BDNF serum levels in subjects developing or not post-traumatic stress disorder after trauma exposure

Brain and Cognition

Volumn 84, Issue 1, 2014, Pages 118-122

  Angelucci, Francesco ^a   Ricci, Valerio ^a   Gelfo, Francesca ^a   Martinotti, Giovanni ^b   Brunetti, Marcella ^b   Sepede, Gianna ^b   Signorelli, Maria ^c   Aguglia, Eugenio ^c   Pettorruso, Mauro ^d   Vellante, Federica ^b   Di Giannantonio, Massimo ^b   Caltagirone, Carlo ^a  

^a IRCCS FONDAZIONE SANTA LUCIA   (Italy)

^b UNIVERSITY OF CHIETI   (Italy)

^c UNIVERSITY OF CATANIA   (Italy)

^d CATHOLIC UNIVERSITY   (Italy)

Author keywords

BDNF; ELISA; Post traumatic stress disorder; Trauma exposure

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR;

ADULT; ARTICLE; BLOOD ANALYSIS; CLINICAL ARTICLE; CONTROLLED STUDY; DISEASE ASSOCIATION; DOWN REGULATION; FEMALE; HUMAN; LIFE EVENT; MALE; NEUROPATHOLOGY; POSTTRAUMATIC STRESS DISORDER; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; PROTEIN FUNCTION; PROTEIN SYNTHESIS; PSYCHOTRAUMA; BLOOD; INJURY SCALE;

ADULT; BRAIN-DERIVED NEUROTROPHIC FACTOR; FEMALE; HUMANS; MALE; STRESS DISORDERS, POST-TRAUMATIC; TRAUMA SEVERITY INDICES;

EID: 84890837664     PISSN: 02782626     EISSN: 10902147     Source Type: Journal    
DOI: 10.1016/j.bandc.2013.11.012     Document Type: Article

References (59)

