Synthesis and pharmacological evaluation of a series of the agomelatine analogues as melatonin MT1/MT2 agonist and 5-HT 2C antagonist

ChemMedChem

Volumn 8, Issue 11, 2013, Pages 1830-1845

  Ettaoussi, Mohamed ^a   Sabaouni, Ahmed ^a   Pérès, Basile ^a   Landagaray, Elodie ^a   Nosjean, Olivier ^b   Boutin, Jean A ^b   Caignard, Daniel Henri ^b   Delagrange, Philippe ^b   Berthelot, Pascal ^a   Yous, Saïd ^a  

^a UNIV LILLE   (France)

^b INSTITUT DE RECHERCHES SERVIER   (France)

Author keywords

5 HT2C receptors; Agomelatine; Antidepressant agents; Melatonin receptors; Subtype selectivity

Indexed keywords

AGOMELATINE; HORMONE RECEPTOR STIMULATING AGENT; MELATONIN 1 RECEPTOR; MELATONIN 1 RECEPTOR AGONIST; MELATONIN 2 RECEPTOR; MELATONIN 2 RECEPTOR AGONIST; SEROTONIN 2C ANTAGONIST; UNCLASSIFIED DRUG; ACETAMIDE DERIVATIVE; HYPNOTIC SEDATIVE AGENT; NAPHTHALENE; NAPHTHALENE DERIVATIVE; PROTEIN BINDING; SEROTONIN 2 ANTAGONIST;

ARTICLE; BINDING AFFINITY; DRUG DESIGN; DRUG RECEPTOR BINDING; DRUG SCREENING; DRUG SYNTHESIS; PRIORITY JOURNAL; AGONISTS; ANIMAL; CHEMICAL STRUCTURE; CHEMISTRY; CHO CELL LINE; CRICETULUS; DRUG EFFECTS; HUMAN; SYNTHESIS;

ACETAMIDES; ANIMALS; CHO CELLS; CRICETULUS; HUMANS; HYPNOTICS AND SEDATIVES; MOLECULAR STRUCTURE; NAPHTHALENES; PROTEIN BINDING; RECEPTOR, MELATONIN, MT1; SEROTONIN 5-HT2 RECEPTOR ANTAGONISTS;

EID: 84890861098     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201300294     Document Type: Article

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