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Volumn 27, Issue 10, 2011, Pages 914-922

Influence of N-acetylcysteine against dimethylnitrosamine induced hepatotoxicity in rats

Author keywords

Dimethylnitrosamine; hepatotoxicity; lipid peroxidation; N acetylcysteine; oxidative stress.

Indexed keywords

ACETYLCYSTEINE; ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; ALPHA TOCOPHEROL; ASCORBIC ACID; ASPARTATE AMINOTRANSFERASE; CATALASE; DIMETHYLNITROSAMINE; GAMMA GLUTAMYLTRANSFERASE; LACTATE DEHYDROGENASE; SUPEROXIDE DISMUTASE;

EID: 81255189019     PISSN: 07482337     EISSN: 14770393     Source Type: Journal    
DOI: 10.1177/0748233711399323     Document Type: Article
Times cited : (14)

References (46)
  • 1
    • 81255141600 scopus 로고
    • US Public Health Service. in collaboration with US Environmental Protection Agency (EPA)
    • US Public Health Service. In collaboration with US Environmental Protection Agency (EPA). Toxicological profile for N-nitrosodimethylamine. 1989 ;: 1-119
    • (1989) Toxicological Profile for N-nitrosodimethylamine , pp. 1-119
  • 2
    • 0024501654 scopus 로고
    • Preventive effect of malotilate on dimethylnitrosamine induced liver fibrosis in the rat
    • Ala-Kokko L, Stenback F, Ryhanen L. Preventive effect of malotilate on dimethylnitrosamine induced liver fibrosis in the rat. The Journal of Laboratory Clinical Medicine. 1989 ; 113: 177-18
    • (1989) The Journal of Laboratory Clinical Medicine , vol.113 , pp. 177-18
    • Ala-Kokko, L.1    Stenback, F.2    Ryhanen, L.3
  • 3
    • 0024394697 scopus 로고
    • The antioxidant action of N-acetylcysteine: Its reaction with hydrogen peroxide, hydroxyl radical, superoxide, and hypochlorous acid
    • DOI 10.1016/0891-5849(89)90066-X
    • Aruoma OI, Halliwell B. The antioxidant action of N-acetylcysteine: its reaction with hydrogen peroxide, hydroxyl radical, superoxide and hypochlorous acid. Free Radical Biology and Medicine. 1989 ; 6: 593-597 (Pubitemid 19147809)
    • (1989) Free Radical Biology and Medicine , vol.6 , Issue.6 , pp. 593-597
    • Aruoma, O.I.1    Halliwell, B.2    Hoey, B.M.3    Butler, J.4
  • 5
    • 33746004980 scopus 로고    scopus 로고
    • The protein fraction of Phyllanthus niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties
    • DOI 10.1002/ptr.1933
    • Bhattacharjee R, Sil PC. The protein fraction of Phyllanthus Niruri plays a protective role against acetaminophen induced hepatic disorder via its antioxidant properties. Phytotheraphy Research. 2006 ; 20: 595-601 (Pubitemid 44065144)
    • (2006) Phytotherapy Research , vol.20 , Issue.7 , pp. 595-601
    • Bhattacharjee, R.1    Sil, P.C.2
  • 6
    • 0027251053 scopus 로고
    • The pecking order of free radicals and antioxidants: Lipid peroxidation, α-tocopherol, and ascorbate
    • DOI 10.1006/abbi.1993.1074
    • Buettner GR. The pecking order of free radicals and antioxidants: lipid peroxidation, α-tocopherol, and ascorbate. Archives of Biochemistry and Biophysics. 1993 ; 300: 535-543 (Pubitemid 23232908)
    • (1993) Archives of Biochemistry and Biophysics , vol.300 , Issue.2 , pp. 535-543
    • Buettner, G.R.1
  • 7
    • 0034958078 scopus 로고    scopus 로고
