A chiral rhodium complex for rapid asymmetric transfer hydrogenation of imines with high enantioselectivity

Organic Letters

Volumn 1, Issue 6, 1999, Pages 841-843

  Mao, Jianmin ^a   Baker, David C ^a  

^a UNIVERSITY OF TENNESSEE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HYDROGEN; IMINE; RHODIUM;

ARTICLE; CHEMISTRY; STEREOISOMERISM;

HYDROGEN; IMINES; RHODIUM; STEREOISOMERISM;

EID: 0033598249     PISSN: 15237060     EISSN: None     Source Type: Journal    
DOI: 10.1021/ol990098q     Document Type: Article

References (42)

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30. After our work had been carried out, the catalyst described herein has been advanced for the transfer hydrogenation of carbonyl compounds. See: Mashina, K.; Abe, T.; Tani, K. Chem. Lett. 1998, 1199-1200, 1201-1202. Kunikiko, K.; Ikariya, T.; Noyori, R. J. Org. Chem. 1999, 64, 2186-2187. We find that 1 is more successful in reducing imines than ketones as evidenced by higher yields of products with generally excellent enantioselectivity.
31. After our work had been carried out, the catalyst described herein has been advanced for the transfer hydrogenation of carbonyl compounds. See: Mashina, K.; Abe, T.; Tani, K. Chem. Lett. 1998, 1199-1200, 1201-1202. Kunikiko, K.; Ikariya, T.; Noyori, R. J. Org. Chem. 1999, 64, 2186-2187. We find that 1 is more successful in reducing imines than ketones as evidenced by higher yields of products with generally excellent enantioselectivity.
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41. Baker, D. C., and co-workers, unpublished work. Details on the synthesis and structural identification of 7d will be reported in the full paper.
42. The absolute configuration was confirmed by single-crystal X-ray diffraction carried out on the N-Me derivative of 7d.