메뉴 건너뛰기




Volumn 105, Issue 12, 2013, Pages 2629-2640

Analytic approaches to stochastic gene expression in multicellular systems

Author keywords

[No Author keywords available]

Indexed keywords

ANIMAL; GENE EXPRESSION REGULATION; GENETIC TRANSCRIPTION; REVIEW; STATISTICS; THEORETICAL MODEL;

EID: 84890756547     PISSN: 00063495     EISSN: 15420086     Source Type: Journal    
DOI: 10.1016/j.bpj.2013.10.033     Document Type: Review
Times cited : (16)

References (74)
  • 1
    • 84865812140 scopus 로고    scopus 로고
    • Genomics. ENCODE project writes eulogy for junk DNA
    • E. Pennisi Genomics. ENCODE project writes eulogy for junk DNA Science 337 2012 1159 1161
    • (2012) Science , vol.337 , pp. 1159-1161
    • Pennisi, E.1
  • 2
    • 46249121558 scopus 로고    scopus 로고
    • Quantitative approaches to the study of bistability in the lac operon of Escherichia coli
    • M. Santillán, and M.C. Mackey Quantitative approaches to the study of bistability in the lac operon of Escherichia coli J. R. Soc. Interface 5 2008 S29 S39
    • (2008) J. R. Soc. Interface , vol.5
    • Santillán, M.1    Mackey, M.C.2
  • 3
    • 84879218169 scopus 로고    scopus 로고
    • Systems biophysics of gene expression
    • J.M.G. Vilar, and L. Saiz Systems biophysics of gene expression Biophys. J. 104 2013 2574 2585
    • (2013) Biophys. J. , vol.104 , pp. 2574-2585
    • Vilar, J.M.G.1    Saiz, L.2
  • 4
    • 7444241154 scopus 로고    scopus 로고
    • 3rd Ed. Cold Spring Harbor Laboratory Press New York
    • M. Ptashne A Genetic Switch 3rd Ed. 2004 Cold Spring Harbor Laboratory Press New York
    • (2004) A Genetic Switch
    • Ptashne, M.1
  • 5
    • 1442354192 scopus 로고    scopus 로고
    • Multistability in the lactose utilization network of Escherichia coli
    • E.M. Ozbudak, and M. Thattai A. van Oudenaarden Multistability in the lactose utilization network of Escherichia coli Nature 427 2004 737 740
    • (2004) Nature , vol.427 , pp. 737-740
    • Ozbudak, E.M.1    Thattai, M.2    Van Oudenaarden, A.3
  • 6
    • 84865249952 scopus 로고    scopus 로고
    • Transcription factors: From enhancer binding to developmental control
    • F. Spitz, and E.E.M. Furlong Transcription factors: from enhancer binding to developmental control Nat. Rev. Genet. 13 2012 613 626
    • (2012) Nat. Rev. Genet. , vol.13 , pp. 613-626
    • Spitz, F.1    Furlong, E.E.M.2
  • 7
    • 77956495708 scopus 로고    scopus 로고
    • Transcriptional enhancers in animal development and evolution
    • M. Levine Transcriptional enhancers in animal development and evolution Curr. Biol. 20 2010 R754 R763
    • (2010) Curr. Biol. , vol.20
    • Levine, M.1
  • 8
    • 79956064734 scopus 로고    scopus 로고
    • Chromatin: Constructing the big picture
    • B. van Steensel Chromatin: constructing the big picture EMBO J. 30 2011 1885 1895
    • (2011) EMBO J. , vol.30 , pp. 1885-1895
    • Van Steensel, B.1
  • 9
    • 78751590899 scopus 로고    scopus 로고
    • Silencing chromatin: Comparing modes and mechanisms
    • C. Beisel, and R. Paro Silencing chromatin: comparing modes and mechanisms Nat. Rev. Genet. 12 2011 123 135
    • (2011) Nat. Rev. Genet. , vol.12 , pp. 123-135
    • Beisel, C.1    Paro, R.2
  • 10
    • 79958252915 scopus 로고    scopus 로고
    • Chromatin connections to pluripotency and cellular reprogramming
    • S.H. Orkin, and K. Hochedlinger Chromatin connections to pluripotency and cellular reprogramming Cell 145 2011 835 850
    • (2011) Cell , vol.145 , pp. 835-850
    • Orkin, S.H.1    Hochedlinger, K.2
  • 11
    • 0033582718 scopus 로고    scopus 로고
