Catalytic Asymmetric Reduction of a 3,4-Dihydroisoquinoline for the Large-Scale Production of Almorexant: Hydrogenation or Transfer Hydrogenation?

Organic Process Research and Development

Volumn 17, Issue 12, 2013, Pages 1531-1539

  Verzijl, Gerard K M ^a   De Vries, André H M ^a   De Vries, Johannes G ^a   Kapitan, Peter ^b   Dax, Thomas ^b   Helms, Matthias ^b   Nazir, Zarghun ^b   Skranc, Wolfgang ^b   Imboden, Christoph ^d,e   Stichler, Juergen ^d   Ward, Richard A ^c   Abele, Stefan ^d   Lefort, Laurent ^a  

^a DSM RESOLVE   (Netherlands)

^b DSM Fine Chemicals Austria Nfg GmbH & Co KG   (Netherlands)

^c GLAXOSMITHKLINE   (United Kingdom)

^d ACTELION PHARMACEUTICALS LTD   (Switzerland)

^e Newron SA   (Switzerland)

Author keywords

[No Author keywords available]

Indexed keywords

ASYMMETRIC HYDROGENATION; ASYMMETRIC REDUCTION; ASYMMETRIC TRANSFER HYDROGENATION; CATALYST PRETREATMENT; ENANTIOSELECTIVE SYNTHESIS; LARGE-SCALE PRODUCTION; TETRAHYDROISOQUINOLINES; TRANSFER HYDROGENATIONS;

AROMATIC COMPOUNDS; CATALYSIS; CATALYSTS; ENANTIOSELECTIVITY; MANUFACTURE;

HYDROGENATION;

EID: 84890846068     PISSN: 10836160     EISSN: 1520586X     Source Type: Journal    
DOI: 10.1021/op400268f     Document Type: Article

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