1. Alderson R.F., Alterman A.L., Barde Y.A., Lindsay R.M. Brain-derived neurotrophic factor increases survival and differentiated functions of rat septal cholinergic neurons in culture. Neuron 1990, 5:297-306.
2. American Psychiatric Association Diagnostic and statistical manual of mental disorders 2000, American Psychiatric Press, Text Revision, Washington DC. 4th ed.
3. Andero R., Ressler K.J. Fear extinction and BDNF: Translating animal models of PTSD to the clinic. Genes, Brain and Behavior 2012, 1:503-512.
4. Angelucci F., Aloe L., Iannitelli A., Gruber S.H., Mathé A.A. Effect of chronic olanzapine treatment on nerve growth factor and brain-derived neurotrophic factor in the rat brain. European Neuropsychopharmacology 2005, 5:311-317.
5. Angelucci F., Aloe L., Jiménez-Vasquez P., Mathé A.A. Lithium treatment alters brain concentrations of nerve growth factor, brain-derived neurotrophic factor and glial cell line-derived neurotrophic factor in a rat model of depression. International Journal of Neuropsychopharmacology 2003, 3:225-231.
6. Angelucci F., Mathé A.A., Aloe L. Neurotrophic factors and CNS disorders: Findings in rodent models of depression and schizophrenia. Progress in Brain Research 2004, 146:151-165.
7. Beck K.D. Functions of brain-derived neurotrophic factor, insulin-like growth factor-I and basic fibroblast growth factor in the development and maintenance of dopaminergic neurons. Progress in Neurobiology 1994, 44:497-516.
8. Berger W., Mehra A., Lenoci M., Metzler T.J., Otte C., Arasovsky G., et al. Serum brain-derived neurotrophic factor predicts responses to escitalopram in chronic posttraumatic stress disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2010, 34:1279-1284.
9. Blake D.D., Weathers F.W., Nagy L.M., Kaloupek D.G., Gusman F.D., Charney D.S., et al. The development of a clinician-administered PTSD scale. Journal of Traumatic Stress 1995, 8:75-90.
10. Bonne O., Gill J., Luckenbaugh D., Owens M., Alesci S., Neumeister A., et al. Corticotropin-releasing factor, interleukin-6, brainderived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine. Journal of Clinical Psychiatry 2011, 72:1124-1128.
11. Bremner J.D. Stress and brain atrophy. CNS and Neurological Disorders: Drug Targets 2006, 5:503-512.
12. Bremner J.D., Randall P., Vermetten E., Staib L., Bronen R.A., Mazure C., et al. Magnetic resonance imaging-based measurement of hippocampal volume in posttraumatic stress disorder related to childhood physical and sexual abuse-A preliminary report. Biological Psychiatry 1997, 41:23-32.
13. Bremner J.D., Vythilingam M., Vermetten E., Southwick S.M., McGlashan T., Nazeer A., et al. MRI and PET study of deficits in hippocampal structure and function in women with childhood sexual abuse and posttraumatic stress disorder. American Journal of Psychiatry 2003, 160:924-932.
14. Brunetti M., Sepede G., Mingoia G., Catani C., Ferretti A., Merla A., et al. Elevated response of human amygdala to neutral stimuli in mild post traumatic stress disorder: Neural correlates of generalized emotional response. Neuroscience 2010, 168:670-679.
15. Chao L., Weiner M., Neylan T. Regional cerebral volumes in veterans with current versus remitted posttraumatic stress disorder. Psychiatry Research 2013, [Epub ahead of print].
16. Choi S.W., Bhang S., Ahn J.H. Diurnal variation and gender differences of plasma brain-derived neurotrophic factor in healthy human subjects. Psychiatry Research 2011, 186:427-430.
17. Cohen H., Liu T., Kozlovsky N., Kaplan Z., Zohar J., Mathé A.A. The neuropeptide Y (NPY)-ergic system is associated with behavioral resilience to stress exposure in an animal model of post-traumatic stress disorder. Neuropsychopharmacology 2012, 37:350-363.
18. Connor B., Dragunow M. The role of neuronal growth factors in neurodegenerative disorders of the human brain. Brain Research. Brain Research Reviews 1998, 27:1-39.
19. Croce N., Dinallo V., Ricci V., Federici G., Caltagirone C., Bernardini S., et al. Neuroprotective effect of neuropeptide Y against β-amyloid 25-35 toxicity in SH-SY5Y neuroblastoma cells is associated with increased neurotrophin production. Neurodegenerative Diseases 2011, 8:300-309.