    • A mathematical model for synergistic eukaryotic gene activation
    • J. Wang, and K. Ellwood Z.S. She A mathematical model for synergistic eukaryotic gene activation J. Mol. Biol. 286 1999 315 325
    • (1999) J. Mol. Biol. , vol.286 , pp. 315-325
    • Wang, J.1    Ellwood, K.2    She, Z.S.3
  • 12
    • 0036901602 scopus 로고    scopus 로고
    • Modeling transcriptional regulatory networks
    • H. Bolouri, and E.H. Davidson Modeling transcriptional regulatory networks Bioessays 24 2002 1118 1129
    • (2002) Bioessays , vol.24 , pp. 1118-1129
    • Bolouri, H.1    Davidson, E.H.2
  • 13
    • 0042424655 scopus 로고    scopus 로고
    • Transcriptional regulatory cascades in development: Initial rates, not steady state, determine network kinetics
    • H. Bolouri, and E.H. Davidson Transcriptional regulatory cascades in development: initial rates, not steady state, determine network kinetics Proc. Natl. Acad. Sci. USA 100 2003 9371 9376
    • (2003) Proc. Natl. Acad. Sci. USA , vol.100 , pp. 9371-9376
    • Bolouri, H.1    Davidson, E.H.2
  • 14
    • 33745658106 scopus 로고    scopus 로고
    • Computational models for neurogenic gene expression in the Drosophila embryo
    • R.P. Zinzen, and K. Senger D. Papatsenko Computational models for neurogenic gene expression in the Drosophila embryo Curr. Biol. 16 2006 1358 1365
    • (2006) Curr. Biol. , vol.16 , pp. 1358-1365
    • Zinzen, R.P.1    Senger, K.2    Papatsenko, D.3
  • 15
    • 34249722123 scopus 로고    scopus 로고
    • Enhancer responses to similarly distributed antagonistic gradients in development
    • R.P. Zinzen, and D. Papatsenko Enhancer responses to similarly distributed antagonistic gradients in development PLOS Comput. Biol. 3 2007 e84
    • (2007) PLOS Comput. Biol. , vol.3 , pp. 84
    • Zinzen, R.P.1    Papatsenko, D.2
  • 17
    • 38749127589 scopus 로고    scopus 로고
    • Predicting expression patterns from regulatory sequence in Drosophila segmentation
    • E. Segal, and T. Raveh-Sadka U. Gaul Predicting expression patterns from regulatory sequence in Drosophila segmentation Nature 451 2008 535 540
    • (2008) Nature , vol.451 , pp. 535-540
    • Segal, E.1    Raveh-Sadka, T.2    Gaul, U.3
  • 18
    • 58149120776 scopus 로고    scopus 로고
    • Modeling the dynamics of transcriptional gene regulatory networks for animal development
    • S. Ben-Tabou de-Leon, and E.H. Davidson Modeling the dynamics of transcriptional gene regulatory networks for animal development Dev. Biol. 325 2009 317 328
    • (2009) Dev. Biol. , vol.325 , pp. 317-328
    • Ben-Tabou De-Leon, S.1    Davidson, E.H.2
  • 19
    • 65949084005 scopus 로고    scopus 로고
    • Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation
    • S. Manu, and Surkova J. Reinitz Canalization of gene expression in the Drosophila blastoderm by gap gene cross regulation PLoS Biol. 7 2009 e1000049
    • (2009) PLoS Biol. , vol.7 , pp. 1000049
    • Manu, S.1    Reinitz, S.J.2
  • 20
    • 78049450019 scopus 로고    scopus 로고
    • Thermodynamics-based models of transcriptional regulation by enhancers: The roles of synergistic activation, cooperative binding and short-range repression
    • X. He, and M.A.H. Samee S. Sinha Thermodynamics-based models of transcriptional regulation by enhancers: the roles of synergistic activation, cooperative binding and short-range repression PLOS Comput. Biol. 6 2010 e1000935
    • (2010) PLOS Comput. Biol. , vol.6 , pp. 1000935
    • He, X.1    Samee, M.A.H.2    Sinha, S.3
  • 21
    • 0025127307 scopus 로고
