007. EURL guidance document: EURL's view on state of the art analytical methods for national residue control plans. Available from: http://www.rivm.nl/bibliotheek/digitaaldepot/crlguidance2007.pdf/
7. Getahun SM, Chung FL. 1999. Conversion of glucosinolates to isothiocyanates in humans after ingestion of cooked watercress. Cancer Epidemiol Biomarkers Prev. 8:447-451.
8. Heeremans A, Ermens L, De Wasch KK, Van Peteghem C, De Brabander HF. 1998. Elimination profile of methylthiouracil in cows after oral administration. Analyst. 123:2629-2632.
9. International Agency for Research on Cancer (IARC). 2010. IARC monographs on the evaluation of carcinogenic risks to humans. Last updated August 2010. Available from: http://monographs.iarc.fr/ENG/Classification/index.php/
10. Kotter L, Terplan G, Schulz J. 1959. Biological demonstration of inhibitors in foodstuff of animal origin. Arch Lebensmittelhyg. 10:145-152.
11. Lohmus M, Kallaste K, Le Bizec B. 2009. Determination of thyreostats in urine and thyroid gland by ultra high performance liquid chromatography tandem mass spectrometry. J Chromatogr A. 1216:8080-8089.
12. Mackenzie CG, Mackenzie JB. 1943. Effect of sulfonamides and thioureas on the thyroid gland and basal metabolism. Endocrinology. 32:185-193.
13. Pinel G, Bichon E, Pouponneau K, Maume D, Andre F, Le Bizec B. 2005. Multi-residue method for the determination of thyreostats in urine samples using liquid chromatography coupled to tandem mass spectrometry after derivatisation with 3-iodobenzylbromide. J Chromatogr A. 1085:247-252.
14. Pinel G, Mathieu S, Cesbron N, Maume D, De Brabander HF, Andre F, Le Bizec B. 2006. Evidence that urinary excretion of thiouracil in adult bovine submitted to a cruciferous diet can give erroneous indications of the possible illegal use of thyreostats in meat production. Food Addit Contam A. 23:974-980.
15. Ross MM, Sterk SS, Verhagen H, Stalenhoef AFH, De Jong N. 2007. Phytosterol consumption and the anabolic steroid boldenone in humans: a hypothesis piloted. Food Addit Contam A. 24:679-684.
16. Rouzaud G, Young SA, Duncan AJ. 2004. Hydrolysis of glucosinolates to isothiocyanates after ingestion of raw or microwaved cabbage by human volunteers. Cancer Epidemiol Biomarkers Prev. 13:125-131.
17. Vanden Bussche J, Noppe H, Verheyden K, Wille K, Pinel G, Le Bizec B, De Brabander HF. 2009. Analysis of thyreostats: a history of 35 years. Anal Chim Acta. 637:2-12.
18. Vanden Bussche J, Vanhaecke L, Deceuninck Y, Verheyden K, Wille K, Bekaert K, Le Bizec B, De Brabander HF. 2010. Development and validation of an ultra-high-performance liquid chromatography tandem mass spectrometry method for quantifying thyreostats in urine without derivatisation. J Chromatogr A. 1217:4285-4293.