20. Croce N., Gelfo F., Ciotti M.T., Federici G., Caltagirone C., Bernardini S., et al. NPY modulates miR-30a-5p and BDNF in opposite direction in an in vitro model of Alzheimer disease: A possible role in neuroprotection?. Molecular and Cellular Biochemistry 2013, 376:189-195.
21. Cunha A.B., Frey B.N., Andreazza A.C., Goi J.D., Rosa A.R., Gonçalves C.A., et al. Serum brain-derived neurotrophic factor is decreased in bipolar disorder during depressive and manic episodes. Neuroscience Letters 2006, 398:215-219.
22. Dell'Osso L., Carmassi C., Del Debbio A., Catena Dell'Osso M., Bianchi C., da Pozzo E., et al. Brain-derived neurotrophic factor plasma levels in patients suffering from post-traumatic stress disorder. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2009, 33:899-902.
23. Dennis N.A., Cabeza R., Need A.C., Waters-Metenier S., Goldstein D.B., LaBar K.S. Brain-derived neurotrophic factor val66met polymorphism and hippocampal ctivation during episodic encoding and retrieval tasks. Hippocampus 2010, 21:980-989.
24. Egan M.F., Kojima M., Callicott J.H., Goldberg T.E., Kolachana B.S., Bertolino A., et al. The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 2003, 112:257-269.
25. Elfving B., Plougmann P.H., Wegener G. Detection of brain-derived neurotrophic factor (BDNF) in rat blood and brain preparations using ELISA: Pitfalls and solutions. Journal of Neuroscience Methods 2010, 187:73-77.
26. Felmingham K.L., Dobson-Stone C., Schofield P.R., Quirk G.J., Bryant R.A. The brain-derived neurotrophic factor Val66Met polymorphism predicts response to exposure therapy in posttraumatic stress disorder. Biological Psychiatry 2013, 3223:1034-1037.
27. First M.B., Spietzer R.L., Gibbon M., William J.B.W. Structured clinical interview for DSM-1V axis 1 disorders clinical version 1997, American Psychiatric Press, Washington (DC).
28. Gelfo F., Tirassa P., De Bartolo P., Croce N., Bernardini S., Caltagirone C., et al. NPY intraperitoneal injections produce antidepressant-like effects and downregulate BDNF in the rat hypothalamus. CNS Neuroscience and Therapeutics 2012, 18:487-492.
29. Ghosh A., Carnahan J., Greenberg M.E. Requirement for BDNF in activity-dependent survival of cortical neurons. Science 1994, 263:1618-1623.
30. Gil-Bea F.J., Solas M., Mateos L., Winblad B., Ramírez M.J., Cedazo-Mínguez A. Cholinergic hypofunction impairs memory acquisition possibly through hippocampal Arc and BDNF downregulation. Hippocampus 2011, 21:999-1009.
31. Gonul A.S., Kitis O., Eker M.C., Eker O.D., Ozan E., Coburn K. Association of the brain-derived neurotrophic factor Val66Met polymorphism with hippocampus volumes in drug-free depressed patients. World Journal of Biological Psychiatry 2011, 12:110-118.
32. Hajcak G., Castille C., Olvet D.M., Dunning J.P., Roohi J., Hatchwell E. Genetic variation in brain-derived neurotrophic factor and human fear conditioning. Genes, Brain and Behavior 2009, 8:80-85.
33. Hauck S., Kapczinski F., Roesler R., de Moura Silveira E., Magalhães P.V., Kruel L.R., et al. Serum brain-derived neurotrophic factor in patients with trauma psychopathology. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2010, 34:459-462.
34. Heimer L., Van Hoesen G.W. The limbic lobe and its output channels: Implications for emotional functions and adaptive behavior. Neuroscience and Biobehavioral Reviews 2006, 30:126-147.
35. Hemmings S.M., Martin L.I., Klopper M., van der Merwe L., Aitken L., de Wit E., et al. BDNF Val66Met and DRD2 Taq1A polymorphisms interact to influence PTSD symptom severity: A preliminary investigation in a South African population. Progress in Neuro-Psychopharmacology and Biological Psychiatry 2013, 10:273-280.
36. Hovens J.E., van der Ploeg H.M., Klaarenbeek M.T., Bramsen I., Schreuder J.N., Rivero V.V. The assessment of posttraumatic stress disorder: With the clinician administered PTSD scale: Dutch results. Journal of Clinical Psychology 1994, 50:325-340.
37. Hyman C., Hofer M., Barde Y.A., Juhasz M., Yancopoulos G.D., Squinto S.P., et al. BDNF is a neurotrophic factor for dopaminergic neurons of the substantia nigra. Nature 1991, 350:230-232.
38. Johansen J.P., Cain C.K., Ostroff L.E., LeDoux J.E. Molecular mechanisms of fear learning and memory. Cell 2011, 147:509-524.
39. Keane T.M., Marshall A.D., Taft C.T. Posttraumatic stress disorder: Etiology, epidemiology, and treatment outcome. Annual Review of Clinical Psychology 2006, 2:161-197.
