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(Ed.: R. Epten), Mayflower Worldwide Ltd, Birmingham (UK)
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For a further approach to stereochemical combinatorial synthesis, see: U. Müllenmeister, W-D. Fessner in Innovation and Perspectives in Solid Phase Synthesis and Combinatorial Libraries (Ed.: R. Epten), Mayflower Worldwide Ltd, Birmingham (UK), 2001, p. 149-152.
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85007631095
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note
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Reagent-controlled reactions in which enantiomerically pure auxiliaries are used are likewise possible.
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28
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0029933891
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29
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85007628567
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note
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4. The solvent was removed under reduced pressure to yield the dihydroisoquinoline 3 as a pale yellow oil, which was used without further purification (24.7 g, 90%).
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30
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85007628575
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note
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4. After removal of the solvent under reduced pressure, the brown crude product was purified by chromatography on silica gel (AcOEt/NEt3, 100:1) to yield 2a as a yellow oil (20.2 g, 93 %, > 95 % ee).
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32
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0001847186
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37
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85007633616
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note
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3).
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38
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85007628572
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note
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3).
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