    • The dose dependence of 95 glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates
    • M.S.H. Ko, H. Nakauchi, and N. Takahashi The dose dependence of 95 glucocorticoid-inducible gene expression results from changes in the number of transcriptionally active templates EMBO J 9 1990 2835 2842
    • (1990) EMBO J , vol.9 , pp. 2835-2842
    • Ko, M.S.H.1    Nakauchi, H.2    Takahashi, N.3
  • 22
    • 0032496358 scopus 로고    scopus 로고
    • The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes
    • J.E. Ferrell Jr., and E.M. Machleder The biochemical basis of an all-or-none cell fate switch in Xenopus oocytes Science 280 1998 895 898
    • (1998) Science , vol.280 , pp. 895-898
    • Ferrell, Jr.J.E.1    Machleder, E.M.2
  • 23
    • 0026045994 scopus 로고
    • The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos
    • J. Jiang, and D. Kosman M. Levine The dorsal morphogen gradient regulates the mesoderm determinant twist in early Drosophila embryos Genes Dev. 5 1991 1881 1891
    • (1991) Genes Dev. , vol.5 , pp. 1881-1891
    • Jiang, J.1    Kosman, D.2    Levine, M.3
  • 24
    • 0026654687 scopus 로고
    • Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo
    • J. Jiang, and C.A. Rushlow M. Levine Individual dorsal morphogen binding sites mediate activation and repression in the Drosophila embryo EMBO J. 11 1992 3147 3154
    • (1992) EMBO J. , vol.11 , pp. 3147-3154
    • Jiang, J.1    Rushlow, C.A.2    Levine, M.3
  • 25
    • 0026728302 scopus 로고
    • The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo
    • Y.T. Ip, and R.E. Park M. Levine The dorsal gradient morphogen regulates stripes of rhomboid expression in the presumptive neuroectoderm of the Drosophila embryo Genes Dev. 6 1992 1728 1739
    • (1992) Genes Dev. , vol.6 , pp. 1728-1739
    • Ip, Y.T.1    Park, R.E.2    Levine, M.3
  • 26
    • 0027511507 scopus 로고
    • Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen
    • J. Jiang, and M. Levine Binding affinities and cooperative interactions with bHLH activators delimit threshold responses to the dorsal gradient morphogen Cell 72 1993 741 752
    • (1993) Cell , vol.72 , pp. 741-752
    • Jiang, J.1    Levine, M.2
  • 28
    • 3843139305 scopus 로고    scopus 로고
    • Multiplex detection of RNA expression in Drosophila embryos
    • D. Kosman, and C.M. Mizutani E. Bier Multiplex detection of RNA expression in Drosophila embryos Science 305 2004 846
    • (2004) Science , vol.305 , pp. 846
    • Kosman, D.1    Mizutani, C.M.2    Bier, E.3
  • 29
    • 67749106610 scopus 로고    scopus 로고
    • Synchronous and stochastic patterns of gene activation in the Drosophila embryo
    • A.N. Boettiger, and M. Levine Synchronous and stochastic patterns of gene activation in the Drosophila embryo Science 325 2009 471 473
    • (2009) Science , vol.325 , pp. 471-473
    • Boettiger, A.N.1    Levine, M.2
  • 30
    • 77956521381 scopus 로고    scopus 로고
    • Shadow enhancers foster robustness of Drosophila gastrulation
    • M.W. Perry, and A.N. Boettiger M. Levine Shadow enhancers foster robustness of Drosophila gastrulation Curr. Biol. 20 2010 1562 1567
    • (2010) Curr. Biol. , vol.20 , pp. 1562-1567
    • Perry, M.W.1    Boettiger, A.N.2    Levine, M.3
  • 31
    • 77955764031 scopus 로고    scopus 로고
    • The time to measure positional information: Maternal hunchback is required for the synchrony of the Bicoid transcriptional response at the onset of zygotic transcription
    • A. Porcher, and A. Abu-Arish N. Dostatni The time to measure positional information: maternal hunchback is required for the synchrony of the Bicoid transcriptional response at the onset of zygotic transcription Development 137 2010 2795 2804