    • Effects of aminoguanidine and desferrioxamine on some vascular and biochemical changes associated with streptozotocin-induced hyperglycaemia in rats
    • DOI 10.1006/phrs.2000.0772
    • El-Khatib S, Moustafa AM, Hamid AA, Al-Shabanah OA, El-Khassef HA. Effect of aminoguanidine and desferrioxamine on some biochemical changes associated with streptozotocin induced hyperglycemia in rats. Pharmacological Research. 2001 ; 43: 233-240 (Pubitemid 32601429)
    • (2001) Pharmacological Research , vol.43 , Issue.3 , pp. 233-240
    • El-Khatib, A.S.1    Moustafa, A.M.2    Abdel-Aziz, A.-A.H.3    Al-Shabanah, O.A.4    El-Kashef, H.A.5
  • 8
    • 58149460655 scopus 로고    scopus 로고
    • Kolaviron inhibits dimethylnitrosamine induced liver injury by suppressing COX-2 and iNOS expression via NF-κB and AP-1
    • Farombi EO, Shrotriya S, Surh YJ. Kolaviron inhibits dimethylnitrosamine induced liver injury by suppressing COX-2 and iNOS expression via NF-κB and AP-1. Life Sciences. 2009 ; 84: 149-155
    • (2009) Life Sciences , vol.84 , pp. 149-155
    • Farombi, E.O.1    Shrotriya, S.2    Surh, Y.J.3
  • 10
    • 79551592262 scopus 로고    scopus 로고
    • N-acetylcysteine reverses cirrhosis induced by CCl4 in the rat
    • Galicia M, Aldaba LR, Muriel P. N-acetylcysteine reverses cirrhosis induced by CCl4 in the rat.. Journal of Hepatology. 2010 ; 52: S206
    • (2010) Journal of Hepatology , vol.52 , pp. 206
    • Galicia, M.1    Aldaba, L.R.2    Muriel, P.3
  • 11
    • 0344413735 scopus 로고    scopus 로고
    • Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats
    • DOI 10.1016/S1357-2725(03)00253-X
    • George J, Tsutsumi M, Takase S. Expression of hyaluronic acid in N-nitrosodimethylamine induced hepatic fibrosis in rats. The International Journal of Biochemistry and Cell Biology. 2004 ; 36: 307-319 (Pubitemid 37487765)
    • (2004) International Journal of Biochemistry and Cell Biology , vol.36 , Issue.2 , pp. 307-319
    • George, J.1    Tsutsumi, M.2    Takase, S.3
  • 12
    • 0025316879 scopus 로고
    • Role of metabolism in dimethylnitrosamine-induced immunosuppression: A review
    • DOI 10.1016/0300-483X(90)90064-N
    • Haggerty HG, Holsapple MP. Role of metabolism in dimethylnitrosamine induced immunosupression: a review. Toxicology. 1990 ; 63: 1-23 (Pubitemid 20223221)
    • (1990) Toxicology , vol.63 , Issue.1 , pp. 1-23
    • Haggerty, H.G.1    Holsapple, M.P.2
  • 14
    • 34447096863 scopus 로고    scopus 로고
    • Hepatic and renal concentrations of vitamins E and C in lead- and ethanol-exposed rats. An assessment of their involvement in the mechanisms of peroxidative damage
    • DOI 10.1016/j.fct.2007.02.007, PII S027869150700066X
    • Jurczuk M, Moniuszko-Jakoniuk J, Brzóska MM. Hepatic and renal concentrations of vitamins E and C in lead and ethanol exposed rats. An assessment of their involvement in the mechanisms of peroxidative damage. Food and Chemical Toxicology. 2007 ; 45: 1478-1486 (Pubitemid 47031392)
    • (2007) Food and Chemical Toxicology , vol.45 , Issue.8 , pp. 1478-1486
    • Jurczuk, M.1    Brzoska, M.M.2    Moniuszko-Jakoniuk, J.3
  • 16
    • 0002794972 scopus 로고
    • The phosphohydrolases-acid and alkaline phosphatases
    • King J. The phosphohydrolases-acid and alkaline phosphatases. Practical Clinical Enzymology. 1965a ;: 191-208