40. Kuczewski N., Porcher C., Gaiarsa J.L. Activity-dependent dendritic secretion of brain-derived neurotrophic factor modulates synaptic plasticity. European Journal of Neuroscience 2010, 32:1239-1244.
41. Laske C., Stellos K., Hoffmann N., Stransky E., Straten G., Eschweiler G.W., et al. Higher BDNF serum levels predict slower cognitive decline in Alzheimer's disease patients. International Journal of Neuropsychopharmacology 2011, 14:399-404.
42. Liberzon I., Sripada C.S. The functional neuroanatomy of PTSD: A critical review. Progress in Brain Research 2008, 167:151-169.
43. Lindholm D., Carroll P., Tzimagiogis G., Thoenen H. Autocrine-paracrine regulation of hippocampal neuron survival by IGF-1 and the neurotrophins BDNF, NT-3, and NT-4. European Journal of Neuroscience 1996, 8:1452-1460.
44. Lonsdorf T.B., Weike A.I., Golkar A., Schalling M., Hamm A.O., Ohman A. Amygdala-dependent fear conditioning in humans is modulated by the BDNFval66met polymorphism. Behavioral Neuroscience 2010, 124:9-15.
45. Martinotti G., Di Iorio G., Marini S., Ricci V., De Berardis D., Di Giannantonio M. Nerve growth factor and brain-derived neurotrophic factor concentrations in schizophrenia: A review. Journal of Biological Regulators and Homeostatic Agents 2012, 26:347-356.
46. Martinotti G., Ricci V., Di Nicola M., Caltagirone C., Bria P., Angelucci F. Brain-derived neurotrophic factor and electroconvulsive therapy in a schizophrenic patient with treatment-resistant paranoid-hallucinatory symptoms. The Journal of ECT 2011, 27:44-46.
47. Nathan P.J., Cobb S.R., Lu B., Bullmore E.T., Davies C.H. Studying synaptic plasticity in the human brain and opportunities for drug discovery. Current Opinion in Pharmacology 2011, 11:540-548.
48. Newport D.J., Nemeroff C.B. Neurobiology of posttraumatic stress disorder. Current Opinion in Neurobiology 2000, 10:211-218.
49. Park H., Poo M.M. Neurotrophin regulation of neural circuit development and function. Nature Reviews Neuroscience 2013, 14:7-23.
50. Qureshi S.U., Long M.E., Bradshaw M.R., Pyne J.M., Magruder K.M., Kimbrell T., et al. Does PTSD impair cognition beyond the effect of trauma?. Journal of Neuropsychiatry and Clinical Neurosciences 2011, 23:16-28.
51. Rasmusson A.M., Shi L., Duman R. Downregulation of BDNF mRNA in the hippocampal dentate gyrus after re-exposure to cues previously associated with footshock. Neuropsychopharmacology 2002, 27:133-142.
52. Sen S., Duman R., Sanacora G. Serum brain-derived neurotrophic factor, depression, and antidepressant medications: Meta-analyses and implications. Biological Psychiatry 2008, 64:527-532.
53. Stevens J.S., Jovanovic T., Fani N., Ely T.D., Glover E.M., Bradley B., et al. Disrupted amygdala-prefrontal functional connectivity in civilian women with posttraumatic stress disorder. Journal of Psychiatric Research 2013, [Epub ahead of print].
54. Teixeira A.L., Barbosa I.G., Diniz B.S., Kummer A. Circulating levels of brain-derived neurotrophic factor: Correlation with mood, cognition and motor function. Biomarkers in Medicine 2010, 4:871-887.
55. van Wingen G., Rijpkema M., Franke B., van Eijndhoven P., Tendolkar I., Verkes R.J., et al. The brain-derived neurotrophic factor Val66Met polymorphism affects memory formation and retrieval of biologically salient stimuli. Neuroimage 2010, 50:1212-1218.
56. Weathers F.W., Keane T.M., Davidson J.R. Clinician-administered PTSD scale: A review of the first ten years of research. Depression and Anxiety 2001, 13:132-156.
57. Zhang X.Y., Liang J., Chen da C., Xiu M.H., Yang F.D., Kosten T.A., et al. Low BDNF is associated with cognitive impairment in chronic patients with schizophrenia. Psychopharmacology (Berl) 2012, 222:277-284.
58. Zhang H., Ozbay F., Lappalainen J., Kranzler H.R., van Dyck C.H., Charney D.S., et al. Brain derived neurotrophic factor (BDNF) gene variants and Alzheimer's disease, affective disorders, posttraumatic stress disorder, schizophrenia, and substance dependence. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics 2006, 141B:387-393.
59. Zhen Y.F., Zhang J., Liu X.Y., Fang H., Tian L.B., Zhou D.H., et al. Low BDNF is associated with cognitive deficits in patients with type 2 diabetes. Psychopharmacology (Berl) 2013, 227:93-100.