DDT and malaria prevention: Addressing the paradox

Environmental Health Perspectives

Volumn 119, Issue 6, 2011, Pages 744-747

  Bouwman, Hindrik ^a   van den Berg, Henk ^b   Kylin, Henrik ^c  

^a NORTH WEST UNIVERSITY   (South Africa)

^b WAGENINGEN UNIVERSITY   (Netherlands)

^c LINKÖPING UNIVERSITY   (Sweden)

Author keywords

Effects; Health; Indoor residual spraying; Malaria vector management; Precaution

Indexed keywords

CHLORPHENOTANE;

ADVERSE OUTCOME; ARTICLE; ENDOCRINE DISEASE; ENVIRONMENTAL EXPOSURE; ENVIRONMENTAL HEALTH; HEALTH HAZARD; HUMAN; INDOOR RESIDUAL SPRAYING; INSECTICIDAL ACTIVITY; MALARIA; MALARIA CONTROL; MOSQUITO; NONHUMAN; OOCYTE DEVELOPMENT; OVARY DISEASE; PARASITE TRANSMISSION; PESTICIDE SPRAYING; PRIORITY JOURNAL; PRODUCT SAFETY; PUBLIC HEALTH; RISK ASSESSMENT; RISK BENEFIT ANALYSIS; RISK REDUCTION; SEMINIFEROUS TUBULE; SKELETON MALFORMATION; SURVIVAL TIME; UROGENITAL TRACT MALFORMATION;

DDT; ENVIRONMENTAL EXPOSURE; HUMANS; INSECTICIDES; MALARIA; MOSQUITO CONTROL; PUBLIC HEALTH; RISK ASSESSMENT;

EID: 79958858355     PISSN: 00916765     EISSN: 15529924     Source Type: Journal    
DOI: 10.1289/ehp.1002127     Document Type: Article

References (47)