    • (1965) Practical Clinical Enzymology , pp. 191-208
    • King, J.1
  • 20
    • 0016272750 scopus 로고
    • Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase
    • Marklund S, Marklund G. Involvement of the superoxide anion radical in the autooxidation of pyrogallol and a convenient assay for superoxide dismutase. European Journal of Biochemistry. 1974 ; 47: 469-474
    • (1974) European Journal of Biochemistry , vol.47 , pp. 469-474
    • Marklund, S.1    Marklund, G.2
  • 21
    • 33846345425 scopus 로고    scopus 로고
    • Protective effect of silymarin on oxidative stress in rat brain
    • DOI 10.1016/j.phymed.2006.02.005, PII S0944711306000419
    • Nencini C, Giorgi G, Micheli L. Protective effect of silymarin on oxidative stress in rat brain. Phytomedicine. 2007 ; 14: 129-135 (Pubitemid 46136941)
    • (2007) Phytomedicine , vol.14 , Issue.2-3 , pp. 129-135
    • Nencini, C.1    Giorgi, G.2    Micheli, L.3
  • 22
    • 0017169161 scopus 로고
    • Physicochemical alterations in the conformation of rat liver chromatin induced by carcinogens in vivo
    • Nicolini C, Ramanathan R, Kendall F, Murphy J, Parodi S, Sarma DSR. Physicochemical alterations in the conformation of rat liver chromatin induced by carcinogens in vivo. Cancer Research. 1976 ; 36: 1725-1730
    • (1976) Cancer Research , vol.36 , pp. 1725-1730
    • Nicolini, C.1    Ramanathan, R.2    Kendall, F.3    Murphy, J.4    Parodi, S.5    Sarma, D.S.R.6
  • 23
    • 8844226799 scopus 로고    scopus 로고
    • The effect of N-acetylcysteine on oxidative stress in intestine and bacterial translocation after thermal injury
    • DOI 10.1016/j.burns.2004.05.006, PII S0305417904001330
    • Ocal K, Avlan D, Cinel I, et al. N-acetylcysteine on oxidative stress in intestine and bacterial translocation after thermal injury. Burns. 2004 ; 30: 778-784 (Pubitemid 39536043)
    • (2004) Burns , vol.30 , Issue.8 , pp. 778-784
    • Ocal, K.1    Avlan, D.2    Cinel, I.3    Unlu, A.4    Ozturk, C.5    Yaylak, F.6    Dirlik, M.7    Camdeviren, H.8    Aydin, S.9
  • 24
    • 0018384650 scopus 로고
    • Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction
    • DOI 10.1016/0003-2697(79)90738-3
    • Ohkawa H, Ohishi N, Yagi K. Assay for lipid peroxides in animal tissues by thiobarbituric acid reaction. Analytical Biochemistry. 1979 ; 95: 351-358 (Pubitemid 9194347)
    • (1979) Analytical Biochemistry , vol.95 , Issue.2 , pp. 351-358
    • Ohkawa, H.1    Ohishi, N.2    Yagi, K.3
  • 25
    • 0018369625 scopus 로고
    • Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids
    • Omaye ST, Turnbull JD, Sauberlich HE. Selected methods for the determination of ascorbic acid in animal cells, tissues and fluids. Methods in Enzymology. 1979 ; 62: 1-11
    • (1979) Methods in Enzymology , vol.62 , pp. 1-11
    • Omaye, S.T.1    Turnbull, J.D.2    Sauberlich, H.E.3
  • 27
    • 33847368051 scopus 로고    scopus 로고
    • Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats
    • DOI 10.1016/j.ejphar.2006.12.023, PII S001429990700043X
    • Pradeep K, Victor Raj Mohan C, Gobianand K, Karthikeyan S. Silymarin modulates the oxidant-antioxidant imbalance during diethylnitrosamine induced oxidative stress in rats. European Journal of Pharmacology. 2007 ; 560: 110-116 (Pubitemid 46341309)