    • (2010) Development , vol.137 , pp. 2795-2804
    • Porcher, A.1    Abu-Arish, A.2    Dostatni, N.3
  • 32
    • 80052007879 scopus 로고    scopus 로고
    • Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo
    • M.W. Perry, A.N. Boettiger, and M. Levine Multiple enhancers ensure precision of gap gene-expression patterns in the Drosophila embryo Proc. Natl. Acad. Sci. USA 108 2011 13570 13575
    • (2011) Proc. Natl. Acad. Sci. USA , vol.108 , pp. 13570-13575
    • Perry, M.W.1    Boettiger, A.N.2    Levine, M.3
  • 33
    • 80055074510 scopus 로고    scopus 로고
    • Temporal coordination of gene networks by Zelda in the early Drosophila embryo
    • C.-Y. Nien, and H.-L. Liang C. Rushlow Temporal coordination of gene networks by Zelda in the early Drosophila embryo PLoS Genet. 7 2011 e1002339
    • (2011) PLoS Genet. , vol.7 , pp. 1002339
    • Nien, C.-Y.1    Liang, H.-L.2    Rushlow, C.3
  • 34
    • 79955537506 scopus 로고    scopus 로고
    • A multiscale investigation of bicoid-dependent transcriptional events in Drosophila embryos
    • F. He, and J. Ren J. Ma A multiscale investigation of bicoid-dependent transcriptional events in Drosophila embryos PLoS ONE 6 2011 e19122
    • (2011) PLoS ONE , vol.6 , pp. 19122
    • He, F.1    Ren, J.2    Ma, J.3
  • 35
    • 33748994704 scopus 로고    scopus 로고
    • Stochastic mRNA synthesis in mammalian cells
    • A. Raj, and C.S. Peskin S. Tyagi Stochastic mRNA synthesis in mammalian cells PLoS Biol. 4 2006 e309
    • (2006) PLoS Biol. , vol.4 , pp. 309
    • Raj, A.1    Peskin, C.S.2    Tyagi, S.3
  • 36
    • 53349161901 scopus 로고    scopus 로고
    • Imaging individual mRNA molecules using multiple singly labeled probes
    • A. Raj, and P. van den Bogaard S. Tyagi Imaging individual mRNA molecules using multiple singly labeled probes Nat. Methods 5 2008 877 879
    • (2008) Nat. Methods , vol.5 , pp. 877-879
    • Raj, A.1    Van Den Bogaard, P.2    Tyagi, S.3
  • 37
    • 71649113974 scopus 로고    scopus 로고
    • Visualization of individual Scr mRNAs during Drosophila embryogenesis yields evidence for transcriptional bursting
    • A. Paré, and D. Lemons W. McGinnis Visualization of individual Scr mRNAs during Drosophila embryogenesis yields evidence for transcriptional bursting Curr. Biol. 19 2009 2037 2042
    • (2009) Curr. Biol. , vol.19 , pp. 2037-2042
    • Paré, A.1    Lemons, D.2    McGinnis, W.3
  • 38
    • 77249114260 scopus 로고    scopus 로고
    • Variability in gene expression underlies incomplete penetrance
    • A. Raj, and S.A. Rifkin A. van Oudenaarden Variability in gene expression underlies incomplete penetrance Nature 463 2010 913 918
    • (2010) Nature , vol.463 , pp. 913-918
    • Raj, A.1    Rifkin, S.A.2    Van Oudenaarden, A.3
  • 39
    • 57149101122 scopus 로고    scopus 로고
    • Single-RNA counting reveals alternative modes of gene expression in yeast
    • D. Zenklusen, D.R. Larson, and R.H. Singer Single-RNA counting reveals alternative modes of gene expression in yeast Nat. Struct. Mol. Biol. 15 2008 1263 1271
    • (2008) Nat. Struct. Mol. Biol. , vol.15 , pp. 1263-1271
    • Zenklusen, D.1    Larson, D.R.2    Singer, R.H.3
  • 40
    • 77951101695 scopus 로고    scopus 로고
    • Transcript counting in single cells reveals dynamics of rDNA transcription
    • R.Z. Tan, and A. van Oudenaarden Transcript counting in single cells reveals dynamics of rDNA transcription Mol. Syst. Biol. 6 2010 358
