DDT induces apoptosis in human mononuclear cells in vitro and is associated with increased apoptosis in exposed children

Environmental Research

Volumn 94, Issue 1, 2004, Pages 38-46

  Pérez Maldonado, Iván N ^a   Díaz Barriga, Fernando ^a   De La Fuente, Hortensia ^a   González Amaro, Roberto ^a   Calderón, Jaqueline ^a   Yáñez, Leticia ^b  

^a UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

^b UNIVERSIDAD AUTÓNOMA DE SAN LUIS POTOSÍ   (Mexico)

Author keywords

Apoptosis; Children; DDE; DDT; Malaria

Indexed keywords

1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHANE; 1,1 DICHLORO 2,2 BIS(4 CHLOROPHENYL)ETHYLENE; CHLORPHENOTANE; DNA;

CHILD; DDT; HEALTH IMPACT; PESTICIDE; POLLUTION EXPOSURE;

ADULT; APOPTOSIS; ARTICLE; BLOOD LEVEL; CELL ISOLATION; CHILD; CONCENTRATION RESPONSE; CONTROLLED STUDY; CYTOPATHOGENIC EFFECT; DNA CONTENT; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENOTOXICITY; HUMAN; INCUBATION TIME; MONONUCLEAR CELL; NICK END LABELING; NORMAL HUMAN; PRIORITY JOURNAL;

EID: 0344982948     PISSN: 00139351     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0013-9351(03)00112-9     Document Type: Article

References (33)

