Protective mechanisms of N-acetyl-cysteine against pyrrolizidine alkaloid clivorine-induced hepatotoxicity

Journal of Cellular Biochemistry

Volumn 108, Issue 2, 2009, Pages 424-432

  Ji, Lili ^a,b   Liu, Tianyu ^a   Chen, Ying ^a   Wang, Zhengtao ^a,b  

^a SHANGHAI UNIVERSITY OF TRADITIONAL CHINESE MEDICINE   (China)

^b Shanghai R and D Centre for Standardization of Chinese Medicines   (China)

Author keywords

Apoptosis; Caspase; clivorine; GSH; NAC; Pyrrolizidine alkaloids; Thioredoxin

Indexed keywords

ACETYLCYSTEINE; CASPASE 3; CASPASE 9; CELL DNA; CLIVORINE; CYTOCHROME C; GLUTATHIONE; GLUTATHIONE DISULFIDE; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; THIOREDOXIN 1;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CYTOTOXICITY; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME RELEASE; HUMAN; HUMAN CELL; LIVER PROTECTION; LIVER TOXICITY; PRIORITY JOURNAL; PROTEIN DETERMINATION; WESTERN BLOTTING;

ACETYLCYSTEINE; APOPTOSIS; BCL-X PROTEIN; CASPASE 3; CASPASE 9; CELL LINE; CELL SURVIVAL; CYTOCHROMES C; CYTOTOXINS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG-INDUCED LIVER INJURY; ENZYME ACTIVATION; GLUTATHIONE; GLUTATHIONE PEROXIDASE; GLUTATHIONE SYNTHASE; GLUTATHIONE TRANSFERASE; HEPATOCYTES; HUMANS; PYRROLIZIDINE ALKALOIDS; REACTIVE OXYGEN SPECIES; THIOREDOXINS;

LIGULARIA HODGSONII;

EID: 70349255591     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22269     Document Type: Article

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