    • (2010) Mol. Syst. Biol. , vol.6 , pp. 358
    • Tan, R.Z.1    Van Oudenaarden, A.2
  • 41
    • 84355162740 scopus 로고    scopus 로고
    • Single-molecule transcript counting of stem-cell markers in the mouse intestine
    • S. Itzkovitz, and A. Lyubimova A. van Oudenaarden Single-molecule transcript counting of stem-cell markers in the mouse intestine Nat. Cell Biol. 14 2012 106 114
    • (2012) Nat. Cell Biol. , vol.14 , pp. 106-114
    • Itzkovitz, S.1    Lyubimova, A.2    Van Oudenaarden, A.3
  • 42
    • 84873115462 scopus 로고    scopus 로고
    • Rapid transcription fosters coordinate snail expression in the Drosophila embryo
    • A.N. Boettiger, and M. Levine Rapid transcription fosters coordinate snail expression in the Drosophila embryo Cell Rep 3 2013 8 15
    • (2013) Cell Rep , vol.3 , pp. 8-15
    • Boettiger, A.N.1    Levine, M.2
  • 43
    • 84873801555 scopus 로고    scopus 로고
    • Systematic identification of signal-activated stochastic gene regulation
    • G. Neuert, and B. Munsky A. van Oudenaarden Systematic identification of signal-activated stochastic gene regulation Science 339 2013 584 587
    • (2013) Science , vol.339 , pp. 584-587
    • Neuert, G.1    Munsky, B.2    Van Oudenaarden, A.3
  • 44
    • 84878318299 scopus 로고    scopus 로고
    • Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo
    • M. Lagha, and J.P. Bothma M.S. Levine Paused Pol II coordinates tissue morphogenesis in the Drosophila embryo Cell 153 2013 976 987
    • (2013) Cell , vol.153 , pp. 976-987
    • Lagha, M.1    Bothma, J.P.2    Levine, M.S.3
  • 45
    • 84855804140 scopus 로고    scopus 로고
    • Shadow enhancers: Frequently asked questions about distributed cis-regulatory information and enhancer redundancy
    • S. Barolo Shadow enhancers: frequently asked questions about distributed cis-regulatory information and enhancer redundancy Bioessays 34 2012 135 141
    • (2012) Bioessays , vol.34 , pp. 135-141
    • Barolo, S.1
  • 46
    • 77954960062 scopus 로고    scopus 로고
    • Phenotypic robustness conferred by apparently redundant transcriptional enhancers
    • N. Frankel, and G.K. Davis D.L. Stern Phenotypic robustness conferred by apparently redundant transcriptional enhancers Nature 466 2010 490 493
    • (2010) Nature , vol.466 , pp. 490-493
    • Frankel, N.1    Davis, G.K.2    Stern, D.L.3
  • 47
    • 33644856456 scopus 로고    scopus 로고
    • Stochastic spineless expression creates the retinal mosaic for color vision
    • M.F. Wernet, and E.O. Mazzoni C. Desplan Stochastic spineless expression creates the retinal mosaic for color vision Nature 440 2006 174 180
    • (2006) Nature , vol.440 , pp. 174-180
    • Wernet, M.F.1    Mazzoni, E.O.2    Desplan, C.3
  • 48
    • 41749107942 scopus 로고    scopus 로고
    • Stochasticity and cell fate
    • R. Losick, and C. Desplan Stochasticity and cell fate Science 320 2008 65 68
    • (2008) Science , vol.320 , pp. 65-68
    • Losick, R.1    Desplan, C.2
  • 49
    • 1342306698 scopus 로고    scopus 로고
    • Odorant receptor gene choice in olfactory sensory neurons: The one receptor-one neuron hypothesis revisited
    • P. Mombaerts Odorant receptor gene choice in olfactory sensory neurons: the one receptor-one neuron hypothesis revisited Curr. Opin. Neurobiol. 14 2004 31 36
    • (2004) Curr. Opin. Neurobiol. , vol.14 , pp. 31-36
    • Mombaerts, P.1
  • 50
    • 81055125638 scopus 로고    scopus 로고
    • Regulation of the probability of mouse odorant receptor gene choice
    • M. Khan, E. Vaes, and P. Mombaerts Regulation of the probability of mouse odorant receptor gene choice Cell 147 2011 907 921
