Reactive oxygen species from the uncoupling of human cytochrome P450 1B1 may contribute to the carcinogenicity of dioxin-like polychlorinated biphenyls

Mutagenesis

Volumn 23, Issue 6, 2008, Pages 457-463

  Green, Richard M ^a   Hodges, Nikolas J ^a   Chipman, J Kevin ^a   O'Donovan, Michael R ^b   Graham, Mark ^b  

^a UNIVERSITY OF BIRMINGHAM   (United Kingdom)

^b ASTRAZENECA   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

2,3,7,8 TETRACHLORODIBENZO PARA DIOXIN; 3,3',4,4' TETRACHLOROBIPHENYL; 3,3',4,4',4,4' HEXACHLOROBIPHENYL; 3,3',4,4',5 PENTACHLOROBIPHENYL; BIPHENYL DERIVATIVE; CYTOCHROME P450 1A1; CYTOCHROME P450 1B1; POLYCHLORINATED BIPHENYL; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER RISK; CARCINOGENESIS; CARCINOGENICITY; DNA DAMAGE; ENZYME ACTIVITY; ENZYME INHIBITION; GENOTOXICITY; HAMSTER; LIPID PEROXIDATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL;

ANIMALS; ARYL HYDROCARBON HYDROXYLASES; CARCINOGENICITY TESTS; CELL LINE; CRICETINAE; DIOXINS; ENVIRONMENTAL POLLUTANTS; HUMANS; LIPID PEROXIDATION; OXIDATIVE STRESS; POLYCHLORINATED BIPHENYLS; REACTIVE OXYGEN SPECIES;

EID: 55349114755     PISSN: 02678357     EISSN: 14643804     Source Type: Journal    
DOI: 10.1093/mutage/gen035     Document Type: Article

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