Low BDNF is associated with cognitive deficits in patients with type 2 diabetes

Psychopharmacology

Volumn 227, Issue 1, 2013, Pages 93-100

  Zhen, Yan Feng ^a   Zhang, Jia ^a   Liu, Xing Yu ^a   Fang, Hui ^a   Tian, Luo Bing ^a   Zhou, Dong Hao ^b   Kosten, Thomas R ^d,e   Zhang, Xiang Yang ^c,d,e  

^a HEBEI MEDICAL UNIVERSITY   (China)

^b LINYI PEOPLE'S HOSPITAL   (China)

^c PEKING UNIVERSITY   (China)

^d MICHAEL E DEBAKEY VETERANS AFFAIRS MEDICAL CENTER   (United States)

^e BAYLOR COLLEGE OF MEDICINE   (United States)

Author keywords

Brain derived neurotrophic factor; Cognition; Serum; Type 2 diabetes

Indexed keywords

BRAIN DERIVED NEUROTROPHIC FACTOR; CHOLESTEROL; GLUCOSE; METFORMIN; REPAGLINIDE; TRIACYLGLYCEROL;

ADULT; AGED; ARTICLE; CHOLESTEROL BLOOD LEVEL; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; CORRELATION ANALYSIS; DISEASE DURATION; EDUCATIONAL STATUS; FEMALE; GLUCOSE BLOOD LEVEL; HIPPOCAMPUS; HUMAN; MAJOR CLINICAL STUDY; MALE; MEMORY DISORDER; NERVE CELL PLASTICITY; NON INSULIN DEPENDENT DIABETES MELLITUS; PATHOPHYSIOLOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN BLOOD LEVEL; PROTEIN FUNCTION; RATING SCALE; REPEATABLE BATTERY FOR THE ASSESSMENT OF NEUROPSYCHOLOGICAL STATUS; TRIACYLGLYCEROL BLOOD LEVEL;

ADULT; AGED; BIOLOGICAL MARKERS; BRAIN-DERIVED NEUROTROPHIC FACTOR; COGNITION DISORDERS; DIABETES MELLITUS, TYPE 2; FEMALE; HUMANS; MALE; MIDDLE AGED; NEUROPSYCHOLOGICAL TESTS; PSYCHOMOTOR PERFORMANCE; YOUNG ADULT;

EID: 84876056822     PISSN: 00333158     EISSN: 14322072     Source Type: Journal    
DOI: 10.1007/s00213-012-2942-3     Document Type: Article

References (44)

