Synthesis, antimicrobial activity, and membrane permeabilizing properties of C-terminally modified nisin conjugates accessed by CuAAC

Bioconjugate Chemistry

Volumn 24, Issue 12, 2013, Pages 2058-2066

  Slootweg, Jack C ^a   Van Der Wal, Steffen ^a   Quarles Van Ufford, H C ^a   Breukink, Eefjan ^b   Liskamp, Rob M J ^a,c   Rijkers, Dirk T S ^a  

^a UTRECHT UNIVERSITY   (Netherlands)

^b UTRECHT UNIVERSITY   (Netherlands)

^c UNIVERSITY OF GLASGOW   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

BIOACTIVITY; COPPER COMPOUNDS; CYCLOADDITION; MICROORGANISMS; MOLECULES; PEPTIDES;

ANTI-MICROBIAL ACTIVITY; ANTIMICROBIAL PEPTIDE; FLUORESCENT REPORTER; FUNCTIONALIZATIONS; LANTIBIOTICS; MODE OF ACTION; MULTIMERIZATION; PROPERTY; REPORTER MOLECULES; TERMINAL MODIFICATIONS;

ANTIBIOTICS;

ALKYNE DERIVATIVE; AZIDE; CARBOXYFLUORESCEIN; CUPROUS ION; DANSYL CHLORIDE; DIMER; NISIN; NISIN ALKYNE; NISIN DANSYL; NISIN DIMER; NISSIN CARBOXYFLUORESCEIN; O (3 AMINOPROPYL) O' (N BOC AMINOPROPYL)DIETHYLENE GLYCOL; O (3 AZIDOPROPYL) O' (AMINOPROPYL)DIETHYLENE GLYCOL HYDROCHLORIDE; O (3 AZIDOPROPYL) O' (N BOC AMINOPROPYL)DIETHYLENE GLYCOL; O (3 AZIDOPROPYL) O' (N DANSYL AMINOPROPYL)DIETHYLENE GLYCOL; O (3 AZIDOPROPYL) O' [N [5(6) CARBOXYFLUORESCEINYL]AMINOPROPYL]DIETHYLENE GLYCOL; O,O BIS(3 AMINOPROPYL)DIETHYLENE GLYCOL; O,O BIS(3 AZIDOPROPYL)DIETHYLENE GLYCOL; UNCLASSIFIED DRUG;

ANTIBACTERIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; BACTERIAL GROWTH; BROTH DILUTION; CATALYSIS; CLICK CHEMISTRY; COLONY FORMING UNIT; CYCLOADDITION; DRUG CONJUGATION; DRUG SYNTHESIS; GROWTH INHIBITION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; MEMBRANE PERMEABILITY; MICROWAVE IRRADIATION; MINIMUM BACTERICIDAL CONCENTRATION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; STAPHYLOCOCCUS AUREUS; STEREOSPECIFICITY;

BACTERIA (MICROORGANISMS);

ALKYNES; ANTI-INFECTIVE AGENTS; AZIDES; BACILLUS SUBTILIS; CATALYSIS; CELL MEMBRANE PERMEABILITY; CHEMISTRY TECHNIQUES, SYNTHETIC; COPPER; DIMERIZATION; MICROBIAL SENSITIVITY TESTS; MODELS, MOLECULAR; MOLECULAR CONFORMATION; NISIN; STAPHYLOCOCCUS AUREUS;

EID: 84890834216     PISSN: 10431802     EISSN: 15204812     Source Type: Journal    
DOI: 10.1021/bc400401k     Document Type: Article

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