    • (2007) European Journal of Pharmacology , vol.560 , Issue.2-3 , pp. 110-116
    • Pradeep, K.1    Mohan, C.V.R.2    Gobianand, K.3    Karthikeyan, S.4
  • 28
    • 7444227560 scopus 로고    scopus 로고
    • Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride-induced peroxidative damage
    • Rajesh MG, Latha MS. Protective activity of Glycyrrhiza glabra Linn. on carbon tetrachloride induced peroxidative damage. Indian Journal of Pharmacology. 2004 ; 36: 284-287 (Pubitemid 39440037)
    • (2004) Indian Journal of Pharmacology , vol.36 , Issue.5 , pp. 284-287
    • Rajesh, M.G.1    Latha, M.S.2
  • 29
    • 0037398812 scopus 로고    scopus 로고
    • A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine
    • DOI 10.1016/S1532-0456(03)00022-X, PII S153204560300022X
    • Raza M, Ahmad M, Gado A, Al-Shabanah OA. A comparison of hepatoprotective activities of aminoguanidine and N-acetylcysteine in rat against the toxic damage induced by azathioprine. Comparative Biochemistry and Physiology. 2003 ; 134: 451-456 (Pubitemid 36514994)
    • (2003) Comparative Biochemistry and Physiology - C Toxicology and Pharmacology , vol.134 , Issue.4 , pp. 451-456
    • Raza, M.1    Ahmad, M.2    Gado, A.3    Al-Shabanah, O.A.4
  • 30
    • 66349129125 scopus 로고
    • A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases
    • Reitman S, Frankel S. A colorimetric method for the determination of serum glutamic oxalacetic and glutamic pyruvic transaminases. American Journal of Clinical Pathology. 1957 ; 28: 56-63
    • (1957) American Journal of Clinical Pathology , vol.28 , pp. 56-63
    • Reitman, S.1    Frankel, S.2
  • 32
    • 0015354234 scopus 로고
    • Serum γ-glutamyl transpeptidase activity in alcoholism
    • Rosalki SB, Rau D. Serum γ-glutamyl transpeptidase activity in alcoholism. Clinical Chimical Acta. 1972 ; 39: 41-47
    • (1972) Clinical Chimical Acta , vol.39 , pp. 41-47
    • Rosalki, S.B.1    Rau, D.2
  • 33
    • 33750484015 scopus 로고    scopus 로고
    • Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Discordant in vitro and in vivo dose-effects: A review
    • DOI 10.1016/j.pupt.2005.12.007, PII S1094553905001860
    • Sadowska AM, Keenoy BM, De Backer WA. Antioxidant and anti-inflammatory efficacy of NAC in the treatment of COPD: Dicordant in vitro and in vivo dose effects: A review. Pulmonary Pharmacology and Therapeutics. 2007 ; 20: 9-22 (Pubitemid 44648802)
    • (2007) Pulmonary Pharmacology and Therapeutics , vol.20 , Issue.1 , pp. 9-22
    • Sadowska, A.M.1    Manuel-y-Keenoy, B.2    De Backer, W.A.3
  • 34
    • 0015353270 scopus 로고
    • Colorimetric assay of catalase
    • Sinha AK. Colorimetric assay of catalase. Analytical Biochemistry. 1972 ; 47: 389-394
    • (1972) Analytical Biochemistry , vol.47 , pp. 389-394
    • Sinha, A.K.1
  • 35
    • 77952320210 scopus 로고    scopus 로고
    • Metabonomics study of the protective effects of Lonicera japonica extract on acute liver injury in dimethylnitrosamine treated rats
    • Sun C, Teng Y, Li G, et al. Metabonomics study of the protective effects of Lonicera japonica extract on acute liver injury in dimethylnitrosamine treated rats. Journal of Pharmaceutical and Biomedical Analysis. 2010 ; 53: 98-102
    • (2010) Journal of Pharmaceutical and Biomedical Analysis , vol.53 , pp. 98-102