    • (2011) Cell , vol.147 , pp. 907-921
    • Khan, M.1    Vaes, E.2    Mombaerts, P.3
  • 51
    • 0004117869 scopus 로고    scopus 로고
    • Essentials of stochastic processes
    • Springer New York
    • R. Durrett Essentials of stochastic processes Springer Texts in Statistics 2012 Springer New York
    • (2012) Springer Texts in Statistics
    • Durrett, R.1
  • 53
    • 0036111831 scopus 로고    scopus 로고
    • Attenuation of noise in ultrasensitive signaling cascades
    • M. Thattai, and A. van Oudenaarden Attenuation of noise in ultrasensitive signaling cascades Biophys. J. 82 2002 2943 2950
    • (2002) Biophys. J. , vol.82 , pp. 2943-2950
    • Thattai, M.1    Van Oudenaarden, A.2
  • 54
    • 15544388848 scopus 로고    scopus 로고
    • Noise propagation in gene networks
    • J.M. Pedraza, and A. van Oudenaarden Noise propagation in gene networks Science 307 2005 1965 1969
    • (2005) Science , vol.307 , pp. 1965-1969
    • Pedraza, J.M.1    Van Oudenaarden, A.2
  • 55
    • 50449099063 scopus 로고    scopus 로고
    • The role of input noise in transcriptional regulation
    • G. Tkacik, T. Gregor, and W. Bialek The role of input noise in transcriptional regulation PLoS ONE 3 2008 e2774
    • (2008) PLoS ONE , vol.3 , pp. 2774
    • Tkacik, G.1    Gregor, T.2    Bialek, W.3
  • 56
    • 0242490781 scopus 로고    scopus 로고
    • Fast evaluation of fluctuations in biochemical networks with the linear noise approximation
    • J. Elf, and M. Ehrenberg Fast evaluation of fluctuations in biochemical networks with the linear noise approximation Genome Res. 13 2003 2475 2484
    • (2003) Genome Res. , vol.13 , pp. 2475-2484
    • Elf, J.1    Ehrenberg, M.2
  • 57
    • 0842285841 scopus 로고    scopus 로고
    • Summing up the noise in gene networks
    • J. Paulsson Summing up the noise in gene networks Nature 427 2004 415 418
    • (2004) Nature , vol.427 , pp. 415-418
    • Paulsson, J.1
  • 58
    • 33749842033 scopus 로고    scopus 로고
    • Deviant effects in molecular reaction pathways
    • M.S. Samoilov, and A.P. Arkin Deviant effects in molecular reaction pathways Nat. Biotechnol. 24 2006 1235 1240
    • (2006) Nat. Biotechnol. , vol.24 , pp. 1235-1240
    • Samoilov, M.S.1    Arkin, A.P.2
  • 59
    • 34147131574 scopus 로고    scopus 로고
    • From fluctuations to phenotypes: The physiology of noise
    • M.S. Samoilov, G. Price, and A.P. Arkin From fluctuations to phenotypes: the physiology of noise Sci. STKE 2006 2006 re17
    • (2006) Sci. STKE , vol.2006 , pp. 17
    • Samoilov, M.S.1    Price, G.2    Arkin, A.P.3
  • 61
    • 0000111447 scopus 로고
    • Markovian modeling of gene-product synthesis
    • J. Peccoud, and B. Ycart Markovian modeling of gene-product synthesis Theor. Popul. Biol. 48 1995 222 234
    • (1995) Theor. Popul. Biol. , vol.48 , pp. 222-234
    • Peccoud, J.1    Ycart, B.2
  • 62
    • 42449140138 scopus 로고    scopus 로고
    • Transcriptional control of noise in gene expression
    • A. Sánchez, and J. Kondev Transcriptional control of noise in gene expression Proc. Natl. Acad. Sci. USA 105 2008 5081 5086
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 5081-5086
    • Sánchez, A.1    Kondev, J.2
  • 63
    • 79953661480 scopus 로고    scopus 로고
    • Effect of promoter architecture on the cell-to-cell variability in gene expression
    • A. Sánchez, and H.G. Garcia J. Kondev Effect of promoter architecture on the cell-to-cell variability in gene expression PLOS Comput. Biol. 7 2011 e1001100
    • (2011) PLOS Comput. Biol. , vol.7 , pp. 1001100