1. Alison M.R., Sarraf C.E. Apoptosis. regulation and relevance to toxicology Hum. Exp. Toxicol. 14:1995;355-362.
2. ATSDR, 2002. Toxicological profile for DDT/DDD/DDE. Agency for Toxic Substances and Diseases Registry. US Public Health Service, Atlanta, Georgia.
3. Banerjee B.D. Effects of sub-chronic DDT exposure on humoral and cell-mediated immune responses in albino rats. Bull. Environ. Contam. Toxicol. 39:1987;827-834.
4. Banerjee B.D. The influence of various factors on immune toxicity assessment of pesticide chemicals. Toxicol. Lett. 107:1999;21-31.
5. Banerjee B.D., Ray A., Pasha S.T. A comparative evaluation of immunotoxicity of DDT and its metabolites in rats. Indian J. Exp. Biol. 34:1996;517-522.
6. Banerjee B.D., Koner B.C., Ray A. Influence of stress on DDT-induced humoral immune responsiveness in mice. Environ. Res. 74:1997;127-131.
7. Banerjee B.D., Koner B.C., Pasha S.T. Influence of DDT exposure on susceptibility to human leprosy bacilli in mice. Int. J. Lepr. Mycobact. Dis. 65:1997;97-99.
8. Belles-Isles M., Ayotte P., Dewailly E., Weber J.P., Roy R. Cord blood lymphocyte functions in newborns from a remote maritime population exposed to organochlorines and methylmercury. J. Toxicol. Environ. Health A. 65:2002;165-182.
9. Chang W.K., Yang K.D., Chuang H., Jan J.T., Shaio M.F. Glutamine protects activated human T cells from apoptosis by up-regulating glutathione and Bcl-2 levels. Clin. Immunol. 104:2002;151-160.
10. Chen Y.C., Lin-Shiau S.Y., Lin J.K. Involvement of reactive oxygen species and caspase 3 activation in arsenite-induced apoptosis. J. Cell Physiol. 177:1998;324-333.
11. De la Fuente H., Portales-Pérez D.P., Baranda L., Diaz-Barriga F., Saavedra-Alanís V., Layseca E., González-Amaro R. Effect of arsenic, cadmium and lead on the induction of apoptosis of normal human mononuclear cells. Clin. Exp. Immunol. 129:2002;69-77.
12. Dewailly E., Ayotte P., Bruneau S., Gingras S., Belles-Isles M., Roy R. Susceptibility to infections and immune status in Inuit infants exposed to organochlorines. Environ. Health Perspect. 108:2000;205-211.
13. Díaz-Barriga F., Borja-Aburto V., Waliszewski S.M., Yáñez L. DDT in Mexico. Fiedler H. The Handbook of Environmental Chemistry Part O Persistant Organic Pollutants. Vol. 3:2002;371-388 Springer, Berlin, Heidelberg.
14. Franek F., Sramkova K. Protection of B lymphocyte hybridoma against starvation-induced apoptosis. survival-signal role of some amino acids Immunol. Lett. 52:1996;139-144.
15. Froelich C.J., Orth K., Turbov J., Seth P., Gottlieb R., Babior B., Shah G.M., Bleackley R.C., Dixit V.M., Hanna W. New paradigm for lymphocyte granule-mediated cytotoxicity. J. Biol. Chem. 271:1996;29073-29079.
16. Gougeon M.L., Lecoeur H., Dulioust A. Programmed cell death in peripheral lympocytes from HIV-infected persons. J. Immunol. 156:1996;3509-3520.
17. Greenlee A.R., Quail C.A., Berg R.L. Development alteration in murine embryos exposed in vitro to an estrogenic pesticide, o′p-DDT. Reprod. Toxicol. 13:1999;555-565.
18. Greenlee A.R., Quail C.A., Berg R.L. The antiestrogen ICI 182,780 abolishes developmental injury for murine embryos exposed in vitro to o,p′-DDT. Reprod. Toxicol. 14:2000;225-234.
19. Guardino X., Serra C., Obiols J., Rosell M.G., Berenguer M.J., Lopez F., Brosa J. Determination of DDT and related compounds in blood samples from agricultural workers. J. Chromatogr. A. 719:1996;141-147.
20. Ioulia B.E., Sergei V.Z., Boris Z., Martin K., Suad E., Sten O., Per-Olof B. Glucose and tolbutamide induce apoptosis in pancreatic β-cells. J. Biol. Chem. 273:1998;33501-33507.
21. Planche T., Dzeing A., Emmerson A.C., Onanga M., Kremsner P.G., Engel K., Kombila M., Ngou-Milama E., Krishna S. Plasma glutamine and glutamate concentrations in Gabonese children with Plasmodium falciparum infection. QJM. 95:2002;89-97.
22. Roan C., Morgan D., Paschal E.H. Urinary excretion of DDA following ingestion of DDT and DDT metabolites in man. Arch. Environ. Health. 22:1971;309-315.
23. Rodgers K. The immunotoxicity of pesticides in rodents. Hum. Exp. Toxicol. 14:1995;111-113.
24. Simbulan-Rosenthal S., Rosenthal D.S., Iyer S., Boulares A.H., Smulson M.E. Transient poly(ADP-ribosyl)ation of nuclear proteins and role of poly(ADP-ribose) polymerase in the early stages of apoptosis. J. Biol. Chem. 273:1998;13703-13712.
25. Stapleton D.H. The dawn of DDT and its experimental use by the Rockefeller foundation in Mexico, 1943-1952. Parassitologia. 40:1998;149-158.
26. Teoburi O., Rhouma K.B., Sakli M. DDT induces apoptosis in rat thymocytes. Bull. Environ. Contam. Toxicol. 61:1998;216-223.
27. Thompson C.B. Apoptosis in the pathogenesis and treatment of disease. Science. 267:1995;1456-1462.
28. Villalpando S., Butte N.F., Flores-Huerta S., Thotathuchery M. Qualitative analysis of human milk produced by women consuming a maize-predominant diet typical of rural Mexico. Ann. Nutr. Metab. 42:1998;23-32.
29. Vine M.F., Stein L., Weigle K., Schroeder J., Degnan D., Tse C.K.J., Backer L. Plasma 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) levels and immune response. Am. J. Epidemiol. 153:2001;53-63.
30. Waliszewski S.M., Aguirre A.A., Infanzon R.M., Benitez A., Rivera J. Comparison of organochlorine pesticide levels in adipose tissue and human milk of mothers living in Veracruz, Mexico. Bull. Environ. Contam. Toxicol. 62:1999;685-690.
31. Waliszewski S.M., Aguirre A.A., Infanzon R.M. Levels of organochlorine pesticides in blood serum and umbilical blood serum of mothers living in Veracruz, Mexico. Fresenius Environ. Bull. 8:1999;171-178.
32. Yáñez L., Ortiz-Pérez D., Batres L.E., Borja-Aburto V.H., Díaz-Barriga F. Levels of dichlorodiphenyltrichloroethane and deltamethrin in humans and environmental samples in malarious areas of Mexico. Environ. Res. 88:2002;174-181.
33. Yoshimura S., Banno Y., Nakashima S., Takenaka K., Sakai H., Nishimura Y., Sakai N., Shimizu S., Eguchi Y., Tsujimoto Y., Nozawa Y. Ceramide formation leads to caspase-3 activation during hypoxic PC12 cell death. J. Biol. Chem. 273:1998;6921-6927.