1. Adlard PA, Perreau VM, Engesser-Cesar C, Cotman CW (2004) The time course of induction of brain-derived neurotrophic factor mRNA and protein in the rat hippocampus following voluntary exercise. Neurosci Lett 363(1):43-48
2. Alberti KG, Zimmet PZ (1998) Definition, diagnosis and classification of diabetes mellitus and its complications. Part 1: diagnosis and classification of diabetes mellitus provisional report of a WHO consultation. Diabet Med 15(7):539-553
3. Arvanitakis Z, Wilson RS, Li Y, Aggarwal NT, Bennett DA (2006) Diabetes and function in different cognitive systems in older individuals without dementia. Diabetes Care 29(3):560-565
4. Biessels GJ, Staekenborg S, Brunner E, Brayne C, Scheltens P (2006) Risk of dementia in diabetes mellitus: a systematic review. Lancet Neurol 5(1):64-74
5. Bloomgarden ZT, Einhorn D (2012) Hypoglycemia in type 2 diabetes: current controversies and changing practices. Front Endocrinol (Lausanne) 3:66
6. Bruehl H, Wolf OT, Sweat V, Tirsi A, Richardson S, Convit A (2009) Modifiers of cognitive function and brain structure in middle-aged and elderly individuals with type 2 diabetes mellitus. Brain Res 1280:186-194
7. Ciammola A, Sassone J, Cannella M, Calza S, Poletti B, Frati L, Squitieri F, Silani V (2007) Low brain-derived neurotrophic factor (BDNF) levels in serum of Huntington's disease patients. Am J Med Genet B Neuropsychiatr Genet 144B(4):574-577
8. Crosby-Nwaobi R, Sivaprasad S, Forbes A (2012) A systematic review of the association of diabetic retinopathy and cognitive impairment in people with Type 2 diabetes. Diabetes Res Clin Pract 96(2):101-110
9. Diógenes MJ, Costenla AR, Lopes LV, Jerónimo-Santos A, Sousa VC, Fontinha BM, Ribeiro JA, Sebastião AM (2011) Enhancement of LTP in aged rats is dependent on endogenous BDNF. Neuropsychopharmacology 36(9):1823-1836
10. Egan MF, Kojima M, Callicott JH, Goldberg TE, Kolachana BS, Bertolino A, Zaitsev E, Gold B, Goldman D, Dean M, Lu B, Weinberger DR (2003) The BDNF val66met polymorphism affects activity-dependent secretion of BDNF and human memory and hippocampal function. Cell 112(2):257-269
11. Fujinami A, Ohta K, Obayashi H, Fukui M, Hasegawa G, Nakamura N, Kozai H, Imai S, Ohta M (2008) Serum brain-derived neurotrophic factor in patients with type 2 diabetes mellitus: Relationship to glucose metabolism and biomarkers of insulin resistance. Clin Biochem 41(10-11):812-817
12. Gobbo OL, O'Mara SM (2005) Exercise, but not environmental enrichment, improves learning after kainic acid-induced hippocampal neurodegeneration in association with an increase in brain-derived neurotrophic factor. Behav Brain Res 159(1):21-26
13. Gold SM, Dziobek I, Sweat V, Tirsi A, Rogers K, Bruehl H, Tsui W, Richardson S, Javier E, Convit A (2007) Hippocampal damage and memory impairments as possible early brain complications of type 2 diabetes. Diabetologia 50(4):711-719
14. Griffin EW, Bechara RG, Birch AM, Kelly AM (2009) Exercise enhances hippocampal-dependent learning in the rat: evidence for a BDNF-related mechanism. Hippocampus 19(10):973-980
15. Griffin EW, Mullally S, Foley C, Warmington SA, O'Mara SM, Kelly AM (2011) Aerobic exercise improves hippocampal function and increases BDNF in the serum of young adult males. Physiol Behav 104(5):934-941
16. Gross JL, de Azevedo MJ, Silveiro SP, Canani LH, Caramori ML, Zelmanovitz T (2005) Diabetic nephropathy: diagnosis, prevention, and treatment. Diabetes Care 28(1):164-176
17. Gunstad J, Benitez A, Smith J, Glickman E, Spitznagel MB, Alexander T, Juvancic-Heltzel J, Murray L (2008) Serum brain-derived neurotrophic factor is associated with cognitive function in healthy older adults. J Geriatr Psychiatry Neurol 21(3):166-170
18. Guzowski JF, Lyford GL, Stevenson GD, Houston FP, McGaugh JL, Worley PF, Barnes CA (2000) Inhibition of activity-dependent arc protein expression in the rat hippocampus impairs the maintenance of long-term potentiation and the consolidation of long-term memory. J Neurosci 20(11):3993-4001
19. Hristova M, Aloe L (2006) Metabolic syndrome - neurotrophic hypothesis. Med Hypotheses 66(3):545-549
20. Kanaya AM, Barrett-Connor E, Gildengorin G, Yaffe K (2004) Change in cognitive function by glucose tolerance status in older adults: a 4-year prospective study of the Rancho Bernando study cohort. Arch Intern Med 164(12):1327-1333
21. Karege F, Schwald M, Cisse M (2002) Postnatal developmental profile of brain-derived neurotrophic factor in rat brain and platelets. Neurosci Lett 328(3):261-264
22. Komulainen P, Pedersen M, Hänninen T, Bruunsgaard H, Lakka TA, Kivipelto M, Hassinen M, Rauramaa TH, Pedersen BK, Rauramaa R (2008) BDNF is a novel marker of cognitive function in ageing women: the DR's EXTRA Study. Neurobiol Learn Mem 90(4):596-603