    • Sánchez, A.1    Garcia, H.G.2    Kondev, J.3
  • 64
    • 79958078747 scopus 로고    scopus 로고
    • Transcriptional regulation: Effects of promoter proximal pausing on speed, synchrony and reliability
    • A.N. Boettiger, P.L. Ralph, and S.N. Evans Transcriptional regulation: effects of promoter proximal pausing on speed, synchrony and reliability PLOS Comput. Biol. 7 2011 e1001136
    • (2011) PLOS Comput. Biol. , vol.7 , pp. 1001136
    • Boettiger, A.N.1    Ralph, P.L.2    Evans, S.N.3
  • 65
    • 0034667792 scopus 로고    scopus 로고
    • Orchestrated response: A symphony of transcription factors for gene control
    • B. Lemon, and R. Tijan Orchestrated response: a symphony of transcription factors for gene control Genes Dev. 14 2000 2551 2569
    • (2000) Genes Dev. , vol.14 , pp. 2551-2569
    • Lemon, B.1    Tijan, R.2
  • 66
    • 38349185928 scopus 로고    scopus 로고
    • Effects of molecular memory and bursting on fluctuations in gene expression
    • J.M. Pedraza, and J. Paulsson Effects of molecular memory and bursting on fluctuations in gene expression Science 319 2008 339 343
    • (2008) Science , vol.319 , pp. 339-343
    • Pedraza, J.M.1    Paulsson, J.2
  • 67
    • 75449108347 scopus 로고    scopus 로고
    • The simplicity of completion time distributions for common complex biochemical processes
    • G. Bel, B. Munsky, and I. Nemenman The simplicity of completion time distributions for common complex biochemical processes Phys. Biol. 7 2010 016003
    • (2010) Phys. Biol. , vol.7 , pp. 016003
    • Bel, G.1    Munsky, B.2    Nemenman, I.3
  • 68
    • 77949523739 scopus 로고    scopus 로고
    • On the spontaneous stochastic dynamics of a single gene: Complexity of the molecular interplay at the promoter
    • A. Coulon, O. Gandrillon, and G. Beslon On the spontaneous stochastic dynamics of a single gene: complexity of the molecular interplay at the promoter BMC Syst. Biol. 4 2010 2
    • (2010) BMC Syst. Biol. , vol.4 , pp. 2
    • Coulon, A.1    Gandrillon, O.2    Beslon, G.3
  • 70
    • 0000825747 scopus 로고
    • The least variable phase type distribution is Erlang
    • D. Aldous, and L. Shepp The least variable phase type distribution is Erlang Commun. Statist. Stoch. Models. 3 1987 467 473
    • (1987) Commun. Statist. Stoch. Models. , vol.3 , pp. 467-473
    • Aldous, D.1    Shepp, L.2
  • 71
    • 58749087869 scopus 로고    scopus 로고
    • Intersubunit coordination in a homomeric ring ATPase
    • J.R. Moffitt, and Y.R. Chemla C. Bustamante Intersubunit coordination in a homomeric ring ATPase Nature 457 2009 446 450
    • (2009) Nature , vol.457 , pp. 446-450
    • Moffitt, J.R.1    Chemla, Y.R.2    Bustamante, C.3
  • 73
    • 77957689590 scopus 로고    scopus 로고
    • Mechanistic constraints from the substrate concentration dependence of enzymatic fluctuations
    • J.R. Moffitt, Y.R. Chemla, and C. Bustamante Mechanistic constraints from the substrate concentration dependence of enzymatic fluctuations Proc. Natl. Acad. Sci. USA 107 2010 15739 15744
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 15739-15744
    • Moffitt, J.R.1    Chemla, Y.R.2    Bustamante, C.3
  • 74
    • 36549013619 scopus 로고    scopus 로고
    • RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo
    • J. Zeitlinger, and A. Stark R.A. Young RNA polymerase stalling at developmental control genes in the Drosophila melanogaster embryo Nat. Genet. 39 2007 1512 1516
    • (2007) Nat. Genet. , vol.39 , pp. 1512-1516
    • Zeitlinger, J.1    Stark, A.2    Young, R.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.