1. Africa Fighting Malaria. 2010. Africa Fighting Malaria. Indoor Residual Spraying and DDT. Available: http://www.fightingmalaria.org/pdfs/Africa%20Fighting%20Malaria% 20IRS%20DDT%20issues.pdf [accessed 22 February 2010].
2. Barnhoorn IEJ, Bornman MS, Jansen van Rensburg C, Bouwman H. 2009. DDT residues in water, sediment, domestic and indigenous biota from a currently DDT-sprayed area. Chemosphere 77:1236-1241.
3. Barnhoorn IEJ, van Dyk JC, Pieterse GM, Bornman MS. 2010. Intersex in feral indigenous freshwater Oreochromis mossambicus, from various parts of the Luvuvhu River, Limpopo Province, South Africa. Ecotoxicol Environ Saf 73:1537-1542.
4. Bimenya GS, Harabulema M, Okot JP, Francis O, Lugemwa M, Okwi AL. 2010. Plasma levels of DDT/DDE and liver function in malaria control personnel 6 months after indoor residual spraying with DDT in Uganda, 2008. S Afr Med J 100:118-121.
5. Blair A, Saracci R, Vineis P, Cocco P, Forastiere F, Grandjean P, et al. 2009. Epidemiology, public health, and the rhetoric of false positives. Environ Health Perspect 117:1809-1813.
6. Bornman MS, de Jager C, Worku Z, Farias P, Reif S. 2010. DDT and urogenital malformations in newborn boys in a malaria area. BJU Int 106:405-411.
7. Bouwman H, Cooppan RM, Botha MJ, Becker PJ. 1991. Serum levels of DDT and liver function of malaria control personnel. S Afr Med J 79:362-329.
8. Bouwman H, Cooppan RM, Reinecke AJ, Becker PJ. 1990. Levels of DDT and metabolites in breast milk from Kwa-Zulu mothers after DDT application for malaria control. Bull World Health Organ 68:761-768.
9. Bouwman H, Kylin H. 2009. Malaria control insecticide residues in breast milk: the need to consider infant health risks. Environ Health Perspect 117:1477-1480.
10. Bouwman H, Sereda B, Meinhardt HM. 2006. Simultaneous presence of DDT and pyrethroid residues in human breast milk from a malaria endemic area in South Africa. Environ Pollut 144:902-917.
11. Burton A. 2009. Toward DDT-free malaria control. Environ Health Perspect 117:A344.
12. Cohn BA, Wolff MS, Cirillo PM, Sholtz RI. 2007. DDT and breast cancer in young women: new data on the significance of age at exposure. Environ Health Perspect 115:1406-1414.
13. Eskenazi B, Chevrier J, Rosas LG, Anderson HA, Bornman MS, Bouwman H, et al. 2009. The Pine River Statement: human health consequences of DDT use. Environ Health Pespect 117:1359-1367.
14. Eskenazi B, Marks AR, Bradman A, Fenster L, Johnson C, Barr DB, et al. 2006. In utero exposure to dichlorodiphenyltrichloroethane (DDT) and dichlorodiphenyldichloroethylene (DDE) and neurodevelopment among young Mexican American children. Pediatrics 118:233-241.
15. Gelbke HP, Hofman A, Owens JW, Freyberger A. 2007. The enhancement of the subacute repeat dose toxicity test OECD TG 407 for the detection of endocrine active chemicals: comparison with tests of longer duration. Arch Toxicol 81:227-250.
16. Grieco JP, Achee NL, Chareonviriyaphap T, Suwonkerd W, Chauhan K, Sardelis MR, et al. 2007. A new classification system for the actions of IRS chemicals traditionally used for malaria control. PloS ONE 2:e716; doi: 10.1371/journal.pone.0000716 [Online 18 August 2007].
17. Kang IH, Kim HS, Shin JH, Kim TS, Moon HJ, et al. 2004. Comparison of anti-androgenic activity of flutamide, vinclozolin, procymidone, linuron, and p,p'-DDE in rodent 10-day Hershberger assay. Toxicology 199:145-159.
18. Karmaus W, Asakevich S, Indurkhya A, Witten J, Kruse H. 2002. Childhood growth and exposure to dichlorodiphenyldichloroethene and polychlorinated biphenyls. J Pediatr 140:33-39.
19. Kelce W, Stone C, Laws S, Gray LE, Kemppainen JA, Wilson EM. 1995. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature 375:581-585.
20. Knipling EF. 1953. Presidential address, sixty-fourth annual meeting, American Association of Economic Entomologists. J Econ Entomol 46:1-7.
21. Leavens TL, Sparrow BR, Devitto MJ. 2002. Lack of antiandrogenic effects in adult male rats following acute exposure to 2,2-bis(4-chlorophenyl)-1,1-dichloroethylene (p,p'-DDE). Toxicology 174:69-78.
22. Lewis K. 2008. DDT stalemate stymies malaria control initiative. CMAJ 179:999-1000.
23. Lioy PJ. 2006. Employing dynamical and chemical processes for contaminant mixtures outdoors to the indoor environment: the implications for total human exposure analysis and prevention. J Expo Sci Environ Epidemiol 16:207-224.
24. Longnecker MP. 2005. Invited commentary: why DDT matters now? Am J Epidemiol 162:726-728.