23. Korte M, Griesbeck O, Gravel C, Carroll P, Staiger V, Thoenen H, Bonhoeffer T (1996) Virus-mediated gene transfer into hippocampal CA1 region restores long-term potentiation in brain-derived neurotrophic factor mutant mice. Proc Natl Acad Sci U S A 93(22):12547-12552
24. Krabbe KS, Nielsen AR, Krogh-Madsen R, Plomgaard P, Rasmussen P, Erikstrup C, Fischer CP, Lindegaard B, Petersen AM, Taudorf S, Secher NH, Pilegaard H, Bruunsgaard H, Pedersen BK (2007) Brain-derived neurotrophic factor (BDNF) and type 2 diabetes. Diabetologia 50(2):431-438
25. Lambourne K, Tomporowski P (2010) The effect of exercise-induced arousal on cognitive task performance: a meta-regression analysis. Brain Res 1341:12-24
26. Lu B, Gottschalk W (2000) Modulation of hippocampal synaptic transmission and plasticity by neurotrophins. Prog Brain Res 128:231-241
27. Lu Y, Christian K, Lu B (2008) BDNF: a key regulator for protein synthesis-dependent LTP and long-term memory? Neurobiol Learn Mem 89(3):312-323
28. Nitta A, Murai R, Suzuki N, Ito H, Nomoto H, Katoh G, Furukawa Y, Furukawa S (2002) Diabetic neuropathies in brain are induced by deficiency of BDNF. Neurotoxicol Teratol 24(5):695-701
29. Nooyens AC, Baan CA, Spijkerman AM, Verschuren WM (2010) Type 2 diabetes and cognitive decline in middle-aged men and women: the Doetinchem Cohort Study. Diabetes Care 33(9):1964-1969
30. Pan W, Banks WA, Fasold MB, Bluth J, Kastin AJ (1998) Transport of brain-derived neurotrophic factor across the blood-brain barrier. Neuropharmacology 37(12):1553-1561
31. Patterson SL, Abel T, Deuel TA, Martin KC, Rose JC, Kandel ER (1996) Recombinant BDNF rescues deficits in basal synaptic transmission and hippocampal LTP in BDNF knockout mice. Neuron 16(6):1137-1145
32. Poo MM (2001) Neurotrophins as synaptic modulators. Nat Rev Neurosci 2(1):24-32
33. Punthakee Z, Miller ME, Launer LJ, Williamson JD, Lazar RM, Cukierman-Yaffee T, Seaquist ER, Ismail-Beigi F, Sullivan MD, Lovato LC, Bergenstal RM, Gerstein HC, ACCORD Group of Investigators, ACCORD-MIND Investigators (2012) Poor cognitive function and risk of severe hypoglycemia in type 2 diabetes: post hoc epidemiologic analysis of the ACCORD trial. Diabetes Care 35(4):787-793
34. Randolph C, Tierney MC, Mohr E, Chase TN (1998) The Repeatable Battery for the Assessment of Neuropsychological Status (RBANS): preliminary clinical validity. J Clin Exp Neuropsychol 20(3):310-319
35. Sarchielli P, Greco L, Stipa A, Floridi A, Gallai V (2002) Brain-derived neurotrophic factor in patients with multiple sclerosis. J Neuroimmunol 132(1-2):180-188
36. Stewart R, Liolitsa D (1999) Type 2 diabetes mellitus, cognitive impairment and dementia. Diabet Med 16(2):93-112
37. Suwa M, Kishimoto H, Nofuji Y, Nakano H, Sasaki H, Radak Z, Kumagai S (2006) Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. Metabolism 55(7):852-857
38. Szémán B, Nagy G, Varga T, Veres-Székely A, Sasvári M, Fitala D, Szollosi A, Katonai R, Kotyuk E, Somogyi A (2012) Changes in cognitive function in patients with diabetes mellitus. Orv Hetil 153(9):323-329
39. Tyler WJ, Alonso M, Bramham CR, Pozzo-Miller LD (2002) From acquisition to consolidation: on the role of brain-derived neurotrophic factor signaling in hippocampal-dependent learning. Learn Mem 9(5):224-237
40. Wessels AM, Lane KA, Gao S, Hall KS, Unverzagt FW, Hendrie HC (2011) Diabetes and cognitive decline in elderly African Americans: a 15-year follow-up study. Alzheimers Dement 7(4):418-424
41. Xiu MH, Hui L, Dang YF, Hou TD, Zhang CX, Zheng YL, da Chen C, Kosten TR, Zhang XY (2009) Decreased serum BDNF levels in chronic institutionalized schizophrenia on long-term treatment with typical and atypical antipsychotics. Prog Neuropsychopharmacol Biol Psychiatry 33(8):1508-1512
42. Yu H, Zhang Z, Shi Y, Bai F, Xie C, Qian Y, Yuan Y, Deng L (2008) Association study of the decreased serum BDNF concentrations in amnestic mild cognitive impairment and the Val66Met polymorphism in Chinese Han. J Clin Psychiatry 69(7):1104-1111
43. Zhang BH, Tan YL, Zhang WF, Wang ZR, Yang GG, Shi C, Zhang XY, Zhou DF (2009) Repeatable Battery for the Assessment of Neuropsychological Status (RBANS) as a screening test in Chinese: reliability and validity. Chin Ment Health J 28:865-869
44. Zhao Q, Matsumoto K, Tsuneyama K, Tanaka K, Li F, Shibahara N, Miyata T, Yokozawa T (2011) Diabetes-induced central cholinergic neuronal loss and cognitive deficit are attenuated by tacrine and a Chinese herbal prescription, kangen-karyu: elucidation in type 2 diabetes db/db mice. J Pharmacol Sci 117(4):230-242