Prediction of interindividual variation in drug plasma levels in vivo from individual enzyme kinetic data and physiologically based pharmacokinetic modeling

European Journal of Pharmaceutical Sciences

Volumn 12, Issue 2, 2000, Pages 117-124

  Bogaards, Jan J P ^a   Hissink, Erna M ^a   Briggs, Mike ^b   Weaver, Richard ^b   Jochemsen, Roeline ^c   Jackson, Peter ^d   Bertrand, Marc ^d   Van Bladeren, Peter J ^a  

^a TNO   (Netherlands)

^b Servier Research and Development   (United Kingdom)

^c IRIS Institut de Recherches Internationales Servier   (France)

^d INSTITUT DE RECHERCHES INTERNATIONALES SERVIER   (France)

Author keywords

Cytochrome P450; Interindividual variation; Metabolism; Physiologically based pharmacokinetic modeling

Indexed keywords

AGOMELATINE; BUFURALOL; CHLORZOXAZONE; COUMARIN; CYTOCHROME P450; DICLOFENAC; ETHOXYRESORUFIN; MEPHENYTOIN; TESTOSTERONE;

ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DRUG BLOOD LEVEL; ENZYME KINETICS; FOOD DRUG INTERACTION; GENETIC POLYMORPHISM; HUMAN; HUMAN CELL; HUMAN EXPERIMENT; HUMAN TISSUE; LIVER MICROSOME; MALE; MODEL; NORMAL HUMAN; PHASE 1 CLINICAL TRIAL; PHENOTYPE; PRIORITY JOURNAL;

ACETAMIDES; CELL LINE; CYTOCHROME P-450 ENZYME SYSTEM; HUMANS; HYPNOTICS AND SEDATIVES; ISOENZYMES; KINETICS; MICROSOMES, LIVER; MODELS, BIOLOGICAL; PHARMACEUTICAL PREPARATIONS; PHARMACOKINETICS; RECOMBINANT PROTEINS; TRANSFECTION;

EID: 0033692454     PISSN: 09280987     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0928-0987(00)00146-9     Document Type: Article

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