    • Sun, C.1    Teng, Y.2    Li, G.3
  • 36
    • 73049126575 scopus 로고
    • Activity of serum gamma glutamyl transpeptidase as a new enzymic test in liver diseases. Comparisons with other enzymic test
    • Szczeklik E, Orlowski M, Szewczuk A. Activity of serum gamma glutamyl transpeptidase as a new enzymic test in liver diseases. Comparisons with other enzymic test. Polski Tygodnik Lekarski. 1961 ; 16: 503-510
    • (1961) Polski Tygodnik Lekarski , vol.16 , pp. 503-510
    • Szczeklik, E.1    Orlowski, M.2    Szewczuk, A.3
  • 39
    • 34249868200 scopus 로고    scopus 로고
    • Vitamin E, antioxidant and nothing more
    • DOI 10.1016/j.freeradbiomed.2007.03.024, PII S0891584907002195
    • Traber MG, Atkinson J. Vitamin E, antioxidant and nothing more. Free Radical Biology and Medicine. 2007 ; 43: 4-15 (Pubitemid 46874839)
    • (2007) Free Radical Biology and Medicine , vol.43 , Issue.1 , pp. 4-15
    • Traber, M.G.1    Atkinson, J.2
  • 40
    • 0000256716 scopus 로고
    • 1976) Hormones, vitamins, drugs and poisons. In: VarleyHGowenlockAHBellM (eds) Practical Clinical Biochemistry. Vol-II, 5th ed. London: William Heinemann Medical Books Ltd, 222-223. Varley H Gowenlock AH Bell M, ed. London: William Heinemann Medical Books Ltd
    • Varley H, Gowenlock AH, Bell M Practical Clinical Biochemistry. 1976 ) Hormones, vitamins, drugs and poisons. In: VarleyHGowenlockAHBellM (eds) Practical Clinical Biochemistry. Vol-II, 5th ed. London: William Heinemann Medical Books Ltd, 222-223. Varley H Gowenlock AH Bell M, ed. London: William Heinemann Medical Books Ltd ; 1976: 222-223.
    • (1976) Practical Clinical Biochemistry , pp. 222-223
    • Varley, H.1    Gowenlock, A.H.2    Bell, M.3
  • 41
    • 33747602149 scopus 로고    scopus 로고
    • 2001) Text Book of Biochemistry for Medical Students. 3rd ed. New Delhi: Japee Brothers Publishers (P) Ltd. New Delhi: Japee Brothers Publishers (P) Ltd
    • Vasudevan DM, Sreekumari S Text Book of Biochemistry for Medical Students. 2001 ) Text Book of Biochemistry for Medical Students. 3rd ed.. New Delhi: Japee Brothers Publishers (P) Ltd. New Delhi: Japee Brothers Publishers (P) Ltd ; 2001 :
    • (2001) Text Book of Biochemistry for Medical Students
    • Vasudevan, D.M.1    Sreekumari, S.2
  • 42
    • 73749084035 scopus 로고    scopus 로고
    • Antifibrotic effects of CGX, a traditional herbal formula, and its mechanisms in rats
    • Wang JH, Shin JW, Son JY, Cho JY, Son CG. Antifibrotic effects of CGX, a traditional herbal formula, and its mechanisms in rats. Journal of Ethanopharmacology. 2010 ; 127: 534-542
    • (2010) Journal of Ethanopharmacology , vol.127 , pp. 534-542
    • Wang, J.H.1    Shin, J.W.2    Son, J.Y.3    Cho, J.Y.4    Son, C.G.5
  • 43
    • 0025167020 scopus 로고
    • Cytochrome P450IIE1: Roles in nitrosamine metabolism and mechanisms of regulation
    • Yang CS, Yoo JSH, Ishizaki H, Hong J. Cytochrome P-450IIE1: role in nitrosamine metabolism and mechanisms of regulation. Drug Metabolism Reviews. 1990 ; 22: 147-159 (Pubitemid 20283477)
    • (1990) Drug Metabolism Reviews , vol.22 , Issue.2-3 , pp. 147-159
    • Yang, C.S.1    Yoo, J.-S.H.2    Ishizaki, H.3    Hong, J.4


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