25. Longnecker MP, Gladen BC, Cupul-Uicab LA, Romano-Riquer SP, Weber JP, Chapin RE, et al. 2007. In utero exposure to the antiandrogen 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in relation to anogenital distance in male newborns from Chiapas, Mexico. Am J Epidemiol 165:1015-1022.
26. Lunder S, Hovander L, Athanassiadis I, Bergman A. 2010. Significantly higher polybrominated diphenylether levels in young U.S. children than in their mothers. Environ Sci Technol 44:5256-5262.
27. Mabaso MLH, Sharp B, Lengeler C. 2004. Historical review of malaria control in southern Africa with an emphasis on the use of indoor residual house-spraying. Trop Med Int Health 9:846-856.
28. Maharaj R, Mthembu DJ, Sharp BL. 2005. Impact of DDT reintroduction on malaria transmission in KwaZulu-Natal. S Afr Med J 95:871-874.
29. Marchand MJ, Pieterse GM, Barnhoorn IEJ. 2008. Preliminary results on sperm motility and testicular histology of two feral species, Oreochromis mossambicus and Clarias gariepinus, from a currently DDT-sprayed area, South Africa. J Appl Ichthyol 24:423-429.
30. Mlambo SS, van Vuren JHJ, Barnhoorn IEJ, Bornman MS. 2009. Histopathological changes in the reproductive system (ovaries and testes) of Oreochromis mossambicus following exposure to DDT. Environ Toxicol Pharmacol 28:133-139.
31. Okonkwo JO, Mutshatshi TN, Botha B, Agyei N. 2008. DDT, DDE and DDD in human milk from South Africa. Bull Environ Contam Toxicol 81:348-354.
32. Ostrea EM, Bielawski DM, Posecion NC, Corrion M, Villanueva-Uy E, Bernardo RC, et al. 2009. Combined analysis of prenatal (maternal hair and blood) and neonatal (infant hair, cord blood, and meconium) matrices to detect fetal exposure to environmental pesticides. Environ Res 109:116-122.
33. Ribas-Fitó N, Torrent M, Carrizo D, Munoz-Ortiz L, Julvez J, Grimalt JO, et al. 2006. In utero exposure to background concentrations of DDT and cognitive functioning among preschoolers. Am J Epidemiol 164:955-962.
34. Roberts D, Laughlin LL, Hsheih P, Legters LJ. 1997. DDT, global strategies, and a malaria control crisis in South America. Emerging Infect Dis 3:295-302.
35. Sadasivaiah S, Tozan Y, Breman JG. 2007. Dichlorodiphenyltrichloroethane (DDT) for indoor residual spraying in Africa: how can it be used for malaria control? Am J Trop Med Hyg 77:249-263.
36. Sapbamrer R, Prapamontol T, Praobvitayakit O, Vaneesorn Y, Mangklabruks A, Hock B. 2008. Placental transfer of DDT in mother infant pairs from northern Thailand. J Environ Sci Health 43:484-489.
37. Sereda B, Bouwman H, Kylin H. 2009. Comparing water, bovine milk, and indoor residual spraying as possible sources of DDT and pyrethroid residues in breast milk. J Toxicol Environ Health A 72:842-851.
38. Shin JH, Moon HJ, Kang IH, Kim TS, Lee SJ, Ahn JY, et al. 2007. OECD validation of the rodent Hershberger assay using three reference chemicals; 17α-methyltestosterone, procymidone, and p,p'-DDE. Arch Toxicol 81:309-318.
39. Steiner A. 2009. Speech by Achim Steiner, UNEP executive director, at fourth meeting of the Conference of the Parties to the Stockholm Convention on Persistent Organic Pollutants 4 -11 May 2009. Geneva. Available: http://www.unep.org/Documents.Multilingual/Default.asp?DocumentID= 588&ArticleID=6149&l=en [accessed 22 February 2010].
40. Stockholm Convention on Persistent Organic Pollutants (POPs). 2010. Overview. Dichloro-diphenyl-trichloroethane (DDT). Available: http://chm.pops.int/Programmes/DDT/Overview/tabid/378/language/en-US/Default.aspx [accessed 23 February 2010].
41. Tren R, Bate R. 2001. Malaria and the DDT story. London:Institute of Economic Affairs.
42. Tren R, Roberts D. 2010. DDT and malaria prevention. Environ Health Perspect 118:A14-A15.
43. van den Berg H. 2009. Global status of DDT and its alternatives for use in vector control to prevent disease. Environ Health Perspect 117:1656-1663.
44. van Dyk JC, Bouwman H, Barnhoorn IEJ, Bornman MS. 2010. DDT contamination from indoor residual spraying for malaria control. Sci Total Environ 408:2745-2752.
45. WHO. 1979. DDT and Its Derivatives. Environmental Health Criteria 9. Geneva:World Health Organization.
46. WHO. 2000. Manual for indoor residual spraying. Geneva:World Health Organization.
47. WHO (World Health Organization). 2010. WHO Pesticide Evaluation Scheme. 50 years of Global Leadership. Available: http://www.who.int/whopes/en/ [accessed 17 November 2010].